Brett Nixon Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences University of Newcastle Biography Publications Institution JoVE Articles Brett Nixon has not added a biography. If you are Brett Nixon and would like to personalize this page please email our Author Liaison for assistance. Publications Proteomic Profiling of Crocodile Spermatozoa Refutes the Tenet That Post-testicular Maturation is Restricted to Mammals Molecular & Cellular Proteomics : MCP. Aug, 2018 | Pubmed ID: 30072580 Double Strand Break DNA Repair Occurs Via Non-Homologous End-Joining in Mouse MII Oocytes Scientific Reports. Jun, 2018 | Pubmed ID: 29946146 Mouse Quiescin Sulfhydryl Oxidases Exhibit Distinct Epididymal Luminal Distribution with Segment-Specific Sperm Surface Associations Biology of Reproduction. May, 2018 | Pubmed ID: 29800099 Improved Methods of DNA Extraction from Human Spermatozoa That Mitigate Experimentally-induced Oxidative DNA Damage PloS One. 2018 | Pubmed ID: 29579126 Pharmacological Inhibition of Arachidonate 15-lipoxygenase Protects Human Spermatozoa Against Oxidative Stress Biology of Reproduction. Jun, 2018 | Pubmed ID: 29546268 Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage Frontiers in Endocrinology. 2018 | Pubmed ID: 29541061 Heat Exposure Induces Oxidative Stress and DNA Damage in the Male Germ Line Biology of Reproduction. Apr, 2018 | Pubmed ID: 29351587 Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 29312475 Characterization of a Novel Role for the Dynamin Mechanoenzymes in the Regulation of Human Sperm Acrosomal Exocytosis Molecular Human Reproduction. Oct, 2017 | Pubmed ID: 29044420 Analysis of the Small Non-protein-coding RNA Profile of Mouse Spermatozoa Reveals Specific Enrichment of PiRNAs Within Mature Spermatozoa RNA Biology. 12, 2017 | Pubmed ID: 28816603 The Lipid Peroxidation Product 4-hydroxynonenal Contributes to Oxidative Stress-mediated Deterioration of the Ageing Oocyte Scientific Reports. Jul, 2017 | Pubmed ID: 28740075 Electrophilic Aldehyde Products of Lipid Peroxidation Selectively Adduct to Heat Shock Protein 90 and Arylsulfatase A in Stallion Spermatozoa Biology of Reproduction. 01, 2017 | Pubmed ID: 28395341 Developmental Expression of the Dynamin Family of Mechanoenzymes in the Mouse Epididymis Biology of Reproduction. 01, 2017 | Pubmed ID: 28395327 Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function Advances in Anatomy, Embryology, and Cell Biology. 2017 | Pubmed ID: 28389751 Epididymal CYP2E1 Plays a Critical Role in Acrylamide-induced DNA Damage in Spermatozoa and Paternally Mediated Embryonic Resorptions† Biology of Reproduction. Apr, 2017 | Pubmed ID: 28379345 Inhibition of Arachidonate 15-lipoxygenase Prevents 4-hydroxynonenal-induced Protein Damage in Male Germ Cells Biology of Reproduction. 03, 2017 | Pubmed ID: 28339608 Proteolytic Degradation of Heat Shock Protein A2 Occurs in Response to Oxidative Stress in Male Germ Cells of the Mouse Molecular Human Reproduction. 02, 2017 | Pubmed ID: 27932549 Non-surgical Sterilisation Methods May Offer a Sustainable Solution to Feral Horse (Equus Caballus) Overpopulation Reproduction, Fertility, and Development. Sep, 2017 | Pubmed ID: 27700983 Biochemical Alterations in the Oocyte in Support of Early Embryonic Development Cellular and Molecular Life Sciences : CMLS. 02, 2017 | Pubmed ID: 27604868 Dynamin 2 is Essential for Mammalian Spermatogenesis Scientific Reports. 10, 2016 | Pubmed ID: 27725702 Formation and Dissociation of Sperm Bundles in Monotremes Biology of Reproduction. 10, 2016 | Pubmed ID: 27557648 Characterisation of Mouse Epididymosomes Reveals a Complex Profile of MicroRNAs and a Potential Mechanism for Modification of the Sperm Epigenome Scientific Reports. 08, 2016 | Pubmed ID: 27549865 Data on the Concentrations of Etoposide, PSC833, BAPTA-AM, and Cycloheximide That Do Not Compromise the Vitality of Mature Mouse Oocytes, Parthenogencially Activated and Fertilized Embryos Data in Brief. Sep, 2016 | Pubmed ID: 27547800 Identification of a Key Role for Permeability Glycoprotein in Enhancing the Cellular Defense Mechanisms of Fertilized Oocytes Developmental Biology. 09, 2016 | Pubmed ID: 27397031 Chronic Acrylamide Exposure in Male Mice Induces DNA Damage to Spermatozoa; Potential for Amelioration by Resveratrol Reproductive Toxicology (Elmsford, N.Y.). 08, 2016 | Pubmed ID: 27174446 The Australian Saltwater Crocodile (Crocodylus Porosus) Provides Evidence That the Capacitation of Spermatozoa May Extend Beyond the Mammalian Lineage Proceedings. Biological Sciences. 05, 2016 | Pubmed ID: 27147099 A Novel Germ Cell Protein, SPIF (sperm PKA Interacting Factor), is Essential for the Formation of a PKA/TCP11 Complex That Undergoes Conformational and Phosphorylation Changes Upon Capacitation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27105888 Heat Shock Protein Member A2 Forms a Stable Complex with Angiotensin Converting Enzyme and Protein Disulfide Isomerase A6 in Human Spermatozoa Molecular Human Reproduction. Feb, 2016 | Pubmed ID: 26676989 Assessment of MicroRNA Expression in Mouse Epididymal Epithelial Cells and Spermatozoa by Next Generation Sequencing Genomics Data. Dec, 2015 | Pubmed ID: 26697376 The Impact of Oxidative Stress on Chaperone-mediated Human Sperm-egg Interaction Human Reproduction (Oxford, England). Nov, 2015 | Pubmed ID: 26345691 The MicroRNA Signature of Mouse Spermatozoa is Substantially Modified During Epididymal Maturation Biology of Reproduction. Oct, 2015 | Pubmed ID: 26333995 Next Generation Sequencing Analysis Reveals Segmental Patterns of MicroRNA Expression in Mouse Epididymal Epithelial Cells PloS One. 2015 | Pubmed ID: 26270822 Novel Characterization of the HSPA2-stabilizing Protein BAG6 in Human Spermatozoa Molecular Human Reproduction. Oct, 2015 | Pubmed ID: 26153132 Are Sperm Capacitation and Apoptosis the Opposite Ends of a Continuum Driven by Oxidative Stress? Asian Journal of Andrology. Jul-Aug, 2015 | Pubmed ID: 25999358 The 12 (th) International Symposium on Spermatology Asian Journal of Andrology. Jul-Aug, 2015 | Pubmed ID: 25994646 The Role of the Molecular Chaperone Heat Shock Protein A2 (HSPA2) in Regulating Human Sperm-egg Recognition Asian Journal of Andrology. Jul-Aug, 2015 | Pubmed ID: 25865850 Glycogen Synthase Kinase 3 Regulates Acrosomal Exocytosis in Mouse Spermatozoa Via Dynamin Phosphorylation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2015 | Pubmed ID: 25808536 Mouse Spermatocytes Express CYP2E1 and Respond to Acrylamide Exposure PloS One. 2014 | Pubmed ID: 24788432 Post-testicular Sperm Maturation and Identification of an Epididymal Protein in the Japanese Quail (Coturnix Coturnix Japonica) Reproduction (Cambridge, England). Mar, 2014 | Pubmed ID: 24298048 Capacitation in the Presence of Methyl-β-cyclodextrin Results in Enhanced Zona Pellucida-binding Ability of Stallion Spermatozoa Reproduction (Cambridge, England). Feb, 2014 | Pubmed ID: 24194571 The Rise of Testicular Germ Cell Tumours: the Search for Causes, Risk Factors and Novel Therapeutic Targets F1000Research. 2013 | Pubmed ID: 24555040 Sperm Capacitation: a Distant Landscape Glimpsed but Unexplored Molecular Human Reproduction. Dec, 2013 | Pubmed ID: 24071444 Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization in Vitro Biology of Reproduction. Mar, 2013 | Pubmed ID: 23365415 Investigation of the Mechanisms by Which the Molecular Chaperone HSPA2 Regulates the Expression of Sperm Surface Receptors Involved in Human Sperm-oocyte Recognition Molecular Human Reproduction. Mar, 2013 | Pubmed ID: 23247813 The Function of Chaperone Proteins in the Assemblage of Protein Complexes Involved in Gamete Adhesion and Fusion Processes Reproduction (Cambridge, England). Feb, 2013 | Pubmed ID: 23166368 The Molecular Chaperone HSPA2 Plays a Key Role in Regulating the Expression of Sperm Surface Receptors That Mediate Sperm-egg Recognition PloS One. 2012 | Pubmed ID: 23209833 Dynamin Regulates Specific Membrane Fusion Events Necessary for Acrosomal Exocytosis in Mouse Spermatozoa The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22977254 Proteomic Insights into the Maturation and Capacitation of Mammalian Spermatozoa Systems Biology in Reproductive Medicine. Aug, 2012 | Pubmed ID: 22788533 Chronic Exposure to Acrylamide Induces DNA Damage in Male Germ Cells of Mice Toxicological Sciences : an Official Journal of the Society of Toxicology. Sep, 2012 | Pubmed ID: 22610608 A Unique Combination of Male Germ Cell MiRNAs Coordinates Gonocyte Differentiation PloS One. 2012 | Pubmed ID: 22536405 The Role of Molecular Chaperones in Spermatogenesis and the Post-testicular Maturation of Mammalian Spermatozoa Human Reproduction Update. Jul, 2012 | Pubmed ID: 22523110 Staying Alive: PI3K Pathway Promotes Primordial Follicle Activation and Survival in Response to 3MC-induced Ovotoxicity Toxicological Sciences : an Official Journal of the Society of Toxicology. Jul, 2012 | Pubmed ID: 22505044 The Chaperonin Containing TCP1 Complex (CCT/TRiC) is Involved in Mediating Sperm-oocyte Interaction The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21880732 Proteomic and Functional Analysis of Human Sperm Detergent Resistant Membranes Journal of Cellular Physiology. Oct, 2011 | Pubmed ID: 21792924 Involvement of Multimeric Protein Complexes in Mediating the Capacitation-dependent Binding of Human Spermatozoa to Homologous Zonae Pellucidae Developmental Biology. Aug, 2011 | Pubmed ID: 21672535 Monotremes Provide a Key to Understanding the Evolutionary Significance of Epididymal Sperm Maturation Journal of Andrology. Nov-Dec, 2011 | Pubmed ID: 21441429 Cellular Mechanisms Regulating Sperm-zona Pellucida Interaction Asian Journal of Andrology. Jan, 2011 | Pubmed ID: 21042304 Sperm-zona Pellucida Interaction: Molecular Mechanisms and the Potential for Contraceptive Intervention Handbook of Experimental Pharmacology. 2010 | Pubmed ID: 20839091 New Insights into Sperm Physiology and Pathology Handbook of Experimental Pharmacology. 2010 | Pubmed ID: 20839089 Elucidation of the Signaling Pathways That Underpin Capacitation-associated Surface Phosphotyrosine Expression in Mouse Spermatozoa Journal of Cellular Physiology. Jul, 2010 | Pubmed ID: 20232304 The Biological Significance of Detergent-resistant Membranes in Spermatozoa Journal of Reproductive Immunology. Dec, 2009 | Pubmed ID: 19857901 DNA Damage in Human Spermatozoa is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-hydroxy-2'-deoxyguanosine, a Marker of Oxidative Stress Biology of Reproduction. Sep, 2009 | Pubmed ID: 19494251 Composition and Significance of Detergent Resistant Membranes in Mouse Spermatozoa Journal of Cellular Physiology. Jan, 2009 | Pubmed ID: 18726997 Genome Analysis of the Platypus Reveals Unique Signatures of Evolution Nature. May, 2008 | Pubmed ID: 18464734 Identification of the Molecular Chaperone, Heat Shock Protein 1 (chaperonin 10), in the Reproductive Tract and in Capacitating Spermatozoa in the Male Mouse Biology of Reproduction. Jun, 2008 | Pubmed ID: 18276932 Investigation of the Role of SRC in Capacitation-associated Tyrosine Phosphorylation of Human Spermatozoa Molecular Human Reproduction. Apr, 2008 | Pubmed ID: 18245108 Molecular and Functional Characterization of the Rabbit Epididymal Secretory Protein 52, REP52 Biology of Reproduction. May, 2008 | Pubmed ID: 18199886 Proteomic Changes in Mammalian Spermatozoa During Epididymal Maturation Asian Journal of Andrology. Jul, 2007 | Pubmed ID: 17589795 Role of the Epididymis in Sperm Competition Asian Journal of Andrology. Jul, 2007 | Pubmed ID: 17589786 The Identification of Mouse Sperm-surface-associated Proteins and Characterization of Their Ability to Act As Decapacitation Factors Biology of Reproduction. Feb, 2006 | Pubmed ID: 16221991 Evidence for the Involvement of PECAM-1 in a Receptor Mediated Signal-transduction Pathway Regulating Capacitation-associated Tyrosine Phosphorylation in Human Spermatozoa Journal of Cell Science. Oct, 2005 | Pubmed ID: 16219692 The Role of Molecular Chaperones in Mouse Sperm-egg Interactions Molecular and Cellular Endocrinology. Aug, 2005 | Pubmed ID: 16043280 Localization and Significance of Molecular Chaperones, Heat Shock Protein 1, and Tumor Rejection Antigen Gp96 in the Male Reproductive Tract and During Capacitation and Acrosome Reaction Biology of Reproduction. Feb, 2005 | Pubmed ID: 15456702 Tyrosine Phosphorylation Activates Surface Chaperones Facilitating Sperm-zona Recognition Journal of Cell Science. Jul, 2004 | Pubmed ID: 15252132 Identification of RARhoGAP, a Novel Putative RhoGAP Gene Expressed in Male Germ Cells Genomics. Aug, 2004 | Pubmed ID: 15234003 Rabbit Epididymal Secretory Proteins. I. Characterization and Hormonal Regulation Biology of Reproduction. Jul, 2002 | Pubmed ID: 12080009 Epididimal Protein sentezi ve salgı Analizi Wei Zhou1,2, Petra Sipilä3, Geoffry N. De Iuliis1,2, Matthew D. Dun2,4, Brett Nixon1,2 1Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, 2Hunter Medical Research Institute, 3Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, 4School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle JoVE 58308 Developmental Biology
Epididimal Protein sentezi ve salgı Analizi Wei Zhou1,2, Petra Sipilä3, Geoffry N. De Iuliis1,2, Matthew D. Dun2,4, Brett Nixon1,2 1Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, 2Hunter Medical Research Institute, 3Department of Physiology, Turku Center for Disease Modeling, Institute of Biomedicine, University of Turku, 4School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle JoVE 58308 Developmental Biology