Christine Allen Leslie Dan Faculty of Pharmacy University of Toronto Biography Publications Institution JoVE Articles Christine Allen has not added a biography. If you are Christine Allen and would like to personalize this page please email our Author Liaison for assistance. Publications The Burden of Cancer in Mexico, 1990-2013 Salud Pública De México. Apr, 2016 | Pubmed ID: 27557370 Why I'm Holding Onto Hope for Nano in Oncology Molecular Pharmaceutics. Aug, 2016 | Pubmed ID: 27404330 Thermosensitive Liposomal Cisplatin in Combination with Local Hyperthermia Results in Tumor Growth Delay and Changes in Tumor Microenvironment in Xenograft Models of Lung Carcinoma Journal of Drug Targeting. Jun, 2016 | Pubmed ID: 27310112 Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer Radiation Research. May, 2016 | Pubmed ID: 27135970 Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG. Jan-Feb, 2016 | Pubmed ID: 26997930 Gold Nanoparticles for Applications in Cancer Radiotherapy: Mechanisms and Recent Advancements Advanced Drug Delivery Reviews. Dec, 2015 | Pubmed ID: 26712711 592: VANCOMYCIN DOSING AND PHARMACOKINETICS IN POSTOPERATIVE PEDIATRIC CARDIOTHORACIC SURGERY PATIENTS Critical Care Medicine. Dec, 2015 | Pubmed ID: 26570253 Preclinical Imaging and Translational Animal Models of Cancer for Accelerated Clinical Implementation of Nanotechnologies and Macromolecular Agents Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015 | Pubmed ID: 26409122 Integration of Imaging into Clinical Practice to Assess the Delivery and Performance of Macromolecular and Nanotechnology-based Oncology Therapies Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015 | Pubmed ID: 26403800 Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease Molecular Pharmaceutics. Nov, 2015 | Pubmed ID: 26394060 A Multimodal Nano Agent for Image-guided Cancer Surgery Biomaterials. Oct, 2015 | Pubmed ID: 26218742 The Global Burden of Cancer 2013 JAMA Oncology. Jul, 2015 | Pubmed ID: 26181261 The Intra-tumoral Relationship Between Microcirculation, Interstitial Fluid Pressure and Liposome Accumulation Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2015 | Pubmed ID: 26070245 Development of a Liposome Formulation for Improved Biodistribution and Tumor Accumulation of Pentamidine for Oncology Applications International Journal of Pharmaceutics. Jul, 2015 | Pubmed ID: 25910415 Spatial and Temporal Mapping of Heterogeneity in Liposome Uptake and Microvascular Distribution in an Orthotopic Tumor Xenograft Model Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2015 | Pubmed ID: 25862513 (125)I-Labelled 2-Iodoestrone-3-sulfate: Synthesis, Characterization and OATP Mediated Transport Studies in Hormone Dependent and Independent Breast Cancer Cells Nuclear Medicine and Biology. Mar, 2015 | Pubmed ID: 25542669 The Challenges Facing Block Copolymer Micelles for Cancer Therapy: In Vivo Barriers and Clinical Translation Advanced Drug Delivery Reviews. Aug, 2015 | Pubmed ID: 25308250 Hypoxia and Cellular Localization Influence the Radiosensitizing Effect of Gold Nanoparticles (AuNPs) in Breast Cancer Cells Radiation Research. Nov, 2014 | Pubmed ID: 25361396 Expression of Membrane Transporters and Metabolic Enzymes Involved in Estrone-3-sulphate Disposition in Human Breast Tumour Tissues Breast Cancer Research and Treatment. Jun, 2014 | Pubmed ID: 24831777 Heat-activated Thermosensitive Liposomal Cisplatin (HTLC) Results in Effective Growth Delay of Cervical Carcinoma in Mice Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2014 | Pubmed ID: 24440663 Image-based Analysis of the Size- and Time-dependent Penetration of Polymeric Micelles in Multicellular Tumor Spheroids and Tumor Xenografts International Journal of Pharmaceutics. Apr, 2014 | Pubmed ID: 24440400 Multi-arm PEG/silica Hydrogel for Sustained Ocular Drug Delivery Journal of Pharmaceutical Sciences. Jan, 2014 | Pubmed ID: 24285503 The Impact of Sustained and Intermittent Docetaxel Chemotherapy Regimens on Cognition and Neural Morphology in Healthy Mice Psychopharmacology. Mar, 2014 | Pubmed ID: 24101158 A Mathematical Model of the Enhanced Permeability and Retention Effect for Liposome Transport in Solid Tumors PloS One. 2013 | Pubmed ID: 24312530 Active Targeting of Block Copolymer Micelles with Trastuzumab Fab Fragments and Nuclear Localization Signal Leads to Increased Tumor Uptake and Nuclear Localization in HER2-overexpressing Xenografts Molecular Pharmaceutics. Nov, 2013 | Pubmed ID: 24066900 Tumor Perfusion Imaging Predicts the Intra-tumoral Accumulation of Liposomes Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013 | Pubmed ID: 24021358 Continuous Intraperitoneal Carboplatin Delivery for the Treatment of Late-stage Ovarian Cancer Molecular Pharmaceutics. Sep, 2013 | Pubmed ID: 23924289 Thermosensitive Depot-forming Injectable Phosphatidylcholine Blends Tailored for Localized Drug Delivery Journal of Pharmaceutical Sciences. Oct, 2013 | Pubmed ID: 23873505 A Novel Minimally Invasive Technique to Create a Rabbit VX2 Lung Tumor Model for Nano-sized Image Contrast and Interventional Studies PloS One. 2013 | Pubmed ID: 23840673 Estrone-3-sulphate, a Potential Novel Ligand for Targeting Breast Cancers PloS One. 2013 | Pubmed ID: 23717534 Multicellular Tumor Spheroids for Evaluation of Cytotoxicity and Tumor Growth Inhibitory Effects of Nanomedicines in Vitro: a Comparison of Docetaxel-loaded Block Copolymer Micelles and Taxotere® PloS One. 2013 | Pubmed ID: 23626842 Comparison of Computed Tomography- and Optical Image-based Assessment of Liposome Distribution Molecular Imaging. May, 2013 | Pubmed ID: 23490441 Neoplastic Cell Response to Tiopronin-coated Gold Nanoparticles Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2013 | Pubmed ID: 22687897 Hydrogel Containing Silica Shell Cross-linked Micelles for Ocular Drug Delivery Journal of Pharmaceutical Sciences. Nov, 2012 | Pubmed ID: 23203974 Differential Role of Organic Anion-transporting Polypeptides in Estrone-3-sulphate Uptake by Breast Epithelial Cells and Breast Cancer Cells The Journal of Pharmacology and Experimental Therapeutics. Aug, 2012 | Pubmed ID: 22588260 Recent Advances in Drug Delivery Strategies for Treatment of Ovarian Cancer Expert Opinion on Drug Delivery. May, 2012 | Pubmed ID: 22452661 Block Copolymer Micelles Target Auger Electron Radiotherapy to the Nucleus of HER2-positive Breast Cancer Cells Biomacromolecules. Feb, 2012 | Pubmed ID: 22191486 An Injectable Depot System for Sustained Intraperitoneal Chemotherapy of Ovarian Cancer Results in Favorable Drug Distribution at the Whole Body, Peritoneal and Intratumoral Levels Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2012 | Pubmed ID: 22154933 Influence of Formulation Variables on the Biodistribution of Multifunctional Block Copolymer Micelles Journal of Controlled Release : Official Journal of the Controlled Release Society. Feb, 2012 | Pubmed ID: 21982897 Computational Approaches to the Rational Design of Nanoemulsions, Polymeric Micelles, and Dendrimers for Drug Delivery Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2012 | Pubmed ID: 21669300 Hydrogels Containing Core Cross-Linked Block Co-Polymer Micelles Journal of Biomaterials Science. Polymer Edition. 2012 | Pubmed ID: 21619728 APN/CD13-targeting As a Strategy to Alter the Tumor Accumulation of Liposomes Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2011 | Pubmed ID: 21640146 Chemotherapy Dosing Schedule Influences Drug Resistance Development in Ovarian Cancer Molecular Cancer Therapeutics. Jul, 2011 | Pubmed ID: 21551263 Docetaxel Distribution Following Intraperitoneal Administration in Mice Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques. 2011 | Pubmed ID: 21501556 Combination Drug Delivery Strategy for the Treatment of Multidrug Resistant Ovarian Cancer Molecular Pharmaceutics. Feb, 2011 | Pubmed ID: 21166459 Neurologic Withdrawal Symptoms Following Abrupt Discontinuation of a Prolonged Dexmedetomidine Infusion in a Child The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG. Jan, 2010 | Pubmed ID: 22477791 Liposome Contrast Agent for CT-based Detection and Localization of Neoplastic and Inflammatory Lesions in Rabbits: Validation with FDG-PET and Histology Contrast Media & Molecular Imaging. May-Jun, 2010 | Pubmed ID: 20586032 Continuous Docetaxel Chemotherapy Improves Therapeutic Efficacy in Murine Models of Ovarian Cancer Molecular Cancer Therapeutics. Jun, 2010 | Pubmed ID: 20530719 Gold Nanoparticles As Radiation Sensitizers in Cancer Therapy Radiation Research. Jun, 2010 | Pubmed ID: 20518651 Utility of Transdermal Fentanyl for Prevention of Iatrogenic Opioid Abstinence Syndrome in Children Journal of Opioid Management. Mar-Apr, 2010 | Pubmed ID: 20481176 The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles Molecular Pharmaceutics. Aug, 2010 | Pubmed ID: 20476759 Polymeric Drug Delivery Systems for Localized Cancer Chemotherapy Drug Delivery. Aug, 2010 | Pubmed ID: 20429844 Poly(ethylene Glycol)-b-poly(epsilon-caprolactone) Micelles Containing Chemically Conjugated and Physically Entrapped Docetaxel: Synthesis, Characterization, and the Influence of the Drug on Micelle Morphology Biomacromolecules. May, 2010 | Pubmed ID: 20369884 In Vivo Distribution of Polymeric Nanoparticles at the Whole-body, Tumor, and Cellular Levels Pharmaceutical Research. Nov, 2010 | Pubmed ID: 20195708 Multifunctional Block Copolymer Micelles for the Delivery of 111In to EGFR-positive Breast Cancer Cells for Targeted Auger Electron Radiotherapy Molecular Pharmaceutics. Feb, 2010 | Pubmed ID: 19924993 Cellular Uptake and Transport of Gold Nanoparticles Incorporated in a Liposomal Carrier Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2010 | Pubmed ID: 19447206 Noninvasive Monitoring of the Fate of 111In-labeled Block Copolymer Micelles by High Resolution and High Sensitivity MicroSPECT/CT Imaging Molecular Pharmaceutics. Mar-Apr, 2009 | Pubmed ID: 19718806 Enhancement of Docetaxel Solubility Via Conjugation of Formulation-compatible Moieties Organic & Biomolecular Chemistry. Sep, 2009 | Pubmed ID: 19675898 Sixth International Nanomedicine and Drug Delivery Symposium (NanoDDS'08) Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2009 | Pubmed ID: 19567258 Intracellular Uptake, Transport, and Processing of Nanostructures in Cancer Cells Nanomedicine : Nanotechnology, Biology, and Medicine. Jun, 2009 | Pubmed ID: 19480047 Chitosan-phospholipid Blend for Sustained and Localized Delivery of Docetaxel to the Peritoneal Cavity International Journal of Pharmaceutics. Jul, 2009 | Pubmed ID: 19442712 Biocompatibility of Injectable Chitosan-phospholipid Implant Systems Biomaterials. Aug, 2009 | Pubmed ID: 19394688 Block Copolymer Micelles for Delivery of Cancer Therapy: Transport at the Whole Body, Tissue and Cellular Levels Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2009 | Pubmed ID: 19376167 Quantitative CT Imaging of the Spatial and Temporal Distribution of Liposomes in a Rabbit Tumor Model Molecular Pharmaceutics. Mar-Apr, 2009 | Pubmed ID: 19298061 Morphological Control of Poly(ethylene Glycol)-block-poly(epsilon-caprolactone) Copolymer Aggregates in Aqueous Solution Biomacromolecules. Sep, 2008 | Pubmed ID: 18702541 Intermolecular Interactions and Morphology of Aqueous Polymer/surfactant Mixtures Containing Cationic Chitosan and Nonionic Sorbitan Esters Biomacromolecules. Aug, 2008 | Pubmed ID: 18605692 Influence of Molecular Organization and Interactions on Drug Release for an Injectable Polymer-lipid Blend International Journal of Pharmaceutics. Aug, 2008 | Pubmed ID: 18550303 Effects of Sustained and Intermittent Paclitaxel Therapy on Tumor Repopulation in Ovarian Cancer Molecular Cancer Therapeutics. Mar, 2008 | Pubmed ID: 18347149 Drug Release Mechanism of Paclitaxel from a Chitosan-lipid Implant System: Effect of Swelling, Degradation and Morphology European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. May, 2008 | Pubmed ID: 18164931 Nano-sized Assemblies of a PEG-docetaxel Conjugate As a Formulation Strategy for Docetaxel Journal of Pharmaceutical Sciences. Aug, 2008 | Pubmed ID: 18064681 Predicting the Solubility of the Anti-cancer Agent Docetaxel in Small Molecule Excipients Using Computational Methods Pharmaceutical Research. Jan, 2008 | Pubmed ID: 17705028 Diblock Copolymer Micelles Deliver Hydrophobic Protoporphyrin IX for Photodynamic Therapy Photochemistry and Photobiology. Nov-Dec, 2007 | Pubmed ID: 18028227 Apoptotic Epidermal Growth Factor (EGF)-conjugated Block Copolymer Micelles As a Nanotechnology Platform for Targeted Combination Therapy Molecular Pharmaceutics. Sep-Oct, 2007 | Pubmed ID: 17867644 Long-circulating Poly(ethylene Glycol)-coated Emulsions to Target Solid Tumors European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Sep, 2007 | Pubmed ID: 17490868 Influence of Poly(ethylene Glycol) Grafting Density and Polymer Length on Liposomes: Relating Plasma Circulation Lifetimes to Protein Binding Biochimica Et Biophysica Acta. Jun, 2007 | Pubmed ID: 17400180 Novel Biocompatible Intraperitoneal Drug Delivery System Increases Tolerability and Therapeutic Efficacy of Paclitaxel in a Human Ovarian Cancer Xenograft Model Cancer Chemotherapy and Pharmacology. Nov, 2007 | Pubmed ID: 17375303 In Vivo Performance of a Liposomal Vascular Contrast Agent for CT and MR-based Image Guidance Applications Pharmaceutical Research. Jun, 2007 | Pubmed ID: 17373581 In Vivo Fate of Unimers and Micelles of a Poly(ethylene Glycol)-block-poly(caprolactone) Copolymer in Mice Following Intravenous Administration European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Mar, 2007 | Pubmed ID: 17257817 Impact of Intraperitoneal, Sustained Delivery of Paclitaxel on the Expression of P-glycoprotein in Ovarian Tumors Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2007 | Pubmed ID: 17113177 Synthesis and Physicochemical and Dynamic Mechanical Properties of a Water-soluble Chitosan Derivative As a Biomaterial Biomacromolecules. Dec, 2006 | Pubmed ID: 17154488 Synthesis and Physicochemical and Dynamic Mechanical Properties of a Water-soluble Chitosan Derivative As a Biomaterial Biomacromolecules. Oct, 2006 | Pubmed ID: 17025361 Epidermal Growth Factor-conjugated Poly(ethylene Glycol)-block- Poly(delta-valerolactone) Copolymer Micelles for Targeted Delivery of Chemotherapeutics Bioconjugate Chemistry. Mar-Apr, 2006 | Pubmed ID: 16536472 Multimodal Contrast Agent for Combined Computed Tomography and Magnetic Resonance Imaging Applications Investigative Radiology. Mar, 2006 | Pubmed ID: 16481918 Liposome Formulation of a Novel Hydrophobic Aryl-imidazole Compound for Anti-cancer Therapy Cancer Chemotherapy and Pharmacology. Sep, 2006 | Pubmed ID: 16333677 Methoxy Poly(ethylene Glycol)-block-poly(delta-valerolactone) Copolymer Micelles for Formulation of Hydrophobic Drugs Biomacromolecules. Nov-Dec, 2005 | Pubmed ID: 16283736 How Well Are We Caring for Caregivers? Prevalence of Grief-related Symptoms and Need for Bereavement Support Among Long-term Care Staff Journal of Pain and Symptom Management. Sep, 2005 | Pubmed ID: 16183006 Synthesis and Characterization of Six-arm Star Poly(delta-valerolactone)-block-methoxy Poly(ethylene Glycol) Copolymers Biomacromolecules. Jul-Aug, 2005 | Pubmed ID: 16004456 In Vitro and in Vivo Characterization of a Novel Biocompatible Polymer-lipid Implant System for the Sustained Delivery of Paclitaxel Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2005 | Pubmed ID: 15866344 Influence of Serum Protein on Polycarbonate-based Copolymer Micelles As a Delivery System for a Hydrophobic Anti-cancer Agent Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2005 | Pubmed ID: 15763628 Monodisperse Chitosan Nanoparticles for Mucosal Drug Delivery Biomacromolecules. Nov-Dec, 2004 | Pubmed ID: 15530064 Engineering Lipobeads: Properties of the Hydrogel Core and the Lipid Bilayer Shell Biomacromolecules. Nov-Dec, 2004 | Pubmed ID: 15530037 Synthesis and Characterization of Biodegradable Poly(ethylene Glycol)-block-poly(5-benzyloxy-trimethylene Carbonate) Copolymers for Drug Delivery Biomacromolecules. Sep-Oct, 2004 | Pubmed ID: 15360292 PH Gradient Loading of Anthracyclines into Cholesterol-free Liposomes: Enhancing Drug Loading Rates Through Use of Ethanol Biochimica Et Biophysica Acta. Feb, 2004 | Pubmed ID: 14967474 Polymer-drug Compatibility: a Guide to the Development of Delivery Systems for the Anticancer Agent, Ellipticine Journal of Pharmaceutical Sciences. Jan, 2004 | Pubmed ID: 14648643 "Swollen" Macrocycles: Palladium(II)-Directed Template Syntheses of Pendant-Arm 14-, 16-, and 18-Membered Macrocycles Inorganic Chemistry. Aug, 1996 | Pubmed ID: 11666700 Aniônico polimerização de um copolímero anfifílicas para Preparação de copolímero em bloco As micelas estabilizada por interacções de empilhamento π-¸ Frantz Le Dévédec1, Loujin Houdaihed1, Christine Allen1 1Leslie Dan Faculty of Pharmacy, University of Toronto JoVE 54422 Chemistry Medidas espaciais de Perfusão, intersticial pressão do produto e lipossomas Acumulação em tumores sólidos Shawn Stapleton1,2,3, Daniel Mirmilshteyn2, Jinzi Zheng3,4, Christine Allen2,4,5, David A. Jaffray1,2,3,4,5,6 1Department of Medical Biophysics, University of Toronto, 2Leslie Dan Faculty of Pharmacy, University of Toronto, 3STTARR Innovation Centre, Princess Margaret Cancer Centre, 4Institute of Biomaterials and Biomedical Engineering, University of Toronto, 5Techna Institute, University Health Network, 6Radiation Medicine Program, Princess Margaret Cancer Centre Medicine Customizado aparelho de aquecimento à base de laser para lançamento acionado de cisplatina de termossensível lipossomas com Ressonância Magnética Orientação Imagem Yannan N. Dou1, Robert A. Weersink2,5, Warren D. Foltz5,6, Jinzi Zheng5,6, Naz Chaudary7, David A. Jaffray2,3,4,5,6, Christine Allen1 1Leslie Dan Faculty of Pharmacy, University of Toronto, 2Department of Radiation Oncology, University of Toronto, 3Medical Biophysics, University of Toronto, 4Institute of Biomaterials & Biomedical Engineering, University of Toronto, 5Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, 6STTARR Innovation Center, University Health Network, 7Ontario Cancer Institute, University Health Network JoVE 53055 Bioengineering
Aniônico polimerização de um copolímero anfifílicas para Preparação de copolímero em bloco As micelas estabilizada por interacções de empilhamento π-¸ Frantz Le Dévédec1, Loujin Houdaihed1, Christine Allen1 1Leslie Dan Faculty of Pharmacy, University of Toronto JoVE 54422 Chemistry
Medidas espaciais de Perfusão, intersticial pressão do produto e lipossomas Acumulação em tumores sólidos Shawn Stapleton1,2,3, Daniel Mirmilshteyn2, Jinzi Zheng3,4, Christine Allen2,4,5, David A. Jaffray1,2,3,4,5,6 1Department of Medical Biophysics, University of Toronto, 2Leslie Dan Faculty of Pharmacy, University of Toronto, 3STTARR Innovation Centre, Princess Margaret Cancer Centre, 4Institute of Biomaterials and Biomedical Engineering, University of Toronto, 5Techna Institute, University Health Network, 6Radiation Medicine Program, Princess Margaret Cancer Centre Medicine
Customizado aparelho de aquecimento à base de laser para lançamento acionado de cisplatina de termossensível lipossomas com Ressonância Magnética Orientação Imagem Yannan N. Dou1, Robert A. Weersink2,5, Warren D. Foltz5,6, Jinzi Zheng5,6, Naz Chaudary7, David A. Jaffray2,3,4,5,6, Christine Allen1 1Leslie Dan Faculty of Pharmacy, University of Toronto, 2Department of Radiation Oncology, University of Toronto, 3Medical Biophysics, University of Toronto, 4Institute of Biomaterials & Biomedical Engineering, University of Toronto, 5Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, 6STTARR Innovation Center, University Health Network, 7Ontario Cancer Institute, University Health Network JoVE 53055 Bioengineering