Daniel Metzger CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258 Université de Strasbourg Biography Publications Institution JoVE Articles Daniel Metzger has not added a biography. If you are Daniel Metzger and would like to personalize this page please email our Author Liaison for assistance. Publications Androgen Receptor Coordinates Muscle Metabolic and Contractile Functions Journal of Cachexia, Sarcopenia and Muscle. May, 2023 | Pubmed ID: 37208984 Hypoxia-inducible Factor 1A Inhibition Overcomes Castration Resistance of Prostate Tumors EMBO Molecular Medicine. Jun, 2023 | Pubmed ID: 37070472 Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants International Journal of Molecular Sciences. Jul, 2022 | Pubmed ID: 35955580 Hypoxia-mediated Stabilization of HIF1A in Prostatic Intraepithelial Neoplasia Promotes Cell Plasticity and Malignant Progression Science Advances. Jul, 2022 | Pubmed ID: 35867798 TRPC3 Shapes the ER-mitochondria Ca Transfer Characterizing Tumour-promoting Senescence Nature Communications. Feb, 2022 | Pubmed ID: 35177596 Single-cell Analyses Unravel Cell Type-specific Responses to a Vitamin D Analog in Prostatic Precancerous Lesions Science Advances. Jul, 2021 | Pubmed ID: 34330705 Myod1 and GR Coordinate Myofiber-specific Transcriptional Enhancers Nucleic Acids Research. May, 2021 | Pubmed ID: 33836079 Tyrosine Hydroxylase Conditional KO Mice Reveal Peripheral Tissue-dependent Differences in Dopamine Biosynthetic Pathways The Journal of Biological Chemistry. 2021 | Pubmed ID: 33737022 Cytosolic Sequestration of the Vitamin D Receptor As a Therapeutic Option for Vitamin D-induced Hypercalcemia Nature Communications. Dec, 2020 | Pubmed ID: 33288743 Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle Antioxidants (Basel, Switzerland). Jun, 2019 | Pubmed ID: 31181751 Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis Diabetes. Jun, 2019 | Pubmed ID: 30936140 Senescence Controls Prostatic Neoplasia Driven by Pten Loss Molecular & Cellular Oncology. 2019 | Pubmed ID: 30788414 PGC-1β Modulates Statin-associated Myotoxicity in Mice Archives of Toxicology. Feb, 2019 | Pubmed ID: 30511338 [How to Limit the Progression of PTEN-deficient Prostatic Tumors?] Medecine Sciences : M/S. Nov, 2018 | Pubmed ID: 30526823 Short-Term Fasting Reveals Amino Acid Metabolism As a Major Sex-Discriminating Factor in the Liver Cell Metabolism. Aug, 2018 | Pubmed ID: 29909969 Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? Frontiers in Physiology. 2018 | Pubmed ID: 29872405 Deletion in Luminal Cells of Mature Prostate Induces Replication Stress and Senescence in Vivo The Journal of Experimental Medicine. Jun, 2018 | Pubmed ID: 29743291 The Histone Code Reader Spin1 Controls Skeletal Muscle Development Cell Death & Disease. Nov, 2017 | Pubmed ID: 29168801 Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Regulates Lactase Expression and Activity in the Gut EMBO Molecular Medicine. Sep, 2017 | Pubmed ID: 28947679 Moderate Exercise Allows for Shorter Recovery Time in Critical Limb Ischemia Frontiers in Physiology. 2017 | Pubmed ID: 28790926 BRG1-SWI/SNF-dependent Regulation of the Wt1 Transcriptional Landscape Mediates Epicardial Activity During Heart Development and Disease Nature Communications. Jul, 2017 | Pubmed ID: 28737171 IFN-β-induced Reactive Oxygen Species and Mitochondrial Damage Contribute to Muscle Impairment and Inflammation Maintenance in Dermatomyositis Acta Neuropathologica. Jun, 2017 | Pubmed ID: 28623559 Androgen Signaling Negatively Controls Group 2 Innate Lymphoid Cells The Journal of Experimental Medicine. Jun, 2017 | Pubmed ID: 28484078 The Nuclear Receptor Nr4a1 Acts As a Microglia Rheostat and Serves As a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation Journal of Immunology (Baltimore, Md. : 1950). May, 2017 | Pubmed ID: 28411187 Gonad-related Factors Promote Muscle Performance Gain During Postnatal Development in Male and Female Mice American Journal of Physiology. Endocrinology and Metabolism. Jul, 2017 | Pubmed ID: 28351832 Nur77 Deletion Impairs Muscle Growth During Developmental Myogenesis and Muscle Regeneration in Mice PloS One. 2017 | Pubmed ID: 28170423 Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science (New York, N.Y.). 02, 2017 | Pubmed ID: 28059714 Muscle Expression of a Malonyl-CoA-insensitive Carnitine Palmitoyltransferase-1 Protects Mice Against High-fat/high-sucrose Diet-induced Insulin Resistance American Journal of Physiology. Endocrinology and Metabolism. Sep, 2016 | Pubmed ID: 27507552 SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation Cancer Research. Mar, 2016 | Pubmed ID: 26701805 The Transcriptional Coregulator PGC-1β Controls Mitochondrial Function and Anti-oxidant Defence in Skeletal Muscles Nature Communications. Dec, 2015 | Pubmed ID: 26674215 Patrolling Monocytes Control Tumor Metastasis to the Lung Science (New York, N.Y.). Nov, 2015 | Pubmed ID: 26494174 VDR and Gemini Ligands Oncotarget. Oct, 2015 | Pubmed ID: 26356569 A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects Cell Reports. Feb, 2015 | Pubmed ID: 25620699 The Orphan Nuclear Receptor Nur77 is a Determinant of Myofiber Size and Muscle Mass in Mice Molecular and Cellular Biology. Apr, 2015 | Pubmed ID: 25605333 Orphan Nuclear Receptor NR4A1 Regulates Transforming Growth Factor-β Signaling and Fibrosis Nature Medicine. Feb, 2015 | Pubmed ID: 25581517 Retinoid X Receptors Orchestrate Osteoclast Differentiation and Postnatal Bone Remodeling The Journal of Clinical Investigation. Feb, 2015 | Pubmed ID: 25574839 Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell. Dec, 2014 | Pubmed ID: 25465495 Clearance of PML/RARA-bound Promoters Suffice to Initiate APL Differentiation Blood. Dec, 2014 | Pubmed ID: 25258343 Myofiber Androgen Receptor Promotes Maximal Mechanical Overload-induced Muscle Hypertrophy and Fiber Type Transition in Male Mice Endocrinology. Dec, 2014 | Pubmed ID: 25216388 Mammary Stem Cells Have Myoepithelial Cell Properties Nature Cell Biology. Oct, 2014 | Pubmed ID: 25173976 Brg1 Loss Attenuates Aberrant Wnt-signalling and Prevents Wnt-dependent Tumourigenesis in the Murine Small Intestine PLoS Genetics. Jul, 2014 | Pubmed ID: 25010414 LSD1 Promotes Oxidative Metabolism of White Adipose Tissue Nature Communications. Jun, 2014 | Pubmed ID: 24912735 Acute Effect of Androgens on Maximal Force-generating Capacity and Electrically Evoked Calcium Transient in Mouse Skeletal Muscles Steroids. Sep, 2014 | Pubmed ID: 24844204 Skeletal Myofiber VEGF is Essential for the Exercise Training Response in Adult Mice American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Apr, 2014 | Pubmed ID: 24523345 Lysine-specific Demethylase 1 Regulates Differentiation Onset and Migration of Trophoblast Stem Cells Nature Communications. 2014 | Pubmed ID: 24448552 Nurr1 Expression is Regulated by Voltage-dependent Calcium Channels and Calcineurin in Cultured Hippocampal Neurons Neuroscience Letters. Jan, 2014 | Pubmed ID: 24291696 Retinoid Signaling in Progenitors Controls Specification and Regeneration of the Urothelium Developmental Cell. Sep, 2013 | Pubmed ID: 23993789 Smoothened is a Master Regulator of Adult Liver Repair The Journal of Clinical Investigation. Jun, 2013 | Pubmed ID: 23563311 Genetically Engineered Mouse Models of Prostate Cancer Molecular Oncology. Apr, 2013 | Pubmed ID: 23481269 Polyphenols Prevent Ageing-related Impairment in Skeletal Muscle Mitochondrial Function Through Decreased Reactive Oxygen Species Production Experimental Physiology. Feb, 2013 | Pubmed ID: 22903980 PPARβ/δ Affects Pancreatic β Cell Mass and Insulin Secretion in Mice The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093780 Cell Autonomous Lipin 1 Function is Essential for Development and Maintenance of White and Brown Adipose Tissue Molecular and Cellular Biology. Dec, 2012 | Pubmed ID: 23028044 Temporally Controlled Targeted Somatic Mutagenesis in Mouse Eye Pigment Epithelium Genesis (New York, N.Y. : 2000). Nov, 2012 | Pubmed ID: 22730183 Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse Current Protocols in Mouse Biology. Mar, 2011 | Pubmed ID: 26068987 Compensatory Regulation of Dopamine After Ablation of the Tyrosine Hydroxylase Gene in the Nigrostriatal Projection The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22027820 Regenerated Luminal Epithelial Cells Are Derived from Preexisting Luminal Epithelial Cells in Adult Mouse Prostate Molecular Endocrinology (Baltimore, Md.). Nov, 2011 | Pubmed ID: 21940754 Hypoxia-inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21538443 Widespread Negative Response Elements Mediate Direct Repression by Agonist-liganded Glucocorticoid Receptor Cell. Apr, 2011 | Pubmed ID: 21496643 Chromatin Remodelling Complex Dosage Modulates Transcription Factor Function in Heart Development Nature Communications. 2011 | Pubmed ID: 21304516 Chromatin Remodeling Enzyme Brg1 is Required for Mouse Lens Fiber Cell Terminal Differentiation and Its Denucleation Epigenetics & Chromatin. Nov, 2010 | Pubmed ID: 21118511 The Transcriptional Coregulators TIF2 and SRC-1 Regulate Energy Homeostasis by Modulating Mitochondrial Respiration in Skeletal Muscles Cell Metabolism. Nov, 2010 | Pubmed ID: 21035760 Myocytic Androgen Receptor Controls the Strength but Not the Mass of Limb Muscles Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20660752 Thymic Stromal Lymphopoietin Overproduced by Keratinocytes in Mouse Skin Aggravates Experimental Asthma Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19188585 Dual Role of COUP-TF-interacting Protein 2 in Epidermal Homeostasis and Permeability Barrier Formation The Journal of Investigative Dermatology. Jun, 2009 | Pubmed ID: 19092943 LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis Through Modulation of Wnt Signaling The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 18990694 Expanded CTG Repeats Within the DMPK 3' UTR Causes Severe Skeletal Muscle Wasting in an Inducible Mouse Model for Myotonic Dystrophy Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18272483 Temporally Controlled Ablation of PTEN in Adult Mouse Prostate Epithelium Generates a Model of Invasive Prostatic Adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18268330 Loss of Trim24 (Tif1alpha) Gene Function Confers Oncogenic Activity to Retinoic Acid Receptor Alpha Nature Genetics. Dec, 2007 | Pubmed ID: 18026104 Compromised Intestinal Lipid Absorption in Mice with a Liver-specific Deficiency of Liver Receptor Homolog 1 Molecular and Cellular Biology. Dec, 2007 | Pubmed ID: 17908794 LRH-1-mediated Glucocorticoid Synthesis in Enterocytes Protects Against Inflammatory Bowel Disease Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007 | Pubmed ID: 17670946 The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-autonomous and Non-cell-autonomous Tumour Suppressor Activity in Mouse Epidermis Development (Cambridge, England). Aug, 2007 | Pubmed ID: 17626060 Adipose Tissue-specific Inactivation of the Retinoblastoma Protein Protects Against Diabesity Because of Increased Energy Expenditure Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007 | Pubmed ID: 17556545 Malignant Transformation of DMBA/TPA-induced Papillomas and Nevi in the Skin of Mice Selectively Lacking Retinoid-X-receptor Alpha in Epidermal Keratinocytes The Journal of Investigative Dermatology. May, 2007 | Pubmed ID: 17301838 Topical Vitamin D3 and Low-calcemic Analogs Induce Thymic Stromal Lymphopoietin in Mouse Keratinocytes and Trigger an Atopic Dermatitis Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16880407 Genetic and Pharmacological Evidence That a Retinoic Acid Cannot Be the RXR-activating Ligand in Mouse Epidermis Keratinocytes Genes & Development. Jun, 2006 | Pubmed ID: 16751185 Retinoid X Receptor Ablation in Adult Mouse Keratinocytes Generates an Atopic Dermatitis Triggered by Thymic Stromal Lymphopoietin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16199515 Temporally Controlled Targeted Somatic Mutagenesis in Embryonic Surface Ectoderm and Fetal Epidermal Keratinocytes Unveils Two Distinct Developmental Functions of BRG1 in Limb Morphogenesis and Skin Barrier Formation Development (Cambridge, England). Oct, 2005 | Pubmed ID: 16192310 Temporally Controlled Targeted Somatic Mutagenesis in Skeletal Muscles of the Mouse Genesis (New York, N.Y. : 2000). Apr, 2005 | Pubmed ID: 15789425 Targeted Somatic Mutagenesis in the Mouse Epidermis Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15502196 Peroxisome Proliferator-activated Receptor Gamma is Required in Mature White and Brown Adipocytes for Their Survival in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 15070754 Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004 | Pubmed ID: 14985441 Retinal Dystrophy Resulting from Ablation of RXR Alpha in the Mouse Retinal Pigment Epithelium The American Journal of Pathology. Feb, 2004 | Pubmed ID: 14742273 Targeted Conditional Somatic Mutagenesis in the Mouse: Temporally-controlled Knock out of Retinoid Receptors in Epidermal Keratinocytes Methods in Enzymology. 2003 | Pubmed ID: 14631857 TAF10 (TAF(II)30) is Necessary for TFIID Stability and Early Embryogenesis in Mice Molecular and Cellular Biology. Jun, 2003 | Pubmed ID: 12773572 Temporally Controlled Site-specific Mutagenesis in the Germ Cell Lineage of the Mouse Testis Biology of Reproduction. Feb, 2003 | Pubmed ID: 12533419 Physiological and Retinoid-induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled The EMBO Journal. Jul, 2002 | Pubmed ID: 12093741 Germ Cell Expression of the Transcriptional Co-repressor TIF1beta is Required for the Maintenance of Spermatogenesis in the Mouse Development (Cambridge, England). May, 2002 | Pubmed ID: 11973266 Selective Ablation of Retinoid X Receptor Alpha in Hepatocytes Impairs Their Lifespan and Regenerative Capacity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2001 | Pubmed ID: 11287642 Impaired Adipogenesis and Lipolysis in the Mouse Upon Selective Ablation of the Retinoid X Receptor Alpha Mediated by a Tamoxifen-inducible Chimeric Cre Recombinase (Cre-ERT2) in Adipocytes Proceedings of the National Academy of Sciences of the United States of America. Jan, 2001 | Pubmed ID: 11134524 Purification and Identification of P68 RNA Helicase Acting As a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor Alpha Molecular and Cellular Biology. Aug, 1999 | Pubmed ID: 10409727 Spatio-temporally Controlled Site-specific Somatic Mutagenesis in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Dec, 1997 | Pubmed ID: 9405652 Specific and Redundant Functions of Retinoid X Receptor/Retinoic Acid Receptor Heterodimers in Differentiation, Proliferation, and Apoptosis of F9 Embryonal Carcinoma Cells The Journal of Cell Biology. Nov, 1997 | Pubmed ID: 9348290 Cistrome Analysis in Mouse Muscle Stem Cells (Video) | JoVE Kamar Ghaibour*1, Joe Rizk*1, Claudine Ebel1, Tao Ye1, Muriel Philipps1, Valérie Schreiber1, Daniel Metzger1, Delphine Duteil1 1CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, Université de Strasbourg JoVE 65215 Developmental Biology Förbättrat protokoll för kromatin Immunoprecipitation från mus skelettmuskulatur Shilpy Joshi1, Vanessa Ueberschlag-Pitiot1, Daniel Metzger1, Irwin Davidson1 1Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire JoVE 56504 Biochemistry
Cistrome Analysis in Mouse Muscle Stem Cells (Video) | JoVE Kamar Ghaibour*1, Joe Rizk*1, Claudine Ebel1, Tao Ye1, Muriel Philipps1, Valérie Schreiber1, Daniel Metzger1, Delphine Duteil1 1CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, Université de Strasbourg JoVE 65215 Developmental Biology
Förbättrat protokoll för kromatin Immunoprecipitation från mus skelettmuskulatur Shilpy Joshi1, Vanessa Ueberschlag-Pitiot1, Daniel Metzger1, Irwin Davidson1 1Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire JoVE 56504 Biochemistry