Craig A. Simmons Department of Mechanical and Industrial Engineering University of Toronto Biography Publications Institution JoVE Articles Craig A. Simmons has not added a biography. If you are Craig A. Simmons and would like to personalize this page please email our Author Liaison for assistance. Publications A Digital Microfluidic Platform for Primary Cell Culture and Analysis Lab on a Chip. Jan, 2012 | Pubmed ID: 22094822 An Improved Texture Correlation Algorithm to Measure Substrate-cytoskeletal Network Strain Transfer Under Large Compressive Strain Journal of Biomechanics. Jan, 2012 | Pubmed ID: 22030122 Osteocyte Apoptosis Regulates Osteoclast Precursor Adhesion Via Osteocytic IL-6 Secretion and Endothelial ICAM-1 Expression Bone. Jan, 2012 | Pubmed ID: 21986000 The Elastic Properties of Valve Interstitial Cells Undergoing Pathological Differentiation Journal of Biomechanics. Dec, 2011 | Pubmed ID: 22189247 Calcific Aortic Valve Disease: Not Simply a Degenerative Process: A Review and Agenda for Research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive Summary: Calcific Aortic Valve Disease-2011 Update Circulation. Oct, 2011 | Pubmed ID: 22007101 (Micro)managing the Mechanical Microenvironment Integrative Biology : Quantitative Biosciences from Nano to Macro. Oct, 2011 | Pubmed ID: 21931883 Animal Models of Calcific Aortic Valve Disease International Journal of Inflammation. 2011 | Pubmed ID: 21826258 Cell-matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease: Critical Roles for Matricellular, Matricrine, and Matrix Mechanics Cues Circulation Research. Jun, 2011 | Pubmed ID: 21659654 Inhibition of Pathological Differentiation of Valvular Interstitial Cells by C-type Natriuretic Peptide Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2011 | Pubmed ID: 21617139 A Microfluidic Membrane Device to Mimic Critical Components of the Vascular Microenvironment Biomicrofluidics. 2011 | Pubmed ID: 21522499 Functional Characterization of Human Coronary Artery Smooth Muscle Cells Under Cyclic Mechanical Strain in a Degradable Polyurethane Scaffold Biomaterials. Jul, 2011 | Pubmed ID: 21463894 Osteocyte Apoptosis is Mechanically Regulated and Induces Angiogenesis in Vitro Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Apr, 2011 | Pubmed ID: 21337392 The Aortic Valve Microenvironment and Its Role in Calcific Aortic Valve Disease Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. May-Jun, 2011 | Pubmed ID: 21256052 Lessons from (patho)physiological Tissue Stiffness and Their Implications for Drug Screening, Drug Delivery and Regenerative Medicine Advanced Drug Delivery Reviews. Apr, 2011 | Pubmed ID: 21241759 β-catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1-induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2011 | Pubmed ID: 21127288 Measurement of Layer-specific Mechanical Properties in Multilayered Biomaterials by Micropipette Aspiration Acta Biomaterialia. Mar, 2011 | Pubmed ID: 21056128 Single Cell Deposition and Patterning with a Robotic System PloS One. 2010 | Pubmed ID: 21042403 Osteocyte Apoptosis is Mechanically Regulated and Induces Angiogenesis in Vitro Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Oct, 2010 | Pubmed ID: 20979141 A Study of Vascular Smooth Muscle Cell Function Under Cyclic Mechanical Loading in a Polyurethane Scaffold with Optimized Porosity Acta Biomaterialia. Nov, 2010 | Pubmed ID: 20601230 Methylglyoxal-modified Collagen Promotes Myofibroblast Differentiation Matrix Biology : Journal of the International Society for Matrix Biology. Jul, 2010 | Pubmed ID: 20423729 Biaxial Mechanical Testing of Human Sclera Journal of Biomechanics. Jun, 2010 | Pubmed ID: 20399430 A Circular Cross-section PDMS Microfluidics System for Replication of Cardiovascular Flow Conditions Biomaterials. May, 2010 | Pubmed ID: 20167361 Microfabricated Arrays for High-throughput Screening of Cellular Response to Cyclic Substrate Deformation Lab on a Chip. Jan, 2010 | Pubmed ID: 20066251 Macro- and Microscale Fluid Flow Systems for Endothelial Cell Biology Lab on a Chip. Jan, 2010 | Pubmed ID: 20066241 Technique for Real-time Measurements of Endothelial Permeability in a Microfluidic Membrane Chip Using Laser-induced Fluorescence Detection Analytical Chemistry. Feb, 2010 | Pubmed ID: 20050596 Effects of Scleral Stiffness Properties on Optic Nerve Head Biomechanics Annals of Biomedical Engineering. Apr, 2010 | Pubmed ID: 20039133 Integration of Statistical Modeling and High-content Microscopy to Systematically Investigate Cell-substrate Interactions Biomaterials. Mar, 2010 | Pubmed ID: 20034663 Influence of Substrate Stiffness on the Phenotype of Heart Cells Biotechnology and Bioengineering. Apr, 2010 | Pubmed ID: 20014437 A Microfabricated Platform for High-throughput Unconfined Compression of Micropatterned Biomaterial Arrays Biomaterials. Jan, 2010 | Pubmed ID: 19819010 Boning Up on Wolff's Law: Mechanical Regulation of the Cells That Make and Maintain Bone Journal of Biomechanics. Jan, 2010 | Pubmed ID: 19818443 Molecular Markers of Early Orthodontic Tooth Movement The Angle Orthodontist. Nov, 2009 | Pubmed ID: 19852601 Comparison of Analytical and Inverse Finite Element Approaches to Estimate Cell Viscoelastic Properties by Micropipette Aspiration Journal of Biomechanics. Dec, 2009 | Pubmed ID: 19765713 Integrating Polyurethane Culture Substrates into Poly(dimethylsiloxane) Microdevices Biomaterials. Oct, 2009 | Pubmed ID: 19545891 Aortic Valve Mechanics: an Emerging Role for the Endothelium Journal of the American College of Cardiology. Apr, 2009 | Pubmed ID: 19371830 Calcification by Valve Interstitial Cells is Regulated by the Stiffness of the Extracellular Matrix Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2009 | Pubmed ID: 19304575 Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential The American Journal of Pathology. Mar, 2009 | Pubmed ID: 19218344 Augmenting Microgel Flow Via Receptor-ligand Binding in the Constrained Geometries of Microchannels Lab on a Chip. Jan, 2009 | Pubmed ID: 19107286 Techniques for Isolating and Purifying Porcine Aortic Valve Endothelial Cells The Journal of Heart Valve Disease. Nov, 2008 | Pubmed ID: 19137801 Mechanobiology of the Aortic Heart Valve The Journal of Heart Valve Disease. Jan, 2008 | Pubmed ID: 18365571 Substrate Architecture and Fluid-induced Shear Stress During Chondrocyte Seeding: Role of Alpha5beta1 Integrin Biomaterials. Jun, 2008 | Pubmed ID: 18314188 Matrix-dependent Adhesion of Vascular and Valvular Endothelial Cells in Microfluidic Channels Lab on a Chip. Dec, 2007 | Pubmed ID: 18030398 Methylglyoxal Inhibits the Binding Step of Collagen Phagocytosis The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17229729 Spatial Heterogeneity of Endothelial Phenotypes Correlates with Side-specific Vulnerability to Calcification in Normal Porcine Aortic Valves Circulation Research. Apr, 2005 | Pubmed ID: 15761200 Effects of a Bone-like Mineral Film on Phenotype of Adult Human Mesenchymal Stem Cells in Vitro Biomaterials. Jan, 2005 | Pubmed ID: 15262472 A Rapid, Reliable Method to Isolate High Quality Endothelial RNA from Small Spatially-defined Locations Annals of Biomedical Engineering. Oct, 2004 | Pubmed ID: 15535062 Mechanical Stimulation and Mitogen-activated Protein Kinase Signaling Independently Regulate Osteogenic Differentiation and Mineralization by Calcifying Vascular Cells Journal of Biomechanics. Oct, 2004 | Pubmed ID: 15336928 Aortic Valve: Turning over a New Leaf(let) in Endothelial Phenotypic Heterogeneity Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2004 | Pubmed ID: 15297285 Dual Growth Factor Delivery and Controlled Scaffold Degradation Enhance in Vivo Bone Formation by Transplanted Bone Marrow Stromal Cells Bone. Aug, 2004 | Pubmed ID: 15268909 Cyclic Strain Enhances Matrix Mineralization by Adult Human Mesenchymal Stem Cells Via the Extracellular Signal-regulated Kinase (ERK1/2) Signaling Pathway Journal of Biomechanics. Aug, 2003 | Pubmed ID: 12831733 Mikrofabricerade Plattformar för Mekaniskt Dynamic Cell Culture Christopher Moraes1,2, Yu Sun1,2, Craig A. Simmons1,2,3 1Department of Mechanical and Industrial Engineering, University of Toronto, 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, 3Faculty of Dentistry, University of Toronto JoVE 2224 Bioengineering
Mikrofabricerade Plattformar för Mekaniskt Dynamic Cell Culture Christopher Moraes1,2, Yu Sun1,2, Craig A. Simmons1,2,3 1Department of Mechanical and Industrial Engineering, University of Toronto, 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, 3Faculty of Dentistry, University of Toronto JoVE 2224 Bioengineering