Chi-Hao Luan High Throughput Analysis Laboratory, Department of Molecular Biosciences Northwestern University Biography Publications Institution JoVE Articles Chi-Hao Luan has not added a biography. If you are Chi-Hao Luan and would like to personalize this page please email our Author Liaison for assistance. Publications Identification and Characterization of PPARα Ligands in the Hippocampus Nature Chemical Biology. Oct, 2016 | Pubmed ID: 27748752 Crystal Structures of the Transpeptidase Domain of the Mycobacterium Tuberculosis Penicillin-binding Protein PonA1 Reveal Potential Mechanisms of Antibiotic Resistance The FEBS Journal. Jun, 2016 | Pubmed ID: 27101811 Fluorescence-based Thermal Shift Data on Multidrug Regulator AcrR from Salmonella Enterica Subsp. Entrica Serovar Typhimurium Str. LT2 Data in Brief. Jun, 2016 | Pubmed ID: 27054155 Structure and Mechanism of the Essential Two-component Signal-transduction System WalKR in Staphylococcus Aureus Nature Communications. Mar, 2016 | Pubmed ID: 26987594 Loop-to-helix Transition in the Structure of Multidrug Regulator AcrR at the Entrance of the Drug-binding Cavity Journal of Structural Biology. Apr, 2016 | Pubmed ID: 26796657 A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells Cell Reports. Jan, 2016 | Pubmed ID: 26774481 Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons Scientific Reports. Nov, 2015 | Pubmed ID: 26521685 HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice Cell Metabolism. Aug, 2015 | Pubmed ID: 26118928 Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Journal of Biomolecular Screening. Oct, 2015 | Pubmed ID: 26045196 Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers PloS One. 2015 | Pubmed ID: 25928376 Ligand Screening Using Fluorescence Thermal Shift Analysis (FTS) Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24590724 Structural Characterization of a Hypothetical Protein: a Potential Agent Involved in Trimethylamine Metabolism in Catenulispora Acidiphila Journal of Structural and Functional Genomics. Mar, 2014 | Pubmed ID: 24562475 A Fluorescence-based Thermal Shift Assay Identifies Inhibitors of Mitogen Activated Protein Kinase Kinase 4 PloS One. 2013 | Pubmed ID: 24339940 Antagonism of L-type Ca2+ Channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans As Dihydropyridine Mimics Bioorganic & Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23688558 Structure-activity Relationship of N,N'-disubstituted Pyrimidinetriones As Ca(V)1.3 Calcium Channel-selective Antagonists for Parkinson's Disease Journal of Medicinal Chemistry. Jun, 2013 | Pubmed ID: 23651412 Structure of Severe Fever with Thrombocytopenia Syndrome Virus Nucleocapsid Protein in Complex with Suramin Reveals Therapeutic Potential Journal of Virology. Jun, 2013 | Pubmed ID: 23576501 Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth Cancer Cell. Nov, 2012 | Pubmed ID: 23153533 CaV1.3-selective L-type Calcium Channel Antagonists As Potential New Therapeutics for Parkinson's Disease Nature Communications. 2012 | Pubmed ID: 23093183 High-throughput Screen for Identifying Small Molecules That Target Fungal Zinc Homeostasis PloS One. 2011 | Pubmed ID: 21980385 Targeting MgrA-mediated Virulence Regulation in Staphylococcus Aureus Chemistry & Biology. Aug, 2011 | Pubmed ID: 21867918 Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates Toward Voltage-dependent L-type Ca2+ Channels Ca V 1.3 and Ca V 1.2 Bioorganic & Medicinal Chemistry. May, 2010 | Pubmed ID: 20382537 A High Throughput Platform for Eukaryotic Genes Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18542866 Domain Selection Combined with Improved Cloning Strategy for High Throughput Expression of Higher Eukaryotic Proteins BMC Biotechnology. Jul, 2007 | Pubmed ID: 17663785 Antibacterial Nicotinamide Adenine Dinucleotide Synthetase Inhibitors: Amide- and Ether-linked Tethered Dimers with Alpha-amino Acid End Groups Journal of Medicinal Chemistry. May, 2007 | Pubmed ID: 17489580 Improving Solubility of Shewanella Oneidensis MR-1 and Clostridium Thermocellum JW-20 Proteins Expressed into Esherichia Coli Journal of Proteome Research. Nov-Dec, 2005 | Pubmed ID: 16335938 Tethered Dimer Inhibitors of NAD Synthetase: Parallel Synthesis of an Aryl-substituted SAR Library Journal of Combinatorial Chemistry. Nov-Dec, 2005 | Pubmed ID: 16283799 Protein Production and Crystallization at SECSG -- an Overview Journal of Structural and Functional Genomics. 2005 | Pubmed ID: 16211524 Identification and Characterization of Nonsubstrate Based Inhibitors of the Essential Dengue and West Nile Virus Proteases Bioorganic & Medicinal Chemistry. Jan, 2005 | Pubmed ID: 15582469 High-throughput Expression of C. Elegans Proteins Genome Research. Oct, 2004 | Pubmed ID: 15489332 Structural Genomics for Caenorhabditis Elegans: High Throughput Protein Expression Analysis Protein Expression and Purification. Mar, 2004 | Pubmed ID: 14766299 Tethered Dimers As NAD Synthetase Inhibitors with Antibacterial Activity Journal of Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12852767 Crystal Structure of the Cytoskeleton-associated Protein Glycine-rich (CAP-Gly) Domain The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12221106 Identification of the N-terminal Functional Domains of Cdk5 by Molecular Truncation and Computer Modeling Proteins. Aug, 2002 | Pubmed ID: 12112670 שיטה לזיהוי מולקולה קטנה מעכבים של האינטראקציה בין החלבונים בין HCN1 ו TRIP8b Ye Han*1, Kyle A. Lyman*1, Matt Clutter2, Gary E. Schiltz3, Quratul-Ain Ismail1, Xiangying Cheng1, Chi-Hao Luan4, Dane M. Chetkovich1,5 1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University JoVE 54540 Biochemistry
שיטה לזיהוי מולקולה קטנה מעכבים של האינטראקציה בין החלבונים בין HCN1 ו TRIP8b Ye Han*1, Kyle A. Lyman*1, Matt Clutter2, Gary E. Schiltz3, Quratul-Ain Ismail1, Xiangying Cheng1, Chi-Hao Luan4, Dane M. Chetkovich1,5 1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University JoVE 54540 Biochemistry