Constantinos M. Mikelis Department of Pharmaceutical Sciences, School of Pharmacy Texas Tech University Health Sciences Center Biography Publications Institution JoVE Articles Constantinos M. Mikelis has not added a biography. If you are Constantinos M. Mikelis and would like to personalize this page please email our Author Liaison for assistance. Publications Genetic Deletion or Tyrosine Phosphatase Inhibition of PTPRZ1 Activates C-Met to Up-regulate Angiogenesis and Lung Adenocarcinoma Growth International Journal of Cancer. Sep, 2023 | Pubmed ID: 37260355 Endothelial-Specific Targeting of RhoA Signaling Via CD31 Antibody-Conjugated Nanoparticles The Journal of Pharmacology and Experimental Therapeutics. Apr, 2023 | Pubmed ID: 36746610 Chlorotoxin and Lung Cancer: A Targeting Perspective for Drug Delivery Pharmaceutics. Nov, 2022 | Pubmed ID: 36559106 Human Dectin-1 Deficiency Impairs Macrophage-mediated Defense Against Phaeohyphomycosis The Journal of Clinical Investigation. Nov, 2022 | Pubmed ID: 36377664 An in Vitro Model of Glucose Transporter 1 Deficiency Syndrome at the Blood-brain Barrier Using Induced Pluripotent Stem Cells Journal of Neurochemistry. Sep, 2022 | Pubmed ID: 35943296 Chlorinated Benzothiadiazines Inhibit Angiogenesis Through Suppression of VEGFR2 Phosphorylation Bioorganic & Medicinal Chemistry. Aug, 2022 | Pubmed ID: 35635929 Angiopoietin-2-induced Lymphatic Endothelial Cell Migration Drives Lymphangiogenesis Via the β1 Integrin-RhoA-formin Axis Angiogenesis. Aug, 2022 | Pubmed ID: 35103877 Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis ACS Chemical Neuroscience. Jan, 2022 | Pubmed ID: 34978174 Protein Tyrosine Phosphatase Receptor-ζ1 Deletion Triggers Defective Heart Morphogenesis in Mice and Zebrafish American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2022 | Pubmed ID: 34767486 MiRNAs As Anti-Angiogenic Adjuvant Therapy in Cancer: Synopsis and Potential Frontiers in Oncology. 2021 | Pubmed ID: 34956857 Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders Drugs. Oct, 2021 | Pubmed ID: 34586603 Role of BFGF in Acquired Resistance Upon Anti-VEGF Therapy in Cancer Cancers. Mar, 2021 | Pubmed ID: 33804681 Advanced Bioinformatic Analysis and Pathway Prediction of NSCLC Cells Upon Cisplatin Resistance Scientific Reports. Mar, 2021 | Pubmed ID: 33753779 Delayed Exercise-induced Upregulation of Angiogenic Proteins and Recovery of Motor Function After Photothrombotic Stroke in Mice Neuroscience. May, 2021 | Pubmed ID: 33667592 Glycolysis is Integral to Histamine-induced Endothelial Hyperpermeability FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2021 | Pubmed ID: 33566443 Design, Synthesis and Structure-activity Relationship Study of Novel Urea Compounds As FGFR1 Inhibitors to Treat Metastatic Triple-negative Breast Cancer European Journal of Medicinal Chemistry. Jan, 2021 | Pubmed ID: 33039722 Identification of Rho GEF and RhoA Activation by Pull-Down Assays Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 32808262 In Vivo Ear Sponge Lymphangiogenesis Assay Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 32808261 Investigating Epidermal Interactions Through an In Vivo Cutaneous Wound-Healing Assay Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 32808253 An IPSC-Derived Neuron Model of CLN3 Disease Facilitates Small Molecule Phenotypic Screening ACS Pharmacology & Translational Science. Oct, 2020 | Pubmed ID: 33073192 Pleiotrophin Selectively Binds to Vascular Endothelial Growth Factor Receptor 2 and Inhibits or Stimulates Cell Migration Depending on αβ Integrin Expression Angiogenesis. Nov, 2020 | Pubmed ID: 32681389 S1PR1 Regulates the Quiescence of Lymphatic Vessels by Inhibiting Laminar Shear Stress-dependent VEGF-C Signaling JCI Insight. Jul, 2020 | Pubmed ID: 32544090 Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview Cancers. May, 2020 | Pubmed ID: 32429547 Anti-angiogenic Effects of VEGF Stimulation on Endothelium Deficient in Phosphoinositide Recycling Nature Communications. Mar, 2020 | Pubmed ID: 32139674 Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis International Journal of Molecular Sciences. Jan, 2020 | Pubmed ID: 31979394 In Vitro Wound Healing Assays to Investigate Epidermal Migration Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 31123996 Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg? Frontiers in Oncology. 2019 | Pubmed ID: 31799190 Endothelial RhoA GTPase is Essential for in Vitro Endothelial Functions but Dispensable for Physiological in Vivo Angiogenesis Scientific Reports. Aug, 2019 | Pubmed ID: 31406143 Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology Cells. May, 2019 | Pubmed ID: 31108880 Matrigel Plug Assay for In Vivo Evaluation of Angiogenesis Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30825178 In Vitro Spheroid Sprouting Assay of Angiogenesis Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30825177 DNA Repair Response Adaptors: Novel Targets for Vasoproliferative Retinopathy? Thrombosis and Haemostasis. Mar, 2019 | Pubmed ID: 30620993 Analogs of Penfluridol As Chemotherapeutic Agents with Reduced Central Nervous System Activity Bioorganic & Medicinal Chemistry Letters. Dec, 2018 | Pubmed ID: 30389290 Multipronged Activity of Combinatorial MiR-143 and MiR-506 Inhibits Lung Cancer Cell Cycle Progression and Angiogenesis in Vitro Scientific Reports. Jul, 2018 | Pubmed ID: 30002440 Conception, Synthesis, and Characterization of a Rofecoxib-combretastatin Hybrid Drug with Potent Cyclooxygenase-2 (COX-2) Inhibiting and Microtubule Disrupting Activities in Colon Cancer Cell Culture and Xenograft Models Oncotarget. May, 2018 | Pubmed ID: 29899846 GM-CSF Therapy in Human Caspase Recruitment Domain-containing Protein 9 Deficiency The Journal of Allergy and Clinical Immunology. Oct, 2018 | Pubmed ID: 29890237 The Homozygous CX3CR1-M280 Mutation Impairs Human Monocyte Survival JCI Insight. Feb, 2018 | Pubmed ID: 29415879 Mechanisms of Angiogenesis in Microbe-regulated Inflammatory and Neoplastic Conditions Angiogenesis. Feb, 2018 | Pubmed ID: 29110215 Epidermal Loss of Gαq Confers a Migratory and Differentiation Defect in Keratinocytes PloS One. 2017 | Pubmed ID: 28301547 Extrapulmonary Infection in Patients with CARD9 Deficiency JCI Insight. Oct, 2016 | Pubmed ID: 27777981 Inactivating Mutations in GNA13 and RHOA in Burkitt's Lymphoma and Diffuse Large B-cell Lymphoma: a Tumor Suppressor Function for the Gα13/RhoA Axis in B Cells Oncogene. 07, 2016 | Pubmed ID: 26616858 CARD9-Dependent Neutrophil Recruitment Protects Against Fungal Invasion of the Central Nervous System PLoS Pathogens. Dec, 2015 | Pubmed ID: 26679537 Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells Racheal Grace Akwii*1, Margarita Lamprou*2, Maria Georgomanoli3, Andriana Plevriti2, Antonia Marazioti4, Athanasia Mouzaki5, George Mattheolabakis6, Constantinos M. Mikelis1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 2Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 3Division of Flow Cytometry and Division of MDx & Life Sciences, SB BioAnalytica, 4Basic Sciences Laboratory, Department of Physiotherapy, University of Peloponnese, 5Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, 6School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe Biology
Author Spotlight: Magnetic Bead-Based Isolation of Murine Dermal Lymphatic Endothelial Cells Racheal Grace Akwii*1, Margarita Lamprou*2, Maria Georgomanoli3, Andriana Plevriti2, Antonia Marazioti4, Athanasia Mouzaki5, George Mattheolabakis6, Constantinos M. Mikelis1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 2Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 3Division of Flow Cytometry and Division of MDx & Life Sciences, SB BioAnalytica, 4Basic Sciences Laboratory, Department of Physiotherapy, University of Peloponnese, 5Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, 6School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe Biology