Barbara Gatto Department of Pharmaceutical and Pharmacological Sciences University of Padova Biography Publications Institution JoVE Articles Barbara Gatto has not added a biography. If you are Barbara Gatto and would like to personalize this page please email our Author Liaison for assistance. Publications Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties Viruses. Sep, 2022 | Pubmed ID: 36298688 Decoding Mechanism of Action and Sensitivity to Drug Candidates from Integrated Transcriptome and Chromatin State ELife. Aug, 2022 | Pubmed ID: 36043458 Computationally Driven Discovery of SARS-CoV-2 M Inhibitors: from Design to Experimental Validation Chemical Science. Mar, 2022 | Pubmed ID: 35432906 In Vitro Evaluation of Bis-3-Chloropiperidines As RNA Modulators Targeting TAR and TAR-Protein Interaction International Journal of Molecular Sciences. Jan, 2022 | Pubmed ID: 35054766 B-CePs As Cross-linking Probes for the Investigation of RNA Higher-order Structure Nucleic Acids Research. Jul, 2021 | Pubmed ID: 34125908 Bis-3-Chloropiperidines Targeting TAR RNA As A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein Molecules (Basel, Switzerland). Mar, 2021 | Pubmed ID: 33810333 Appended Aromatic Moieties in Flexible Bis-3-chloropiperidines Confer Tropism Against Pancreatic Cancer Cells ChemMedChem. Mar, 2021 | Pubmed ID: 33200541 Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells ChemMedChem. Nov, 2020 | Pubmed ID: 32744774 Multiple Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA ACS Medicinal Chemistry Letters. May, 2020 | Pubmed ID: 32435410 Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines As Potential Anticancer Agents ACS Medicinal Chemistry Letters. Apr, 2019 | Pubmed ID: 30996795 Identification of Novel 2-benzoxazolinone Derivatives with Specific Inhibitory Activity Against the HIV-1 Nucleocapsid Protein European Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29324338 Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G ChemMedChem. Sep, 2017 | Pubmed ID: 28724198 Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA Chemical Research in Toxicology. Feb, 2017 | Pubmed ID: 28068470 Synthesis and Evaluation of a Bis-3-chloropiperidine Derivative Incorporating an Anthraquinone Pharmacophore Bioorganic & Medicinal Chemistry Letters. Oct, 2015 | Pubmed ID: 26342869 Bis-3-chloropiperidines Containing Bridging Lysine Linkers: Influence of Side Chain Structure on DNA Alkylating Activity Bioorganic & Medicinal Chemistry. Mar, 2015 | Pubmed ID: 25693786 Synthesis and DNA Cleavage Activity of Bis-3-chloropiperidines As Alkylating Agents ChemMedChem. Sep, 2014 | Pubmed ID: 24616300 Enzymatic Formation of PEGylated Oligonucleotides Bioconjugate Chemistry. Feb, 2014 | Pubmed ID: 24450424 Development of a Multiplex Sandwich Aptamer Microarray for the Detection of VEGF165 and Thrombin Sensors (Basel, Switzerland). 2013 | Pubmed ID: 24097233 Development and Optimization of a Thrombin Sandwich Aptamer Microarray Microarrays (Basel, Switzerland). Aug, 2012 | Pubmed ID: 27605338 Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: an in Vitro Study Journal of Agricultural and Food Chemistry. Sep, 2012 | Pubmed ID: 22924519 Human Thrombin Detection Through a Sandwich Aptamer Microarray: Interaction Analysis in Solution and in Solid Phase Sensors (Basel, Switzerland). 2011 | Pubmed ID: 22163703 The Evolving World of Protein-G-quadruplex Recognition: a Medicinal Chemist's Perspective Biochimie. Aug, 2011 | Pubmed ID: 21549174 Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-vinyl Derivatives ChemMedChem. Nov, 2010 | Pubmed ID: 20928882 Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-selective Peptidyl Congeners of Ametantrone ChemMedChem. Jul, 2010 | Pubmed ID: 20458714 The 6-aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-early 2 Protein Antimicrobial Agents and Chemotherapy. May, 2010 | Pubmed ID: 20194695 Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor Journal of Medicinal Chemistry. May, 2009 | Pubmed ID: 19388645 2-Phenylquinolones As Inhibitors of the HIV-1 Tat-TAR Interaction ChemMedChem. Jun, 2009 | Pubmed ID: 19283692 Synthesis and Biological Evaluation of 2-phenylquinolones Targeted at Tat/TAR Recognition Bioorganic & Medicinal Chemistry Letters. Feb, 2009 | Pubmed ID: 19109014 Effective DNA Inhibitors of Cathepsin G by in Vitro Selection International Journal of Molecular Sciences. Jun, 2008 | Pubmed ID: 19325843 Atacicept, a Homodimeric Fusion Protein for the Potential Treatment of Diseases Triggered by Plasma Cells Current Opinion in Investigational Drugs (London, England : 2000). Nov, 2008 | Pubmed ID: 18951301 Perylene Side Chains Modulate G-quadruplex Conformation in Biologically Relevant DNA Sequences Bioorganic & Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18819816 From Proteins to Nucleic Acid-based Drugs: the Role of Biotech in Anti-VEGF Therapy Anti-cancer Agents in Medicinal Chemistry. Jul, 2006 | Pubmed ID: 16842232 Biologics Targeted at TNF: Design, Production and Challenges Reumatismo. 2006 | Pubmed ID: 16829986 Clerocidin Interacts with the Cleavage Complex of Streptococcus Pneumoniae Topoisomerase IV to Induce Selective Irreversible DNA Damage Nucleic Acids Research. 2006 | Pubmed ID: 16614448 Antiviral 6-amino-quinolones: Molecular Basis for Potency and Selectivity Bioorganic & Medicinal Chemistry Letters. Oct, 2005 | Pubmed ID: 16054362 Monoclonal Antibodies in Cancer Therapy Current Medicinal Chemistry. Anti-cancer Agents. Sep, 2004 | Pubmed ID: 15379694 Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-activation-responsive Region Interaction by an Antiviral Quinolone Derivative Antimicrobial Agents and Chemotherapy. May, 2004 | Pubmed ID: 15105155 Effects of Common Buffer Systems on Drug Activity: the Case of Clerocidin Chemical Research in Toxicology. Apr, 2004 | Pubmed ID: 15089091 Clerocidin Alkylates DNA Through Its Epoxide Function: Evidence for a Fine Tuned Mechanism of Action Nucleic Acids Research. Sep, 2003 | Pubmed ID: 12930966 Involvement of P53 in Specific Anti-neuroectodermal Tumor Activity of Aloe-emodin International Journal of Cancer. Journal International Du Cancer. Oct, 2003 | Pubmed ID: 12918060 Design, Synthesis, and Biological Properties of New Bis(acridine-4-carboxamides) As Anticancer Agents Journal of Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12825949 Drugs Acting on the Beta Isoform of Human Topoisomerase II (p180) Current Medicinal Chemistry. Anti-cancer Agents. May, 2003 | Pubmed ID: 12769776 New Anti-human Immunodeficiency Virus Type 1 6-aminoquinolones: Mechanism of Action Antimicrobial Agents and Chemotherapy. Mar, 2003 | Pubmed ID: 12604517 Sequence-specific Interactions of Drugs Interfering with the Topoisomerase-DNA Cleavage Complex Biochimica Et Biophysica Acta. Jul, 2002 | Pubmed ID: 12084456 2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-binding Agents Journal of Medicinal Chemistry. Jan, 2002 | Pubmed ID: 11806721 The Topoisomerase II Poison Clerocidin Alkylates Non-paired Guanines of DNA: Implications for Irreversible Stimulation of DNA Cleavage Nucleic Acids Research. Oct, 2001 | Pubmed ID: 11600711 Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping (Video) | JoVE Alice Sosic1, Cristina Dal Lago1, Richard Göttlich2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Institute of Organic Chemistry, Justus Liebig University Giessen JoVE 65373 Biochemistry Nucleocapsid Annealing-medieret Electrophoresis (NAME) Indhold Tillader hurtig identifikation af HIV-1 nucleocapsid inhibitorer Alice Sosic1, Marta Cappellini1, Matteo Scalabrin2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2The RNA Institute, SUNY Albany Immunology and Infection
Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping (Video) | JoVE Alice Sosic1, Cristina Dal Lago1, Richard Göttlich2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Institute of Organic Chemistry, Justus Liebig University Giessen JoVE 65373 Biochemistry
Nucleocapsid Annealing-medieret Electrophoresis (NAME) Indhold Tillader hurtig identifikation af HIV-1 nucleocapsid inhibitorer Alice Sosic1, Marta Cappellini1, Matteo Scalabrin2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2The RNA Institute, SUNY Albany Immunology and Infection