Daniel T. Laskowitz Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology Duke University Biography Publications Institution JoVE Articles Daniel T. Laskowitz has not added a biography. If you are Daniel T. Laskowitz and would like to personalize this page please email our Author Liaison for assistance. Publications Statins and Delirium During Critical Illness: A Multicenter, Prospective Cohort Study Critical Care Medicine. May, 2014 | Pubmed ID: 24810528 Response to Letter Regarding Article, "Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery" Stroke; a Journal of Cerebral Circulation. Mar, 2014 | Pubmed ID: 24448987 The Role of Neuroendocrine Pathways in Prognosis After Stroke Expert Review of Neurotherapeutics. Feb, 2014 | Pubmed ID: 24428141 PH-sensitive NMDA Inhibitors Improve Outcome in a Murine Model of SAH Neurocritical Care. Feb, 2014 | Pubmed ID: 24420693 Genetic Influences and Neuropathological Sequelae of Repetitive Brain Injury Annals of Neurology. Apr, 2014 | Pubmed ID: 24243027 3-D Transcranial Ultrasound Imaging with Bilateral Phase Aberration Correction of Multiple Isoplanatic Patches: a Pilot Human Study with Microbubble Contrast Enhancement Ultrasound in Medicine & Biology. Jan, 2014 | Pubmed ID: 24239360 Predictors of Extraventricular Drain-associated Bacterial Ventriculitis Journal of Critical Care. Feb, 2014 | Pubmed ID: 24125770 A Blood-based Biomarker Panel to Detect Acute Stroke Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. May-Jun, 2014 | Pubmed ID: 24119630 Gender and Age Interact to Affect Early Outcome After Intracerebral Hemorrhage PloS One. 2013 | Pubmed ID: 24312335 Intraoperative Magnesium Administration Does Not Improve Neurocognitive Function After Cardiac Surgery Stroke; a Journal of Cerebral Circulation. Dec, 2013 | Pubmed ID: 24105697 Predictors of Late Neurological Deterioration After Spontaneous Intracerebral Hemorrhage Neurocritical Care. Dec, 2013 | Pubmed ID: 23979796 Tumor Necrosis Factor α Antagonism Improves Neurological Recovery in Murine Intracerebral Hemorrhage Journal of Neuroinflammation. 2013 | Pubmed ID: 23962089 Teaching Neuroimages: Vein of Galen Aneurysm Mimicking Pineal Mass in a Young Adult Neurology. May, 2013 | Pubmed ID: 23713094 Simultaneous Bilateral Real-time 3-d Transcranial Ultrasound Imaging at 1 MHz Through Poor Acoustic Windows Ultrasound in Medicine & Biology. Apr, 2013 | Pubmed ID: 23415287 Discovery and Validation of Cell Cycle Arrest Biomarkers in Human Acute Kidney Injury Critical Care (London, England). Feb, 2013 | Pubmed ID: 23388612 Lacosamide Improves Outcome in a Murine Model of Traumatic Brain Injury Neurocritical Care. Aug, 2013 | Pubmed ID: 23269559 ApolipoproteinE Mimetic Peptides Improve Outcome After Focal Ischemia Experimental Neurology. Mar, 2013 | Pubmed ID: 23219883 Interaction Between Sex and Apolipoprotein E Genetic Background in a Murine Model of Intracerebral Hemorrhage Translational Stroke Research. Mar, 2012 | Pubmed ID: 23935764 Letter by El Husseini Et Al Regarding Article, "What Causes Disability After Transient Ischemic Attack and Minor Stroke?" Stroke; a Journal of Cerebral Circulation. Dec, 2012 | Pubmed ID: 23160877 Apolipoproteins and Apolipoprotein Mimetic Peptides Modulate Phagocyte Trafficking Through Chemotactic Activity The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23118226 Biomarkers in Traumatic Brain Injury Current Neurology and Neuroscience Reports. Oct, 2012 | Pubmed ID: 22811071 Correlation of Leukocytosis with Early Neurological Deterioration Following Supratentorial Intracerebral Hemorrhage Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Aug, 2012 | Pubmed ID: 22704946 TT-301 Inhibits Microglial Activation and Improves Outcome After Central Nervous System Injury in Adult Mice Anesthesiology. Jun, 2012 | Pubmed ID: 22487803 Depression and Antidepressant Use After Stroke and Transient Ischemic Attack Stroke; a Journal of Cerebral Circulation. Jun, 2012 | Pubmed ID: 22461330 Evolving Role of Biomarkers in Acute Cerebrovascular Disease Annals of Neurology. Mar, 2012 | Pubmed ID: 22451199 Statine Verbessert Ergebnis Im Murinen Modelle Intrakranielle Blutung Und Schädel-Hirn-Verletzungen: Ein Translationaler Ansatz Journal of Neurotrauma. Jan, 2012 | Pubmed ID: 22233347 The ApoE-mimetic Peptide, COG1410, Improves Functional Recovery in a Murine Model of Intracerebral Hemorrhage Neurocritical Care. Apr, 2012 | Pubmed ID: 21989844 Use of Emergency Department Transcranial Doppler Assessment of Reperfusion After Intravenous TPA for Ischemic Stroke The Journal of Emergency Medicine. Jan, 2012 | Pubmed ID: 19111426 The Ultrasound Brain Helmet: New Transducers and Volume Registration for in Vivo Simultaneous Multi-transducer 3-D Transcranial Imaging IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. Jun, 2011 | Pubmed ID: 21693401 A Reversible Aptamer Improves Outcome and Safety in Murine Models of Stroke and Hemorrhage Oligonucleotides. Feb, 2011 | Pubmed ID: 21142878 Discriminative Capacity of Biomarkers for Acute Stroke in the Emergency Department The Journal of Emergency Medicine. Sep, 2011 | Pubmed ID: 20417054 Neuroprotection in Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Oct, 2010 | Pubmed ID: 20876512 Progressive Multifocal Leukoencephalopathy with Occult Waldenström Macroglobulinemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2010 | Pubmed ID: 20855833 Biomarkers in Stroke: when Will They Impact Care? Journal of the American College of Cardiology. Sep, 2010 | Pubmed ID: 20846605 Traumatic Brain Injury Exacerbates Neurodegenerative Pathology: Improvement with an Apolipoprotein E-based Therapeutic Journal of Neurotrauma. Nov, 2010 | Pubmed ID: 20812776 A Phase 2 Multiple Ascending Dose Trial of Bapineuzumab in Mild to Moderate Alzheimer Disease Neurology. Jun, 2010 | Pubmed ID: 20548049 Defining Optimal Cerebral Perfusion Pressures in Acute Brain Injury: a Step Toward Individualization of Care? Critical Care Medicine. May, 2010 | Pubmed ID: 20404636 Cognitive Function After Major Noncardiac Surgery, Apolipoprotein E4 Genotype, and Biomarkers of Brain Injury Anesthesiology. Apr, 2010 | Pubmed ID: 20216394 Engaging Students in Dedicated Research and Scholarship During Medical School: the Long-term Experiences at Duke and Stanford Academic Medicine : Journal of the Association of American Medical Colleges. Mar, 2010 | Pubmed ID: 20182114 Clinical Application of Blood Biomarkers in Cerebrovascular Disease Expert Review of Neurotherapeutics. Feb, 2010 | Pubmed ID: 20136376 Statins in Traumatic Brain Injury Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2010 | Pubmed ID: 20129498 Brain Natriuretic Peptide Improves Long-term Functional Recovery After Acute CNS Injury in Mice Journal of Neurotrauma. Jan, 2010 | Pubmed ID: 19803787 Simvastatin Treatment Duration and Cognitive Preservation in Experimental Subarachnoid Hemorrhage Journal of Neurosurgical Anesthesiology. Oct, 2009 | Pubmed ID: 19955895 S100B and Brain Natriuretic Peptide Predict Functional Neurological Outcome After Intracerebral Haemorrhage Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Sep, 2009 | Pubmed ID: 19505208 Apolipoprotein E Modifies Neurological Outcome by Affecting Cerebral Edema but Not Hematoma Size After Intracerebral Hemorrhage in Humans Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. Mar-Apr, 2009 | Pubmed ID: 19251191 Randomized, Double-blinded, Placebo Controlled Study of Neuroprotection with Lidocaine in Cardiac Surgery Stroke; a Journal of Cerebral Circulation. Mar, 2009 | Pubmed ID: 19164788 Pharmacogenomic Effects of Apolipoprotein E on Intracerebral Hemorrhage Stroke; a Journal of Cerebral Circulation. Feb, 2009 | Pubmed ID: 19109539 Klinische Nützlichkeit Eines Biomarker-basierten Diagnostischen Tests Für Akuten Schlaganfall: Die Biomarker Rapid Assessment in Ischämischen Schädigung (Gehirn)-Studie Stroke; a Journal of Cerebral Circulation. Jan, 2009 | Pubmed ID: 18948614 The Ultrasound Brain Helmet: Feasibility Study of Multiple Simultaneous 3D Scans of Cerebral Vasculature Ultrasound in Medicine & Biology. Feb, 2009 | Pubmed ID: 18947918 The Use of S100B As a Biomarker in Subarachnoid Hemorrhage: Clarity in Its Promise and Limits Critical Care Medicine. Aug, 2008 | Pubmed ID: 18664797 Long-term Cognitive Dysfunction Following Experimental Subarachnoid Hemorrhage: New Perspectives Experimental Neurology. Oct, 2008 | Pubmed ID: 18625221 Management of Post-subarachnoid Hemorrhage Vasospasm Current Atherosclerosis Reports. Aug, 2008 | Pubmed ID: 18606107 Real-time 3-D Contrast-enhanced Transcranial Ultrasound and Aberration Correction Ultrasound in Medicine & Biology. Sep, 2008 | Pubmed ID: 18395321 Challenges in Enrollment of Minority, Pediatric, and Geriatric Patients in Emergency and Acute Care Clinical Research Annals of Emergency Medicine. Jun, 2008 | Pubmed ID: 18191297 Statins in Acute Brain Injury: Getting the Cart Before the Horse Neurocritical Care. 2008 | Pubmed ID: 18094941 Preclinical Models of Intracerebral Hemorrhage: a Translational Perspective Neurocritical Care. 2008 | Pubmed ID: 18058257 Apolipoprotein E and Neurological Disease: Therapeutic Potential and Pharmacogenomic Interactions Pharmacogenomics. Aug, 2007 | Pubmed ID: 17716229 COG1410, a Novel Apolipoprotein E-based Peptide, Improves Functional Recovery in a Murine Model of Traumatic Brain Injury Journal of Neurotrauma. Jul, 2007 | Pubmed ID: 17610350 Simvastatin and Atorvastatin Improve Behavioral Outcome, Reduce Hippocampal Degeneration, and Improve Cerebral Blood Flow After Experimental Traumatic Brain Injury Experimental Neurology. Jul, 2007 | Pubmed ID: 17521631 Apolipoprotein E Modifies the CNS Response to Injury Via a Histamine-mediated Pathway Neurological Research. Apr, 2007 | Pubmed ID: 17509222 Apolipoprotein E4 Polymorphism As a Genetic Predisposition to Delirium in Critically Ill Patients Critical Care Medicine. Jan, 2007 | Pubmed ID: 17133176 Risk of Cerebral Vasopasm After Subarachnoid Hemorrhage Reduced by Statin Therapy: A Multivariate Analysis of an Institutional Experience Journal of Neurosurgery. Nov, 2006 | Pubmed ID: 17121126 Can D-dimer Levels Identify Patients at Risk for Early Neurological Deterioration in Acute Ischemic Stroke? Nature Clinical Practice. Neurology. Nov, 2006 | Pubmed ID: 17057742 Dissociation Between Vasospasm and Functional Improvement in a Murine Model of Subarachnoid Hemorrhage Neurosurgical Focus. 2006 | Pubmed ID: 17029343 Levetiracetam is Neuroprotective in Murine Models of Closed Head Injury and Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16960300 Central Nervous System Injury Associated with Cardiac Surgery Lancet. Aug, 2006 | Pubmed ID: 16920475 Apolipoprotein E-derived Peptides Ameliorate Clinical Disability and Inflammatory Infiltrates into the Spinal Cord in a Murine Model of Multiple Sclerosis The Journal of Pharmacology and Experimental Therapeutics. Sep, 2006 | Pubmed ID: 16740622 Association of Neurocognitive Function and Quality of Life 1 Year After Coronary Artery Bypass Graft (CABG) Surgery Psychosomatic Medicine. May-Jun, 2006 | Pubmed ID: 16738066 Changing Outcome from Aneurysmal Subarachnoid Hemorrhage: Another Step Closer Anesthesiology. Apr, 2006 | Pubmed ID: 16571953 A Novel ApoE-derived Therapeutic Reduces Vasospasm and Improves Outcome in a Murine Model of Subarachnoid Hemorrhage Neurocritical Care. 2006 | Pubmed ID: 16498192 Effects of a Manganese (III) Porphyrin Catalytic Antioxidant in a Mouse Closed Head Injury Model European Journal of Pharmacology. Feb, 2006 | Pubmed ID: 16455070 Galbraith Award: Simvastatin Attenuates Experimental Cerebral Vasospasm and Ameliorates Serum Markers of Neuronal and Endothelial Injury in Patients After Subarachnoid Hemorrhage: a Dose-response Effect Dependent on Endothelial Nitric Oxide Synthase Clinical Neurosurgery. 2005 | Pubmed ID: 16626096 APOE Polymorphism is Associated with Risk of Severe Sepsis in Surgical Patients Critical Care Medicine. Nov, 2005 | Pubmed ID: 16276176 Preoperative Statin Therapy Does Not Reduce Cognitive Dysfunction After Cardiopulmonary Bypass Journal of Cardiothoracic and Vascular Anesthesia. Jun, 2005 | Pubmed ID: 16130053 Simvastatin Reduces Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Results of a Pilot Randomized Clinical Trial Stroke; a Journal of Cerebral Circulation. Sep, 2005 | Pubmed ID: 16051891 Intrathecal Administration of a Novel ApoE-derived Therapeutic Peptide Improves Outcome Following Perinatal Hypoxic-ischemic Injury Neuroscience Letters. Jun, 2005 | Pubmed ID: 15896489 A Novel Therapeutic Derived from Apolipoprotein E Reduces Brain Inflammation and Improves Outcome After Closed Head Injury Experimental Neurology. Mar, 2005 | Pubmed ID: 15698624 Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the Treatment of Neurological Injury: a Role Beyond Cholesterol Lowering Clinical Neurosurgery. 2004 | Pubmed ID: 15571161 Correlation of Serum Brain Natriuretic Peptide with Hyponatremia and Delayed Ischemic Neurological Deficits After Subarachnoid Hemorrhage Neurosurgery. Jun, 2004 | Pubmed ID: 15157293 Novel Diagnostic Test for Acute Stroke Stroke; a Journal of Cerebral Circulation. Jan, 2004 | Pubmed ID: 14671250 APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14507923 Early Biomarkers of Stroke Clinical Chemistry. Oct, 2003 | Pubmed ID: 14500614 Leukocytosis As an Independent Risk Factor for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage Journal of Neurosurgery. Jun, 2003 | Pubmed ID: 12816268 Lower Endotoxin Immunity Predicts Increased Cognitive Dysfunction in Elderly Patients After Cardiac Surgery Stroke; a Journal of Cerebral Circulation. Feb, 2003 | Pubmed ID: 12574568 Apolipoprotein E4 Increases Aortic Atheroma Burden in Cardiac Surgical Patients The Journal of Thoracic and Cardiovascular Surgery. Jan, 2003 | Pubmed ID: 12539012 Apolipoprotein E Expression and Behavioral Toxicity of High Charge, High Energy (HZE) Particle Radiation Journal of Radiation Research. Dec, 2002 | Pubmed ID: 12793762 Simvastatin Increases Endothelial Nitric Oxide Synthase and Ameliorates Cerebral Vasospasm Resulting from Subarachnoid Hemorrhage Stroke; a Journal of Cerebral Circulation. Dec, 2002 | Pubmed ID: 12468796 Apolipoprotein E Protects Against NMDA Excitotoxicity Neurobiology of Disease. Oct, 2002 | Pubmed ID: 12460559 Serum Von Willebrand Factor, Matrix Metalloproteinase-9, and Vascular Endothelial Growth Factor Levels Predict the Onset of Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage Neurosurgery. Nov, 2002 | Pubmed ID: 12383357 Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice Overexpressing Extracellular Superoxide Dismutase Stroke; a Journal of Cerebral Circulation. Sep, 2002 | Pubmed ID: 12215605 Mouse Model of Subarachnoid Hemorrhage Associated Cerebral Vasospasm: Methodological Analysis Neurological Research. Jul, 2002 | Pubmed ID: 12117325 Differential Cerebral Gene Expression During Cardiopulmonary Bypass in the Rat: Evidence for Apoptosis? Anesthesia and Analgesia. Jun, 2002 | Pubmed ID: 12031994 Apolipoprotein E Isoform Mediated Regulation of Nitric Oxide Release Free Radical Biology & Medicine. Jun, 2002 | Pubmed ID: 12031891 The Impact of Postoperative Atrial Fibrillation on Neurocognitive Outcome After Coronary Artery Bypass Graft Surgery Anesthesia and Analgesia. Feb, 2002 | Pubmed ID: 11812686 Apolipoprotein E Affects the Central Nervous System Response to Injury and the Development of Cerebral Edema Annals of Neurology. Jan, 2002 | Pubmed ID: 11782990 Intrastriataler Injektion von Eigenblut oder Clostridien-Kollagenase als Murine Modelle der Hirnblutung Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University Medicine
Intrastriataler Injektion von Eigenblut oder Clostridien-Kollagenase als Murine Modelle der Hirnblutung Beilei Lei1, Huaxin Sheng1, Haichen Wang2, Christopher D. Lascola3, David S. Warner1,4, Daniel T. Laskowitz1,2,4, Michael L. James1,2 1Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University, 2Department of Neurology, Duke University, 3Department of Radiology, Duke University, 4Department of Neurobiology, Duke University Medicine