Christian Grillon Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health National Institutes of Health (NIH) Biography Publications Institution JoVE Articles Christian Grillon has not added a biography. If you are Christian Grillon and would like to personalize this page please email our Author Liaison for assistance. Publications Threat of Shock Increases Excitability and Connectivity of the Intraparietal Sulcus ELife. May, 2017 | Pubmed ID: 28555565 Intrinsic Functional Connectivity of the Central Nucleus of the Amygdala and Bed Nucleus of the Stria Terminalis NeuroImage. Apr, 2017 | Pubmed ID: 28392491 Resting State Connectivity of the Human Habenula at Ultra-high Field NeuroImage. Feb, 2017 | Pubmed ID: 27780778 Anxiety-mediated Facilitation of Behavioral Inhibition: Threat Processing and Defensive Reactivity During a Go/no-go Task Emotion (Washington, D.C.). 03, 2017 | Pubmed ID: 27642657 Prediction Error Representation in Individuals With Generalized Anxiety Disorder During Passive Avoidance The American Journal of Psychiatry. Feb, 2017 | Pubmed ID: 27631963 Striatum on the Anxiety Map: Small Detours into Adolescence Brain Research. Jan, 2017 | Pubmed ID: 27276526 Anxiety Patients Show Reduced Working Memory Related DlPFC Activation During Safety and Threat Depression and Anxiety. Jan, 2017 | Pubmed ID: 27110997 Effect of Anxiety on Behavioural Pattern Separation in Humans Cognition & Emotion. Feb, 2017 | Pubmed ID: 26480349 Altered Pain Perception and Fear-Learning Deficits in Subjects With Posttraumatic Stress Disorder The Journal of Pain : Official Journal of the American Pain Society. Dec, 2016 | Pubmed ID: 27641312 Gain in Translation: Is It Time for Thigmotaxis Studies in Humans? Biological Psychiatry. Sep, 2016 | Pubmed ID: 27499012 The Effects of Methylphenidate and Propranolol on the Interplay Between Induced-anxiety and Working Memory Psychopharmacology. Oct, 2016 | Pubmed ID: 27492789 Working Memory Maintenance is Sufficient to Reduce State Anxiety Psychophysiology. Nov, 2016 | Pubmed ID: 27434207 The Neural Basis of Improved Cognitive Performance by Threat of Shock Social Cognitive and Affective Neuroscience. Nov, 2016 | Pubmed ID: 27369069 Induced-anxiety Differentially Disrupts Working Memory in Generalized Anxiety Disorder BMC Psychiatry. Mar, 2016 | Pubmed ID: 26976146 Abnormal Decision-making in Generalized Anxiety Disorder: Aversion of Risk or Stimulus-reinforcement Impairment? Psychiatry Research. Mar, 2016 | Pubmed ID: 26822065 Age and Social Context Modulate the Effect of Anxiety on Risk-taking in Pediatric Samples Journal of Abnormal Child Psychology. 08, 2016 | Pubmed ID: 26659306 Interaction of Threat and Verbal Working Memory in Adolescents Psychophysiology. Apr, 2016 | Pubmed ID: 26589772 Vasopressin Boosts Placebo Analgesic Effects in Women: A Randomized Trial Biological Psychiatry. May, 2016 | Pubmed ID: 26321018 Effect of Attention Control on Sustained Attention During Induced Anxiety Cognition & Emotion. 2016 | Pubmed ID: 25899613 Resting State Connectivity of the Bed Nucleus of the Stria Terminalis at Ultra-high Field Human Brain Mapping. Oct, 2015 | Pubmed ID: 26178381 Mental Fatigue Impairs Emotion Regulation Emotion (Washington, D.C.). Jun, 2015 | Pubmed ID: 25706833 FMRI Functional Connectivity Applied to Adolescent Neurodevelopment Annual Review of Clinical Psychology. 2015 | Pubmed ID: 25581237 Oxytocin and Vasopressin Modulate Risk-taking Physiology & Behavior. Feb, 2015 | Pubmed ID: 25446228 The CRH1 Antagonist GSK561679 Increases Human Fear but Not Anxiety As Assessed by Startle Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2015 | Pubmed ID: 25430779 Towards a Mechanistic Understanding of Pathological Anxiety: the Dorsal Medial Prefrontal-amygdala 'aversive Amplification' Circuit in Unmedicated Generalized and Social Anxiety Disorders The Lancet. Psychiatry. Sep, 2014 | Pubmed ID: 25722962 Pain and Placebo in Pediatrics: a Comprehensive Review of Laboratory and Clinical Findings Pain. Nov, 2014 | Pubmed ID: 25180010 Sustained Anxiety Increases Amygdala-dorsomedial Prefrontal Coupling: a Mechanism for Maintaining an Anxious State in Healthy Adults Journal of Psychiatry & Neuroscience : JPN. Sep, 2014 | Pubmed ID: 24886788 Understanding Placebo and Nocebo Responses for Pain Management Current Pain and Headache Reports. Jun, 2014 | Pubmed ID: 24771206 Increased Fear-potentiated Startle in Major Depressive Disorder Patients with Lifetime History of Suicide Attempt Journal of Affective Disorders. Jun, 2014 | Pubmed ID: 24767002 Evidence of MAOA Genotype Involvement in Spatial Ability in Males Behavioural Brain Research. Jul, 2014 | Pubmed ID: 24671068 Developmental Investigation of Fear-potentiated Startle Across Puberty Biological Psychology. Mar, 2014 | Pubmed ID: 24334108 Generalized Anxiety Disorder is Associated with Overgeneralization of Classically Conditioned Fear Biological Psychiatry. Jun, 2014 | Pubmed ID: 24001473 Neural Substrates of Classically Conditioned Fear-generalization in Humans: a Parametric FMRI Study Social Cognitive and Affective Neuroscience. Aug, 2014 | Pubmed ID: 23748500 Major Depression is Not Associated with Blunting of Aversive Responses; Evidence for Enhanced Anxious Anticipation PloS One. 2013 | Pubmed ID: 23951057 Response to Learned Threat: An FMRI Study in Adolescent and Adult Anxiety The American Journal of Psychiatry. Oct, 2013 | Pubmed ID: 23929092 The Impact of Anxiety Upon Cognition: Perspectives from Human Threat of Shock Studies Frontiers in Human Neuroscience. 2013 | Pubmed ID: 23730279 The Role of Serotonin in the Neurocircuitry of Negative Affective Bias: Serotonergic Modulation of the Dorsal Medial Prefrontal-amygdala 'aversive Amplification' Circuit NeuroImage. Sep, 2013 | Pubmed ID: 23583742 The Complex Interaction Between Anxiety and Cognition: Insight from Spatial and Verbal Working Memory Frontiers in Human Neuroscience. 2013 | Pubmed ID: 23542914 The Impact of Induced Anxiety on Response Inhibition Frontiers in Human Neuroscience. 2013 | Pubmed ID: 23471118 Passive Avoidance is Linked to Impaired Fear Extinction in Humans Learning & Memory (Cold Spring Harbor, N.Y.). Feb, 2013 | Pubmed ID: 23427168 El Estrés Aumenta La Señal De Error De Predicción Aversivo En El Cuerpo Estriado Ventral Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23401511 Enhanced Discrimination Between Threatening and Safe Contexts in High-anxious Individuals Biological Psychology. Apr, 2013 | Pubmed ID: 23384512 Synaptic Potentiation is Critical for Rapid Antidepressant Response to Ketamine in Treatment-resistant Major Depression Biological Psychiatry. Oct, 2012 | Pubmed ID: 22521148 Acute Tryptophan Depletion Increases Translational Indices of Anxiety but Not Fear: Serotonergic Modulation of the Bed Nucleus of the Stria Terminalis? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jul, 2012 | Pubmed ID: 22491355 Distinct Contributions of Human Hippocampal Theta to Spatial Cognition and Anxiety Hippocampus. Sep, 2012 | Pubmed ID: 22467298 Through the Eyes of Anxiety: Dissecting Threat Bias Via Emotional-binocular Rivalry Emotion (Washington, D.C.). Oct, 2012 | Pubmed ID: 22390706 Assessing Fear and Anxiety in Humans Using the Threat of Predictable and Unpredictable Aversive Events (the NPU-threat Test) Nature Protocols. Feb, 2012 | Pubmed ID: 22362158 Testing the Effects of Δ9-THC and D-cycloserine on Extinction of Conditioned Fear in Humans Journal of Psychopharmacology (Oxford, England). Apr, 2012 | Pubmed ID: 22351380 Describing the Interplay Between Anxiety and Cognition: from Impaired Performance Under Low Cognitive Load to Reduced Anxiety Under High Load Psychophysiology. Jun, 2012 | Pubmed ID: 22332819 Anxiety, a Benefit and Detriment to Cognition: Behavioral and Magnetoencephalographic Evidence from a Mixed-saccade Task Brain and Cognition. Apr, 2012 | Pubmed ID: 22289426 The Adaptive Threat Bias in Anxiety: Amygdala-dorsomedial Prefrontal Cortex Coupling and Aversive Amplification NeuroImage. Mar, 2012 | Pubmed ID: 22178453 In the Face of Fear: Anxiety Sensitizes Defensive Responses to Fearful Faces Psychophysiology. Dec, 2011 | Pubmed ID: 21824155 The Effect of Induced Anxiety on Cognition: Threat of Shock Enhances Aversive Processing in Healthy Individuals Cognitive, Affective & Behavioral Neuroscience. Jun, 2011 | Pubmed ID: 21484411 Measuring Anxious Responses to Predictable and Unpredictable Threat in Children and Adolescents Journal of Experimental Child Psychology. Oct, 2011 | Pubmed ID: 21440905 Anxiety Overrides the Blocking Effects of High Perceptual Load on Amygdala Reactivity to Threat-related Distractors Neuropsychologia. Apr, 2011 | Pubmed ID: 21376745 Distinct Neural Signatures of Threat Learning in Adolescents and Adults Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21368210 Acute Hydrocortisone Treatment Increases Anxiety but Not Fear in Healthy Volunteers: a Fear-potentiated Startle Study Biological Psychiatry. Mar, 2011 | Pubmed ID: 21277566 Phasic and Sustained Fear in Humans Elicits Distinct Patterns of Brain Activity NeuroImage. Mar, 2011 | Pubmed ID: 21111828 Becoming the Center of Attention in Social Anxiety Disorder: Startle Reactivity to a Virtual Audience During Speech Anticipation The Journal of Clinical Psychiatry. Jul, 2011 | Pubmed ID: 21034683 Development of Anxiety: the Role of Threat Appraisal and Fear Learning Depression and Anxiety. Jan, 2011 | Pubmed ID: 20734364 Effect of Acute Psychological Stress on Prefrontal GABA Concentration Determined by Proton Magnetic Resonance Spectroscopy The American Journal of Psychiatry. Oct, 2010 | Pubmed ID: 20634372 Abnormal Hippocampal Functioning and Impaired Spatial Navigation in Depressed Individuals: Evidence from Whole-head Magnetoencephalography The American Journal of Psychiatry. Jul, 2010 | Pubmed ID: 20439387 Anterior Cingulate Desynchronization and Functional Connectivity with the Amygdala During a Working Memory Task Predict Rapid Antidepressant Response to Ketamine Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jun, 2010 | Pubmed ID: 20393460 Overgeneralization of Conditioned Fear As a Pathogenic Marker of Panic Disorder The American Journal of Psychiatry. Jan, 2010 | Pubmed ID: 19917595 Phasic Vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear Vs Anxiety Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2010 | Pubmed ID: 19693004 Impaired Spatial Navigation in Pediatric Anxiety Journal of Child Psychology and Psychiatry, and Allied Disciplines. Oct, 2009 | Pubmed ID: 19594834 D-cycloserine Facilitation of Fear Extinction and Exposure-based Therapy Might Rely on Lower-level, Automatic Mechanisms Biological Psychiatry. Oct, 2009 | Pubmed ID: 19520359 Startle Response in Behaviorally Inhibited Adolescents with a Lifetime Occurrence of Anxiety Disorders Journal of the American Academy of Child and Adolescent Psychiatry. Jun, 2009 | Pubmed ID: 19454917 Working Memory Performance After Acute Exposure to the Cold Pressor Stress in Healthy Volunteers Neurobiology of Learning and Memory. May, 2009 | Pubmed ID: 19340949 Increased Anxiety During Anticipation of Unpredictable Aversive Stimuli in Posttraumatic Stress Disorder but Not in Generalized Anxiety Disorder Biological Psychiatry. Jul, 2009 | Pubmed ID: 19217076 Impaired Discriminative Fear-conditioning Resulting from Elevated Fear Responding to Learned Safety Cues Among Individuals with Panic Disorder Behaviour Research and Therapy. Feb, 2009 | Pubmed ID: 19027893 Increased Anterior Cingulate Cortical Activity in Response to Fearful Faces: a Neurophysiological Biomarker That Predicts Rapid Antidepressant Response to Ketamine Biological Psychiatry. Feb, 2009 | Pubmed ID: 18822408 Two-week Treatment with the Selective Serotonin Reuptake Inhibitor Citalopram Reduces Contextual Anxiety but Not Cued Fear in Healthy Volunteers: a Fear-potentiated Startle Study Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2009 | Pubmed ID: 18800069 Startle Reactivity in Children at Risk for Migraine Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. Dec, 2008 | Pubmed ID: 18951839 Evoked Amygdala Responses to Negative Faces Revealed by Adaptive MEG Beamformers Brain Research. Dec, 2008 | Pubmed ID: 18930036 Modality-specific Attention Under Imminent but Not Remote Threat of Shock: Evidence from Differential Prepulse Inhibition of Startle Psychological Science. Jun, 2008 | Pubmed ID: 18578853 Contextual Fear Conditioning in Humans: Cortical-hippocampal and Amygdala Contributions The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18550763 Greater Sustained Anxiety but Not Phasic Fear in Women Compared to Men Emotion (Washington, D.C.). Jun, 2008 | Pubmed ID: 18540756 Human Hippocampal and Parahippocampal Theta During Goal-directed Spatial Navigation Predicts Performance on a Virtual Morris Water Maze The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18524903 Contextual Specificity of Extinction of Delay but Not Trace Eyeblink Conditioning in Humans Learning & Memory (Cold Spring Harbor, N.Y.). Jun, 2008 | Pubmed ID: 18509111 Generalization of Conditioned Fear-potentiated Startle in Humans: Experimental Validation and Clinical Relevance Behaviour Research and Therapy. May, 2008 | Pubmed ID: 18394587 It is Time to Take a Stand for Medical Research and Against Terrorism Targeting Medical Scientists Biological Psychiatry. Apr, 2008 | Pubmed ID: 18371494 Increased Anxiety During Anticipation of Unpredictable but Not Predictable Aversive Stimuli As a Psychophysiologic Marker of Panic Disorder The American Journal of Psychiatry. Jul, 2008 | Pubmed ID: 18347001 Fear Conditioning in Adolescents with Anxiety Disorders: Results from a Novel Experimental Paradigm Journal of the American Academy of Child and Adolescent Psychiatry. Jan, 2008 | Pubmed ID: 18174830 Models and Mechanisms of Anxiety: Evidence from Startle Studies Psychopharmacology. Aug, 2008 | Pubmed ID: 18058089 Elevated Fear Conditioning to Socially Relevant Unconditioned Stimuli in Social Anxiety Disorder The American Journal of Psychiatry. Jan, 2008 | Pubmed ID: 18006874 Acute Stress Potentiates Anxiety in Humans Biological Psychiatry. Nov, 2007 | Pubmed ID: 17692829 Emotion Regulation and Potentiated Startle Across Affective Picture and Threat-of-shock Paradigms Biological Psychology. Sep, 2007 | Pubmed ID: 17692453 Startle Potentiation in Rapidly Alternating Conditions of High and Low Predictability of Threat Biological Psychology. Sep, 2007 | Pubmed ID: 17644240 Neural Responses to Auditory Stimulus Deviance Under Threat of Electric Shock Revealed by Spatially-filtered Magnetoencephalography NeuroImage. Aug, 2007 | Pubmed ID: 17566766 Cerebral Blood Flow in Immediate and Sustained Anxiety The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2007 | Pubmed ID: 17554005 Fear-potentiated Startle to Threat, and Prepulse Inhibition Among Young Adult Nonsmokers, Abstinent Smokers, and Nonabstinent Smokers Biological Psychiatry. Nov, 2007 | Pubmed ID: 17543892 Comments on Fearful and Sexual Pictures Not Consciously Seen Modulate the Startle Reflex in Human Beings Biological Psychiatry. Sep, 2007 | Pubmed ID: 17531204 Acute Exposure to Stress Improves Performance in Trace Eyeblink Conditioning and Spatial Learning Tasks in Healthy Men Learning & Memory (Cold Spring Harbor, N.Y.). May, 2007 | Pubmed ID: 17522023 Sensitivity to Masked Conditioned Stimuli Predicts Conditioned Response Magnitude Under Masked Conditions Psychophysiology. May, 2007 | Pubmed ID: 17433097 Contextual-specificity of Short-delay Extinction in Humans: Renewal of Fear-potentiated Startle in a Virtual Environment Learning & Memory (Cold Spring Harbor, N.Y.). Apr, 2007 | Pubmed ID: 17412963 Luteal-phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2007 | Pubmed ID: 17314917 Reduction of Trace but Not Delay Eyeblink Conditioning in Panic Disorder The American Journal of Psychiatry. Feb, 2007 | Pubmed ID: 17267792 A Single Dose of the Selective Serotonin Reuptake Inhibitor Citalopram Exacerbates Anxiety in Humans: a Fear-potentiated Startle Study Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2007 | Pubmed ID: 16971899 Attentional Blink and Prepulse Inhibition of Startle Are Positively Correlated Psychophysiology. Sep, 2006 | Pubmed ID: 16965613 Context Conditioning and Behavioral Avoidance in a Virtual Reality Environment: Effect of Predictability Biological Psychiatry. Oct, 2006 | Pubmed ID: 16950216 The Benzodiazepine Alprazolam Dissociates Contextual Fear from Cued Fear in Humans As Assessed by Fear-potentiated Startle Biological Psychiatry. Oct, 2006 | Pubmed ID: 16631127 Brainstem Correlates of Defensive States in Humans Biological Psychiatry. Apr, 2006 | Pubmed ID: 16388780 The Strong Situation: a Potential Impediment to Studying the Psychobiology and Pharmacology of Anxiety Disorders Biological Psychology. Jun, 2006 | Pubmed ID: 16343731 Anticipation of Public Speaking in Virtual Reality Reveals a Relationship Between Trait Social Anxiety and Startle Reactivity Biological Psychiatry. Apr, 2006 | Pubmed ID: 16325155 Hydrocortisone Impairs Hippocampal-dependent Trace Eyeblink Conditioning in Post-traumatic Stress Disorder Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jan, 2006 | Pubmed ID: 16123770 Cortisol and DHEA-S Are Associated with Startle Potentiation During Aversive Conditioning in Humans Psychopharmacology. Jun, 2006 | Pubmed ID: 16052364 Using Affect-modulated Startle to Study Phenotypes of Pediatric Bipolar Disorder Bipolar Disorders. Dec, 2005 | Pubmed ID: 16403179 Sensation Seeking and the Aversive Motivational System Emotion (Washington, D.C.). Dec, 2005 | Pubmed ID: 16366744 Positron Emission Tomographic Imaging of Neural Correlates of a Fear Acquisition and Extinction Paradigm in Women with Childhood Sexual-abuse-related Post-traumatic Stress Disorder Psychological Medicine. Jun, 2005 | Pubmed ID: 15997600 Acondicionado De Miedo Clásico En Los Trastornos De Ansiedad: a Meta-analysis Behaviour Research and Therapy. Nov, 2005 | Pubmed ID: 15885654 Families at High and Low Risk for Depression: a Three-generation Startle Study Biological Psychiatry. May, 2005 | Pubmed ID: 15860334 An Investigation of Prepulse Inhibition in Pediatric Bipolar Disorder Bipolar Disorders. Apr, 2005 | Pubmed ID: 15762862 Electroencephalographic Measures of Regional Hemispheric Activity in Offspring at Risk for Depressive Disorders Biological Psychiatry. Feb, 2005 | Pubmed ID: 15705347 Families at High and Low Risk for Depression: a 3-generation Study Archives of General Psychiatry. Jan, 2005 | Pubmed ID: 15630070 Airpuff Startle Probes: an Efficacious and Less Aversive Alternative to White-noise Biological Psychology. Mar, 2005 | Pubmed ID: 15620795 Deficits in Hippocampus-mediated Pavlovian Conditioning in Endogenous Hypercortisolism Biological Psychiatry. Dec, 2004 | Pubmed ID: 15576060 Anxious Responses to Predictable and Unpredictable Aversive Events Behavioral Neuroscience. Oct, 2004 | Pubmed ID: 15506874 Fear Conditioning in Virtual Reality Contexts: a New Tool for the Study of Anxiety Biological Psychiatry. Jun, 2004 | Pubmed ID: 15158423 Adaptive and Maladaptive Psychobiological Responses to Severe Psychological Stress: Implications for the Discovery of Novel Pharmacotherapy Neuroscience and Biobehavioral Reviews. Mar, 2004 | Pubmed ID: 15036934 Effects of the Beta-blocker Propranolol on Cued and Contextual Fear Conditioning in Humans Psychopharmacology. Sep, 2004 | Pubmed ID: 15007536 A Neuroimaging Method for the Study of Threat in Adolescents Developmental Psychobiology. Dec, 2003 | Pubmed ID: 15027419 A Review of the Modulation of the Startle Reflex by Affective States and Its Application in Psychiatry Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. Sep, 2003 | Pubmed ID: 12948786 Emotional Arousal Does Not Affect Delay Eyeblink Conditioning Brain Research. Cognitive Brain Research. Jul, 2003 | Pubmed ID: 12880910 Anxiolytic Effects of a Novel Group II Metabotropic Glutamate Receptor Agonist (LY354740) in the Fear-potentiated Startle Paradigm in Humans Psychopharmacology. Aug, 2003 | Pubmed ID: 12709777 Startle Reactivity and Anxiety Disorders: Aversive Conditioning, Context, and Neurobiology Biological Psychiatry. Nov, 2002 | Pubmed ID: 12437937 Associative Learning Deficits Increase Symptoms of Anxiety in Humans Biological Psychiatry. Jun, 2002 | Pubmed ID: 12022957 Benzodiazepines Have No Effect on Fear-potentiated Startle in Humans Psychopharmacology. May, 2002 | Pubmed ID: 12021826 Reducción de la ansiedad estatal mediante el mantenimiento de la memoria de trabajo Nicholas L. Balderston1, Abigail Hsiung1, Jeffrey Liu1, Monique Ernst1, Christian Grillon1 1Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health (NIH) JoVE 55727 Behavior
Reducción de la ansiedad estatal mediante el mantenimiento de la memoria de trabajo Nicholas L. Balderston1, Abigail Hsiung1, Jeffrey Liu1, Monique Ernst1, Christian Grillon1 1Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, National Institutes of Health (NIH) JoVE 55727 Behavior