Eckhard Wolf Institute of Molecular Animal Breeding and Biotechnology Ludwig-Maximilian University Biography Publications Institution JoVE Articles Eckhard Wolf has not added a biography. If you are Eckhard Wolf and would like to personalize this page please email our Author Liaison for assistance. Publications Standardized, Systemic Phenotypic Analysis Reveals Kidney Dysfunction As Main Alteration of Kctd1 (I27N) Mutant Mice Journal of Biomedical Science. Aug, 2017 | Pubmed ID: 28818080 Every-other-day Feeding Extends Lifespan but Fails to Delay Many Symptoms of Aging in Mice Nature Communications. Jul, 2017 | Pubmed ID: 28761067 The Munich MIDY Pig Biobank - A Unique Resource for Studying Organ Crosstalk in Diabetes Molecular Metabolism. Aug, 2017 | Pubmed ID: 28752056 Surface Modification of Pig Endothelial Cells with a Branched Heparin Conjugate Improves Their Compatibility with Human Blood Scientific Reports. Jun, 2017 | Pubmed ID: 28667310 Meis1: Effects on Motor Phenotypes and the Sensorimotor System in Mice Disease Models & Mechanisms. Aug, 2017 | Pubmed ID: 28645892 Extensive Phenotypic Characterization of a New Transgenic Mouse Reveals Pleiotropic Perturbations in Physiology Due to Mesenchymal HGH Minigene Expression Scientific Reports. May, 2017 | Pubmed ID: 28546545 Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016 Molecular and Cellular Pediatrics. May, 2017 | Pubmed ID: 28516419 Retinopathy with Central Oedema in an INS (C94Y) Transgenic Pig Model of Long-term Diabetes Diabetologia. Aug, 2017 | Pubmed ID: 28480495 Chromatin-remodeling Factor SMARCD2 Regulates Transcriptional Networks Controlling Differentiation of Neutrophil Granulocytes Nature Genetics. May, 2017 | Pubmed ID: 28369036 Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-cell Interactions in Situ and is Altered After Transplantation Endocrinology. Jan, 2017 | Pubmed ID: 28324008 INS-eGFP Transgenic Pigs: a Novel Reporter System for Studying Maturation, Growth and Vascularisation of Neonatal Islet-like Cell Clusters Diabetologia. Jun, 2017 | Pubmed ID: 28315950 Bezafibrate Ameliorates Diabetes Via Reduced Steatosis and Improved Hepatic Insulin Sensitivity in Diabetic TallyHo Mice Molecular Metabolism. Mar, 2017 | Pubmed ID: 28271032 Modification of the Fatty Acid Composition of an Obesogenic Diet Improves the Maternal and Placental Metabolic Environment in Obese Pregnant Mice Biochimica Et Biophysica Acta. Jun, 2017 | Pubmed ID: 28235645 Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD) Scientific Reports. Feb, 2017 | Pubmed ID: 28220896 Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium Journal of the American College of Cardiology. Jan, 2017 | Pubmed ID: 28081822 Direct Introduction of Gene Constructs into the Pronucleus-like Structure of Cloned Embryos: a New Strategy for the Generation of Genetically Modified Pigs Transgenic Research. Apr, 2017 | Pubmed ID: 27943082 Loss of DRO1/CCDC80 Results in Obesity and Promotes Adipocyte Differentiation Molecular and Cellular Endocrinology. Jan, 2017 | Pubmed ID: 27645901 Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms Molecular Neurobiology. Dec, 2016 | Pubmed ID: 27914009 The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations G3 (Bethesda, Md.). Dec, 2016 | Pubmed ID: 27815347 Viable Ednra (Y129F) Mice Feature Human Mandibulofacial Dysostosis with Alopecia (MFDA) Syndrome Due to the Homologue Mutation Mammalian Genome : Official Journal of the International Mammalian Genome Society. Dec, 2016 | Pubmed ID: 27671791 Progressive Muscle Proteome Changes in a Clinically Relevant Pig Model of Duchenne Muscular Dystrophy Scientific Reports. Sep, 2016 | Pubmed ID: 27634466 A Mouse Model for Ulcerative Colitis Based on NOD-scid IL2R γnull Mice Reconstituted with Peripheral Blood Mononuclear Cells from Affected Individuals Disease Models & Mechanisms. Sep, 2016 | Pubmed ID: 27491073 Progress in Clinical Encapsulated Islet Xenotransplantation Transplantation. Nov, 2016 | Pubmed ID: 27482959 Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus Musculus) Journal of the American Association for Laboratory Animal Science : JAALAS. 2016 | Pubmed ID: 27423143 Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle PloS One. 2016 | Pubmed ID: 27420727 Efficient Production of Multi-modified Pigs for Xenotransplantation by 'combineering', Gene Stacking and Gene Editing Scientific Reports. Jun, 2016 | Pubmed ID: 27353424 Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice Diabetes. Sep, 2016 | Pubmed ID: 27284107 Comparative Aspects of Rodent and Nonrodent Animal Models for Mechanistic and Translational Diabetes Research Theriogenology. Jul, 2016 | Pubmed ID: 27180329 Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs PloS One. 2016 | Pubmed ID: 27175998 Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation Transplantation. Sep, 2016 | Pubmed ID: 27077599 Chimeric 2C10R4 Anti-CD40 Antibody Therapy is Critical for Long-term Survival of GTKO.hCD46.hTBM Pig-to-primate Cardiac Xenograft Nature Communications. Apr, 2016 | Pubmed ID: 27045379 Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice PloS One. 2016 | Pubmed ID: 27003440 Growth Hormone (GH)-transgenic Insulin-like Growth Factor 1 (IGF1)-deficient Mice Allow Dissociation of Excess GH and IGF1 Effects on Glomerular and Tubular Growth Physiological Reports. Mar, 2016 | Pubmed ID: 26997624 First Update of the International Xenotransplantation Association Consensus Statement on Conditions for Undertaking Clinical Trials of Porcine Islet Products in Type 1 Diabetes--Chapter 2b: Genetically Modified Source Pigs Xenotransplantation. Jan-Feb, 2016 | Pubmed ID: 26926888 Tissue Sampling Guides for Porcine Biomedical Models Toxicologic Pathology. Apr, 2016 | Pubmed ID: 26883152 Mildly Compromised Tetrahydrobiopterin Cofactor Biosynthesis Due to Pts Variants Leads to Unusual Body Fat Distribution and Abdominal Obesity in Mice Journal of Inherited Metabolic Disease. Mar, 2016 | Pubmed ID: 26830550 Exome Sequencing Identifies a Nonsense Mutation in Fam46a Associated with Bone Abnormalities in a New Mouse Model for Skeletal Dysplasia Mammalian Genome : Official Journal of the International Mammalian Genome Society. Apr, 2016 | Pubmed ID: 26803617 Inhibition of Complement Component C5 Prevents Clotting in an Ex Vivo Model of Xenogeneic Activation of Coagulation Xenotransplantation. Mar, 2016 | Pubmed ID: 26773447 Oxalate-induced Chronic Kidney Disease with Its Uremic and Cardiovascular Complications in C57BL/6 Mice American Journal of Physiology. Renal Physiology. Apr, 2016 | Pubmed ID: 26764204 Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23-33 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2016 | Pubmed ID: 26685313 Developmental Endothelial Locus-1 Modulates Platelet-monocyte Interactions and Instant Blood-mediated Inflammatory Reaction in Islet Transplantation Thrombosis and Haemostasis. Apr, 2016 | Pubmed ID: 26676803 Stage-dependent Remodeling of the Nuclear Envelope and Lamina During Rabbit Early Embryonic Development The Journal of Reproduction and Development. Apr, 2016 | Pubmed ID: 26640117 MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016 | Pubmed ID: 26564819 Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies Toxicologic Pathology. Apr, 2016 | Pubmed ID: 26511847 Dissociation of Somatic Growth, Time of Sexual Maturity, and Life Expectancy by Overexpression of an RGD-deficient IGFBP-2 Variant in Female Transgenic Mice Aging Cell. Feb, 2016 | Pubmed ID: 26507795 Incretin Actions and Consequences of Incretin-based Therapies: Lessons from Complementary Animal Models The Journal of Pathology. Jan, 2016 | Pubmed ID: 26455904 Metamizol Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice Pancreas. Apr, 2016 | Pubmed ID: 26418910 Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells Cardiovascular Toxicology. Jan, 2016 | Pubmed ID: 25666561 3D Structured Illumination Microscopy of Mammalian Embryos and Spermatozoa BMC Developmental Biology. Nov, 2015 | Pubmed ID: 26610350 Pre-clinical Heterotopic Intrathoracic Heart Xenotransplantation: a Possibly Useful Clinical Technique Xenotransplantation. Nov-Dec, 2015 | Pubmed ID: 26602740 Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets PloS One. 2015 | Pubmed ID: 26600426 Engraftment and Reversal of Diabetes After Intramuscular Transplantation of Neonatal Porcine Islet-like Clusters Xenotransplantation. Nov-Dec, 2015 | Pubmed ID: 26490671 Pigs Pave a Way to De Novo Formation of Functional Human Kidneys Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26460047 Phytohemagglutinin Facilitates the Aggregation of Blastomere Pairs from Day 5 Donor Embryos with Day 4 Host Embryos for Chimeric Bovine Embryo Multiplication Theriogenology. Dec, 2015 | Pubmed ID: 26409823 EIF6 Coordinates Insulin Sensitivity and Lipid Metabolism by Coupling Translation to Transcription Nature Communications. Sep, 2015 | Pubmed ID: 26383020 Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127 Advances in Experimental Medicine and Biology. 2015 | Pubmed ID: 26306448 Analysis of Mammalian Gene Function Through Broad-based Phenotypic Screens Across a Consortium of Mouse Clinics Nature Genetics. Jul, 2015 | Pubmed ID: 26214591 Functional Compensation Among HMGN Variants Modulates the DNase I Hypersensitive Sites at Enhancers Genome Research. Sep, 2015 | Pubmed ID: 26156321 Dysregulated IGFBP5 Expression Causes Axon Degeneration and Motoneuron Loss in Diabetic Neuropathy Acta Neuropathologica. Sep, 2015 | Pubmed ID: 26025657 Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions Transplantation. Oct, 2015 | Pubmed ID: 25965410 Virus Safety of Islet Cell Transplantation from Transgenic Pigs to Marmosets Virus Research. Jun, 2015 | Pubmed ID: 25956348 Remodeling of the Nuclear Envelope and Lamina During Bovine Preimplantation Development and Its Functional Implications PloS One. 2015 | Pubmed ID: 25932910 Effects of the Glucagon-like Peptide-1 Receptor Agonist Liraglutide in Juvenile Transgenic Pigs Modeling a Pre-diabetic Condition Journal of Translational Medicine. Feb, 2015 | Pubmed ID: 25890210 Inactivation of Itf2 Promotes Intestinal Tumorigenesis in Apc(Min/+) Mice Biochemical and Biophysical Research Communications. May, 2015 | Pubmed ID: 25869068 Pig-to-baboon Heterotopic Heart Transplantation--exploratory Preliminary Experience with Pigs Transgenic for Human Thrombomodulin and Comparison of Three Costimulation Blockade-based Regimens Xenotransplantation. May-Jun, 2015 | Pubmed ID: 25847282 Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice Current Protocols in Mouse Biology. Mar, 2015 | Pubmed ID: 25727201 Viable Pigs with a Conditionally-activated Oncogenic KRAS Mutation Transgenic Research. Jun, 2015 | Pubmed ID: 25716163 Commentary on "Meta-analysis of the Independent and Cumulative Effects of Multiple Genetic Modifications on Pig Lung Xenograft Performance During Ex Vivo Perfusion with Human Blood" (by Harris Et Al.): Tailoring Donor Pigs for Xenotransplantation-how to Find the Right Combination of Genetic Modifications? Xenotransplantation. Mar-Apr, 2015 | Pubmed ID: 25711248 Screen for Alterations of Iron Related Parameters in N-ethyl-N-nitrosourea-treated Mice Identified Mutant Lines with Increased Plasma Ferritin Levels Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine. Apr, 2015 | Pubmed ID: 25636453 Uterine Responses to the Preattachment Embryo in Domestic Ungulates: Recognition of Pregnancy and Preparation for Implantation Annual Review of Animal Biosciences. 2015 | Pubmed ID: 25387113 Nuclear Transfer and Transgenesis in the Pig Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25287337 Proteome Analysis of Early Lineage Specification in Bovine Embryos Proteomics. Feb, 2015 | Pubmed ID: 25143135 Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice Diabetes. Jan, 2015 | Pubmed ID: 25071027 Expression Pattern of STAT5A Gene During Early Bovine Embryogenesis Zygote (Cambridge, England). Apr, 2015 | Pubmed ID: 23981721 Positional Changes of a Pluripotency Marker Gene During Structural Reorganization of Fibroblast Nuclei in Cloned Early Bovine Embryos Nucleus (Austin, Tex.). 2014 | Pubmed ID: 25495180 Reprogramming of Fibroblast Nuclei in Cloned Bovine Embryos Involves Major Structural Remodeling with Both Striking Similarities and Differences to Nuclear Phenotypes of in Vitro Fertilized Embryos Nucleus (Austin, Tex.). 2014 | Pubmed ID: 25482066 Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-associated Kidney Disease PloS One. 2014 | Pubmed ID: 25409434 Calcitonin Controls Bone Formation by Inhibiting the Release of Sphingosine 1-phosphate from Osteoclasts Nature Communications. 2014 | Pubmed ID: 25333900 Pleiotropic Functions for Transcription Factor Zscan10 PloS One. 2014 | Pubmed ID: 25111779 Stage-specific Proteome Signatures in Early Bovine Embryo Development Journal of Proteome Research. Oct, 2014 | Pubmed ID: 25102770 Standardized, Systemic Phenotypic Analysis of Slc12a1I299F Mutant Mice Journal of Biomedical Science. Aug, 2014 | Pubmed ID: 25084970 DRO1 Inactivation Drives Colorectal Carcinogenesis in ApcMin/+ Mice Molecular Cancer Research : MCR. Nov, 2014 | Pubmed ID: 25053805 Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus PloS One. 2014 | Pubmed ID: 25025770 Uniformity of Nucleosome Preservation Pattern in Mammalian Sperm and Its Connection to Repetitive DNA Elements Developmental Cell. Jul, 2014 | Pubmed ID: 24998597 Genome Activation in Bovine Embryos: Review of the Literature and New Insights from RNA Sequencing Experiments Animal Reproduction Science. Sep, 2014 | Pubmed ID: 24975847 Abnormal Brain Iron Metabolism in Irp2 Deficient Mice is Associated with Mild Neurological and Behavioral Impairments PloS One. 2014 | Pubmed ID: 24896637 Complement Dependent Early Immunological Responses During Ex Vivo Xenoperfusion of HCD46/HLA-E Double Transgenic Pig Forelimbs with Human Blood Xenotransplantation. May-Jun, 2014 | Pubmed ID: 24635052 Homologous Recombination Contributes to the Repair of Zinc-finger-nuclease Induced Double Strand Breaks in Pig Primary Cells and Facilitates Recombination with Exogenous DNA Journal of Biotechnology. May, 2014 | Pubmed ID: 24613297 Fine Mapping of Genome Activation in Bovine Embryos by RNA Sequencing Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014 | Pubmed ID: 24591639 No Amelioration of Uromodulin Maturation and Trafficking Defect by Sodium 4-phenylbutyrate in Vivo: Studies in Mouse Models of Uromodulin-associated Kidney Disease The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24567330 Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43 The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24515116 The ABC of BTC: Structural Properties and Biological Roles of Betacellulin Seminars in Cell & Developmental Biology. Apr, 2014 | Pubmed ID: 24440602 Comparative and Retrospective Molecular Analysis of Parapoxvirus (PPV) Isolates Virus Research. Mar, 2014 | Pubmed ID: 24373950 Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs Transplantation. Jan, 2014 | Pubmed ID: 24150517 Genetically Engineered Pig Models for Diabetes Research Transgenic Research. Feb, 2014 | Pubmed ID: 24065178 Blood Collection from Mice and Hematological Analyses on Mouse Blood Current Protocols in Mouse Biology. Jun, 2013 | Pubmed ID: 26069060 Clinical Chemistry and Other Laboratory Tests on Mouse Plasma or Serum Current Protocols in Mouse Biology. Jun, 2013 | Pubmed ID: 26069059 Phenotypic Comparison of Common Mouse Strains Developing High-fat Diet-induced Hepatosteatosis Molecular Metabolism. 2013 | Pubmed ID: 24327959 Protein O-mannosylation is Crucial for E-cadherin-mediated Cell Adhesion Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24297939 A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington's Disease CAG Knock-in Mice PloS One. 2013 | Pubmed ID: 24278347 Standardized, Systemic Phenotypic Analysis of Umod(C93F) and Umod(A227T) Mutant Mice PloS One. 2013 | Pubmed ID: 24205203 Ligand-independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice Experimental Dermatology. Oct, 2013 | Pubmed ID: 24079739 Activation of the Lectin Pathway of Complement in Pig-to-human Xenotransplantation Models Transplantation. Nov, 2013 | Pubmed ID: 23958924 Increased Activation of the Epidermal Growth Factor Receptor in Transgenic Mice Overexpressing Epigen Causes Peripheral Neuropathy Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 23899604 Rapamycin Extends Murine Lifespan but Has Limited Effects on Aging The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23863708 An ENU Mutagenesis-derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease The American Journal of Pathology. Aug, 2013 | Pubmed ID: 23791841 Dystrophin-deficient Pigs Provide New Insights into the Hierarchy of Physiological Derangements of Dystrophic Muscle Human Molecular Genetics. Nov, 2013 | Pubmed ID: 23784375 Type of Uromodulin Mutation and Allelic Status Influence Onset and Severity of Uromodulin-associated Kidney Disease in Mice Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23748428 Factors Influencing the Efficiency of Generating Genetically Engineered Pigs by Nuclear Transfer: Multi-factorial Analysis of a Large Data Set BMC Biotechnology. May, 2013 | Pubmed ID: 23688045 High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner The Journal of Biological Chemistry. Jun, 2013 | Pubmed ID: 23620591 Cytoplasmic Mislocalization of POU3F4 Due to Novel Mutations Leads to Deafness in Humans and Mice Human Mutation. Aug, 2013 | Pubmed ID: 23606368 ITRAQ Proteome Analysis Reflects a Progressed Differentiation State of Epiblast Derived Versus Inner Cell Mass Derived Murine Embryonic Stem Cells Journal of Proteomics. Sep, 2013 | Pubmed ID: 23603003 Mouse Nuclear Myosin I Knock-out Shows Interchangeability and Redundancy of Myosin Isoforms in the Cell Nucleus PloS One. 2013 | Pubmed ID: 23593477 Tissue-specific and Minor Inter-individual Variation in Imprinting of IGF2R is a Common Feature of Bos Taurus Concepti and Not Correlated with Fetal Weight PloS One. 2013 | Pubmed ID: 23593146 Modeling Hepatic Osteodystrophy in Abcb4 Deficient Mice Bone. Aug, 2013 | Pubmed ID: 23545228 SMC6 is an Essential Gene in Mice, but a Hypomorphic Mutant in the ATPase Domain Has a Mild Phenotype with a Range of Subtle Abnormalities DNA Repair. May, 2013 | Pubmed ID: 23518413 Immune Aspects of Embryo-maternal Cross-talk in the Bovine Uterus Journal of Reproductive Immunology. Mar, 2013 | Pubmed ID: 23432868 NOD-scid IL2R γnull Mice Engrafted with Human Peripheral Blood Mononuclear Cells As a Model to Test Therapeutics Targeting Human Signaling Pathways Journal of Translational Medicine. Jan, 2013 | Pubmed ID: 23294516 Permanent Neonatal Diabetes in INS(C94Y) Transgenic Pigs Diabetes. May, 2013 | Pubmed ID: 23274907 Genetic Deletion of the EGFR Ligand Epigen Does Not Affect Mouse Embryonic Development and Tissue Homeostasis Experimental Cell Research. Feb, 2013 | Pubmed ID: 23142483 Induction of Oxazolone-mediated Features of Atopic Dermatitis in NOD-scid IL2Rγ(null) Mice Engrafted with Human Peripheral Blood Mononuclear Cells Disease Models & Mechanisms. Jan, 2013 | Pubmed ID: 22822046 Hosting the Preimplantation Embryo: Potentials and Limitations of Different Approaches for Analysing Embryo-endometrium Interactions in Cattle Reproduction, Fertility, and Development. 2012 | Pubmed ID: 23244829 The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers PloS One. 2012 | Pubmed ID: 23226392 Completion of the Swine Genome Will Simplify the Production of Swine As a Large Animal Biomedical Model BMC Medical Genomics. Nov, 2012 | Pubmed ID: 23151353 Potential of Primary Kidney Cells for Somatic Cell Nuclear Transfer Mediated Transgenesis in Pig BMC Biotechnology. Nov, 2012 | Pubmed ID: 23140586 Truncation of MIMT1 Gene in the PEG3 Domain Leads to Major Changes in Placental Gene Expression and Stillbirth in Cattle Biology of Reproduction. Jun, 2012 | Pubmed ID: 23100617 Inactivation and Inducible Oncogenic Mutation of P53 in Gene Targeted Pigs PloS One. 2012 | Pubmed ID: 23071491 The Hepatic Phosphatidylcholine Transporter ABCB4 As Modulator of Glucose Homeostasis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2012 | Pubmed ID: 22982378 In-vivo Biodegradation of Extruded Lipid Implants in Rabbits Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2012 | Pubmed ID: 22964393 Innovations in Phenotyping of Mouse Models in the German Mouse Clinic Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012 | Pubmed ID: 22926221 Transcriptome Analyses of Bovine, Porcine and Equine Endometrium During the Pre-implantation Phase Animal Reproduction Science. Sep, 2012 | Pubmed ID: 22917876 A Porcine Model of Familial Adenomatous Polyposis Gastroenterology. Nov, 2012 | Pubmed ID: 22864254 Does Enamelin Have Pleiotropic Effects on Organs Other Than the Teeth? Lessons from a Phenotyping Screen of Two Enamelin-mutant Mouse Lines European Journal of Oral Sciences. Aug, 2012 | Pubmed ID: 22813216 Cytochrome C Oxidase Subunit 4 Isoform 2-knockout Mice Show Reduced Enzyme Activity, Airway Hyporeactivity, and Lung Pathology FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2012 | Pubmed ID: 22730437 Large-scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System PloS One. 2012 | Pubmed ID: 22701626 Cytomegalovirus Replicon-based Regulation of Gene Expression in Vitro and in Vivo PLoS Pathogens. 2012 | Pubmed ID: 22685399 A New Mouse Model for Studying EGFR-dependent Gastric Polyps Biochimica Et Biophysica Acta. Aug, 2012 | Pubmed ID: 22579588 New Mouse Models for Metabolic Bone Diseases Generated by Genome-wide ENU Mutagenesis Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2012 | Pubmed ID: 22527485 Xenografted Islet Cell Clusters from INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice Diabetes. Jun, 2012 | Pubmed ID: 22522620 Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model with Impaired Incretin Function and Reduced β-cell Mass Diabetes. Aug, 2012 | Pubmed ID: 22492530 Neurobeachin, a Regulator of Synaptic Protein Targeting, is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-mass Index in Humans PLoS Genetics. 2012 | Pubmed ID: 22438821 Human TNF-related Apoptosis-inducing Ligand-expressing Dendritic Cells from Transgenic Pigs Attenuate Human Xenogeneic T Cell Responses Xenotransplantation. Jan-Feb, 2012 | Pubmed ID: 22360752 Negative Feedback Mechanisms Surpass the Effect of Intrinsic EGFR Activation During Skin Chemical Carcinogenesis The American Journal of Pathology. Apr, 2012 | Pubmed ID: 22306420 Clinical Chemistry of Human FcRn Transgenic Mice Mammalian Genome : Official Journal of the International Mammalian Genome Society. Apr, 2012 | Pubmed ID: 22193411 First Inducible Transgene Expression in Porcine Large Animal Models FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2012 | Pubmed ID: 22138035 Normal Epidermal Growth Factor Receptor Signaling is Dispensable for Bone Anabolic Effects of Parathyroid Hormone Bone. Jan, 2012 | Pubmed ID: 22056328 Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium Biology of Reproduction. Feb, 2012 | Pubmed ID: 22034527 Gene Expression Profiling of Bovine Peripartal Placentomes: Detection of Molecular Pathways Potentially Involved in the Release of Foetal Membranes Reproduction (Cambridge, England). Jan, 2012 | Pubmed ID: 22031715 Lack of Pur-alpha Alters Postnatal Brain Development and Causes Megalencephaly Human Molecular Genetics. Feb, 2012 | Pubmed ID: 22010047 A Transgenic Mouse Line Expressing Cre Recombinase in Pancreatic β-cells Genesis (New York, N.Y. : 2000). May, 2012 | Pubmed ID: 21998080 In Vivo Evidence for Epidermal Growth Factor Receptor (EGFR)-mediated Release of Prolactin from the Pituitary Gland The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21914800 Postnatal Development of Numbers and Mean Sizes of Pancreatic Islets and Beta-cells in Healthy Mice and GIPR(dn) Transgenic Diabetic Mice PloS One. 2011 | Pubmed ID: 21818396 Cell Arrest and Cell Death in Mammalian Preimplantation Development: Lessons from the Bovine Model PloS One. 2011 | Pubmed ID: 21811561 Reduced Amino Acids in the Bovine Uterine Lumen of Cloned Versus in Vitro Fertilized Pregnancies Prior to Implantation Cellular Reprogramming. Oct, 2011 | Pubmed ID: 21774685 Toxicity Modelling of Plk1-targeted Therapies in Genetically Engineered Mice and Cultured Primary Mammalian Cells Nature Communications. 2011 | Pubmed ID: 21772266 Generation of N-ethyl-N-nitrosourea-induced Mouse Mutants with Deviations in Hematological Parameters Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2011 | Pubmed ID: 21553221 Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21467037 Missing-in-metastasis MIM/MTSS1 Promotes Actin Assembly at Intercellular Junctions and is Required for Integrity of Kidney Epithelia Journal of Cell Science. Apr, 2011 | Pubmed ID: 21406566 Increase of Essential Amino Acids in the Bovine Uterine Lumen During Preimplantation Development Reproduction (Cambridge, England). May, 2011 | Pubmed ID: 21383026 Decreased Incidence of Papillomas in Mice with Impaired EGFR Function During Multi-stage Skin Carcinogenesis Experimental Dermatology. Mar, 2011 | Pubmed ID: 21323750 A Novel N-ethyl-N-nitrosourea-induced Mutation in Phospholipase Cγ2 Causes Inflammatory Arthritis, Metabolic Defects, and Male Infertility in Vitro in a Murine Model Arthritis and Rheumatism. May, 2011 | Pubmed ID: 21305534 Formation of Nucleoli in Interspecies Nuclear Transfer Embryos Derived from Bovine, Porcine, and Rabbit Oocytes and Nuclear Donor Cells of Various Species Reproduction (Cambridge, England). Apr, 2011 | Pubmed ID: 21239525 Utilization of a Mutagenesis Screen to Generate Mouse Models of Hyperaldosteronism Endocrinology. Jan, 2011 | Pubmed ID: 21068155 Bovine Endometrial Metallopeptidases MMP14 and MMP2 and the Metallopeptidase Inhibitor TIMP2 Participate in Maternal Preparation of Pregnancy Molecular and Cellular Endocrinology. Jan, 2011 | Pubmed ID: 20887771 Mouse Phenotyping Methods (San Diego, Calif.). Feb, 2011 | Pubmed ID: 20708688 Genomic Integration of Adenoviral Gene Transfer Vectors Following Transduction of Fertilized Mouse Oocytes Transgenic Research. Feb, 2011 | Pubmed ID: 20464633 A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation PloS One. Dec, 2010 | Pubmed ID: 21179475 Actions and Interactions of Progesterone and Estrogen on Transcriptome Profiles of the Bovine Endometrium Physiological Genomics. Nov, 2010 | Pubmed ID: 20876846 FISH on 3D Preserved Bovine and Murine Preimplantation Embryos Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20809333 Quantification of Leukocyte Genomic 5-methylcytosine Levels Reveals Epigenetic Plasticity in Healthy Adult Cloned Cattle Cellular Reprogramming. Apr, 2010 | Pubmed ID: 20677931 Differential Endometrial Gene Expression in Pregnant and Nonpregnant Sows Biology of Reproduction. Aug, 2010 | Pubmed ID: 20393170 Transgenic Pigs As Models for Translational Biomedical Research Journal of Molecular Medicine (Berlin, Germany). Jul, 2010 | Pubmed ID: 20339830 Mutation of the Na(+)-K(+)-2Cl(-) Cotransporter NKCC2 in Mice is Associated with Severe Polyuria and a Urea-selective Concentrating Defect Without Hyperreninemia American Journal of Physiology. Renal Physiology. Jun, 2010 | Pubmed ID: 20219826 Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice PloS One. Mar, 2010 | Pubmed ID: 20209148 Glucose Intolerance and Reduced Proliferation of Pancreatic Beta-cells in Transgenic Pigs with Impaired Glucose-dependent Insulinotropic Polypeptide Function Diabetes. May, 2010 | Pubmed ID: 20185813 Escherichia Coli Infection Induces Distinct Local and Systemic Transcriptome Responses in the Mammary Gland BMC Genomics. Feb, 2010 | Pubmed ID: 20184744 Transgenic Pigs for Xenotransplantation: Selection of Promoter Sequences for Reliable Transgene Expression Current Opinion in Organ Transplantation. Apr, 2010 | Pubmed ID: 20061949 Betacellulin Protects from Pancreatitis by Activating Stress-activated Protein Kinase Gastroenterology. Apr, 2010 | Pubmed ID: 20038432 Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3 ( 416insG ) Mice Mammalian Genome : Official Journal of the International Mammalian Genome Society. Feb, 2010 | Pubmed ID: 20033184 Genetic Modification of Pigs As Organ Donors for Xenotransplantation Molecular Reproduction and Development. Mar, 2010 | Pubmed ID: 19998476 EGFR Ligands Exert Diverging Effects on Male Reproductive Organs Experimental and Molecular Pathology. Feb, 2010 | Pubmed ID: 19931240 Germ-line Transmission of Lentiviral PGK-EGFP Integrants in Transgenic Cattle: New Perspectives for Experimental Embryology Transgenic Research. Aug, 2010 | Pubmed ID: 19862638 Epigen Transgenic Mice Develop Enlarged Sebaceous Glands The Journal of Investigative Dermatology. Feb, 2010 | Pubmed ID: 19693025 Specific Transgene Expression in Mouse Pancreatic Beta-cells Under the Control of the Porcine Insulin Promoter Molecular and Cellular Endocrinology. Feb, 2010 | Pubmed ID: 19682540 Novel Missense Mutation of Uromodulin in Mice Causes Renal Dysfunction with Alterations in Urea Handling, Energy, and Bone Metabolism American Journal of Physiology. Renal Physiology. Nov, 2009 | Pubmed ID: 19692485 Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to Trypanosoma Congolense Infection Infection and Immunity. Sep, 2009 | Pubmed ID: 19596769 Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes PloS One. Jun, 2009 | Pubmed ID: 19562077 Reprogramming of Active and Repressive Histone Modifications Following Nuclear Transfer with Rabbit Mesenchymal Stem Cells and Adult Fibroblasts Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508112 N-ethyl-N-nitrosourea Mutagenesis Produced a Small Number of Mice with Altered Plasma Electrolyte Levels Journal of Biomedical Science. Jun, 2009 | Pubmed ID: 19505327 Evidence for Estrogen-dependent Uterine Serpin (SERPINA14) Expression During Estrus in the Bovine Endometrial Glandular Epithelium and Lumen Biology of Reproduction. Oct, 2009 | Pubmed ID: 19494250 Chronic Growth Hormone Excess is Associated with Increased Aldosterone: a Study in Patients with Acromegaly and in Growth Hormone Transgenic Mice Experimental Biology and Medicine (Maywood, N.J.). Aug, 2009 | Pubmed ID: 19491373 A Humanized Version of Foxp2 Affects Cortico-basal Ganglia Circuits in Mice Cell. May, 2009 | Pubmed ID: 19490899 A New Fgf10 Mutation in the Mouse Leads to Atrophy of the Harderian Gland and Slit-eye Phenotype in Heterozygotes: a Novel Model for Dry-eye Disease? Investigative Ophthalmology & Visual Science. Sep, 2009 | Pubmed ID: 19407009 Distribution and Expression of Porcine Endogenous Retroviruses in Multi-transgenic Pigs Generated for Xenotransplantation Xenotransplantation. Mar-Apr, 2009 | Pubmed ID: 19392721 The C-terminal Cytoplasmic Domain of Human ProEGF is a Negative Modulator of Body and Organ Weights in Transgenic Mice FEBS Letters. Apr, 2009 | Pubmed ID: 19328792 Scrapie-infected Transgenic Mice Expressing a Laminin Receptor Decoy Mutant Reveal a Prolonged Incubation Time Associated with Low Levels of PrPres Journal of Molecular Biology. May, 2009 | Pubmed ID: 19324055 The Endometrium Responds Differently to Cloned Versus Fertilized Embryos Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19307558 Maternal Inexperience As a Risk Factor of Innate Fear and PTSD-like Symptoms in Mice Journal of Psychiatric Research. Sep, 2009 | Pubmed ID: 19304295 Systemic First-line Phenotyping Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19266331 Changes of Higher Order Chromatin Arrangements During Major Genome Activation in Bovine Preimplantation Embryos Experimental Cell Research. Jul, 2009 | Pubmed ID: 19254712 Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood Riccardo Sfriso1,2, Anjan Bongoni3, Yara Banz4, Nikolai Klymiuk5, Eckhard Wolf5, Robert Rieben1 1Department of Clinical Research, University of Bern, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, 3Immunology Research Centre, St. Vincent's Hospital Melbourne, 4Institute of Pathology, University of Bern, 5Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University JoVE 56227 Medicine
Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood Riccardo Sfriso1,2, Anjan Bongoni3, Yara Banz4, Nikolai Klymiuk5, Eckhard Wolf5, Robert Rieben1 1Department of Clinical Research, University of Bern, 2Graduate School for Cellular and Biomedical Sciences, University of Bern, 3Immunology Research Centre, St. Vincent's Hospital Melbourne, 4Institute of Pathology, University of Bern, 5Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University JoVE 56227 Medicine