Donald M. Kuhn Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences Wayne State University School of Medicine Biography Publications Institution JoVE Articles Donald M. Kuhn has not added a biography. If you are Donald M. Kuhn and would like to personalize this page please email our Author Liaison for assistance. Publications Ventilatory Long-term Facilitation is Evident After Initial and Repeated Exposure to Intermittent Hypoxia in Mice Genetically Depleted of Brain Serotonin Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2013 | Pubmed ID: 24336886 Effects of Combined Treatment with Mephedrone and Methamphetamine or 3,4-methylenedioxymethamphetamine on Serotonin Nerve Endings of the Hippocampus Life Sciences. Jul, 2013 | Pubmed ID: 23892197 Mephedrone Does Not Damage Dopamine Nerve Endings of the Striatum, but Enhances the Neurotoxicity of Methamphetamine, Amphetamine, and MDMA Journal of Neurochemistry. Apr, 2013 | Pubmed ID: 23205838 Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism PloS One. 2012 | Pubmed ID: 23139830 Evidence of 5-HT Components in Human Sperm: Implications for Protein Tyrosine Phosphorylation and the Physiology of Motility Reproduction (Cambridge, England). Dec, 2012 | Pubmed ID: 23028123 Altered Gene Expression in Cultured Microglia in Response to Simulated Blast Overpressure: Possible Role of Pulse Duration Neuroscience Letters. Jul, 2012 | Pubmed ID: 22698585 Genetic Depletion of Brain 5HT Reveals a Common Molecular Pathway Mediating Compulsivity and Impulsivity Journal of Neurochemistry. Jun, 2012 | Pubmed ID: 22443164 Mephedrone, an Abused Psychoactive Component of 'bath Salts' and Methamphetamine Congener, Does Not Cause Neurotoxicity to Dopamine Nerve Endings of the Striatum Journal of Neurochemistry. Mar, 2012 | Pubmed ID: 22191803 A Mouse Model of Human Repetitive Mild Traumatic Brain Injury Journal of Neuroscience Methods. Jan, 2012 | Pubmed ID: 21930157 Nucleus Accumbens Invulnerability to Methamphetamine Neurotoxicity ILAR Journal / National Research Council, Institute of Laboratory Animal Resources. 2011 | Pubmed ID: 23382149 Tryptophan Hydroxylase 2 Aggregates Through Disulfide Cross-linking Upon Oxidation: Possible Link to Serotonin Deficits and Non-motor Symptoms in Parkinson's Disease Journal of Neurochemistry. Feb, 2011 | Pubmed ID: 21105877 Potential Mechanisms Underlying Anxiety and Depression in Parkinson's Disease: Consequences of L-DOPA Treatment Neuroscience and Biobehavioral Reviews. Jan, 2011 | Pubmed ID: 20615430 MDMA Administration Decreases Serotonin but Not N-acetylaspartate in the Rat Brain Neurotoxicology. Dec, 2010 | Pubmed ID: 20800616 The Role of Endogenous Serotonin in Methamphetamine-induced Neurotoxicity to Dopamine Nerve Endings of the Striatum Journal of Neurochemistry. Nov, 2010 | Pubmed ID: 20722968 Soman Increases Neuronal COX-2 Levels: Possible Link Between Seizures and Protracted Neuronal Damage Neurotoxicology. Dec, 2010 | Pubmed ID: 20600289 Increases in Cytoplasmic Dopamine Compromise the Normal Resistance of the Nucleus Accumbens to Methamphetamine Neurotoxicity Journal of Neurochemistry. Jun, 2009 | Pubmed ID: 19457119 Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine-induced Neurotoxicity Annals of the New York Academy of Sciences. Oct, 2008 | Pubmed ID: 18991856 Methamphetamine-induced Neurotoxicity and Microglial Activation Are Not Mediated by Fractalkine Receptor Signaling Journal of Neurochemistry. Jul, 2008 | Pubmed ID: 18410508 A Serotonergic System in Veins: Serotonin Transporter-independent Uptake The Journal of Pharmacology and Experimental Therapeutics. Jun, 2008 | Pubmed ID: 18322152 The Newly Synthesized Pool of Dopamine Determines the Severity of Methamphetamine-induced Neurotoxicity Journal of Neurochemistry. May, 2008 | Pubmed ID: 18088364 Phosphorylation and Activation of Tryptophan Hydroxylase 2: Identification of Serine-19 As the Substrate Site for Calcium, Calmodulin-dependent Protein Kinase II Journal of Neurochemistry. Nov, 2007 | Pubmed ID: 17727633 Dopamine Quinones Activate Microglia and Induce a Neurotoxic Gene Expression Profile: Relationship to Methamphetamine-induced Nerve Ending Damage Annals of the New York Academy of Sciences. Aug, 2006 | Pubmed ID: 17105901 MDMA and Fenfluramine Reduce L-DOPA-induced Dyskinesia Via Indirect 5-HT1A Receptor Stimulation The European Journal of Neuroscience. May, 2006 | Pubmed ID: 16817869 Differential Tissue Distribution of Tryptophan Hydroxylase Isoforms 1 and 2 As Revealed with Monospecific Antibodies Brain Research. Apr, 2006 | Pubmed ID: 16581041 Mouse Tryptophan Hydroxylase Isoform 2 and the Role of Proline 447 in Enzyme Function Journal of Neurochemistry. Feb, 2006 | Pubmed ID: 16405505 Gene Expression Profile of Activated Microglia Under Conditions Associated with Dopamine Neuronal Damage FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2006 | Pubmed ID: 16384912 S-thiolation of Tyrosine Hydroxylase by Reactive Nitrogen Species in the Presence of Cysteine or Glutathione Antioxidants & Redox Signaling. Jul-Aug, 2005 | Pubmed ID: 15998241 MK-801 and Dextromethorphan Block Microglial Activation and Protect Against Methamphetamine-induced Neurotoxicity Brain Research. Jul, 2005 | Pubmed ID: 15987631 Cyclooxygenase-2 is an Obligatory Factor in Methamphetamine-induced Neurotoxicity The Journal of Pharmacology and Experimental Therapeutics. May, 2005 | Pubmed ID: 15718289 Attenuated Microglial Activation Mediates Tolerance to the Neurotoxic Effects of Methamphetamine Journal of Neurochemistry. Feb, 2005 | Pubmed ID: 15686480 Microglial Activation is a Pharmacologically Specific Marker for the Neurotoxic Amphetamines Neuroscience Letters. Sep, 2004 | Pubmed ID: 15337264 Methamphetamine Neurotoxicity in Dopamine Nerve Endings of the Striatum is Associated with Microglial Activation The Journal of Pharmacology and Experimental Therapeutics. Oct, 2004 | Pubmed ID: 15163680 Nitrotyrosine As a Marker for Peroxynitrite-induced Neurotoxicity: the Beginning or the End of the End of Dopamine Neurons? Journal of Neurochemistry. May, 2004 | Pubmed ID: 15086510 Gene Expression Profile of the Nucleus Accumbens of Human Cocaine Abusers: Evidence for Dysregulation of Myelin Journal of Neurochemistry. Mar, 2004 | Pubmed ID: 15009677 Identification of Differentially Regulated Transcripts in Mouse Striatum Following Methamphetamine Treatment--an Oligonucleotide Microarray Approach Journal of Neurochemistry. Jan, 2004 | Pubmed ID: 14690526 Tetrahydrobiopterin Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide Molecular Pharmacology. Oct, 2003 | Pubmed ID: 14500751 Dopamine Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide: is Nitrotyrosine Formation an Early Step in Dopamine Neuronal Damage? The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12771134 Mass Mapping Sites of Nitration in Tyrosine Hydroxylase: Random Vs Selective Nitration of Three Tyrosine Residues Chemical Research in Toxicology. Apr, 2003 | Pubmed ID: 12703971 Dopamine Biosynthesis is Regulated by S-glutathionylation. Potential Mechanism of Tyrosine Hydroxylast Inhibition During Oxidative Stress The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12376535 Peroxynitrite Inactivates the Human Dopamine Transporter by Modification of Cysteine 342: Potential Mechanism of Neurotoxicity in Dopamine Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2002 | Pubmed ID: 12040046 Reduced Nicotinamide Nucleotides Prevent Nitration of Tyrosine Hydroxylase by Peroxynitrite Brain Research. Apr, 2002 | Pubmed ID: 11929639 Peroxynitrite-induced Nitration of Tyrosine Hydroxylase: Identification of Tyrosines 423, 428, and 432 As Sites of Modification by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry and Tyrosine-scanning Mutagenesis The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11834745 Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice Mariana Angoa-Pérez1, Michael J. Kane1, Denise I. Briggs1, Dina M. Francescutti1, Donald M. Kuhn1 1Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine JoVE 50978 Behavior
Marble Burying and Nestlet Shredding as Tests of Repetitive, Compulsive-like Behaviors in Mice Mariana Angoa-Pérez1, Michael J. Kane1, Denise I. Briggs1, Dina M. Francescutti1, Donald M. Kuhn1 1Research and Development Service, John D. Dingell VA Medical Center and Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine JoVE 50978 Behavior