Bon-Kyoung Koo Wellcome Trust - Medical Research Council Stem Cell Institute University of Cambridge Biography Publications Institution JoVE Articles Bon-Kyoung Koo has not added a biography. If you are Bon-Kyoung Koo and would like to personalize this page please email our Author Liaison for assistance. Publications Stem Cells in Repair of Gastrointestinal Epithelia Physiology (Bethesda, Md.). Jul, 2017 | Pubmed ID: 28615312 Long-term, Hormone-responsive Organoid Cultures of Human Endometrium in a Chemically Defined Medium Nature Cell Biology. May, 2017 | Pubmed ID: 28394884 One-step Generation of Conditional and Reversible Gene Knockouts Nature Methods. Mar, 2017 | Pubmed ID: 28135257 Adult Gastric Stem Cells and Their Niches Wiley Interdisciplinary Reviews. Developmental Biology. Mar, 2017 | Pubmed ID: 28044412 Simultaneous Paralogue Knockout Using a CRISPR-concatemer in Mouse Small Intestinal Organoids Developmental Biology. Dec, 2016 | Pubmed ID: 27983963 Organoids: A New in Vitro Model System for Biomedical Science and Disease Modelling and Promising Source for Cell-based Transplantation Developmental Biology. Dec, 2016 | Pubmed ID: 27983962 Clonal Evolution of Stem Cells in the Gastrointestinal Tract Advances in Experimental Medicine and Biology. 2016 | Pubmed ID: 27573765 Culture and Establishment of Self-renewing Human and Mouse Adult Liver and Pancreas 3D Organoids and Their Genetic Manipulation Nature Protocols. Sep, 2016 | Pubmed ID: 27560176 Adult Stem Cell Lineage Tracing and Deep Tissue Imaging BMB Reports. Dec, 2015 | Pubmed ID: 26634741 Modeling Mouse and Human Development Using Organoid Cultures Development (Cambridge, England). Sep, 2015 | Pubmed ID: 26395140 Porcupine Inhibitor Suppresses Paracrine Wnt-driven Growth of Rnf43;Znrf3-mutant Neoplasia Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 26023187 Ascl2 Acts As an R-spondin/Wnt-responsive Switch to Control Stemness in Intestinal Crypts Cell Stem Cell. Feb, 2015 | Pubmed ID: 25620640 Stem Cells Marked by the R-Spondin Receptor LGR5 Gastroenterology. Aug, 2014 | Pubmed ID: 24859206 Retroviral Gene Expression Control in Primary Organoid Cultures Current Protocols in Stem Cell Biology. 2013 | Pubmed ID: 24510288 Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients Cell Stem Cell. Dec, 2013 | Pubmed ID: 24315439 Generation of BAC Transgenic Epithelial Organoids PloS One. 2013 | Pubmed ID: 24204693 Differentiated Troy+ Chief Cells Act As Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium Cell. Oct, 2013 | Pubmed ID: 24120136 ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness Through Activation of the Unfolded Protein Response Cell Reports. Apr, 2013 | Pubmed ID: 23545496 Tumour Suppressor RNF43 is a Stem-cell E3 Ligase That Induces Endocytosis of Wnt Receptors Nature. Aug, 2012 | Pubmed ID: 22895187 Notch1 Counteracts WNT/β-catenin Signaling Through Chromatin Modification in Colorectal Cancer The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22863622 The Lgr5 Intestinal Stem Cell Signature: Robust Expression of Proposed Quiescent '+4' Cell Markers The EMBO Journal. Jul, 2012 | Pubmed ID: 22692129 A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-renewal Molecular and Cellular Biology. May, 2012 | Pubmed ID: 22393260 Controlled Gene Expression in Primary Lgr5 Organoid Cultures Nature Methods. Jan, 2012 | Pubmed ID: 22138822 Survival and Differentiation of Mammary Epithelial Cells in Mammary Gland Development Require Nuclear Retention of Id2 Due to RANK Signaling Molecular and Cellular Biology. Dec, 2011 | Pubmed ID: 21947283 Lgr5 Homologues Associate with Wnt Receptors and Mediate R-spondin Signalling Nature. Aug, 2011 | Pubmed ID: 21727895 The WNT Antagonist Dickkopf2 Promotes Angiogenesis in Rodent and Human Endothelial Cells The Journal of Clinical Investigation. May, 2011 | Pubmed ID: 21540552 Inactivation of Notch Signaling in the Renal Collecting Duct Causes Nephrogenic Diabetes Insipidus in Mice The Journal of Clinical Investigation. Nov, 2009 | Pubmed ID: 19855135 Wesentliche Rolle Der CR6-Interaktion Faktor 1 (Crif1) in E74-ähnlichen Faktor 3 (ELF3)-vermittelte Intestinale Entwicklung The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19801644 Notch Signaling Promotes the Generation of EphrinB1-positive Intestinal Epithelial Cells Gastroenterology. Jul, 2009 | Pubmed ID: 19332065 Mind Bomb 1 in the Lymphopoietic Niches is Essential for T and Marginal Zone B Cell Development The Journal of Experimental Medicine. Oct, 2008 | Pubmed ID: 18824586 Defective Notch Activation in Microenvironment Leads to Myeloproliferative Disease Blood. Dec, 2008 | Pubmed ID: 18818392 Mind Bomb-1 is Essential for Intraembryonic Hematopoiesis in the Aortic Endothelium and the Subaortic Patches Molecular and Cellular Biology. Aug, 2008 | Pubmed ID: 18505817 Mind Bomb 1-expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells Neuron. May, 2008 | Pubmed ID: 18498734 A Crucial Role of WW45 in Developing Epithelial Tissues in the Mouse The EMBO Journal. Apr, 2008 | Pubmed ID: 18369314 Crif1 is a Novel Transcriptional Coactivator of STAT3 The EMBO Journal. Feb, 2008 | Pubmed ID: 18200042 An Obligatory Role of Mind Bomb-1 in Notch Signaling of Mammalian Development PloS One. 2007 | Pubmed ID: 18043734 Neuralized-2 Regulates a Notch Ligand in Cooperation with Mind Bomb-1 The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 17003037 Snx5, As a Mind Bomb-binding Protein, is Expressed in Hematopoietic and Endothelial Precursor Cells in Zebrafish FEBS Letters. Aug, 2006 | Pubmed ID: 16857196 Receptor Activator of NF-kappaB Ligand Regulates the Proliferation of Mammary Epithelial Cells Via Id2 Molecular and Cellular Biology. Feb, 2006 | Pubmed ID: 16428453 Mind Bomb 1 is Essential for Generating Functional Notch Ligands to Activate Notch Development (Cambridge, England). Aug, 2005 | Pubmed ID: 16000382 Mind Bomb-2 is an E3 Ligase for Notch Ligand The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15824097 Ein Protokoll für mehrfache Gen-Knockout in Maus-Dünndarm-Organoiden mit einem CRISPR-Concatemer Alessandra Merenda1,2, Amanda Andersson-Rolf1,2, Roxana C. Mustata1, Taibo Li1, Hyunki Kim3, Bon-Kyoung Koo1,2 1Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, 2Department of Genetics, University of Cambridge, 3Department of Pathology, Yonsei University College of Medicine JoVE 55916 Bioengineering Ein Video-Protokoll von retrovirale Infektion in der Grunddarm Organoide Kultur Amanda Andersson-Rolf1,2, Juergen Fink1,2, Roxana C. Mustata2, Bon-Kyoung Koo1,2 1Department of Genetics, University of Cambridge, 2Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge JoVE 51765 Biology
Ein Protokoll für mehrfache Gen-Knockout in Maus-Dünndarm-Organoiden mit einem CRISPR-Concatemer Alessandra Merenda1,2, Amanda Andersson-Rolf1,2, Roxana C. Mustata1, Taibo Li1, Hyunki Kim3, Bon-Kyoung Koo1,2 1Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, 2Department of Genetics, University of Cambridge, 3Department of Pathology, Yonsei University College of Medicine JoVE 55916 Bioengineering
Ein Video-Protokoll von retrovirale Infektion in der Grunddarm Organoide Kultur Amanda Andersson-Rolf1,2, Juergen Fink1,2, Roxana C. Mustata2, Bon-Kyoung Koo1,2 1Department of Genetics, University of Cambridge, 2Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge JoVE 51765 Biology