Cecilia Flores Douglas Mental Health University Institute McGill University Biography Publications Institution JoVE Articles Cecilia Flores has not added a biography. If you are Cecilia Flores and would like to personalize this page please email our Author Liaison for assistance. Publications Gains and Losses: Resilience to Social Defeat Stress in Adolescent Female Mice Biological Psychiatry. Jan, 2024 | Pubmed ID: 37355003 Rewiring the Future: Drugs Abused in Adolescence May Predispose to Mental Illness in Adult Life by Altering Dopamine Axon Growth Journal of Neural Transmission (Vienna, Austria : 1996). Dec, 2023 | Pubmed ID: 38036858 RGMa and Neogenin Control Dendritic Spine Morphogenesis Via WAVE Regulatory Complex-mediated Actin Remodeling Frontiers in Molecular Neuroscience. 2023 | Pubmed ID: 37928069 Preparation and Processing of Dried Blood Spots for MicroRNA Sequencing Biology Methods & Protocols. 2023 | Pubmed ID: 37901452 Axo-glial Interactions Between Midbrain Dopamine Neurons and Oligodendrocyte Lineage Cells in the Anterior Corpus Callosum Brain Structure & Function. Nov, 2023 | Pubmed ID: 37668732 Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry Biological Psychiatry Global Open Science. Jul, 2023 | Pubmed ID: 37519472 Relationship Between Insulin and Netrin-1/DCC Guidance Cue Pathway Regulation in the Prefrontal Cortex of Rodents Exposed to Prenatal Dietary Restriction Journal of Developmental Origins of Health and Disease. Aug, 2023 | Pubmed ID: 37431265 Amphetamine Disrupts Dopamine Axon Growth in Adolescence by a Sex-specific Mechanism in Mice Nature Communications. Jul, 2023 | Pubmed ID: 37419977 Awakening the Dormant: Role of Axonal Guidance Cues in Stress-induced Reorganization of the Adult Prefrontal Cortex Leading to Depression-like Behavior Frontiers in Neural Circuits. 2023 | Pubmed ID: 37035502 We're Not in Kansas Anymore: Ectopic Dopaminergic Terminals As an Explanation for the Positive Symptoms in Psychiatric Pathology Journal of Psychiatry & Neuroscience : JPN. 2023 | Pubmed ID: 36810305 Reduced Dopamine Release in Dcc Haploinsufficiency Male Mice Abolishes the Rewarding Effects of Cocaine but Not Those of Morphine and Ethanol Psychopharmacology. Mar, 2023 | Pubmed ID: 36471064 Corticolimbic DCC Gene Co-expression Networks As Predictors of Impulsivity in Children Molecular Psychiatry. Jun, 2022 | Pubmed ID: 35388180 Custom-Built Operant Conditioning Setup for Calcium Imaging and Cognitive Testing in Freely Moving Mice ENeuro. 2022 | Pubmed ID: 35105659 MicroRNAs As Promising Peripheral Sensors of Prefrontal Cortex Developmental Trajectory and Psychiatric Risk Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2022 | Pubmed ID: 34312494 Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development Frontiers in Neural Circuits. 2021 | Pubmed ID: 34566584 Mechanisms of Cortical Development: From the Embryo to Adulthood Seminars in Cell & Developmental Biology. Oct, 2021 | Pubmed ID: 34462250 MicroRNA Regulation of Prefrontal Cortex Development and Psychiatric Risk in Adolescence Seminars in Cell & Developmental Biology. Oct, 2021 | Pubmed ID: 33933350 Unique Effects of Social Defeat Stress in Adolescent Male Mice on the Netrin-1/DCC Pathway, Prefrontal Cortex Dopamine and Cognition (Social Stress in Adolescent Vs. Adult Male Mice) ENeuro. Feb, 2021 | Pubmed ID: 33619036 MiR-218 in Adolescence Predicts and Mediates Vulnerability to Stress Biological Psychiatry. May, 2021 | Pubmed ID: 33384174 Gene Network in the Prefrontal Cortex is Associated with Total Brain Volume in Childhood Journal of Psychiatry & Neuroscience : JPN. Nov, 2020 | Pubmed ID: 33206040 Dopamine Axon Targeting in the Nucleus Accumbens in Adolescence Requires Netrin-1 Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32714924 The Netrin-1/DCC Guidance Cue Pathway As a Molecular Target in Depression: Translational Evidence Biological Psychiatry. Oct, 2020 | Pubmed ID: 32593422 Low-cost Conditioned Place Preference Setup Including Video Recording and Analysis of Behaviour MethodsX. 2020 | Pubmed ID: 32405466 The Netrin-1/DCC Guidance System: Dopamine Pathway Maturation and Psychiatric Disorders Emerging in Adolescence Molecular Psychiatry. Feb, 2020 | Pubmed ID: 31659271 DCC-related Developmental Effects of Abused- Versus Therapeutic-like Amphetamine Doses in Adolescence Addiction Biology. Jul, 2020 | Pubmed ID: 31192517 MiR-218: a Molecular Switch and Potential Biomarker of Susceptibility to Stress Molecular Psychiatry. May, 2020 | Pubmed ID: 30980043 Neural Function in DCC Mutation Carriers with and Without Mirror Movements Annals of Neurology. 03, 2019 | Pubmed ID: 30666715 Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior Cerebral Cortex (New York, N.Y. : 1991). Aug, 2019 | Pubmed ID: 30295713 Guidance Cues: Linking Drug Use in Adolescence with Psychiatric Disorders Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2019 | Pubmed ID: 30275561 Mesocorticolimbic Connectivity and Volumetric Alterations in Mutation Carriers The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 05, 2018 | Pubmed ID: 29712788 Dopamine Development in the Mouse Orbital Prefrontal Cortex Is Protracted and Sensitive to Amphetamine in Adolescence ENeuro. 2018 | Pubmed ID: 29333488 An Optimized Immunohistochemistry Protocol for Detecting the Guidance Cue Netrin-1 in Neural Tissue MethodsX. 2018 | Pubmed ID: 29276694 Non-Contingent Exposure to Amphetamine in Adolescence Recruits MiR-218 to Regulate Dcc Expression in the VTA Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2018 | Pubmed ID: 29154364 DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence Biological Psychiatry. Jan, 2018 | Pubmed ID: 28720317 Adolescence and Reward: Making Sense of Neural and Behavioral Changes Amid the Chaos The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2017 | Pubmed ID: 29118215 Making Dopamine Connections in Adolescence Trends in Neurosciences. Dec, 2017 | Pubmed ID: 29032842 A Non-invasive Restraining System for Awake Mouse Imaging Journal of Neuroscience Methods. Aug, 2017 | Pubmed ID: 28634149 Dcc Haploinsufficiency Regulates Dopamine Receptor Expression Across Postnatal Lifespan Neuroscience. Mar, 2017 | Pubmed ID: 28108253 DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by MiR-218 Biological Psychiatry. Feb, 2017 | Pubmed ID: 27773352 Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon ENeuro. 2016 | Pubmed ID: 27419218 Dcc Haploinsufficiency Results in Blunted Sensitivity to Cocaine Enhancement of Reward Seeking Behavioural Brain Research. Feb, 2016 | Pubmed ID: 26005129 Resilience to Amphetamine in Mouse Models of Netrin-1 Haploinsufficiency: Role of Mesocortical Dopamine Psychopharmacology. Oct, 2015 | Pubmed ID: 26264903 Amphetamine in Adolescence Disrupts the Development of Medial Prefrontal Cortex Dopamine Connectivity in a DCC-dependent Manner Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25336209 The Netrin-1 Receptor DCC is a Regulator of Maladaptive Responses to Chronic Morphine Administration BMC Genomics. May, 2014 | Pubmed ID: 24884839 Haloperidol Treatment Downregulates DCC Expression in the Ventral Tegmental Area Neuroscience Letters. Jul, 2014 | Pubmed ID: 24861518 Adolescence: a Time of Transition for the Phenotype of Dcc Heterozygous Mice Psychopharmacology. Apr, 2014 | Pubmed ID: 23572211 Unc5c Haploinsufficient Phenotype: Striking Similarities with the Dcc Haploinsufficiency Model The European Journal of Neuroscience. Sep, 2013 | Pubmed ID: 23738838 Association Between Schizophrenia and Genetic Variation in DCC: a Case-control Study Schizophrenia Research. May, 2012 | Pubmed ID: 22418395 Juvenile Exposure to Methylphenidate Reduces Cocaine Reward and Alters Netrin-1 Receptor Expression in Adulthood Behavioural Brain Research. Apr, 2012 | Pubmed ID: 22249134 Leptin and Interleukin-6 Alter the Function of Mesolimbic Dopamine Neurons in a Rodent Model of Prenatal Inflammation Psychoneuroendocrinology. Jul, 2012 | Pubmed ID: 22133515 The Netrin Receptor DCC is Required in the Pubertal Organization of Mesocortical Dopamine Circuitry The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21653843 Abolition of the Behavioral Phenotype of Adult Netrin-1 Receptor Deficient Mice by Exposure to Amphetamine During the Juvenile Period Psychopharmacology. Oct, 2011 | Pubmed ID: 21523346 Role of Netrin-1 in the Organization and Function of the Mesocorticolimbic Dopamine System Journal of Psychiatry & Neuroscience : JPN. Sep, 2011 | Pubmed ID: 21481303 Peri-pubertal Emergence of UNC-5 Homologue Expression by Dopamine Neurons in Rodents PloS One. Jul, 2010 | Pubmed ID: 20628609 Prenatal Inflammation-induced Hypoferremia Alters Dopamine Function in the Adult Offspring in Rat: Relevance for Schizophrenia PloS One. Jun, 2010 | Pubmed ID: 20532043 Netrin-1 Receptor in the Ventral Tegmental Area is Required for Sensitization to Amphetamine The European Journal of Neuroscience. Apr, 2010 | Pubmed ID: 20345916 Post-pubertal Emergence of a Dopamine Phenotype in Netrin-1 Receptor-deficient Mice The European Journal of Neuroscience. Oct, 2009 | Pubmed ID: 19788579 Alcohol Dependence-related Increase of Glial Cell Density in the Anterior Cingulate Cortex of Suicide Completers Journal of Psychiatry & Neuroscience : JPN. Jul, 2009 | Pubmed ID: 19568479 The 31st Annual Meeting of the Canadian College of Neuropsychopharmacology: Toronto, Ontario, June 6-9, 2008 Journal of Psychiatry & Neuroscience : JPN. Jan, 2009 | Pubmed ID: 19125215 Altered Netrin-1 Receptor Expression in Dopamine Terminal Regions Following Neonatal Ventral Hippocampal Lesions in the Rat Synapse (New York, N.Y.). Jan, 2009 | Pubmed ID: 18932228 Netrin-1 Receptor-deficient Mice Show Enhanced Mesocortical Dopamine Transmission and Blunted Behavioural Responses to Amphetamine The European Journal of Neuroscience. Dec, 2007 | Pubmed ID: 18005074 Chronic Phencyclidine Treatment Increases Dendritic Spine Density in Prefrontal Cortex and Nucleus Accumbens Neurons Synapse (New York, N.Y.). Dec, 2007 | Pubmed ID: 17879264 Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice Andrea Harée Pantoja-Urbán1, Samuel Richer1, Michel Giroux2, Dominique Nouel2, Cecilia Flores2,3,4,5 1Integrated Program in Neuroscience, McGill University, 2Douglas Mental Health University Institute, McGill University, 3Department of Psychiatry, McGill University, 4Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, 5Ludmer Centre for Neuroinformatics & Mental Health, McGill University JoVE 66455 Neuroscience
Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice Andrea Harée Pantoja-Urbán1, Samuel Richer1, Michel Giroux2, Dominique Nouel2, Cecilia Flores2,3,4,5 1Integrated Program in Neuroscience, McGill University, 2Douglas Mental Health University Institute, McGill University, 3Department of Psychiatry, McGill University, 4Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, 5Ludmer Centre for Neuroinformatics & Mental Health, McGill University JoVE 66455 Neuroscience