Christian Lehmann Department of Anesthesia, Pain Management and Perioperative Medicine Dalhousie University Biography Publications Institution JoVE Articles Christian Lehmann Dr. Christian Lehmann is Professor of Anesthesia, Pharmacology, Microbiology & Immunology and Physiology & Biophysics at Dalhousie University, Halifax, NS. He is Staff Anesthesiologist and Medical Director of Research in the Department of Anesthesia, Pain Management and Perioperative Medicine, Nova Scotia Health Authority, Halifax. Dr. Lehmann has 25 years of experience in experimental and clinical inflammation research including studies on the mechanisms of pain. He is the author of more than 200 original publications, 5 books, and 13 book chapters. He and his collaborators received funding for their research on the therapeutic modulation of the immune response in sepsis and for research in iron metabolism during critical illness from CIHR, NSERC, CFI, MITACS, NSHRF, and Innovacorp. Publications Assessing the Impact of Predatory Journals on Policy and Guidance Documents: a Cross-sectional Study Protocol BMJ Open. Apr, 2022 | Pubmed ID: 35379645 Endothelial Glycocalyx Damage in Patients with Severe COVID-19 on Mechanical Ventilation - a Prospective Observational Pilot Study Clinical Hemorheology and Microcirculation. Mar, 2022 | Pubmed ID: 35342082 Components of the Endogenous Cannabinoid System As Potential Biomarkers for Interstitial Cystitis/Bladder Pain Syndrome Diagnostics (Basel, Switzerland). Dec, 2021 | Pubmed ID: 35054185 Clinical Features of Pneumonia in Severely Malnourished Children with Diarrhoea Compared to Those Without Diarrhoea Frontiers in Bioscience (Landmark Edition). 10, 2021 | Pubmed ID: 34719200 Utility of Intestinal Intravital Microscopy for the Study of CNS Injury-induced Immunodepression Syndrome (CIDS) Clinical Hemorheology and Microcirculation. Month, 2021 | Pubmed ID: 34487026 Rodent Models of Ketamine-induced Cystitis Neurourology and Urodynamics. 09, 2021 | Pubmed ID: 34350618 Anti-inflammatory Iron Chelator, DIBI, Reduces Leukocyte-endothelial Adhesion and Clinical Symptoms of LPS-induced Interstitial Cystitis in Mice Clinical Hemorheology and Microcirculation. Month, 2021 | Pubmed ID: 34250933 Effects of CNS Injury-Induced Immunosuppression on Pulmonary Immunity Life (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34207063 Sensitivity Patterns of Bacterial Pathogens Isolated from Blood Cultures of Under-Five Children with Pneumonia and Clinical Sepsis Life (Basel, Switzerland). May, 2021 | Pubmed ID: 34069789 Real-Time Imaging of Immune Modulation by Cannabinoids Using Intravital Fluorescence Microscopy Cannabis and Cannabinoid Research. 06, 2021 | Pubmed ID: 34042507 Effect of Cannabinoid 2 Receptor Modulation on the Peripheral Immune Response in Central Nervous System Injury-Induced Immunodeficiency Syndrome Cannabis and Cannabinoid Research. 08, 2021 | Pubmed ID: 33998888 Iron-withdrawing Anti-infectives for New Host-directed Therapies Based on Iron Dependence, the Achilles' Heel of Antibiotic-resistant Microbes Environmental Chemistry Letters. Month, 2021 | Pubmed ID: 33907538 A Porcine Model of Endothelial Glycocalyx Damage by Enzymatic Digestion: A Pilot Study Clinical Hemorheology and Microcirculation. Month, 2021 | Pubmed ID: 33843666 National Preclinical Sepsis Platform: Developing a Framework for Accelerating Innovation in Canadian Sepsis Research Intensive Care Medicine Experimental. Mar, 2021 | Pubmed ID: 33738642 A.L. Copley Best Paper Prize 2020 Clinical Hemorheology and Microcirculation. Month, 2021 | Pubmed ID: 33720877 Cannabinoid Receptor 1 and 2 Signaling Pathways Involved in Sepsis Shock (Augusta, Ga.). 11, 2021 | Pubmed ID: 33625115 Comparison of Treatment Effects of Different Iron Chelators in Experimental Models of Sepsis Life (Basel, Switzerland). Jan, 2021 | Pubmed ID: 33466819 Iron Chelation in Local Infection Molecules (Basel, Switzerland). Jan, 2021 | Pubmed ID: 33401708 Intravital Imaging of Pulmonary Immune Response in Inflammation and Infection Frontiers in Cell and Developmental Biology. Month, 2020 | Pubmed ID: 33520993 Imaging of the Intestinal Microcirculation During Acute and Chronic Inflammation Biology. Nov, 2020 | Pubmed ID: 33255906 The Novel Iron Chelator, DIBI, Attenuates Inflammation and Improves Outcome in Colon Ascendens Stent Peritonitis-induced Experimental Sepsis Clinical Hemorheology and Microcirculation. Month, 2020 | Pubmed ID: 32925011 Personal Protective Equipment During the COVID-19 Pandemic (Letter #2) Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. 11, 2020 | Pubmed ID: 32779004 A.L. Copley Best Paper Prize 2019 Clinical Hemorheology and Microcirculation. Month, 2020 | Pubmed ID: 32568189 Iron Chelation in Murine Models of Systemic Inflammation Induced by Gram-Positive and Gram-Negative Toxins Antibiotics (Basel, Switzerland). May, 2020 | Pubmed ID: 32466384 Molecular Mechanisms by Which INOS Uncoupling Can Induce Cardiovascular Dysfunction During Sepsis: Role of Posttranslational Modifications (PTMs) Life Sciences. Aug, 2020 | Pubmed ID: 32445759 Evaluation of Endothelial Glycocalyx in Healthy Volunteers - An Observational Study Clinical Hemorheology and Microcirculation. Month, 2020 | Pubmed ID: 31683466 Iron Should Be Restricted in Acute Infection Frontiers in Bioscience (Landmark Edition). 01, 2020 | Pubmed ID: 31585910 Microcirculatory Changes in Experimental Models of Stroke and CNS-Injury Induced Immunodepression International Journal of Molecular Sciences. Oct, 2019 | Pubmed ID: 31635068 Selective Cannabinoid 2 Receptor Agonists As Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis Molecules (Basel, Switzerland). Sep, 2019 | Pubmed ID: 31540271 Inflammatory Response to Different Toxins in Experimental Sepsis Models International Journal of Molecular Sciences. Sep, 2019 | Pubmed ID: 31491842 Monoacylglycerol Lipase Inhibition As Potential Treatment for Interstitial Cystitis Medical Hypotheses. Oct, 2019 | Pubmed ID: 31443753 Possible Impact of Spinal Anesthesia and Phenylephrine on Sublingual Microcirculation of Cesarean Delivery Patients Journal of Clinical Medicine Research. Aug, 2019 | Pubmed ID: 31413765 A.L. Copley Best Paper Prize 2018 Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 31306116 Effect of Short-term Administration of Lipid Emulsion on Endothelial Glycocalyx Integrity in ICU Patients - A Microvascular and Biochemical Pilot Study Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 31306112 Challenges for Microcirculation Research in Developing Countries Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 31156150 Bacterial Resistance in Pneumonia in Developing Countries-A Role for Iron Chelation Tropical Medicine and Infectious Disease. Apr, 2019 | Pubmed ID: 30974759 ATP in Red Blood Cells As Biomarker for Sepsis in Humans Medical Hypotheses. Mar, 2019 | Pubmed ID: 30798924 Iron Chelation As Novel Treatment for Interstitial Cystitis Pharmacology. Month, 2019 | Pubmed ID: 30695781 Modulation of the Endocannabinoid System Following Central Nervous System Injury International Journal of Molecular Sciences. Jan, 2019 | Pubmed ID: 30658442 Laser Doppler-based Measurements of Periarticular Blood Flux Can Be Utilized for Assessment of Arthritis Pain: A Hypothesis Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 30562898 Neuraxial Anesthesia is Less Harmful to the Endothelial Glycocalyx During Elective Joint Surgery Compared to General Anesthesia Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 30507566 Effect of Acute Hypernatremia Induced by Hypertonic Saline Administration on Endothelial Glycocalyx in Rabbits Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 30400083 Rapid Clinical Assessment of the Sublingual Microcirculation - Visual Scoring Using MicroVAS in Comparison to Standard Semi-automated Analysis Clinical Hemorheology and Microcirculation. Month, 2019 | Pubmed ID: 30320559 Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients BioMed Research International. Month, 2018 | Pubmed ID: 30519590 Clinical Assessment of Arthritic Knee Pain by Infrared Thermography Journal of Basic and Clinical Physiology and Pharmacology. Oct, 2018 | Pubmed ID: 30375348 Selective Sensitivity of the Gut Microbiome to Iron Chelators in Polybacterial Abdominal Sepsis Medical Hypotheses. Nov, 2018 | Pubmed ID: 30220344 The Ongoing Challenge of Acute Mesenteric Ischemia Visceral Medicine. Jul, 2018 | Pubmed ID: 30140688 Impact of Lipid Modulation on the Intestinal Microcirculation in Experimental Sepsis Microvascular Research. 11, 2018 | Pubmed ID: 29859746 Impact of Insulin on the Intestinal Microcirculation in a Model of Sepsis-related Hyperglycemia Microvascular Research. 09, 2018 | Pubmed ID: 29778648 A.L. Copley Best Paper Prize 2017 Clinical Hemorheology and Microcirculation. Month, 2018 | Pubmed ID: 29660930 Sidestream Dark Field Imaging of the Microcirculation to Assess Preeclampsia Microvascular Dysfunction Journal of Clinical Medicine Research. May, 2018 | Pubmed ID: 29581801 Betacaryophyllene - A Phytocannabinoid As Potential Therapeutic Modality for Human Sepsis? Medical Hypotheses. Jan, 2018 | Pubmed ID: 29317072 Clinical Relevance of Early Sublingual Microcirculation Monitoring in Septic Shock Patients Clinical Hemorheology and Microcirculation. Month, 2018 | Pubmed ID: 29036793 Immune Response to Systemic Inflammation in the Intestinal Microcirculation Frontiers in Bioscience (Landmark Edition). 01, 2018 | Pubmed ID: 28930572 Parameters of the Endocannabinoid System As Novel Biomarkers in Sepsis and Septic Shock Metabolites. Nov, 2017 | Pubmed ID: 29104224 Targeting the Endothelial Glycocalyx in Acute Critical Illness As a Challenge for Clinical and Laboratory Medicine Critical Reviews in Clinical Laboratory Sciences. 08, 2017 | Pubmed ID: 28958185 Glycocalyx in Vivo Measurement Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28922148 Microcirculation Research in Community Hospitals - Challenges and Chances Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28922147 Preliminary Clinical Evaluation of Automated Analysis of the Sublingual Microcirculation in the Assessment of Patients with Septic Shock: Comparison of Automated Versus Semi-automated Software Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28922146 New Developments in Clinical Microcirculation Imaging Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28922145 Anti-inflammatory Effects of a Novel Iron Chelator, DIBI, in Experimental Sepsis Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28869457 Iron Chelation As Novel Treatment for Lung Inflammation in Cystic Fibrosis Medical Hypotheses. Jul, 2017 | Pubmed ID: 28673599 A.L. Copley Best Paper Prize 2016 Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28671109 Tetrahydrobiopterin Improves Microcirculation in Experimental Sepsis Clinical Hemorheology and Microcirculation. Month, 2017 | Pubmed ID: 28598830 Iron Chelation for the Treatment of Uveitis Medical Hypotheses. Jun, 2017 | Pubmed ID: 28571790 Cannabinoid 2 Receptor is a Novel Anti-inflammatory Target in Experimental Proliferative Vitreoretinopathy Neuropharmacology. Feb, 2017 | Pubmed ID: 27569993 An Intravital Microscopy Model to Study Early Pancreatic Inflammation in Type 1 Diabetes in NOD Mice Intravital. Month, 2016 | Pubmed ID: 28243521 Experimental Cannabidiol Treatment Reduces early Pancreatic Inflammation In type 1 Diabetes Clinical Hemorheology and Microcirculation. Month, 2016 | Pubmed ID: 27767974 CB2 and GPR55 Receptors As Therapeutic Targets for Systemic Immune Dysregulation Frontiers in Pharmacology. Month, 2016 | Pubmed ID: 27597829 Effects of Haemoglobin Levels On the sublingual Microcirculation In pregnant Women Clinical Hemorheology and Microcirculation. Nov, 2016 | Pubmed ID: 27258200 Experimental Cannabinoid 2 Receptor Inhibition in CNS Injury-Induced Immunodeficiency Syndrome Microcirculation (New York, N.Y. : 1994). 05, 2016 | Pubmed ID: 26999797 Therapeutic Iron Restriction in Sepsis Medical Hypotheses. Apr, 2016 | Pubmed ID: 26968906 Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation During High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial Anesthesiology. Apr, 2016 | Pubmed ID: 26808629 Analysis of Microcirculation Measurements by Novice Users Trained by a Standardized Interactive Tutorial: An Inter-observer Variability Study Clinical Hemorheology and Microcirculation. Month, 2016 | Pubmed ID: 26444590 Anti-inflammatory and Anti-bacterial Effects of Iron Chelation in Experimental Sepsis The Journal of Surgical Research. Jan, 2016 | Pubmed ID: 26235905 Sidestream Versus Incident Dark Field Imaging: How to Compare Two Different Technologies to Study the Microcirculation? Journal of Clinical Monitoring and Computing. Oct, 2015 | Pubmed ID: 26178887 Experimental TLR4 Inhibition Improves Intestinal Microcirculation in Endotoxemic Rats Microvascular Research. Sep, 2015 | Pubmed ID: 26116862 Evaluation of the Effects of Eserine and JWH-133 on Brain Dysfunction Associated with Experimental Endotoxemia Journal of Neuroimmunology. Apr, 2015 | Pubmed ID: 25867462 New Directions for Sepsis and Septic Shock Research The Journal of Surgical Research. Apr, 2015 | Pubmed ID: 25596653 Adenosine Receptor Activation Improves Microcirculation in Experimental Intestinal Ischemia/reperfusion Clinical Hemorheology and Microcirculation. Month, 2015 | Pubmed ID: 24889778 Impact of Methylene Blue in Addition to Norepinephrine on the Intestinal Microcirculation in Experimental Septic Shock Clinical Hemorheology and Microcirculation. Month, 2014 | Pubmed ID: 25227191 Short Time Impact of Different Hydroxyethyl Starch Solutions on the Mesenteric Microcirculation in Experimental Sepsis in Rats Microvascular Research. Sep, 2014 | Pubmed ID: 25107457 Combination of Dehydroepiandrosterone and Orthovanadate Administration Reduces Intestinal Leukocyte Recruitment in Models of Experimental Sepsis Microvascular Research. Sep, 2014 | Pubmed ID: 25086183 Unanticipated Expanding Neck Mass Under General Anesthesia Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Jul, 2014 | Pubmed ID: 24740311 Inhibition of the Cannabinoid 2 Receptor in CNS-injury Induced Immunodeficiency Syndrome Medical Hypotheses. Jun, 2014 | Pubmed ID: 24702836 Novel Approaches to the Development of Anti-sepsis Drugs Expert Opinion on Drug Discovery. May, 2014 | Pubmed ID: 24697209 Effect of Deletion of CIAP2 on Intestinal Microcirculation in Mouse Endotoxemia and Polybacterial Sepsis Shock (Augusta, Ga.). May, 2014 | Pubmed ID: 24667612 The Last Bite Was Deadly--about Responsibility in Scientific Publishing Clinical Hemorheology and Microcirculation. Month, 2014 | Pubmed ID: 24595128 Physostigmine Reverses Disturbances of the Intestinal Microcirculation During Experimental Endotoxemia Clinical Hemorheology and Microcirculation. Month, 2014 | Pubmed ID: 23736080 Cannabinoid Receptor 1 Inhibition Improves the Intestinal Microcirculation in Experimental Endotoxemia Clinical Hemorheology and Microcirculation. Month, 2014 | Pubmed ID: 23334604 Comparison of Cold Crystalloid and Colloid Infusions for Induction of Therapeutic Hypothermia in a Porcine Model of Cardiac Arrest Critical Care (London, England). Oct, 2013 | Pubmed ID: 24131867 Oxidized LDL and LOX-1 in Experimental Sepsis Mediators of Inflammation. Month, 2013 | Pubmed ID: 24000272 Inhibition of Endocannabinoid Degradation in Experimental Endotoxemia Reduces Leukocyte Adhesion and Improves Capillary Perfusion in the Gut Journal of Basic and Clinical Physiology and Pharmacology. Month, 2013 | Pubmed ID: 23382309 Microcirculation Diagnostics and Applied Studies in Circulatory Shock - Research from the Bench to the Bedside Clinical Hemorheology and Microcirculation. Month, 2012 | Pubmed ID: 22975933 Activated Protein C Improves Pial Microcirculation in Experimental Endotoxemia in Rats Microvascular Research. May, 2012 | Pubmed ID: 22426124 Cannabinoid Receptor 2 Activation Reduces Intestinal Leukocyte Recruitment and Systemic Inflammatory Mediator Release in Acute Experimental Sepsis Critical Care (London, England). Dec, 2012 | Pubmed ID: 22420504 Fructose--the Sweet Poison JPEN. Journal of Parenteral and Enteral Nutrition. Mar, 2011 | Pubmed ID: 21378244 Inhibition of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Reduces Leukocyte Adhesion Within the Intestinal Microcirculation in Experimental Endotoxemia in Rats Critical Care (London, England). Month, 2010 | Pubmed ID: 21143965 Effects of Activated Protein C on the Mesenteric Microcirculation and Cytokine Release During Experimental Endotoxemia Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Mar, 2008 | Pubmed ID: 18310625 Endothelial Glycocalyx in Acute Care Surgery - What Anaesthesiologists Need to Know for Clinical Practice BMC Anesthesiology. Month, | Pubmed ID: 31862008 The Curative Effect of a Cannabinoid 2 Receptor Agonist on Functional Failure and Disruptive Inflammation Caused by Intestinal Ischemia and Reperfusion Fundamental & Clinical Pharmacology. Month, | Pubmed ID: 31774568 Experimental Cannabinoid 2 Receptor Activation by Phyto-Derived and Synthetic Cannabinoid Ligands in LPS-Induced Interstitial Cystitis in Mice Molecules (Basel, Switzerland). Month, | Pubmed ID: 31766439 Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System Stefan Hall1, Sufyan Faridi2, Irene Euodia2,3, Sophie Tanner4, Andrew Krzysztof Chojnacki5, Kamala D. Patel6,7, Juan Zhou2,4, Christian Lehmann1,2,4,8 1Department of Physiology and Biophysics, Dalhousie University, 2Department of Microbiology and Immunology, Dalhousie University, 3Department of Neuroscience, Dalhousie University, 4Department of Anesthesia, Pain Management, and Perioperative Medicine, Dalhousie University, 5Live Cell Imaging Center, University of Calgary, 6Department of Physiology and Pharmacology, University of Calgary, 7Department of Biochemistry and Molecular Biology, University of Calgary, 8Department of Pharmacology, Dalhousie University JoVE 63733 Immunology and Infection
Intravital Widefield Fluorescence Microscopy of Pulmonary Microcirculation in Experimental Acute Lung Injury Using a Vacuum-Stabilized Imaging System Stefan Hall1, Sufyan Faridi2, Irene Euodia2,3, Sophie Tanner4, Andrew Krzysztof Chojnacki5, Kamala D. Patel6,7, Juan Zhou2,4, Christian Lehmann1,2,4,8 1Department of Physiology and Biophysics, Dalhousie University, 2Department of Microbiology and Immunology, Dalhousie University, 3Department of Neuroscience, Dalhousie University, 4Department of Anesthesia, Pain Management, and Perioperative Medicine, Dalhousie University, 5Live Cell Imaging Center, University of Calgary, 6Department of Physiology and Pharmacology, University of Calgary, 7Department of Biochemistry and Molecular Biology, University of Calgary, 8Department of Pharmacology, Dalhousie University JoVE 63733 Immunology and Infection