Cornelis van Breemen Department of Anaesthesiology, Pharmacology, and Therapeutics University of British Columbia Biography Publications Institution JoVE Articles Cornelis van Breemen has not added a biography. If you are Cornelis van Breemen and would like to personalize this page please email our Author Liaison for assistance. Publications Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras PloS One. 2015 | Pubmed ID: 26516777 Drop in Endo/sarcoplasmic Calcium Precedes the Unfolded Protein Response in Brefeldin A-treated Vascular Smooth Muscle Cells European Journal of Pharmacology. Oct, 2015 | Pubmed ID: 26172080 Cytoplasmic Nanojunctions Between Lysosomes and Sarcoplasmic Reticulum Are Required for Specific Calcium Signaling F1000Research. 2014 | Pubmed ID: 25126414 Quantification of Aortic and Cutaneous Elastin and Collagen Morphology in Marfan Syndrome by Multiphoton Microscopy Journal of Structural Biology. Sep, 2014 | Pubmed ID: 25086405 Calcium Regulation in Aortic Smooth Muscle Cells During the Initial Phase of Tunicamycin-induced Endo/sarcoplasmic Reticulum Stress European Journal of Pharmacology. Jul, 2014 | Pubmed ID: 24769510 Calcium Oscillations in Human Mesenteric Vascular Smooth Muscle Biochemical and Biophysical Research Communications. Feb, 2014 | Pubmed ID: 24508261 Waves of Calcium Depletion in the Sarcoplasmic Reticulum of Vascular Smooth Muscle Cells: an Inside View of Spatiotemporal Ca2+ Regulation PloS One. 2013 | Pubmed ID: 23408969 Pan-junctional Sarcoplasmic Reticulum in Vascular Smooth Muscle: Nanospace Ca2+ Transport for Site- and Function-specific Ca2+ Signalling The Journal of Physiology. Apr, 2013 | Pubmed ID: 23339179 The Role of Cytoplasmic Nanospaces in Smooth Muscle Cell Ca2+ Signalling Protoplasma. Feb, 2012 | Pubmed ID: 22083879 The Structure and Functioning of the Couplon in the Mammalian Cardiomyocyte Protoplasma. Feb, 2012 | Pubmed ID: 22057630 Exposure to Diesel Exhaust Up-regulates INOS Expression in ApoE Knockout Mice Toxicology and Applied Pharmacology. Sep, 2011 | Pubmed ID: 21722660 Changes in Atherosclerotic Plaques Induced by Inhalation of Diesel Exhaust Atherosclerosis. Jun, 2011 | Pubmed ID: 21435644 Diosgenin Modulates Vascular Smooth Muscle Cell Function by Regulating Cell Viability, Migration, and Calcium Homeostasis The Journal of Pharmacology and Experimental Therapeutics. Mar, 2011 | Pubmed ID: 21177478 Effectiveness of Combination of Losartan Potassium and Doxycycline Versus Single-drug Treatments in the Secondary Prevention of Thoracic Aortic Aneurysm in Marfan Syndrome The Journal of Thoracic and Cardiovascular Surgery. Aug, 2010 | Pubmed ID: 20189193 Integrin-linked Kinase Functions As a Downstream Signal of Platelet-derived Growth Factor to Regulate Actin Polymerization and Vascular Smooth Muscle Cell Migration BMC Cell Biology. 2010 | Pubmed ID: 20178627 A Comparative Study of Alpha-adrenergic Receptor Mediated Ca(2+) Signals and Contraction in Intact Human and Mouse Vascular Smooth Muscle European Journal of Pharmacology. Mar, 2010 | Pubmed ID: 20004190 Vasomotor Dysfunction in the Thoracic Aorta of Marfan Syndrome is Associated with Accumulation of Oxidative Stress Vascular Pharmacology. Jan-Feb, 2010 | Pubmed ID: 19879959 Long-term Effects of Losartan on Structure and Function of the Thoracic Aorta in a Mouse Model of Marfan Syndrome British Journal of Pharmacology. Nov, 2009 | Pubmed ID: 19814725 A Model for the Generation of Localized Transient [Na+] Elevations in Vascular Smooth Muscle Biochemical and Biophysical Research Communications. Nov, 2009 | Pubmed ID: 19733153 Diabetes Modulates Capacitative Calcium Entry and Expression of Transient Receptor Potential Canonical Channels in Human Saphenous Vein European Journal of Pharmacology. Jun, 2009 | Pubmed ID: 19393642 Mitochondrial Regulation of Sarcoplasmic Reticulum Ca2+ Content in Vascular Smooth Muscle Cells Circulation Research. Jan, 2009 | Pubmed ID: 19023135 Characteristics of Agonist-induced Ca2+ Responses in Diseased Human Valvular Myofibroblasts Proceedings of the Western Pharmacology Society. 2008 | Pubmed ID: 19544665 Ca2+ Signaling in Smooth Muscle: TRPC6, NCX and LNats in Nanodomains Channels (Austin, Tex.). Jan-Feb, 2008 | Pubmed ID: 18690050 P2Y2 Receptor-mediated Ca2+ Signaling and Spontaneous Ca2+ Releases in Human Valvular Myofibroblasts International Heart Journal. Mar, 2008 | Pubmed ID: 18475022 Long-term Doxycycline is More Effective Than Atenolol to Prevent Thoracic Aortic Aneurysm in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 and -9 Circulation Research. Apr, 2008 | Pubmed ID: 18388324 Mechanical and Pharmacological Approaches to Investigate the Pathogenesis of Marfan Syndrome in the Abdominal Aorta Journal of Vascular Research. 2008 | Pubmed ID: 18212506 Arterialization of a Vein Graft Promotes Cell Cycle Progression Through Akt and P38 Mitogen-activated Protein Kinase Pathways: Impact of the Preparation Procedure The Canadian Journal of Cardiology. Dec, 2007 | Pubmed ID: 18060101 Transient Receptor Potential Channel 6-mediated, Localized Cytosolic [Na+] Transients Drive Na+/Ca2+ Exchanger-mediated Ca2+ Entry in Purinergically Stimulated Aorta Smooth Muscle Cells Circulation Research. Nov, 2007 | Pubmed ID: 17872462 Endothelin-1-mediated Wave-like [Ca2+]i Oscillations in Intact Rabbit Inferior Vena Cava Journal of Vascular Research. 2007 | Pubmed ID: 17657165 Loss of Elastic Fiber Integrity and Reduction of Vascular Smooth Muscle Contraction Resulting from the Upregulated Activities of Matrix Metalloproteinase-2 and -9 in the Thoracic Aortic Aneurysm in Marfan Syndrome Circulation Research. Aug, 2007 | Pubmed ID: 17641224 Hyperglycemia and Hyperlipidemia Are Associated with Endothelial Dysfunction During the Development of Type 2 Diabetes Canadian Journal of Physiology and Pharmacology. May, 2007 | Pubmed ID: 17632592 ATP Promotes NCX-reversal in Aortic Smooth Muscle Cells by DAG-activated Na+ Entry Biochemical and Biophysical Research Communications. Jun, 2007 | Pubmed ID: 17466270 A Quantitative Model for Linking Na+/Ca2+ Exchanger to SERCA During Refilling of the Sarcoplasmic Reticulum to Sustain [Ca2+] Oscillations in Vascular Smooth Muscle Cell Calcium. Dec, 2007 | Pubmed ID: 17418403 Enhanced Cell Cycle Entry and Mitogen-activated Protein Kinase-signaling and Downregulation of Matrix Metalloproteinase-1 and -3 in Human Diabetic Arterial Vasculature Atherosclerosis. Nov, 2007 | Pubmed ID: 17316652 Acetylcholine-induced Asynchronous Calcium Waves in Intact Human Bronchial Muscle Bundle American Journal of Respiratory Cell and Molecular Biology. May, 2007 | Pubmed ID: 17170384 Na+ Entry Via TRPC6 Causes Ca2+ Entry Via NCX Reversal in ATP Stimulated Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jan, 2007 | Pubmed ID: 17112478 Pharmacologic Relaxation of Vein Grafts is Beneficial Compared with Pressure Distention Caused by Upregulation of Endothelial Nitric Oxide Synthase and Nitric Oxide Production The Journal of Thoracic and Cardiovascular Surgery. Oct, 2006 | Pubmed ID: 17000306 Mitochondria Buffer NCX-mediated Ca2+-entry and Limit Its Diffusion into Vascular Smooth Muscle Cells Cell Calcium. Oct, 2006 | Pubmed ID: 16806462 Reduced Expression of Vascular Endothelial Growth Factor Paralleled with the Increased Angiostatin Expression Resulting from the Upregulated Activities of Matrix Metalloproteinase-2 and -9 in Human Type 2 Diabetic Arterial Vasculature Circulation Research. Jul, 2006 | Pubmed ID: 16778129 Human Vascular Smooth Muscle Cells from Diabetic Patients Are Resistant to Induced Apoptosis Due to High Bcl-2 Expression Diabetes. May, 2006 | Pubmed ID: 16644678 TRP Proteins: a New Dimension in the Treatment of Occlusive Vascular Disease Circulation Research. Mar, 2006 | Pubmed ID: 16514075 Mechanism of ACh-induced Asynchronous Calcium Waves and Tonic Contraction in Porcine Tracheal Muscle Bundle American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2006 | Pubmed ID: 16214818 Asynchronous Calcium Waves in Smooth Muscle Cells Canadian Journal of Physiology and Pharmacology. Aug-Sep, 2005 | Pubmed ID: 16333375 Pressure Distention Compared with Pharmacologic Relaxation in Vein Grafting Upregulates Matrix Metalloproteinase-2 and -9 Journal of Vascular Surgery. Oct, 2005 | Pubmed ID: 16242564 Compromised Arterial Function in Human Type 2 Diabetic Patients Diabetes. Aug, 2005 | Pubmed ID: 16046309 Rearrangement of the Close Contact Between the Mitochondria and the Sarcoplasmic Reticulum in Airway Smooth Muscle Cell Calcium. Apr, 2005 | Pubmed ID: 15755494 Calyculin-A Disrupts Subplasmalemmal Junction and Recurring Ca2+ Waves in Vascular Smooth Muscle Cell Calcium. Jan, 2005 | Pubmed ID: 15541459 Basal Calcium Entry in Vascular Smooth Muscle European Journal of Pharmacology. Nov, 2004 | Pubmed ID: 15556133 Vectorial Ca2+ Release Via Ryanodine Receptors Contributes to Ca2+ Extrusion from Freshly Isolated Rabbit Aortic Endothelial Cells Cell Calcium. Nov, 2004 | Pubmed ID: 15451626 Estrogen Modulation of Endothelium-derived Relaxing Factors by Human Endothelial Cells Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15325240 Involvement of Inositol 1,4,5-trisphosphate in Nicotinic Calcium Responses in Dystrophic Myotubes Assessed by Near-plasma Membrane Calcium Measurement The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15322099 Vascular Smooth Muscle Mitochondria at the Cross Roads of Ca(2+) Regulation Cell Calcium. Jun, 2004 | Pubmed ID: 15110141 Novel Regulatory Mechanism of Cardiomyocyte Contractility Involving ICAM-1 and the Cytoskeleton American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2004 | Pubmed ID: 15087287 Differential Regulation of Calcium Homeostasis in Adenocarcinoma Cell Line A549 and Its Taxol-resistant Subclone British Journal of Pharmacology. May, 2004 | Pubmed ID: 15066902 Traction Injury During Minimally Invasive Harvesting of the Saphenous Vein is Associated with Impaired Endothelial Function The Journal of Thoracic and Cardiovascular Surgery. Jan, 2004 | Pubmed ID: 14752414 Effect of Moderate Pressure Distention on the Human Saphenous Vein Vasomotor Function The Annals of Thoracic Surgery. Jan, 2004 | Pubmed ID: 14726044 Organellar Junctions Promote Targeted Ca2+ Signaling in Smooth Muscle: Why Two Membranes Are Better Than One Trends in Pharmacological Sciences. Jan, 2004 | Pubmed ID: 14723973 Augmented Contractile Response of Vascular Smooth Muscle in a Diabetic Mouse Model Journal of Vascular Research. Nov-Dec, 2003 | Pubmed ID: 14646372 Relationship Between Asynchronous Ca2+ Waves and Force Development in Intact Smooth Muscle Bundles of the Porcine Trachea American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2003 | Pubmed ID: 12936908 Histamine-induced Ca(2+) Signaling in Human Valvular Myofibroblasts Journal of Molecular and Cellular Cardiology. Apr, 2003 | Pubmed ID: 12689817 Agonist-induced Mitochondrial Ca2+ Transients in Smooth Muscle FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2003 | Pubmed ID: 12522109 Simultaneous in Situ Monitoring of Intracellular Ca2+ and NO in Endothelium of Coronary Arteries American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2002 | Pubmed ID: 12388315 In the Presence of L-NAME SERCA Blockade Induces Endothelium-dependent Contraction of Mouse Aorta Through Activation of Smooth Muscle Prostaglandin H2/thromboxane A2 Receptors British Journal of Pharmacology. Oct, 2002 | Pubmed ID: 12359637 The Mechanism of Excitation-contraction Coupling in Phenylephrine-stimulated Human Saphenous Vein American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2002 | Pubmed ID: 12234776 Relationship Between the Sarcoplasmic Reticulum and the Plasma Membrane Novartis Foundation Symposium. 2002 | Pubmed ID: 12164314 Sequential Opening of IP(3)-sensitive Ca(2+) Channels and SOC During Alpha-adrenergic Activation of Rabbit Vena Cava American Journal of Physiology. Heart and Circulatory Physiology. May, 2002 | Pubmed ID: 11959642 Ca(2+) Oscillations, Gradients, and Homeostasis in Vascular Smooth Muscle American Journal of Physiology. Heart and Circulatory Physiology. May, 2002 | Pubmed ID: 11959618 Raloxifene Enhances Nitric Oxide Release in Rat Aorta Via Increasing Endothelial Nitric Oxide MRNA Expression European Journal of Pharmacology. Jan, 2002 | Pubmed ID: 11779577 Mätning av kalcium Fluktuationer Inom sarkoplasmatiska retiklet av odlade glatta muskelceller Använda FRET-baserade Confocal avbildning Gabriela Ziomek1, Cornelis van Breemen1, Mitra Esfandiarei1,2 1Department of Anaesthesiology, Pharmacology, and Therapeutics, University of British Columbia, 2Department of Biomedical Sciences, Midwestern University Biology
Mätning av kalcium Fluktuationer Inom sarkoplasmatiska retiklet av odlade glatta muskelceller Använda FRET-baserade Confocal avbildning Gabriela Ziomek1, Cornelis van Breemen1, Mitra Esfandiarei1,2 1Department of Anaesthesiology, Pharmacology, and Therapeutics, University of British Columbia, 2Department of Biomedical Sciences, Midwestern University Biology