Gabriel C. Lander Department of Structural and Computational Biology Scripps Research Biography Publications Institution JoVE Articles Gabriel C. Lander has not added a biography. If you are Gabriel C. Lander and would like to personalize this page please email our Author Liaison for assistance. Publications Succinylation of a KEAP1 Sensor Lysine Promotes NRF2 Activation Cell Chemical Biology. Aug, 2023 | Pubmed ID: 37619563 Structural Basis for a Degenerate TRNA Identity Code and the Evolution of Bimodal Specificity in Human Mitochondrial TRNA Recognition Nature Communications. Aug, 2023 | Pubmed ID: 37558671 DELE1 Oligomerization Promotes Integrated Stress Response Activation Nature Structural & Molecular Biology. Aug, 2023 | Pubmed ID: 37550454 Succinylation of a KEAP1 Sensor Lysine Promotes NRF2 Activation BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 37215033 Molecular Glue CELMoD Compounds Are Regulators of Cereblon Conformation Science (New York, N.Y.). Nov, 2022 | Pubmed ID: 36378961 Structure of the Hepatitis C Virus E1E2 Glycoprotein Complex Science (New York, N.Y.). Oct, 2022 | Pubmed ID: 36264808 Structural Basis for Shape-selective Recognition and Aminoacylation of a D-armless Human Mitochondrial TRNA Nature Communications. Aug, 2022 | Pubmed ID: 36042193 Coupling of Distant ATPase Domains in the Circadian Clock Protein KaiC Nature Structural & Molecular Biology. Aug, 2022 | Pubmed ID: 35864165 The YΦ Motif Defines the Structure-activity Relationships of Human 20S Proteasome Activators Nature Communications. Mar, 2022 | Pubmed ID: 35264557 Allosteric Differences Dictate GroEL Complementation Of E. coli FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2022 | Pubmed ID: 35199390 Cryo-EM Structure of Hexameric Yeast Lon Protease (PIM1) Highlights the Importance of Conserved Structural Elements The Journal of Biological Chemistry. Mar, 2022 | Pubmed ID: 35143841 A Case for Glycerol As an Acceptable Additive for Single-particle CryoEM Samples Acta Crystallographica. Section D, Structural Biology. Jan, 2022 | Pubmed ID: 34981768 Conquer by Cryo-EM Without Physically Dividing Biochemical Society Transactions. Nov, 2021 | Pubmed ID: 34709401 Structural Basis for PiRNA Targeting Nature. Sep, 2021 | Pubmed ID: 34471284 Structures of the Human LONP1 Protease Reveal Regulatory Steps Involved in Protease Activation Nature Communications. May, 2021 | Pubmed ID: 34050165 A Guided Approach for Subtomogram Averaging of Challenging Macromolecular Assemblies Journal of Structural Biology: X. 2020 | Pubmed ID: 33319208 Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis Biophysical Journal. Oct, 2020 | Pubmed ID: 32919493 Sub-2 Angstrom Resolution Structure Determination Using Single-particle Cryo-EM at 200 keV Journal of Structural Biology: X. 2020 | Pubmed ID: 32647824 How Low Can We Go? Structure Determination of Small Biological Complexes Using Single-particle Cryo-EM Current Opinion in Structural Biology. Oct, 2020 | Pubmed ID: 32599507 Structural Basis for Distinct Operational Modes and Protease Activation in AAA+ Protease Lon Science Advances. May, 2020 | Pubmed ID: 32490208 AcrIF9 Tethers Non-sequence Specific DsDNA to the CRISPR RNA-guided Surveillance Complex Nature Communications. Jun, 2020 | Pubmed ID: 32483187 Author Correction: An Allosteric Network in Spastin Couples Multiple Activities Required for Microtubule Severing Nature Structural & Molecular Biology. Apr, 2020 | Pubmed ID: 32203494 Dynamics at the Serine Loop Underlie Differential Affinity of Cryptochromes for CLOCK:BMAL1 to Control Circadian Timing ELife. Feb, 2020 | Pubmed ID: 32101164 The Molecular Principles Governing the Activity and Functional Diversity of AAA+ Proteins Nature Reviews. Molecular Cell Biology. Jan, 2020 | Pubmed ID: 31754261 Specific Lid-base Contacts in the 26s Proteasome Control the Conformational Switching Required for Substrate Degradation ELife. Nov, 2019 | Pubmed ID: 31778111 Current Outcomes when Optimizing 'standard' Sample Preparation for Single-particle Cryo-EM Journal of Microscopy. Oct, 2019 | Pubmed ID: 31553060 Visualizing Structural Transitions of Ligand-dependent Gating of the TRPM2 Channel Nature Communications. Aug, 2019 | Pubmed ID: 31431622 Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease Molecular Cell. Sep, 2019 | Pubmed ID: 31327635 An Allosteric Network in Spastin Couples Multiple Activities Required for Microtubule Severing Nature Structural & Molecular Biology. Aug, 2019 | Pubmed ID: 31285604 Setting the Dynein Motor in Motion: New Insights from Electron Tomography The Journal of Biological Chemistry. Sep, 2019 | Pubmed ID: 31285262 Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry Molecular Cell. Apr, 2019 | Pubmed ID: 30872121 High-resolution Structure Determination of Sub-100 kDa Complexes Using Conventional Cryo-EM Nature Communications. Mar, 2019 | Pubmed ID: 30833564 A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality Structure (London, England : 1993). Feb, 2019 | Pubmed ID: 30449687 The Rod-shaped ATG2A-WIPI4 Complex Tethers Membranes in Vitro Contact (Thousand Oaks (Ventura County, Calif.)). 2018 | Pubmed ID: 30766969 Conformational Ensemble of the Human TRPV3 Ion Channel Nature Communications. Nov, 2018 | Pubmed ID: 30429472 Substrate-engaged 26 Proteasome Structures Reveal Mechanisms for ATP-hydrolysis-driven Translocation Science (New York, N.Y.). Nov, 2018 | Pubmed ID: 30309908 Insights into Autophagosome Biogenesis from Structural and Biochemical Analyses of the ATG2A-WIPI4 Complex Proceedings of the National Academy of Sciences of the United States of America. Oct, 2018 | Pubmed ID: 30185561 Cryo-EM Structure of a Mitochondrial Calcium Uniporter Science (New York, N.Y.). Aug, 2018 | Pubmed ID: 29954988 Exploring Applications of Crowdsourcing to Cryo-EM Journal of Structural Biology. Jul, 2018 | Pubmed ID: 29486249 Author Correction: Cryo-electron Tomography Reveals That Dynactin Recruits a Team of Dyneins for Processive Motility Nature Structural & Molecular Biology. Apr, 2018 | Pubmed ID: 29476122 Cryo-electron Tomography Reveals That Dynactin Recruits a Team of Dyneins for Processive Motility Nature Structural & Molecular Biology. Mar, 2018 | Pubmed ID: 29416113 The Peroxisomal AAA-ATPase Pex1/Pex6 Unfolds Substrates by Processive Threading Nature Communications. Jan, 2018 | Pubmed ID: 29321502 Structure of the Cold- and Menthol-sensing Ion Channel TRPM8 Science (New York, N.Y.). Jan, 2018 | Pubmed ID: 29217583 Structure of the Mitochondrial Inner Membrane AAA+ Protease YME1 Gives Insight into Substrate Processing Science (New York, N.Y.). Nov, 2017 | Pubmed ID: 29097521 Cryo-electron Microscopy Structure of the Lysosomal Calcium-permeable Channel TRPML3 Nature. Oct, 2017 | Pubmed ID: 29019979 Achieving Better-than-3-Å Resolution by Single-particle Cryo-EM at 200 KeV Nature Methods. Nov, 2017 | Pubmed ID: 28991891 The Endoplasmic Reticulum HSP40 Co-chaperone ERdj3/DNAJB11 Assembles and Functions As a Tetramer The EMBO Journal. Aug, 2017 | Pubmed ID: 28655754 Cas1 and the Csy Complex Are Opposing Regulators of Cas2/3 Nuclease Activity Proceedings of the National Academy of Sciences of the United States of America. Jun, 2017 | Pubmed ID: 28438998 Structure Reveals Mechanisms of Viral Suppressors That Intercept a CRISPR RNA-Guided Surveillance Complex Cell. Mar, 2017 | Pubmed ID: 28340349 What's the Key to Unlocking the Proteasome's Gate? Structure (London, England : 1993). Dec, 2016 | Pubmed ID: 27926830 Isolation of Yeast Complex IV in Native Lipid Nanodiscs Biochimica Et Biophysica Acta. Dec, 2016 | Pubmed ID: 27620332 A Novel Cereblon Modulator Recruits GSPT1 to the CRL4(CRBN) Ubiquitin Ligase Nature. 07, 2016 | Pubmed ID: 27338790 Cryo-electron Microscopy Structure of the TRPV2 Ion Channel Nature Structural & Molecular Biology. Feb, 2016 | Pubmed ID: 26779611 Atomic Structure of the 26S Proteasome Lid Reveals the Mechanism of Deubiquitinase Inhibition ELife. Jan, 2016 | Pubmed ID: 26744777 Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex Biophysical Journal. Oct, 2015 | Pubmed ID: 26488657 Site-specific Labeling of Proteins for Electron Microscopy Journal of Structural Biology. Nov, 2015 | Pubmed ID: 26409249 Ubp6 Deubiquitinase Controls Conformational Dynamics and Substrate Degradation of the 26S Proteasome Nature Structural & Molecular Biology. Sep, 2015 | Pubmed ID: 26301997 Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22 Journal of Molecular Biology. Oct, 2015 | Pubmed ID: 26301600 Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases Cell. May, 2015 | Pubmed ID: 25959773 Structural Organization of the Dynein-dynactin Complex Bound to Microtubules Nature Structural & Molecular Biology. Apr, 2015 | Pubmed ID: 25751425 The Pex1/Pex6 Complex is a Heterohexameric AAA+ Motor with Alternating and Highly Coordinated Subunits Journal of Molecular Biology. Mar, 2015 | Pubmed ID: 25659908 Solid-to-fluid-like DNA Transition in Viruses Facilitates Infection Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271319 DNA Bending-induced Phase Transition of Encapsidated Genome in Phage λ Nucleic Acids Research. Apr, 2013 | Pubmed ID: 23449219 Capsomer Dynamics and Stabilization in the T = 12 Marine Bacteriophage SIO-2 and Its Procapsid Studied by CryoEM Structure (London, England : 1993). Mar, 2012 | Pubmed ID: 22405008 Peering Down the Barrel of a Bacteriophage Portal: the Genome Packaging and Release Valve in P22 Structure (London, England : 1993). Apr, 2011 | Pubmed ID: 21439834 Subunits Fold at Position-dependent Rates During Maturation of a Eukaryotic RNA Virus Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20660783 An Automated Procedure for Detecting Protein Folds from Sub-nanometer Resolution Electron Density Journal of Structural Biology. Jun, 2010 | Pubmed ID: 20026407 A Toolbox for Ab Initio 3-D Reconstructions in Single-particle Electron Microscopy Journal of Structural Biology. Mar, 2010 | Pubmed ID: 20018246 The P22 Tail Machine at Subnanometer Resolution Reveals the Architecture of an Infection Conduit Structure (London, England : 1993). Jun, 2009 | Pubmed ID: 19523897 Drosophila A Virus is an Unusual RNA Virus with a T=3 Icosahedral Core and Permuted RNA-dependent RNA Polymerase The Journal of General Virology. Sep, 2009 | Pubmed ID: 19474243 Ab Initio Maximum Likelihood Reconstruction from Cryo Electron Microscopy Images of an Infectious Virion of the Tailed Bacteriophage P22 and Maximum Likelihood Versions of Fourier Shell Correlation Appropriate for Measuring Resolution of Spherical or Cylindrical Objects Journal of Structural Biology. Sep, 2009 | Pubmed ID: 19457456 Appion: an Integrated, Database-driven Pipeline to Facilitate EM Image Processing Journal of Structural Biology. Apr, 2009 | Pubmed ID: 19263523 Bacteriophage Lambda Stabilization by Auxiliary Protein GpD: Timing, Location, and Mechanism of Attachment Determined by Cryo-EM Structure (London, England : 1993). Sep, 2008 | Pubmed ID: 18786402 Assembly Architecture and DNA Binding of the Bacteriophage P22 Terminase Small Subunit Journal of Molecular Biology. Nov, 2008 | Pubmed ID: 18775728 A Test-bed for Optimizing High-resolution Single Particle Reconstructions Journal of Structural Biology. Jul, 2008 | Pubmed ID: 18534866 Polyvalent Display of Heme on Hepatitis B Virus Capsid Protein Through Coordination to Hexahistidine Tags Chemistry & Biology. May, 2008 | Pubmed ID: 18482703 Automated CryoEM Data Acquisition and Analysis of 284742 Particles of GroEL Journal of Structural Biology. Sep, 2006 | Pubmed ID: 16762565 The Structure of an Infectious P22 Virion Shows the Signal for Headful DNA Packaging Science (New York, N.Y.). Jun, 2006 | Pubmed ID: 16709746 Exploring Icosahedral Virus Structures with VIPER Nature Reviews. Microbiology. Oct, 2005 | Pubmed ID: 16205712 Enhancing CryoEM Resolution Using Graphene-Coated Grids (Video) | JoVE Benjamin Basanta*1, Wenqian Chen*1, Daniel E. Pride1, Gabriel C. Lander1 1Department of Structural and Computational Biology, Scripps Research JoVE 65702 Biology
Enhancing CryoEM Resolution Using Graphene-Coated Grids (Video) | JoVE Benjamin Basanta*1, Wenqian Chen*1, Daniel E. Pride1, Gabriel C. Lander1 1Department of Structural and Computational Biology, Scripps Research JoVE 65702 Biology