Barbara Rothen-Rutishauser Adolphe Merkle Institute University of Fribourg, Switzerland Biography Publications Institution JoVE Articles Barbara Rothen-Rutishauser Prof. Dr. Barbara Rothen-Rutishauser has received her Ph.D. in 1996 in cell biology at the Swiss Federal Institute of Technology in Zurich (ETHZ). She worked as postdoc and group leader at ETHZ and University of Bern, Switzerland. She is an expert in the field of cell-nanoparticle interactions, with a special focus on human 3D tissue models. Since 2011 she is the chair in BioNanomaterials at the Adolphe Merkle Institute, University of Fribourg, Switzerland, the position is shared equally with Prof. Alke Fink. Prof. Rothen-Rutishauser has published more than 290 peer-reviewed papers and is associate editor of “Particle and Fibre Toxicology”. Publications Characterization of the Shape Anisotropy of Superparamagnetic Iron Oxide Nanoparticles During Thermal Decomposition Materials (Basel, Switzerland). Apr, 2020 | Pubmed ID: 32344889 A Novel 3D Intestine Barrier Model to Study the Immune Response Upon Exposure to Microplastics Archives of Toxicology. Apr, 2020 | Pubmed ID: 32307674 From Bioinspired Glue to Medicine: Polydopamine As a Biomedical Material Materials (Basel, Switzerland). Apr, 2020 | Pubmed ID: 32272786 Bioprinting for Human Respiratory and Gastrointestinal In Vitro Models Methods in Molecular Biology (Clifton, N.J.). Month, 2020 | Pubmed ID: 32207114 Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes ACS Nano. Apr, 2020 | Pubmed ID: 32167743 Innovative Preclinical Models for Pulmonary Drug Delivery Research Expert Opinion on Drug Delivery. Apr, 2020 | Pubmed ID: 32057260 Versatile Macroscale Concentration Gradients of Nanoparticles in Soft Nanocomposites Small (Weinheim an Der Bergstrasse, Germany). Feb, 2020 | Pubmed ID: 31971354 Corrigendum to "The Crux of Positive Controls - Pro-inflammatory Responses in Lung Cell Models" [Toxicology in Vitro 54 (2019) 189-193] Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2020 | Pubmed ID: 31866176 Resolution Limit of Taylor Dispersion: An Exact Theoretical Study Analytical Chemistry. 01, 2020 | Pubmed ID: 31815450 Understanding the Assembly of Amphiphilic Additives in Bulk and Dispersed Non-lamellar Lipid-based Matrices: Phosphorylation, H-bonding and Ionisation Journal of Colloid and Interface Science. Mar, 2020 | Pubmed ID: 31791695 Lipid Nanoparticles Biocompatibility and Cellular Uptake in a 3D Human Lung Model Nanomedicine (London, England). 02, 2020 | Pubmed ID: 31789097 Mimicking Cigarette Smoke Exposure to Assess Cutaneous Toxicity Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2020 | Pubmed ID: 31669394 Quantification of Carbon Nanotube Doses in Adherent Cell Culture Assays Using UV-VIS-NIR Spectroscopy Nanomaterials (Basel, Switzerland). Dec, 2019 | Pubmed ID: 31835823 Assessment of the Potential for In-plume Sulphur Dioxide Gas-ash Interactions to Influence the Respiratory Toxicity of Volcanic Ash Environmental Research. 12, 2019 | Pubmed ID: 31629947 Publisher Correction: On the Issue of Transparency and Reproducibility in Nanomedicine Nature Nanotechnology. Sep, 2019 | Pubmed ID: 31358944 Publisher Correction: On the Issue of Transparency and Reproducibility in Nanomedicine Nature Nanotechnology. Aug, 2019 | Pubmed ID: 31289407 Reduction of Nanoparticle Load in Cells by Mitosis but Not Exocytosis ACS Nano. 07, 2019 | Pubmed ID: 31276366 On the Issue of Transparency and Reproducibility in Nanomedicine Nature Nanotechnology. Jul, 2019 | Pubmed ID: 31270452 Precision of Taylor Dispersion Analytical Chemistry. 08, 2019 | Pubmed ID: 31246027 A Hydrofluoric Acid-free Method to Dissolve and Quantify Silica Nanoparticles in Aqueous and Solid Matrices Scientific Reports. 05, 2019 | Pubmed ID: 31138841 Polymer-Coated Gold Nanospheres Do Not Impair the Innate Immune Function of Human B Lymphocytes in Vitro ACS Nano. 06, 2019 | Pubmed ID: 31117377 A Simple Method to Determine Cytotoxicity of Water-Soluble Organic Compounds and Solid Particles from Biomass Combustion in Lung Cells in Vitro Environmental Science & Technology. 04, 2019 | Pubmed ID: 30821962 Emergence of Nanoplastic in the Environment and Possible Impact on Human Health Environmental Science & Technology. 02, 2019 | Pubmed ID: 30629421 The Crux of Positive Controls - Pro-inflammatory Responses in Lung Cell Models Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2019 | Pubmed ID: 30290203 Polydopamine/Transferrin Hybrid Nanoparticles for Targeted Cell-Killing Nanomaterials (Basel, Switzerland). Dec, 2018 | Pubmed ID: 30562983 Revealing the Role of Epithelial Mechanics and Macrophage Clearance During Pulmonary Epithelial Injury Recovery in the Presence of Carbon Nanotubes Advanced Materials (Deerfield Beach, Fla.). Dec, 2018 | Pubmed ID: 30370701 Publisher Correction: Subcellular Imaging of Liquid Silicone Coated-Intestinal Epithelial Cells Scientific Reports. Sep, 2018 | Pubmed ID: 30262809 Carbon Nanodots: Opportunities and Limitations to Study Their Biodistribution at the Human Lung Epithelial Tissue Barrier Biointerphases. 09, 2018 | Pubmed ID: 30205690 A Rational and Iterative Process for Targeted Nanoparticle Design and Validation Colloids and Surfaces. B, Biointerfaces. Nov, 2018 | Pubmed ID: 30098536 Mimicking the Chemistry of Natural Eumelanin Synthesis: The KE Sequence in Polypeptides and in Proteins Allows for a Specific Control of Nanosized Functional Polydopamine Formation Biomacromolecules. 09, 2018 | Pubmed ID: 30060653 Subcellular Imaging of Liquid Silicone Coated-Intestinal Epithelial Cells Scientific Reports. Jul, 2018 | Pubmed ID: 30018393 A Novel Sample Holder for 4D Live Cell Imaging to Study Cellular Dynamics in Complex 3D Tissue Cultures Scientific Reports. 06, 2018 | Pubmed ID: 29959370 Distribution of Polymer-coated Gold Nanoparticles in a 3D Lung Model and Indication of Apoptosis After Repeated Exposure Nanomedicine (London, England). 05, 2018 | Pubmed ID: 29874145 Acute Effects of Multi-walled Carbon Nanotubes on Primary Bronchial Epithelial Cells from COPD Patients Nanotoxicology. 09, 2018 | Pubmed ID: 29804489 Biological Response of an in Vitro Human 3D Lung Cell Model Exposed to Brake Wear Debris Varies Based on Brake Pad Formulation Archives of Toxicology. 07, 2018 | Pubmed ID: 29748788 Probing Nano-scale Viscoelastic Response in Air and in Liquid with Dynamic Atomic Force Microscopy Soft Matter. May, 2018 | Pubmed ID: 29740651 A Realistic in Vitro Exposure Revealed Seasonal Differences in (pro-)inflammatory Effects from Ambient Air in Fribourg, Switzerland Inhalation Toxicology. 01, 2018 | Pubmed ID: 29508652 Respiratory Hazard Assessment of Combined Exposure to Complete Gasoline Exhaust and Respirable Volcanic Ash in a Multicellular Human Lung Model at the Air-liquid Interface Environmental Pollution (Barking, Essex : 1987). Jul, 2018 | Pubmed ID: 29455917 Biodistribution, Clearance, and Long-Term Fate of Clinically Relevant Nanomaterials Advanced Materials (Deerfield Beach, Fla.). May, 2018 | Pubmed ID: 29389049 Nanoparticle-Cell Interaction: A Cell Mechanics Perspective Advanced Materials (Deerfield Beach, Fla.). May, 2018 | Pubmed ID: 29315860 Assessment of Lung Cell Toxicity of Various Gasoline Engine Exhausts Using a Versatile In vitro Exposure System Environmental Pollution (Barking, Essex : 1987). Apr, 2018 | Pubmed ID: 29291526 Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of SiRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier Journal of Aerosol Medicine and Pulmonary Drug Delivery. 06, 2018 | Pubmed ID: 29035132 Exposure to Silver Nanoparticles Affects Viability and Function of Natural Killer Cells, Mostly Via the Release of Ions Cell Biology and Toxicology. 06, 2018 | Pubmed ID: 28721573 Biodistribution of Single and Aggregated Gold Nanoparticles Exposed to the Human Lung Epithelial Tissue Barrier at the Air-liquid Interface Particle and Fibre Toxicology. Nov, 2017 | Pubmed ID: 29187209 Effects of Gasoline and Ethanol-gasoline Exhaust Exposure on Human Bronchial Epithelial and Natural Killer Cells in Vitro Toxicology in Vitro : an International Journal Published in Association with BIBRA. Dec, 2017 | Pubmed ID: 28843492 Characteristics and Properties of Nano-LiCoO Synthesized by Pre-organized Single Source Precursors: Li-ion Diffusivity, Electrochemistry and Biological Assessment Journal of Nanobiotechnology. Aug, 2017 | Pubmed ID: 28830490 Assessing the Stability of Fluorescently Encoded Nanoparticles in Lysosomes by Using Complementary Methods Angewandte Chemie (International Ed. in English). 10, 2017 | Pubmed ID: 28767191 Biokinetics of Aerosolized Liposomal Ciclosporin A in Human Lung Cells In Vitro Using an Air-Liquid Cell Interface Exposure System Journal of Aerosol Medicine and Pulmonary Drug Delivery. Dec, 2017 | Pubmed ID: 28683218 Human Asthmatic Bronchial Cells Are More Susceptible to Subchronic Repeated Exposures of Aerosolized Carbon Nanotubes At Occupationally Relevant Doses Than Healthy Cells ACS Nano. 08, 2017 | Pubmed ID: 28505409 Quantifying Nanoparticle Cellular Uptake: Which Method is Best? Nanomedicine (London, England). 05, 2017 | Pubmed ID: 28447906 Assumption-free Morphological Quantification of Single Anisotropic Nanoparticles and Aggregates Nanoscale. Apr, 2017 | Pubmed ID: 28358404 A Novel Technique to Determine the Cell Type Specific Response Within an in Vitro Co-culture Model Via Multi-colour Flow Cytometry Scientific Reports. 03, 2017 | Pubmed ID: 28348366 A Rapid Screening Method to Evaluate the Impact of Nanoparticles on Macrophages Nanoscale. Feb, 2017 | Pubmed ID: 28150827 Organometallic Cobalamin Anticancer Derivatives for Targeted Prodrug Delivery Via Transcobalamin-mediated Uptake Dalton Transactions (Cambridge, England : 2003). Feb, 2017 | Pubmed ID: 28121320 Interaction of Biomedical Nanoparticles with the Pulmonary Immune System Journal of Nanobiotechnology. Jan, 2017 | Pubmed ID: 28069025 Identification and Characterization of a Dendritic Cell Precursor in Parenchymal Lung Tissue American Journal of Respiratory Cell and Molecular Biology. 03, 2017 | Pubmed ID: 27779901 Combined Exposure of Diesel Exhaust Particles and Respirable Soufrière Hills Volcanic Ash Causes a (pro-)inflammatory Response in an in Vitro Multicellular Epithelial Tissue Barrier Model Particle and Fibre Toxicology. 12, 2016 | Pubmed ID: 27955700 Hazard Identification of Exhausts from Gasoline-ethanol Fuel Blends Using a Multi-cellular Human Lung Model Environmental Research. Nov, 2016 | Pubmed ID: 27670152 Current in Vitro Approaches to Assess Nanoparticle Interactions with Lung Cells Nanomedicine (London, England). Sep, 2016 | Pubmed ID: 27529369 Predicting Pulmonary Fibrosis in Humans After Exposure to Multi-walled Carbon Nanotubes (MWCNTs) Archives of Toxicology. Jul, 2016 | Pubmed ID: 27215431 Diesel Exhaust: Current Knowledge of Adverse Effects and Underlying Cellular Mechanisms Archives of Toxicology. Jul, 2016 | Pubmed ID: 27165416 Expert Consensus on an in Vitro Approach to Assess Pulmonary Fibrogenic Potential of Aerosolized Nanomaterials Archives of Toxicology. Jul, 2016 | Pubmed ID: 27121469 Pulmonary Delivery of Cationic Gold Nanoparticles Boost Antigen-specific CD4 T Cell Proliferation Nanomedicine : Nanotechnology, Biology, and Medicine. 10, 2016 | Pubmed ID: 27013126 Engineered Nanomaterials: Toward Effective Safety Management in Research Laboratories Journal of Nanobiotechnology. Mar, 2016 | Pubmed ID: 26979818 Articular Cartilage: from Formation to Tissue Engineering Biomaterials Science. May, 2016 | Pubmed ID: 26923076 Directed Cell Growth in Multi-zonal Scaffolds for Cartilage Tissue Engineering Biomaterials. Jan, 2016 | Pubmed ID: 26447554 Plasmonic Nanoparticles and Their Characterization in Physiological Fluids Colloids and Surfaces. B, Biointerfaces. Jan, 2016 | Pubmed ID: 26095471 A Fast and Reliable Method for Screening of Exhaust Emission Toxicity in Lung Cells Chimia. Feb, 2015 | Pubmed ID: 28982470 Ultrathin Ceramic Membranes As Scaffolds for Functional Cell Coculture Models on a Biomimetic Scale BioResearch Open Access. Month, 2015 | Pubmed ID: 26713225 Assessment of a Panel of Interleukin-8 Reporter Lung Epithelial Cell Lines to Monitor the Pro-inflammatory Response Following Zinc Oxide Nanoparticle Exposure Under Different Cell Culture Conditions Particle and Fibre Toxicology. Sep, 2015 | Pubmed ID: 26415698 Investigating the Role of Shape on the Biological Impact of Gold Nanoparticles in Vitro Nanomedicine (London, England). Month, 2015 | Pubmed ID: 26377045 Translocation of Gold Nanoparticles Across the Lung Epithelial Tissue Barrier: Combining in Vitro and in Silico Methods to Substitute in Vivo Experiments Particle and Fibre Toxicology. Jun, 2015 | Pubmed ID: 26116549 Nanoparticle Colloidal Stability in Cell Culture Media and Impact on Cellular Interactions Chemical Society Reviews. Oct, 2015 | Pubmed ID: 26056687 Avoiding Drying-artifacts in Transmission Electron Microscopy: Characterizing the Size and Colloidal State of Nanoparticles Scientific Reports. May, 2015 | Pubmed ID: 25965905 Fate of Cellulose Nanocrystal Aerosols Deposited on the Lung Cell Surface in Vitro Biomacromolecules. Apr, 2015 | Pubmed ID: 25789784 Biomimetics of Fetal Alveolar Flow Phenomena Using Microfluidics Biomicrofluidics. Jan, 2015 | Pubmed ID: 25759753 A Biological Perspective Toward the Interaction of Theranostic Nanoparticles with the Bloodstream - What Needs to Be Considered? Frontiers in Chemistry. Month, 2015 | Pubmed ID: 25713796 Repeated Exposure to Carbon Nanotube-based Aerosols Does Not Affect the Functional Properties of a 3D Human Epithelial Airway Model Nanotoxicology. Month, 2015 | Pubmed ID: 25697181 Engineering an in Vitro Air-blood Barrier by 3D Bioprinting Scientific Reports. Jan, 2015 | Pubmed ID: 25609567 Uptake Efficiency of Surface Modified Gold Nanoparticles Does Not Correlate with Functional Changes and Cytokine Secretion in Human Dendritic Cells in Vitro Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2015 | Pubmed ID: 25555350 Effects of an Iron-based Fuel-borne Catalyst and a Diesel Particle Filter on Exhaust Toxicity in Lung Cells in Vitro Analytical and Bioanalytical Chemistry. Aug, 2015 | Pubmed ID: 24880869 Different Endocytotic Uptake Mechanisms for Nanoparticles in Epithelial Cells and Macrophages Beilstein Journal of Nanotechnology. Month, 2014 | Pubmed ID: 25383275 Quantification of Nanoparticles at the Single-cell Level: an Overview About State-of-the-art Techniques and Their Limitations Nanomedicine (London, England). Month, 2014 | Pubmed ID: 25325243 Thermally Reversible Self-assembly of Nanoparticles Via Polymer Crystallization Macromolecular Rapid Communications. Dec, 2014 | Pubmed ID: 25315899 In Vitro Interaction of Colloidal Nanoparticles with Mammalian Cells: What Have We Learned Thus Far? Beilstein Journal of Nanotechnology. Month, 2014 | Pubmed ID: 25247131 Mimicking Exposures to Acute and Lifetime Concentrations of Inhaled Silver Nanoparticles by Two Different in Vitro Approaches Beilstein Journal of Nanotechnology. Month, 2014 | Pubmed ID: 25247119 An in Vitro Testing Strategy Towards Mimicking the Inhalation of High Aspect Ratio Nanoparticles Particle and Fibre Toxicology. Sep, 2014 | Pubmed ID: 25245637 Size-dependent Accumulation of Particles in Lysosomes Modulates Dendritic Cell Function Through Impaired Antigen Degradation International Journal of Nanomedicine. Month, 2014 | Pubmed ID: 25152619 State-of-the-art of 3D Cultures (organs-on-a-chip) in Safety Testing and Pathophysiology ALTEX. Month, 2014 | Pubmed ID: 25027500 Modeling Nanoparticle-alveolar Epithelial Cell Interactions Under Breathing Conditions Using Captive Bubble Surfactometry Langmuir : the ACS Journal of Surfaces and Colloids. May, 2014 | Pubmed ID: 24731173 Test-methods on the Test-bench: a Comparison of Complete Exhaust and Exhaust Particle Extracts for Genotoxicity/mutagenicity Assessment Environmental Science & Technology. May, 2014 | Pubmed ID: 24697289 Insertion of Nanoparticle Clusters into Vesicle Bilayers ACS Nano. Apr, 2014 | Pubmed ID: 24611878 Fluorescence-encoded Gold Nanoparticles: Library Design and Modulation of Cellular Uptake into Dendritic Cells Small (Weinheim an Der Bergstrasse, Germany). Apr, 2014 | Pubmed ID: 24482355 A Comparative Study of Different in Vitro Lung Cell Culture Systems to Assess the Most Beneficial Tool for Screening the Potential Adverse Effects of Carbon Nanotubes Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2014 | Pubmed ID: 24284789 Quantification of Gold Nanoparticle Cell Uptake Under Controlled Biological Conditions and Adequate Resolution Nanomedicine (London, England). Apr, 2014 | Pubmed ID: 23738633 Fate of TLR-1/TLR-2 Agonist Functionalised PDNA Nanoparticles Upon Deposition at the Human Bronchial Epithelium in Vitro Journal of Nanobiotechnology. Aug, 2013 | Pubmed ID: 23964697 Bioavailability of Silver Nanoparticles and Ions: from a Chemical and Biochemical Perspective Journal of the Royal Society, Interface. Oct, 2013 | Pubmed ID: 23883950 Studying the Oxidative Stress Paradigm in Vitro: a Theoretical and Practical Perspective Methods in Molecular Biology (Clifton, N.J.). Month, 2013 | Pubmed ID: 23740116 Exposure of Silver-nanoparticles and Silver-ions to Lung Cells in Vitro at the Air-liquid Interface Particle and Fibre Toxicology. Apr, 2013 | Pubmed ID: 23557437 Nanomaterials and the Human Lung: What is Known and What Must Be Deciphered to Realise Their Potential Advantages? Swiss Medical Weekly. Month, 2013 | Pubmed ID: 23519981 Gold Nanorods: Controlling Their Surface Chemistry and Complete Detoxification by a Two-step Place Exchange Angewandte Chemie (International Ed. in English). Feb, 2013 | Pubmed ID: 23339128 Surface Charge of Polymer Coated SPIONs Influences the Serum Protein Adsorption, Colloidal Stability and Subsequent Cell Interaction in Vitro Nanoscale. May, 2013 | Pubmed ID: 23334060 Can the Ames Test Provide an Insight into Nano-object Mutagenicity? Investigating the Interaction Between Nano-objects and Bacteria Nanotoxicology. Nov, 2012 | Pubmed ID: 23078217 Cerium Dioxide Nanoparticles Can Interfere with the Associated Cellular Mechanistic Response to Diesel Exhaust Exposure Toxicology Letters. Oct, 2012 | Pubmed ID: 22960666 Effects of Flame Made Zinc Oxide Particles in Human Lung Cells - a Comparison of Aerosol and Suspension Exposures Particle and Fibre Toxicology. Aug, 2012 | Pubmed ID: 22901679 Pulmonary Surfactant Coating of Multi-walled Carbon Nanotubes (MWCNTs) Influences Their Oxidative and Pro-inflammatory Potential in Vitro Particle and Fibre Toxicology. Month, 2012 | Pubmed ID: 22624622 Nanoparticles and Cells: an Interdisciplinary Approach Chimia. Month, 2012 | Pubmed ID: 22546253 Surfactant Protein D Modulates Allergen Particle Uptake and Inflammatory Response in a Human Epithelial Airway Model Respiratory Research. Feb, 2012 | Pubmed ID: 22296755 Interaction and Localization of Synthetic Nanoparticles in Healthy and Cystic Fibrosis Airway Epithelial Cells: Effect of Ozone Exposure Journal of Aerosol Medicine and Pulmonary Drug Delivery. Feb, 2012 | Pubmed ID: 22007674 Investigating the Interaction of Cellulose Nanofibers Derived from Cotton with a Sophisticated 3D Human Lung Cell Coculture Biomacromolecules. Oct, 2011 | Pubmed ID: 21846085 Targeting Specific Membranes with an Azide Derivative of the Pore-forming Peptide Ceratotoxin A Biochimica Et Biophysica Acta. Biomembranes. Month, | Pubmed ID: 31325418 Büyük Ölçekte Üç Boyutlu Yeniden Yapılandırılmış İnsan Epidermisi Yetiştirmek Irini M. Dijkhoff1, Benedetta Petracca1,2, Roxane Prieux3, Giuseppe Valacchi3,4, Barbara Rothen-Rutishauser1, Marc Eeman2 1Adolphe Merkle Institute, University of Fribourg, 2Dow Silicones Belgium SRL, 3Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 4Department of Animal Sciences, Plants for Human Health Institute, North Carolina State University JoVE 61802 Bioengineering Tehlike Değerlendirmesi İçin Epitel Hücreleri ve Primer İmmün Hücrelerden Oluşan Çok Hücreli İnsan Alveoler Modeli Hana Barosova*1, Barbara Drasler*1, Alke Petri-Fink1, Barbara Rothen-Rutishauser1 1Adolphe Merkle Institute, University of Fribourg JoVE 61090 Biology
Büyük Ölçekte Üç Boyutlu Yeniden Yapılandırılmış İnsan Epidermisi Yetiştirmek Irini M. Dijkhoff1, Benedetta Petracca1,2, Roxane Prieux3, Giuseppe Valacchi3,4, Barbara Rothen-Rutishauser1, Marc Eeman2 1Adolphe Merkle Institute, University of Fribourg, 2Dow Silicones Belgium SRL, 3Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 4Department of Animal Sciences, Plants for Human Health Institute, North Carolina State University JoVE 61802 Bioengineering
Tehlike Değerlendirmesi İçin Epitel Hücreleri ve Primer İmmün Hücrelerden Oluşan Çok Hücreli İnsan Alveoler Modeli Hana Barosova*1, Barbara Drasler*1, Alke Petri-Fink1, Barbara Rothen-Rutishauser1 1Adolphe Merkle Institute, University of Fribourg JoVE 61090 Biology