Charles C. Richardson Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Biography Publications Institution JoVE Articles Charles C. Richardson has not added a biography. If you are Charles C. Richardson and would like to personalize this page please email our Author Liaison for assistance. Publications Essential Protein Interactions Within the Replisome Regulate DNA Replication Cell Cycle (Georgetown, Tex.). Oct, 2011 | Pubmed ID: 22067709 Choreography of Bacteriophage T7 DNA Replication Current Opinion in Chemical Biology. Oct, 2011 | Pubmed ID: 21907611 Coupling DTTP Hydrolysis with DNA Unwinding by the DNA Helicase of Bacteriophage T7 The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21840995 Bypass of a Nick by the Replisome of Bacteriophage T7 The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21701044 Pyrovanadolysis, a Pyrophosphorolysis-like Reaction Mediated by Pyrovanadate, Mn2+, and DNA Polymerase of Bacteriophage T7 The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21697085 Helicase-DNA Polymerase Interaction is Critical to Initiate Leading-strand DNA Synthesis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606333 The Glutamate Switch of Bacteriophage T7 DNA Helicase: Role in Coupling Nucleotide Triphosphate (NTP) and DNA Binding to NTP Hydrolysis The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21566126 Simultaneous Single-molecule Measurements of Phage T7 Replisome Composition and Function Reveal the Mechanism of Polymerase Exchange Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21245349 Conformational Dynamics of Bacteriophage T7 DNA Polymerase and Its Processivity Factor, Escherichia Coli Thioredoxin Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20696935 Molecular Basis for Recognition of Nucleoside Triphosphate by Gene 4 Helicase of Bacteriophage T7 The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20688917 A Novel Nucleotide Kinase Encoded by Gene 1.7 of Bacteriophage T7 Molecular Microbiology. Jul, 2010 | Pubmed ID: 20497505 Direct Role for the RNA Polymerase Domain of T7 Primase in Primer Delivery Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20439755 Two Modes of Interaction of the Single-stranded DNA-binding Protein of Bacteriophage T7 with the DNA Polymerase-thioredoxin Complex The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20375019 Residues in the Central Beta-hairpin of the DNA Helicase of Bacteriophage T7 Are Important in DNA Unwinding Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351255 Mechanism of Sequence-specific Template Binding by the DNA Primase of Bacteriophage T7 Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20350931 Thioredoxin Suppresses Microscopic Hopping of T7 DNA Polymerase on Duplex DNA Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20080681 C-terminal Phenylalanine of Bacteriophage T7 Single-stranded DNA-binding Protein is Essential for Strand Displacement Synthesis by T7 DNA Polymerase at a Nick in DNA The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19726688 An in Trans Interaction at the Interface of the Helicase and Primase Domains of the Hexameric Gene 4 Protein of Bacteriophage T7 Modulates Their Activities The Journal of Biological Chemistry. Aug, 2009 | Pubmed ID: 19574219 Rescue of Bacteriophage T7 DNA Polymerase of Low Processivity by Suppressor Mutations Affecting Gene 3 Endonuclease Journal of Virology. Sep, 2009 | Pubmed ID: 19535436 Mutations in the Gene 5 DNA Polymerase of Bacteriophage T7 Suppress the Dominant Lethal Phenotype of Gene 2.5 SsDNA Binding Protein Lacking the C-terminal Phenylalanine Molecular Microbiology. May, 2009 | Pubmed ID: 19400798 Motors, Switches, and Contacts in the Replisome Annual Review of Biochemistry. 2009 | Pubmed ID: 19298182 Promiscuous Usage of Nucleotides by the DNA Helicase of Bacteriophage T7: Determinants of Nucleotide Specificity The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19297330 DNA Recognition by the DNA Primase of Bacteriophage T7: a Structure-function Study of the Zinc-binding Domain Biochemistry. Mar, 2009 | Pubmed ID: 19206208 Dynamics of DNA Replication Loops Reveal Temporal Control of Lagging-strand Synthesis Nature. Jan, 2009 | Pubmed ID: 19029884 Interactions of Escherichia Coli Thioredoxin, the Processivity Factor, with Bacteriophage T7 DNA Polymerase and Helicase The Journal of Biological Chemistry. Nov, 2008 | Pubmed ID: 18757858 Peptide Ligands Specific to the Oxidized Form of Escherichia Coli Thioredoxin Biochimica Et Biophysica Acta. Nov, 2008 | Pubmed ID: 18672101 Gene 1.7 of Bacteriophage T7 Confers Sensitivity of Phage Growth to Dideoxythymidine Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18599435 Communication Between Subunits Critical to DNA Binding by Hexameric Helicase of Bacteriophage T7 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18574147 Acidic C-terminal Tail of the SsDNA-binding Protein of Bacteriophage T7 and SsDNA Compete for the Same Binding Surface Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18238893 Inadequate Inhibition of Host RNA Polymerase Restricts T7 Bacteriophage Growth on Hosts Overexpressing Udk Molecular Microbiology. Jan, 2008 | Pubmed ID: 18067538 Dynamic DNA Helicase-DNA Polymerase Interactions Assure Processive Replication Fork Movement Molecular Cell. Aug, 2007 | Pubmed ID: 17707227 Exchange of DNA Polymerases at the Replication Fork of Bacteriophage T7 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17369350 Genomewide Screens for Escherichia Coli Genes Affecting Growth of T7 Bacteriophage Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17135349 Single Molecule Force Spectroscopy of Salt-dependent Bacteriophage T7 Gene 2.5 Protein Binding to Single-stranded DNA The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17050544 Essential Residues in the C Terminus of the Bacteriophage T7 Gene 2.5 Single-stranded DNA-binding Protein The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16807232 The C-terminal Residues of Bacteriophage T7 Gene 4 Helicase-primase Coordinate Helicase and DNA Polymerase Activities The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16807231 Oligomeric States of Bacteriophage T7 Gene 4 Primase/helicase Journal of Molecular Biology. Jul, 2006 | Pubmed ID: 16777142 Primer Initiation and Extension by T7 DNA Primase The EMBO Journal. May, 2006 | Pubmed ID: 16642036 DNA Primase Acts As a Molecular Brake in DNA Replication Nature. Feb, 2006 | Pubmed ID: 16452983 DNA-induced Switch from Independent to Sequential DTTP Hydrolysis in the Bacteriophage T7 DNA Helicase Molecular Cell. Jan, 2006 | Pubmed ID: 16427007 Acidic Residues in the Nucleotide-binding Site of the Bacteriophage T7 DNA Primase The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15917241 A Unique Loop in T7 DNA Polymerase Mediates the Binding of Helicase-primase, DNA Binding Protein, and Processivity Factor Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15795374 Crystal Structures of 2-acetylaminofluorene and 2-aminofluorene in Complex with T7 DNA Polymerase Reveal Mechanisms of Mutagenesis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15528277 The Highly Processive DNA Polymerase of Bacteriophage T5. Role of the Unique N and C Termini The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15377656 A Unique Region in Bacteriophage T7 DNA Polymerase Important for Exonucleolytic Hydrolysis of DNA The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15292168 The Arginine Finger of Bacteriophage T7 Gene 4 Helicase: Role in Energy Coupling Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 15070725 The Linker Region Between the Helicase and Primase Domains of the Gene 4 Protein of Bacteriophage T7. Role in Helicase Conformation and Activity The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15044475 Effect of Single-stranded DNA-binding Proteins on the Helicase and Primase Activities of the Bacteriophage T7 Gene 4 Protein The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15044449 Proteomic Analysis of Thioredoxin-targeted Proteins in Escherichia Coli Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 15004283 Single-molecule Kinetics of Lambda Exonuclease Reveal Base Dependence and Dynamic Disorder Science (New York, N.Y.). Aug, 2003 | Pubmed ID: 12947199 Modular Architecture of the Bacteriophage T7 Primase Couples RNA Primer Synthesis to DNA Synthesis Molecular Cell. May, 2003 | Pubmed ID: 12769857 The Carboxyl-terminal Domain of Bacteriophage T7 Single-stranded DNA-binding Protein Modulates DNA Binding and Interaction with T7 DNA Polymerase The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12766155 A Single-stranded DNA-binding Protein of Bacteriophage T7 Defective in DNA Annealing The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12748198 A Covalent Linkage Between the Gene 5 DNA Polymerase of Bacteriophage T7 and Escherichia Coli Thioredoxin, the Processivity Factor: Fate of Thioredoxin During DNA Synthesis The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12692131 The DNA Binding Domain of the Gene 2.5 Single-stranded DNA-binding Protein of Bacteriophage T7 The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12496273 Essential Amino Acid Residues in the Single-stranded DNA-binding Protein of Bacteriophage T7. Identification of the Dimer Interface The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12379653 Interaction of Adjacent Primase Domains Within the Hexameric Gene 4 Helicase-primase of Bacteriophage T7 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12228732 Lagging Strand Synthesis in Coordinated DNA Synthesis by Bacteriophage T7 Replication Proteins Journal of Molecular Biology. Feb, 2002 | Pubmed ID: 11829500 ठंड-कतरा डीएनए संश्लेषण की काइनेटिक्स Alfredo J. Hernandez1, Charles C. Richardson1 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Genetics डीएनए नकल एंजाइमों का प्रत्यक्ष प्रेक्षण एक एकल अणु डीएनए परख टूटती का उपयोग Arkadiusz W. Kulczyk1, Nathan A. Tanner1, Joseph J. Loparo1, Charles C. Richardson1, Antoine M. van Oijen1 1Harvard Medical School JoVE 1689 Biology
ठंड-कतरा डीएनए संश्लेषण की काइनेटिक्स Alfredo J. Hernandez1, Charles C. Richardson1 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Genetics
डीएनए नकल एंजाइमों का प्रत्यक्ष प्रेक्षण एक एकल अणु डीएनए परख टूटती का उपयोग Arkadiusz W. Kulczyk1, Nathan A. Tanner1, Joseph J. Loparo1, Charles C. Richardson1, Antoine M. van Oijen1 1Harvard Medical School JoVE 1689 Biology