Dietmar Siemann Department of Radiation Oncology, College of Medicine University of Florida Biography Publications Institution JoVE Articles Dietmar Siemann has not added a biography. If you are Dietmar Siemann and would like to personalize this page please email our Author Liaison for assistance. Publications Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer International Journal of Molecular Sciences. Sep, 2021 | Pubmed ID: 34576116 Normal Tissue and Tumor Microenvironment Adaptations to Aerobic Exercise Enhance Doxorubicin Anti-tumor Efficacy and Ameliorate Its Cardiotoxicity in Retired Breeder Mice Oncotarget. Aug, 2021 | Pubmed ID: 34504647 Using a Combination of Gangliosides and Cell Surface Vimentin As Surface Biomarkers for Isolating Osteosarcoma Cells in Microfluidic Devices Journal of Bone Oncology. Jun, 2021 | Pubmed ID: 33912384 Inhibition of the Axl Pathway Impairs Breast and Prostate Cancer Metastasis to the Bones and Bone Remodeling Clinical & Experimental Metastasis. 06, 2021 | Pubmed ID: 33791875 Bioprinting on Live Tissue for Investigating Cancer Cell Dynamics Tissue Engineering. Part A. 04, 2021 | Pubmed ID: 33059528 Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment Cancers. Jul, 2020 | Pubmed ID: 32660000 Cathepsin L Secretion by Host and Neoplastic Cells Potentiates Invasion Oncotarget. Sep, 2019 | Pubmed ID: 31565189 C-Src is Required for Hypoxia-induced Metastasis-associated Functions in Prostate Cancer Cells OncoTargets and Therapy. 2019 | Pubmed ID: 31190858 Prostate Cancer Cell Growth Characteristics in Serum and Prostate-conditioned Media from Moderate-intensity Exercise-trained Healthy and Tumor-bearing Rats American Journal of Cancer Research. 2019 | Pubmed ID: 31105994 Axl Signaling is an Important Mediator of Tumor Angiogenesis Oncotarget. Apr, 2019 | Pubmed ID: 31080559 Reliability of Blood Lactate As a Measure of Exercise Intensity in Different Strains of Mice During Forced Treadmill Running PloS One. 2019 | Pubmed ID: 31050686 Failures in Preclinical and Clinical Trials of C-Met Inhibitors: Evaluation of Pathway Activity As a Promising Selection Criterion Oncotarget. Jan, 2019 | Pubmed ID: 30719213 Tumor Oxygenation and Cancer Therapy-then and Now The British Journal of Radiology. Jan, 2019 | Pubmed ID: 29513032 Stability and Mobility of Magnetic Nanoparticles in Biological Environments Determined from Dynamic Magnetic Susceptibility Measurements Bioconjugate Chemistry. 08, 2018 | Pubmed ID: 30011185 Stromal Cells in Breast Cancer As a Potential Therapeutic Target Oncotarget. May, 2018 | Pubmed ID: 29805773 Treatment with Src Inhibitor Dasatinib Results in Elevated Metastatic Potential in the 4T1 Murine Mammary Carcinoma Model Tumor & Microenvironment. 2018 | Pubmed ID: 29658958 Have Clinical Trials Properly Assessed C-Met Inhibitors? Trends in Cancer. 02, 2018 | Pubmed ID: 29458966 Exercise and the Tumor Microenvironment: Potential Therapeutic Implications Exercise and Sport Sciences Reviews. 01, 2018 | Pubmed ID: 29166299 Epithelial-to-mesenchymal Transition Confers Pericyte Properties on Cancer Cells The Journal of Clinical Investigation. 11, 2016 | Pubmed ID: 27721239 Hypoxia Regulates SOX2 Expression to Promote Prostate Cancer Cell Invasion and Sphere Formation American Journal of Cancer Research. 2016 | Pubmed ID: 27294000 Cathepsin L in Tumor Angiogenesis and Its Therapeutic Intervention by the Small Molecule Inhibitor KGP94 Clinical & Experimental Metastasis. 06, 2016 | Pubmed ID: 27055649 Chemosensitizing AML Cells by Targeting Bone Marrow Endothelial Cells Experimental Hematology. May, 2016 | Pubmed ID: 26898708 Cathepsin L Inactivation Leads to Multimodal Inhibition of Prostate Cancer Cell Dissemination in a Preclinical Bone Metastasis Model International Journal of Cancer. Jun, 2016 | Pubmed ID: 26757413 Targeting the Angiopoietin-2/Tie-2 Axis in Conjunction with VEGF Signal Interference Cancer Letters. 10, 2016 | Pubmed ID: 25312939 Synthesis and Biochemical Evaluation of Benzoylbenzophenone Thiosemicarbazone Analogues As Potent and Selective Inhibitors of Cathepsin L Bioorganic & Medicinal Chemistry. Nov, 2015 | Pubmed ID: 26462052 Cathepsin L Targeting in Cancer Treatment Pharmacology & Therapeutics. Nov, 2015 | Pubmed ID: 26299995 Modulation of the Tumor Vasculature and Oxygenation to Improve Therapy Pharmacology & Therapeutics. Sep, 2015 | Pubmed ID: 26073310 VEGFR Inhibitors Upregulate CXCR4 in VEGF Receptor-expressing Glioblastoma in a TGFβR Signaling-dependent Manner Cancer Letters. Apr, 2015 | Pubmed ID: 25676691 Histone Methyltransferase HSETD1A Is a Novel Regulator of Metastasis in Breast Cancer Molecular Cancer Research : MCR. Mar, 2015 | Pubmed ID: 25373480 Limitations of the Dorsal Skinfold Window Chamber Model in Evaluating Anti-angiogenic Therapy During Early Phase of Angiogenesis Vascular Cell. 2014 | Pubmed ID: 25101168 In Vivo Spectral and Fluorescence Microscopy Comparison of Microvascular Function After Treatment with OXi4503, Sunitinib and Their Combination in Caki-2 Tumors Biomedical Optics Express. Jun, 2014 | Pubmed ID: 24940553 Modulation of Blood Flow, Hypoxia, and Vascular Function in Orthotopic Prostate Tumors During Exercise Journal of the National Cancer Institute. Apr, 2014 | Pubmed ID: 24627275 MRI-based Computational Model of Heterogeneous Tracer Transport Following Local Infusion into a Mouse Hind Limb Tumor PloS One. 2014 | Pubmed ID: 24619021 Effects of Aurothiomalate Treatment on Canine Osteosarcoma in a Murine Xenograft Model Anti-cancer Drugs. Mar, 2014 | Pubmed ID: 24304691 Effects of Exercise Training on Tumor Hypoxia and Vascular Function in the Rodent Preclinical Orthotopic Prostate Cancer Model Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2013 | Pubmed ID: 24177690 Cathepsin L Inhibition by the Small Molecule KGP94 Suppresses Tumor Microenvironment Enhanced Metastasis Associated Cell Functions of Prostate and Breast Cancer Cells Clinical & Experimental Metastasis. Oct, 2013 | Pubmed ID: 23748470 Effect of Bevacizumab on Angiogenesis and Growth of Canine Osteosarcoma Cells Xenografted in Athymic Mice American Journal of Veterinary Research. May, 2013 | Pubmed ID: 23627391 Adenomatous Polyposis Coli-mediated Accumulation of Abasic DNA Lesions Lead to Cigarette Smoke Condensate-induced Neoplastic Transformation of Normal Breast Epithelial Cells Neoplasia (New York, N.Y.). Apr, 2013 | Pubmed ID: 23555190 Transcriptional Repression of VEGF by ZNF24: Mechanistic Studies and Vascular Consequences in Vivo Blood. Jan, 2013 | Pubmed ID: 23212515 Cell-based Selection Provides Novel Molecular Probes for Cancer Stem Cells International Journal of Cancer. Jun, 2013 | Pubmed ID: 23150432 Vascular Development in Mouse Lung Metastases American Journal of Cancer Research. 2012 | Pubmed ID: 22957309 Constitutively Active C-Met Kinase in PC-3 Cells is Autocrine-independent and Can Be Blocked by the Met Kinase Inhibitor BMS-777607 BMC Cancer. May, 2012 | Pubmed ID: 22639908 Src-signaling Interference Impairs the Dissemination of Blood-borne Tumor Cells Cell and Tissue Research. Aug, 2012 | Pubmed ID: 22526632 Inhibition of Endothelial/smooth Muscle Cell Contact Loss by the Investigational Angiopoietin-2 Antibody MEDI3617 Microvascular Research. May, 2012 | Pubmed ID: 22387475 Impact of the Small Molecule Met Inhibitor BMS-777607 on the Metastatic Process in a Rodent Tumor Model with Constitutive C-Met Activation Clinical & Experimental Metastasis. Mar, 2012 | Pubmed ID: 22286523 Impact of the SRC Inhibitor Dasatinib on the Metastatic Phenotype of Human Prostate Cancer Cells Clinical & Experimental Metastasis. Feb, 2012 | Pubmed ID: 22130962 Another Road Leads to HIF-1 Activation: Implications for Prostate Cancer Progression Asian Journal of Andrology. Mar, 2012 | Pubmed ID: 22101943 Development of Optimized AAV3 Serotype Vectors: Mechanism of High-efficiency Transduction of Human Liver Cancer Cells Gene Therapy. Apr, 2012 | Pubmed ID: 21776025 E-cadherin Plasticity in Prostate Cancer Stem Cell Invasion American Journal of Cancer Research. 2011 | Pubmed ID: 21968440 Restraint of Angiogenesis by Zinc Finger Transcription Factor CTCF-dependent Chromatin Insulation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21896759 Vascular Effects of Plinabulin (NPI-2358) and the Influence on Tumour Response when Given Alone or Combined with Radiation International Journal of Radiation Biology. Nov, 2011 | Pubmed ID: 21815749 Impact of Hypoxia on the Metastatic Potential of Human Prostate Cancer Cells International Journal of Radiation Oncology, Biology, Physics. Oct, 2011 | Pubmed ID: 21640519 Support of a Free Radical Mechanism for Enhanced Antitumor Efficacy of the Microtubule Disruptor OXi4503 Microvascular Research. Jan, 2011 | Pubmed ID: 20974154 The Unique Characteristics of Tumor Vasculature and Preclinical Evidence for Its Selective Disruption by Tumor-Vascular Disrupting Agents Cancer Treatment Reviews. Feb, 2011 | Pubmed ID: 20570444 Temporal Aspects of the Action of ASA404 (vadimezan; DMXAA) Expert Opinion on Investigational Drugs. Nov, 2010 | Pubmed ID: 20964495 BMS-777607, a Small-molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor-stimulated Prostate Cancer Metastatic Phenotype in Vitro Molecular Cancer Therapeutics. Jun, 2010 | Pubmed ID: 20515943 Leukemia Regression by Vascular Disruption and Antiangiogenic Therapy Blood. Sep, 2010 | Pubmed ID: 20472832 Expression of Pluripotent Stem Cell Reprogramming Factors by Prostate Tumor Initiating Cells The Journal of Urology. May, 2010 | Pubmed ID: 20303530 In Vivo Functional Differences in Microvascular Response of 4T1 and Caki-1 Tumors After Treatment with OXi4503 Oncology Reports. Mar, 2010 | Pubmed ID: 20127007 Bone Marrow Stem and Progenitor Cell Contribution to Neovasculogenesis is Dependent on Model System with SDF-1 As a Permissive Trigger Blood. Nov, 2009 | Pubmed ID: 19717647 Impact of Tumor Cell VEGF Expression on the in Vivo Efficacy of Vandetanib (ZACTIMA; ZD6474) Anticancer Research. Jun, 2009 | Pubmed ID: 19528456 X Box-binding Protein 1 Regulates Angiogenesis in Human Pancreatic Adenocarcinomas Translational Oncology. Mar, 2009 | Pubmed ID: 19252749 A Review and Update of the Current Status of the Vasculature-disabling Agent Combretastatin-A4 Phosphate (CA4P) Expert Opinion on Investigational Drugs. Feb, 2009 | Pubmed ID: 19236265 The Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor Cediranib (Recentin; AZD2171) Inhibits Endothelial Cell Function and Growth of Human Renal Tumor Xenografts International Journal of Radiation Oncology, Biology, Physics. Mar, 2009 | Pubmed ID: 19215823 Development of an Intramuscular Xenograft Model of Canine Osteosarcoma in Mice for Evaluation of the Effects of Radiation Therapy American Journal of Veterinary Research. Jan, 2009 | Pubmed ID: 19119958 Vascular Targeted Therapies in Oncology Cell and Tissue Research. Jan, 2009 | Pubmed ID: 18752004 Intrinsic Radiosensitivity and Repair of Sublethal Radiation-induced Damage in Canine Osteosarcoma Cell Lines American Journal of Veterinary Research. Sep, 2008 | Pubmed ID: 18764694 Dual Targeting of Tumor Vasculature: Combining Avastin and Vascular Disrupting Agents (CA4P or OXi4503) Anticancer Research. Jul-Aug, 2008 | Pubmed ID: 18751370 Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-induced Immune Suppression in Renal Cell Carcinoma Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18566400 An Update on the Clinical Development of Drugs to Disable Tumor Vasculature Expert Opinion on Drug Discovery. Oct, 2007 | Pubmed ID: 23484531 Monitoring the Treatment Efficacy of the Vascular Disrupting Agent CA4P European Journal of Cancer (Oxford, England : 1990). Jul, 2007 | Pubmed ID: 17451938 Characterizing the Tumor Response to Treatment with Combretastatin A4 Phosphate International Journal of Radiation Oncology, Biology, Physics. May, 2007 | Pubmed ID: 17448875 Impact of VEGF Expression on the Physiological Characteristics of Clonal Cell Lines In Vivo (Athens, Greece). Nov-Dec, 2006 | Pubmed ID: 17203773 Augmented Antitumor Effects of Radiation Therapy by 4-1BB Antibody (BMS-469492) Treatment Anticancer Research. Sep-Oct, 2006 | Pubmed ID: 17094465 Evaluations of Vascular Disrupting Agents CA4P and OXi4503 in Renal Cell Carcinoma (Caki-1) Using a Silicon Based Microvascular Casting Technique European Journal of Cancer (Oxford, England : 1990). Nov, 2006 | Pubmed ID: 16956760 Effect of the Second-generation Vascular Disrupting Agent OXi4503 on Tumor Vascularity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2006 | Pubmed ID: 16818709 VEGF-associated Tyrosine Kinase Inhibition Increases the Tumor Response to Single and Fractionated Dose Radiotherapy International Journal of Radiation Oncology, Biology, Physics. Jul, 2006 | Pubmed ID: 16751064 Recombinant Adeno-associated and Adenoviral Vectors for the Transduction of Pancreatic and Colon Carcinoma Anticancer Research. Jan-Feb, 2006 | Pubmed ID: 16475712 Preclinical Studies of the Novel Vascular Disrupting Agent MN-029 Anticancer Research. Nov-Dec, 2005 | Pubmed ID: 16309177 Targeting the Tumor Vasculature: Enhancing Antitumor Efficacy Through Combination Treatment with ZD6126 and ZD6474 In Vivo (Athens, Greece). Nov-Dec, 2005 | Pubmed ID: 16277020 Radiotherapy Alone or Combined with Carbogen Breathing for Squamous Cell Carcinoma of the Head and Neck: a Prospective, Randomized Trial Cancer. Jul, 2005 | Pubmed ID: 15937906 The Vascular Disrupting Agent ZD6126 Shows Increased Antitumor Efficacy and Enhanced Radiation Response in Large, Advanced Tumors International Journal of Radiation Oncology, Biology, Physics. Jul, 2005 | Pubmed ID: 15936569 Differentiation and Definition of Vascular-targeted Therapies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2005 | Pubmed ID: 15701823 Utility of 19F MRS Detection of the Hypoxic Cell Marker EF5 to Assess Cellular Hypoxia in Solid Tumors Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Dec, 2004 | Pubmed ID: 15588883 Efficacy of Combined Antiangiogenic and Vascular Disrupting Agents in Treatment of Solid Tumors International Journal of Radiation Oncology, Biology, Physics. Nov, 2004 | Pubmed ID: 15519796 Therapeutic Strategies That Selectively Target and Disrupt Established Tumor Vasculature Hematology/oncology Clinics of North America. Oct, 2004 | Pubmed ID: 15474333 Vascular-targeting Therapies for Treatment of Malignant Disease Cancer. Jun, 2004 | Pubmed ID: 15197790 Targeting the Tumor Vasculature: a Strategy to Improve Radiation Therapy Expert Review of Anticancer Therapy. Apr, 2004 | Pubmed ID: 15056061 Simultaneous Targeting of VEGF Message and VEGF Receptor Signaling As a Therapeutic Anticancer Approach Anticancer Research. Jan-Feb, 2004 | Pubmed ID: 15015599 Postoperative Radiation Therapy for Squamous Cell Carcinoma of the Head and Neck American Journal of Otolaryngology. Jan-Feb, 2003 | Pubmed ID: 12579482 Gene Therapy Delivery of Endostatin Enhances the Treatment Efficacy of Radiation Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. Jan, 2003 | Pubmed ID: 12559515 Targeting the Tumor Blood Vessel Network to Enhance the Efficacy of Radiation Therapy Seminars in Radiation Oncology. Jan, 2003 | Pubmed ID: 12520464 Comparison of the EF-1 Alpha and the CMV Promoter for Engineering Stable Tumor Cell Lines Using Recombinant Adeno-associated Virus Anticancer Research. Nov-Dec, 2002 | Pubmed ID: 12530082 Enhancement of Radiation Therapy by Vascular Targeting Agents Current Opinion in Investigational Drugs (London, England : 2000). Nov, 2002 | Pubmed ID: 12476970 Antitumor Efficacy of Conventional Anticancer Drugs is Enhanced by the Vascular Targeting Agent ZD6126 International Journal of Radiation Oncology, Biology, Physics. Dec, 2002 | Pubmed ID: 12459379 Adeno-associated Virus-mediated Gene Transfer of Endostatin Inhibits Angiogenesis and Tumor Growth in Vivo Cancer Gene Therapy. Jun, 2002 | Pubmed ID: 12032662 Enhancement of Radiation Therapy by the Novel Vascular Targeting Agent ZD6126 International Journal of Radiation Oncology, Biology, Physics. May, 2002 | Pubmed ID: 12007956 Preclinical Evaluations of Therapies Combining the Vascular Targeting Agent Combretastatin A-4 Disodium Phosphate and Conventional Anticancer Therapies in the Treatment of Kaposi's Sarcoma Acta Oncologica (Stockholm, Sweden). 2002 | Pubmed ID: 11990525 Vascular Targeting Agents Enhance Chemotherapeutic Agent Activities in Solid Tumor Therapy International Journal of Cancer. May, 2002 | Pubmed ID: 11948484 Полностью оптический механобиологический опрос Yes-ассоциированного белка в раковых и нормальных клетках человека с использованием многофункциональной системы Qin Luo*1, Miao Huang*2, Chenyu Liang2, Justin Zhang3, Gaoming Lin1, Sydney Yu1, Mai Tanaka4,5, Sharon Lepler4,5, Juan Guan5,6,7, Dietmar Siemann4,5, Xin Tang2,5 1Department of Electrical and Computer Engineering, Herbert Wertheim College of Engineering, University of Florida, 2Department of Mechanical and Aerospace Engineering, Herbert Wertheim College of Engineering, University of Florida, 3Department of Electrical and Computer Engineering, University of California, 4Department of Radiation Oncology, College of Medicine, University of Florida, 5UF Health Cancer Center, University of Florida, 6Department of Physics, College of Liberal Arts and Sciences, University of Florida, 7Department of Anatomy and Cell Biology, College of Medicine, University of Florida JoVE 62934 Bioengineering
Полностью оптический механобиологический опрос Yes-ассоциированного белка в раковых и нормальных клетках человека с использованием многофункциональной системы Qin Luo*1, Miao Huang*2, Chenyu Liang2, Justin Zhang3, Gaoming Lin1, Sydney Yu1, Mai Tanaka4,5, Sharon Lepler4,5, Juan Guan5,6,7, Dietmar Siemann4,5, Xin Tang2,5 1Department of Electrical and Computer Engineering, Herbert Wertheim College of Engineering, University of Florida, 2Department of Mechanical and Aerospace Engineering, Herbert Wertheim College of Engineering, University of Florida, 3Department of Electrical and Computer Engineering, University of California, 4Department of Radiation Oncology, College of Medicine, University of Florida, 5UF Health Cancer Center, University of Florida, 6Department of Physics, College of Liberal Arts and Sciences, University of Florida, 7Department of Anatomy and Cell Biology, College of Medicine, University of Florida JoVE 62934 Bioengineering