Berthold Huppertz Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center Medical University of Graz Biography Publications Institution JoVE Articles Berthold Huppertz has not added a biography. If you are Berthold Huppertz and would like to personalize this page please email our Author Liaison for assistance. Publications Placental Physioxia is Based on Spatial and Temporal Variations of Placental Oxygenation Throughout Pregnancy Journal of Reproductive Immunology. Aug, 2023 | Pubmed ID: 37406413 CD39 Abrogates Platelet-derived Factors Induced IL-1β Expression in the Human Placenta Frontiers in Cell and Developmental Biology. 2023 | Pubmed ID: 37325567 The Challenges of Histology Education Clinical Anatomy (New York, N.Y.). Mar, 2023 | Pubmed ID: 36494890 Early Human Trophoblast Development: from Morphology to Function Cellular and Molecular Life Sciences : CMLS. Jun, 2022 | Pubmed ID: 35661923 Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity Biomedicines. May, 2022 | Pubmed ID: 35625806 (Dis)similarities Between the Decidual and Tumor Microenvironment Biomedicines. May, 2022 | Pubmed ID: 35625802 The Endogenous Exposome of the Pregnant Mother: Placental Extracellular Vesicles and Their Effect on the Maternal System Molecular Aspects of Medicine. Oct, 2022 | Pubmed ID: 33612320 Reduced Placental CD24 in Preterm Preeclampsia Is an Indicator for a Failure of Immune Tolerance International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360811 Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34299084 Molecular Characteristics of Established Trophoblast-derived Cell Lines Placenta. May, 2021 | Pubmed ID: 33810901 Maternal Angiotensin Increases Placental Leptin in Early Gestation Via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia Hypertension (Dallas, Tex. : 1979). May, 2021 | Pubmed ID: 33775117 Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 33392174 IJMS Special Issue "Molecular and Cellular Mechanisms of Preeclampsia"-Editorial International Journal of Molecular Sciences. Jul, 2020 | Pubmed ID: 32645926 Platelet-derived Factors Impair Placental Chorionic Gonadotropin Beta-subunit Synthesis Journal of Molecular Medicine (Berlin, Germany). Feb, 2020 | Pubmed ID: 31863152 Biology of Preeclampsia: Combined Actions of Angiogenic Factors, Their Receptors and Placental Proteins Biochimica Et Biophysica Acta. Molecular Basis of Disease. Feb, 2020 | Pubmed ID: 30553017 Traditional and New Routes of Trophoblast Invasion and Their Implications for Pregnancy Diseases International Journal of Molecular Sciences. Dec, 2019 | Pubmed ID: 31906245 Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels During Pregnancy International Journal of Molecular Sciences. Jun, 2019 | Pubmed ID: 31261864 Placental Protein 13 (PP13) Stimulates Rat Uterine Vessels After Slow Subcutaneous Administration International Journal of Women's Health. 2019 | Pubmed ID: 30988643 Amnion-derived Mesenchymal Stem Cells Improve Viability of Endothelial Cells Exposed to Shear Stress in EPTFE Grafts The International Journal of Artificial Organs. Feb, 2019 | Pubmed ID: 30585116 An Updated View on the Origin and Use of Angiogenic Biomarkers for Preeclampsia Expert Review of Molecular Diagnostics. Dec, 2018 | Pubmed ID: 30413130 Impact of Vitamin D and Vitamin D Receptor on the Trophoblast Survival Capacity in Preeclampsia PloS One. 2018 | Pubmed ID: 30408071 Human Trophoblast Invasion: New and Unexpected Routes and Functions Histochemistry and Cell Biology. Oct, 2018 | Pubmed ID: 30046889 Pharmacokinetics of Placental Protein 13 After Intravenous and Subcutaneous Administration in Rabbits Drug Design, Development and Therapy. 2018 | Pubmed ID: 30013317 The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia Current Pharmaceutical Biotechnology. 2018 | Pubmed ID: 29701150 Trophoblast Retrieval and Isolation from the Cervix: Origins of Cervical Trophoblasts and Their Potential Value for Risk Assessment of Ongoing Pregnancies Human Reproduction Update. Jul, 2018 | Pubmed ID: 29608700 Correction To: Expression of Matrix Metalloproteinase 12 is Highly Specific for Non-proliferating Invasive Trophoblasts in the First Trimester and Temporally Regulated by Oxygen-dependent Mechanisms Including HIF-1A Histochemistry and Cell Biology. Jan, 2018 | Pubmed ID: 29236166 Expression of Matrix Metalloproteinase 12 is Highly Specific for Non-proliferating Invasive Trophoblasts in the First Trimester and Temporally Regulated by Oxygen-dependent Mechanisms Including HIF-1A Histochemistry and Cell Biology. Jan, 2018 | Pubmed ID: 28990117 The Trophoblast Survival Capacity in Preeclampsia PloS One. 2017 | Pubmed ID: 29107968 Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function Computational and Structural Biotechnology Journal. 2017 | Pubmed ID: 29034064 Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker Circulation. Nov, 2017 | Pubmed ID: 28904069 A Comparative Study of Five Physiological Key Parameters Between Four Different Human Trophoblast-derived Cell Lines Scientific Reports. Jul, 2017 | Pubmed ID: 28724925 Placental Expression of SFlt-1 and PlGF in Early Preeclampsia Vs. Early IUGR Vs. Age-matched Healthy Pregnancies Hypertension in Pregnancy. May, 2017 | Pubmed ID: 28609172 Placental Protein 13 (PP13)-induced Vasodilation of Resistance Arteries from Pregnant and Nonpregnant Rats Occurs Via Endothelial-signaling Pathways Hypertension in Pregnancy. May, 2017 | Pubmed ID: 28524718 Increased Placental SFlt-1 but Unchanged PlGF Expression in Late-onset Preeclampsia Hypertension in Pregnancy. May, 2017 | Pubmed ID: 28494189 Challenges and Driving Forces for Business Plans in Biobanking Biopreservation and Biobanking. Apr, 2017 | Pubmed ID: 28338345 Implantation and Extravillous Trophoblast Invasion: From Rare Archival Specimens to Modern Biobanking Placenta. Aug, 2017 | Pubmed ID: 28202182 DNA Methylation Heterogeneity Defines a Disease Spectrum in Ewing Sarcoma Nature Medicine. Mar, 2017 | Pubmed ID: 28134926 GDM Alters Paracrine Regulation of Feto-placental Angiogenesis Via the Trophoblast Laboratory Investigation; a Journal of Technical Methods and Pathology. Apr, 2017 | Pubmed ID: 28112754 HO-1 Inhibits Preadipocyte Proliferation and Differentiation at the Onset of Obesity Via ROS Dependent Activation of Akt2 Scientific Reports. Jan, 2017 | Pubmed ID: 28102348 Expression of CD24 and Siglec-10 in First Trimester Placenta: Implications for Immune Tolerance at the Fetal-maternal Interface Histochemistry and Cell Biology. May, 2017 | Pubmed ID: 28012129 Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking Biopreservation and Biobanking. Jun, 2017 | Pubmed ID: 27992240 Biobanking of Different Body Fluids Within the Frame of IVF-a Standard Operating Procedure to Improve Reproductive Biology Research Journal of Assisted Reproduction and Genetics. Feb, 2017 | Pubmed ID: 27889868 Extravillous Trophoblasts Invade More Than Uterine Arteries: Evidence for the Invasion of Uterine Veins Histochemistry and Cell Biology. Mar, 2017 | Pubmed ID: 27774579 The Effects of Nrf2 Deletion on Placental Morphology and Exchange Capacity in the Mouse The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. Sep, 2017 | Pubmed ID: 27633272 Magnetomitotransfer: An Efficient Way for Direct Mitochondria Transfer into Cultured Human Cells Scientific Reports. Oct, 2016 | Pubmed ID: 27767193 The Trophoblast Plug During Early Pregnancy: a Deeper Insight Histochemistry and Cell Biology. Dec, 2016 | Pubmed ID: 27510415 Pigment Epithelium-derived Factor (PEDF): a Novel Trophoblast-derived Factor Limiting Feto-placental Angiogenesis in Late Pregnancy Angiogenesis. Jul, 2016 | Pubmed ID: 27278471 CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia Circulation Research. Jun, 2016 | Pubmed ID: 27199465 Arterial Endothelial Cytokines Guide Extravillous Trophoblast Invasion Towards Spiral Arteries; an In-vitro Study with the Trophoblast Cell Line ACH-3P and Female Non-uterine Endothelial Cells Placenta. Feb, 2016 | Pubmed ID: 26907382 The Salivary Scavenger and Agglutinin (SALSA) in Healthy and Complicated Pregnancy PloS One. 2016 | Pubmed ID: 26828433 Letter from the Guest Editors: Cell Adhesion, Migration, and Fusion in Placenta Cell Adhesion & Migration. Mar, 2016 | Pubmed ID: 26825181 Sustainability in Biobanking: Model of Biobank Graz Biopreservation and Biobanking. Dec, 2015 | Pubmed ID: 26697910 Does 2D-Histologic Identification of Villous Types of Human Placentas at Birth Enable Sensitive and Reliable Interpretation of 3D Structure? Placenta. Dec, 2015 | Pubmed ID: 26494606 A Role for GPR55 in Human Placental Venous Endothelial Cells Histochemistry and Cell Biology. Jul, 2015 | Pubmed ID: 25869640 Maternal-fetal Interactions, Predictive Markers for Preeclampsia, and Programming Journal of Reproductive Immunology. Apr, 2015 | Pubmed ID: 25534924 Phospholipid Scramblase 1 (PLSCR1) in Villous Trophoblast of the Human Placenta Histochemistry and Cell Biology. Apr, 2015 | Pubmed ID: 25362260 Placental Mesenchymal Stromal Cells Derived from Blood Vessels or Avascular Tissues: What is the Better Choice to Support Endothelial Cell Function? Stem Cells and Development. Jan, 2015 | Pubmed ID: 25244528 Oxygenation of the Placenta and Its Role in Pre-eclampsia Pregnancy Hypertension. Jul, 2014 | Pubmed ID: 26104644 Maternal and Fetal Factors and Placentation: Implications for Pre-eclampsia Pregnancy Hypertension. Jul, 2014 | Pubmed ID: 26104643 The Role of the Carbohydrate Recognition Domain of Placental Protein 13 (PP13) in Pregnancy Evaluated with Recombinant PP13 and the DelT221 PP13 Variant PloS One. 2014 | Pubmed ID: 25079598 A Possible Protective Role of Nrf2 in Preeclampsia Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft. Sep, 2014 | Pubmed ID: 24954650 The Vitamin E-binding Protein Afamin Increases in Maternal Serum During Pregnancy Clinica Chimica Acta; International Journal of Clinical Chemistry. Jul, 2014 | Pubmed ID: 24768783 Amnion-derived Mesenchymal Stromal Cells Show a Mesenchymal-epithelial Phenotype in Culture Cell and Tissue Banking. Jun, 2014 | Pubmed ID: 24326460 An Integrative View on the Physiology of Human Early Placental Villi Progress in Biophysics and Molecular Biology. Jan, 2014 | Pubmed ID: 24291663 Trophoblast Invasion and Oxygenation of the Placenta: Measurements Versus Presumptions Journal of Reproductive Immunology. Mar, 2014 | Pubmed ID: 23747129 Developing Potential Biomarkers for Preeclampsia: Why is the Current Strategy Failing? Pregnancy Hypertension. Apr, 2013 | Pubmed ID: 26105841 Differences in D-chiro-inositol-phosphoglycan Expression Between First and Third Trimester Human Placenta Pregnancy Hypertension. Jan, 2013 | Pubmed ID: 26105733 Are Morphological Criteria Sufficient for the Identification of Circulating Tumor Cells in Renal Cancer? Journal of Translational Medicine. Sep, 2013 | Pubmed ID: 24044779 Keratins in the Human Trophoblast Histology and Histopathology. Jul, 2013 | Pubmed ID: 23450430 Placental Protein 13 (PP13): a New Biological Target Shifting Individualized Risk Assessment to Personalized Drug Design Combating Pre-eclampsia Human Reproduction Update. 2013 | Pubmed ID: 23420029 Cytochrome P450 Subfamily 2J Polypeptide 2 Expression and Circulating Epoxyeicosatrienoic Metabolites in Preeclampsia Circulation. Dec, 2012 | Pubmed ID: 23155181 A Role for Nrf2 in Redox Signalling of the Invasive Extravillous Trophoblast in Severe Early Onset IUGR Associated with Preeclampsia PloS One. 2012 | Pubmed ID: 23056578 First Trimester Serum Markers to Predict Preeclampsia Wiener Medizinische Wochenschrift (1946). May, 2012 | Pubmed ID: 22717872 A Variety of Opportunities for Immune Interactions During Trophoblast Development and Invasion American Journal of Reproductive Immunology (New York, N.Y. : 1989). May, 2012 | Pubmed ID: 22593844 Oxygen Modulates the Response of First-trimester Trophoblasts to Hyperglycemia The American Journal of Pathology. Jan, 2012 | Pubmed ID: 22056361 Amnion-derived Mesenchymal Stromal Cells Show Angiogenic Properties but Resist Differentiation into Mature Endothelial Cells Stem Cells and Development. May, 2012 | Pubmed ID: 21762016 Trophoblast Differentiation, Fetal Growth Restriction and Preeclampsia Pregnancy Hypertension. Jan, 2011 | Pubmed ID: 26104234 Nanoparticles: Barrier Thickness Matters Nature Nanotechnology. Nov, 2011 | Pubmed ID: 22056727 Trophoblast Fusion Advances in Experimental Medicine and Biology. 2011 | Pubmed ID: 21432015 Fibulin-5 Expression in the Human Placenta Histochemistry and Cell Biology. Feb, 2011 | Pubmed ID: 21290250 Placental Pathology in Pregnancy Complications Thrombosis Research. Feb, 2011 | Pubmed ID: 21262454 Cryogenic and Low Temperature Preservation of Human Placental Villous Explants - a New Way to Explore Drugs in Pregnancy Disorders Placenta. Feb, 2011 | Pubmed ID: 21257084 The Choriocarcinoma Cell Line BeWo: Syncytial Fusion and Expression of Syncytium-specific Proteins Reproduction (Cambridge, England). Nov, 2010 | Pubmed ID: 20696850 Inhibitory NK Receptor Recognition of HLA-G: Regulation by Contact Residues and by Cell Specific Expression at the Fetal-maternal Interface PloS One. Jan, 2010 | Pubmed ID: 20126612 IFPA Award in Placentology Lecture: Biology of the Placental Syncytiotrophoblast--myths and Facts Placenta. Mar, 2010 | Pubmed ID: 20042237 Oxygen As Modulator of Trophoblast Invasion Journal of Anatomy. Jul, 2009 | Pubmed ID: 19215320 Placenta Trophoblast Fusion Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18979242 Longitudinal Determination of Serum Placental Protein 13 During Development of Preeclampsia Fetal Diagnosis and Therapy. 2008 | Pubmed ID: 18753763 The Feto-maternal Interface: Setting the Stage for Potential Immune Interactions Seminars in Immunopathology. Jun, 2007 | Pubmed ID: 17621696 Regulation of Proliferation and Apoptosis During Development of the Preimplantation Embryo and the Placenta Birth Defects Research. Part C, Embryo Today : Reviews. Dec, 2005 | Pubmed ID: 16425254 Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues (Video) | JoVE Nadja Kupper1, Elisabeth Pritz1, Monika Siwetz1, Jacqueline Guettler1, Berthold Huppertz1 1Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz JoVE 65919 Developmental Biology
Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues (Video) | JoVE Nadja Kupper1, Elisabeth Pritz1, Monika Siwetz1, Jacqueline Guettler1, Berthold Huppertz1 1Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz JoVE 65919 Developmental Biology