Colin W. Pouton Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences Monash University Biography Publications Institution JoVE Articles Colin W. Pouton has not added a biography. If you are Colin W. Pouton and would like to personalize this page please email our Author Liaison for assistance. Publications 'Stealth' Lipid-based Formulations: Poly(ethylene Glycol)-mediated Digestion Inhibition Improves Oral Bioavailability of a Model Poorly Water Soluble Drug Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014 | Pubmed ID: 25058571 Digestion of Phospholipids After Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components Molecular Pharmaceutics. Aug, 2014 | Pubmed ID: 24987935 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 4: Proposing a New Lipid Formulation Performance Classification System Journal of Pharmaceutical Sciences. Aug, 2014 | Pubmed ID: 24985238 SIRPA, VCAM1 and CD34 Identify Discrete Lineages During Early Human Cardiovascular Development Stem Cell Research. Jul, 2014 | Pubmed ID: 24968096 Human Leukocyte Antigen Haplotype Phasing by Allele-specific Enrichment with Peptide Nucleic Acid Probes Molecular Genetics & Genomic Medicine. May, 2014 | Pubmed ID: 24936514 Non-linear Increases in Danazol Exposure with Dose in Older Vs. Younger Beagle Dogs: the Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion Pharmaceutical Research. Jun, 2014 | Pubmed ID: 24477676 Choice of Nonionic Surfactant Used to Formulate Type IIIA Self-emulsifying Drug Delivery Systems and the Physicochemical Properties of the Drug Have a Pronounced Influence on the Degree of Drug Supersaturation That Develops During in Vitro Digestion Journal of Pharmaceutical Sciences. Apr, 2014 | Pubmed ID: 24470073 The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine As Cytotoxic Agents ChemMedChem. Feb, 2014 | Pubmed ID: 24339417 DNA-dependent Protein Kinase is a Context Dependent Regulator of Lmx1a and Midbrain Specification PloS One. 2013 | Pubmed ID: 24194952 Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients Pharmaceutical Research. Dec, 2013 | Pubmed ID: 24092054 Lipid-based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/absorption Pathway Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23824582 In Vitro Assessment of Drug-free and Fenofibrate-containing Lipid Formulations Using Dispersion and Digestion Testing Gives Detailed Insights into the Likely Fate of Formulations in the Intestine European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2013 | Pubmed ID: 23684915 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the in Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-based Formulations Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23661145 Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis Molecular Pharmaceutics. Aug, 2013 | Pubmed ID: 23631696 Strategies to Address Low Drug Solubility in Discovery and Development Pharmacological Reviews. Jan, 2013 | Pubmed ID: 23383426 In Vitro Digestion Testing of Lipid-based Delivery Systems: Calcium Ions Combine with Fatty Acids Liberated from Triglyceride Rich Lipid Solutions to Form Soaps and Reduce the Solubilization Capacity of Colloidal Digestion Products International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23178598 Synthesis and Biological Evaluation of N-substituted Noscapine Analogues ChemMedChem. Dec, 2012 | Pubmed ID: 23055449 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations During in Vitro Digestion Molecular Pharmaceutics. Nov, 2012 | Pubmed ID: 23030411 Colloidal Characteristics and Formulation of Pure Protein Particulate Vaccines The Journal of Pharmacy and Pharmacology. Oct, 2012 | Pubmed ID: 22943169 Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N(6)-substituents As Adenosine A(1) Receptor Agonists ChemMedChem. Jul, 2012 | Pubmed ID: 22684887 Lipid Digestion As a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Molecular Pharmaceutics. Jul, 2012 | Pubmed ID: 22656917 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 1: Method Parameterization and Comparison of in Vitro Digestion Profiles Across a Range of Representative Formulations Journal of Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22644939 Lmx1a Allows Context-specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells Stem Cells (Dayton, Ohio). Jul, 2012 | Pubmed ID: 22495882 Synthesis and Pharmacological Evaluation of Dual Acting Antioxidant A(2A) Adenosine Receptor Agonists Journal of Medicinal Chemistry. Apr, 2012 | Pubmed ID: 22432713 In Vitro Maturation of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Implications for Transplantation PloS One. 2012 | Pubmed ID: 22384125 Enhanced Extravasation, Stability and in Vivo Cardiac Gene Silencing Via in Situ SiRNA-albumin Conjugation Molecular Pharmaceutics. Jan, 2012 | Pubmed ID: 22141328 NKX2-5(eGFP/w) HESCs for Isolation of Human Cardiac Progenitors and Cardiomyocytes Nature Methods. Dec, 2011 | Pubmed ID: 22020065 Using Molecular Dynamics to Study Liquid Phase Behavior: Simulations of the Ternary Sodium Laurate/sodium Oleate/water System Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2011 | Pubmed ID: 21838286 Commercially Supplied Amine-Modified SiRNAs May Require Ultrafiltration Prior to Conjugation with Amine-Reactive Compounds Journal of Nucleic Acids. 2011 | Pubmed ID: 21772990 Extended Periods of Neural Induction and Propagation of Embryonic Stem Cell-derived Neural Progenitors with EGF and FGF2 Enhances Lmx1a Expression and Neurogenic Potential Neurochemistry International. Sep, 2011 | Pubmed ID: 21624410 Directed Expression of Gata2, Mash1, and Foxa2 Synergize to Induce the Serotonergic Neuron Phenotype During in Vitro Differentiation of Embryonic Stem Cells Stem Cells (Dayton, Ohio). Jun, 2011 | Pubmed ID: 21472823 A Targeted NKX2.1 Human Embryonic Stem Cell Reporter Line Enables Identification of Human Basal Forebrain Derivatives Stem Cells (Dayton, Ohio). Mar, 2011 | Pubmed ID: 21425409 Mechanism of Microtubule-facilitated "fast Track" Nuclear Import The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21339293 Using Polymeric Precipitation Inhibitors to Improve the Absorption of Poorly Water-soluble Drugs: A Mechanistic Basis for Utility Journal of Drug Targeting. Dec, 2010 | Pubmed ID: 20973755 Cooperative Cardioprotection Through Adenosine A1 and A2A Receptor Agonism in Ischemia-reperfused Isolated Mouse Heart Journal of Cardiovascular Pharmacology. Oct, 2010 | Pubmed ID: 20930592 Interaction of Viruses with Host Cell Molecular Motors Current Opinion in Biotechnology. Oct, 2010 | Pubmed ID: 20638267 Adenovirus: a Blueprint for Non-viral Gene Delivery Current Opinion in Biotechnology. Oct, 2010 | Pubmed ID: 20638266 A Novel Highly Selective Adenosine A1 Receptor Agonist VCP28 Reduces Ischemia Injury in a Cardiac Cell Line and Ischemia-reperfusion Injury in Isolated Rat Hearts at Concentrations That Do Not Affect Heart Rate Journal of Cardiovascular Pharmacology. Sep, 2010 | Pubmed ID: 20571427 Synthesis and Evaluation of New N6-substituted Adenosine-5'-N-methylcarboxamides As A3 Adenosine Receptor Agonists Bioorganic & Medicinal Chemistry. May, 2010 | Pubmed ID: 20385496 Investigations into the Binding Affinities of Different Human 5-HT4 Receptor Splice Variants Pharmacology. 2010 | Pubmed ID: 20299822 Troubleshooting Immunohistochemical Labelling of Proliferating Cell Nuclear Antigen (PCNA) in Cryocut Tissue Sections of Mouse Prostate Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2010 | Pubmed ID: 19945538 Modulation of Nucleocytoplasmic Trafficking by Retention in Cytoplasm or Nucleus Journal of Cellular Biochemistry. Aug, 2009 | Pubmed ID: 19507231 Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine Journal of Cardiovascular Pharmacology. May, 2009 | Pubmed ID: 19333129 A Stably Engineered, Suicidal Strain of Listeria Monocytogenes Delivers Protein And/or DNA to Fully Differentiated Intestinal Epithelial Monolayers Molecular Pharmaceutics. Jul-Aug, 2009 | Pubmed ID: 19317435 Overcoming Biological Barriers to in Vivo Efficacy of Antisense Oligonucleotides Expert Reviews in Molecular Medicine. 2009 | Pubmed ID: 19302730 Structure and Dynamics of Glyceride Lipid Formulations, with Propylene Glycol and Water Molecular Pharmaceutics. Mar-Apr, 2009 | Pubmed ID: 19260675 Design of Lipid-based Formulations for Oral Administration of Poorly Water-soluble Drugs: Precipitation of Drug After Dispersion of Formulations in Aqueous Solution Journal of Pharmaceutical Sciences. Oct, 2009 | Pubmed ID: 19130605 Preparation and in Vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery Bioconjugate Chemistry. Apr, 2008 | Pubmed ID: 18333604 Enhancing Intestinal Drug Solubilisation Using Lipid-based Delivery Systems Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18155801 Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18068260 Evaluation of the Impact of Surfactant Digestion on the Bioavailability of Danazol After Oral Administration of Lipidic Self-emulsifying Formulations to Dogs Journal of Pharmaceutical Sciences. Feb, 2008 | Pubmed ID: 18064698 Dual Acting Antioxidant A1 Adenosine Receptor Agonists Bioorganic & Medicinal Chemistry Letters. Oct, 2007 | Pubmed ID: 17689079 Targeted Delivery to the Nucleus Advanced Drug Delivery Reviews. Aug, 2007 | Pubmed ID: 17681634 Embryonic Stem Cells As a Source of Models for Drug Discovery Nature Reviews. Drug Discovery. Aug, 2007 | Pubmed ID: 17667955 Dynein Light Chain Association Sequences Can Facilitate Nuclear Protein Import Molecular Biology of the Cell. Aug, 2007 | Pubmed ID: 17567954 A Microtubule-facilitated Nuclear Import Pathway for Cancer Regulatory Proteins Traffic (Copenhagen, Denmark). Jun, 2007 | Pubmed ID: 17511743 Heterogeneous Population of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Preliminary Phenotyping Based on Receptor Expression and Function The European Journal of Neuroscience. Apr, 2007 | Pubmed ID: 17419751 Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs Pharmaceutical Research. Apr, 2007 | Pubmed ID: 17372700 Comparison of 5-HT4 and 5-HT7 Receptor Expression and Function in the Circular Muscle of the Human Colon Life Sciences. Mar, 2007 | Pubmed ID: 17258778 Formulation of Poorly Water-soluble Drugs for Oral Administration: Physicochemical and Physiological Issues and the Lipid Formulation Classification System European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2006 | Pubmed ID: 16815001 Pharmaceutical Applications of Embryonic Stem Cells Advanced Drug Delivery Reviews. Dec, 2005 | Pubmed ID: 16290153 الزنك الاصبع نوكلياز المحسن استهداف الجينات في الخلايا الجذعية الجنينية البشرية Brigham J. Hartley1, Stewart A. Fabb1, Ben A.L. Finnin1, John M. Haynes1, Colin W. Pouton1 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University JoVE 51764 Biology
الزنك الاصبع نوكلياز المحسن استهداف الجينات في الخلايا الجذعية الجنينية البشرية Brigham J. Hartley1, Stewart A. Fabb1, Ben A.L. Finnin1, John M. Haynes1, Colin W. Pouton1 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University JoVE 51764 Biology