Gail V.W. Johnson Departments of Anesthesiology, Pharmacology and Physiology University of Rochester Biography Publications Institution JoVE Articles Gail V.W. Johnson has not added a biography. If you are Gail V.W. Johnson and would like to personalize this page please email our Author Liaison for assistance. Publications Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARγ PloS One. 2012 | Pubmed ID: 22276192 Complete Transglutaminase 2 Ablation Results in Reduced Stroke Volumes and Astrocytes That Exhibit Increased Survival in Response to Ischemia Neurobiology of Disease. Mar, 2012 | Pubmed ID: 22198379 Transglutaminase 2: A Molecular Swiss Army Knife Biochimica Et Biophysica Acta. Feb, 2012 | Pubmed ID: 22015769 Truncated Tau and Aβ Cooperatively Impair Mitochondria in Primary Neurons Neurobiology of Aging. Mar, 2012 | Pubmed ID: 21450370 Decreases in Valosin-containing Protein Result in Increased Levels of Tau Phosphorylated at Ser262/356 FEBS Letters. Nov, 2011 | Pubmed ID: 21983102 Transglutaminase 2 and Its Role in Pulmonary Fibrosis American Journal of Respiratory and Critical Care Medicine. Sep, 2011 | Pubmed ID: 21700912 The Toxicity of Tau in Alzheimer Disease: Turnover, Targets and Potential Therapeutics Journal of Cellular and Molecular Medicine. Aug, 2011 | Pubmed ID: 21348938 Cytosolic Guanine Nucledotide Binding Deficient Form of Transglutaminase 2 (R580a) Potentiates Cell Death in Oxygen Glucose Deprivation PloS One. 2011 | Pubmed ID: 21304968 Split GFP Complementation Assay for Quantitative Measurement of Tau Aggregation in Situ Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 20967587 AES/GRG5: More Than Just a Dominant-negative TLE/GRG Family Member Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2010 | Pubmed ID: 20925119 The Role of Tau Kinases in Alzheimer's Disease Current Opinion in Drug Discovery & Development. Sep, 2010 | Pubmed ID: 20812151 Differential Modulation of TCF/LEF-1 Activity by the Soluble LRP6-ICD PloS One. 2010 | Pubmed ID: 20676368 The Interrelationship Between Mitochondrial Dysfunction and Transcriptional Dysregulation in Huntington Disease Journal of Bioenergetics and Biomembranes. Jun, 2010 | Pubmed ID: 20556492 A Caspase Cleaved Form of Tau is Preferentially Degraded Through the Autophagy Pathway The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20466727 Phosphorylation of PPP(S/T)P Motif of the Free LRP6 Intracellular Domain is Not Required to Activate the Wnt/beta-catenin Pathway and Attenuate GSK3beta Activity Journal of Cellular Biochemistry. Nov, 2009 | Pubmed ID: 19711366 Role of Mitochondrial Dysfunction in the Pathogenesis of Huntington's Disease Brain Research Bulletin. Oct, 2009 | Pubmed ID: 19622387 Intracellular Localization and Conformational State of Transglutaminase 2: Implications for Cell Death PloS One. 2009 | Pubmed ID: 19568436 Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons: Implications for the Pathogenesis of Alzheimer Disease The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19389700 Increased Expression of Bim Contributes to the Potentiation of Serum Deprivation-induced Apoptotic Cell Death in Huntington's Disease Knock-in Striatal Cell Line Neurological Research. Feb, 2009 | Pubmed ID: 18691453 Immortalized Cortical Neurons Expressing Caspase-cleaved Tau Are Sensitized to Endoplasmic Reticulum Stress Induced Cell Death Brain Research. Oct, 2008 | Pubmed ID: 18718455 The Last Tangle of Tau Journal of Alzheimer's Disease : JAD. Aug, 2008 | Pubmed ID: 18688096 Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells: Possible Role of Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) in the Pathogenesis of Huntington Disease The Journal of Biological Chemistry. Sep, 2008 | Pubmed ID: 18640979 Histone Deacetylase 6 Interacts with the Microtubule-associated Protein Tau Journal of Neurochemistry. Sep, 2008 | Pubmed ID: 18636984 New Application of Beta-galactosidase Complementation to Monitor Tau Self-association Journal of Neurochemistry. Aug, 2008 | Pubmed ID: 18498442 Transglutaminase 2 Protects Against Ischemic Insult, Interacts with HIF1beta, and Attenuates HIF1 Signaling FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2008 | Pubmed ID: 18375543 Split GFP Complementation Assay: a Novel Approach to Quantitatively Measure Aggregation of Tau in Situ: Effects of GSK3beta Activation and Caspase 3 Cleavage Journal of Neurochemistry. Dec, 2007 | Pubmed ID: 17908237 Activation of Glycogen Synthase Kinase 3beta Promotes the Intermolecular Association of Tau. The Use of Fluorescence Resonance Energy Transfer Microscopy The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17565981 Ubiquitin-proteasome System Alterations in a Striatal Cell Model of Huntington's Disease Journal of Neuroscience Research. Jun, 2007 | Pubmed ID: 17455294 Type 2 Transglutaminase Differentially Modulates Striatal Cell Death in the Presence of Wild Type or Mutant Huntingtin Journal of Neurochemistry. Jul, 2007 | Pubmed ID: 17403029 Mitochondrial-targeted Active Akt Protects SH-SY5Y Neuroblastoma Cells from Staurosporine-induced Apoptotic Cell Death Journal of Cellular Biochemistry. Sep, 2007 | Pubmed ID: 17340627 Regulated Proteolytic Processing of LRP6 Results in Release of Its Intracellular Domain Journal of Neurochemistry. Apr, 2007 | Pubmed ID: 17326769 Transglutaminase 2 in Neurodegenerative Disorders Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17127346 The Role of Tau Phosphorylation and Cleavage in Neuronal Cell Death Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17127334 The Role of Tau Phosphorylation in the Pathogenesis of Alzheimer's Disease Current Alzheimer Research. Dec, 2006 | Pubmed ID: 17168644 Tau is Hyperphosphorylated at Multiple Sites in Mouse Brain in Vivo After Streptozotocin-induced Insulin Deficiency Diabetes. Dec, 2006 | Pubmed ID: 17130475 Mutant Huntingtin Expression Induces Mitochondrial Calcium Handling Defects in Clonal Striatal Cells: Functional Consequences The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16973623 Tau Phosphorylation and Proteolysis: Insights and Perspectives Journal of Alzheimer's Disease : JAD. 2006 | Pubmed ID: 16914862 Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-microtubule Interactions and Tau Aggregation The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16687396 Tissue Transglutaminase Overexpression in the Brain Potentiates Calcium-induced Hippocampal Damage Journal of Neurochemistry. Apr, 2006 | Pubmed ID: 16539654 The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16365045 The Protective Effects of Cystamine in the R6/2 Huntington's Disease Mouse Involve Mechanisms Other Than the Inhibition of Tissue Transglutaminase Neurobiology of Aging. Jun, 2006 | Pubmed ID: 15896882 Cystamine Treatment is Neuroprotective in the YAC128 Mouse Model of Huntington Disease Journal of Neurochemistry. Oct, 2005 | Pubmed ID: 16181425 Increased Glutathione Levels in Cortical and Striatal Mitochondria of the R6/2 Huntington's Disease Mouse Model Neuroscience Letters. Sep, 2005 | Pubmed ID: 15993538 Mitochondrial Respiration and ATP Production Are Significantly Impaired in Striatal Cells Expressing Mutant Huntingtin The Journal of Biological Chemistry. Sep, 2005 | Pubmed ID: 15983033 14-3-3Zeta Does Not Increase GSK3beta-mediated Tau Phosphorylation in Cell Culture Models Neuroscience Letters. Aug, 2005 | Pubmed ID: 15963640 Verification of Somatic CAG Repeat Expansion by Pre-PCR Fractionation Journal of Neuroscience Methods. May, 2005 | Pubmed ID: 15848234 Role of the Intracellular Domains of LRP5 and LRP6 in Activating the Wnt Canonical Pathway Journal of Cellular Biochemistry. May, 2005 | Pubmed ID: 15778991 Transglutaminases in Neurodegenerative Disorders Progress in Experimental Tumor Research. 2005 | Pubmed ID: 15746534 Tau Phosphorylation: Physiological and Pathological Consequences Biochimica Et Biophysica Acta. Jan, 2005 | Pubmed ID: 15615646 Tissue Transglutaminase Contributes to Disease Progression in the R6/2 Huntington's Disease Mouse Model Via Aggregate-independent Mechanisms Journal of Neurochemistry. Jan, 2005 | Pubmed ID: 15606898 FRAT-2 Preferentially Increases Glycogen Synthase Kinase 3 Beta-mediated Phosphorylation of Primed Sites, Which Results in Enhanced Tau Phosphorylation The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15522877 Developmental Regulation of Tissue Transglutaminase in the Mouse Forebrain Journal of Neurochemistry. Dec, 2004 | Pubmed ID: 15584913 Tau Phosphorylation in Neuronal Cell Function and Dysfunction Journal of Cell Science. Nov, 2004 | Pubmed ID: 15537830 Glycogen Synthase Kinase 3 Beta Induces Caspase-cleaved Tau Aggregation in Situ The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15494420 Tissue Transglutaminase is Not Involved in the Aggregate Formation of Stably Expressed Alpha-synuclein in SH-SY5Y Human Neuroblastoma Cells Archives of Pharmacal Research. Aug, 2004 | Pubmed ID: 15460447 Mutant Huntingtin Directly Increases Susceptibility of Mitochondria to the Calcium-induced Permeability Transition and Cytochrome C Release Human Molecular Genetics. Jul, 2004 | Pubmed ID: 15163634 The Glamour and Gloom of Glycogen Synthase Kinase-3 Trends in Biochemical Sciences. Feb, 2004 | Pubmed ID: 15102436 Effects of Cyclin-dependent Kinase-5 Activity on Apoptosis and Tau Phosphorylation in Immortalized Mouse Brain Cortical Cells Journal of Neuroscience Research. Apr, 2004 | Pubmed ID: 15048935 Validity of Mouse Models for the Study of Tissue Transglutaminase in Neurodegenerative Diseases Molecular and Cellular Neurosciences. Mar, 2004 | Pubmed ID: 15033177 Cyclin-dependent Kinase-5 in Neurodegeneration Journal of Neurochemistry. Mar, 2004 | Pubmed ID: 15009631 Immunoblot Analysis Reveals That Isopeptide Antibodies Do Not Specifically Recognize the Epsilon-(gamma-glutamyl)lysine Bonds Formed by Transglutaminase Activity Journal of Neuroscience Methods. Apr, 2004 | Pubmed ID: 15003381 Striatal Cells from Mutant Huntingtin Knock-in Mice Are Selectively Vulnerable to Mitochondrial Complex II Inhibitor-induced Cell Death Through a Non-apoptotic Pathway Human Molecular Genetics. Apr, 2004 | Pubmed ID: 14962977 Primed Phosphorylation of Tau at Thr231 by Glycogen Synthase Kinase 3beta (GSK3beta) Plays a Critical Role in Regulating Tau's Ability to Bind and Stabilize Microtubules Journal of Neurochemistry. Jan, 2004 | Pubmed ID: 14690523 Intracellular Localization and Activity State of Tissue Transglutaminase Differentially Impacts Cell Death The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14670969 Mutant (R406W) Human Tau is Hyperphosphorylated and Does Not Efficiently Bind Microtubules in a Neuronal Cortical Cell Model The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14660557 The P38 MAP Kinase Signaling Pathway in Alzheimer's Disease Experimental Neurology. Oct, 2003 | Pubmed ID: 14552867 Tissue Transglutaminase Directly Regulates Adenylyl Cyclase Resulting in Enhanced CAMP-response Element-binding Protein (CREB) Activation The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12743114 Cystamine Inhibits Caspase Activity. Implications for the Treatment of Polyglutamine Disorders The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12458211 Glycogen Synthase Kinase 3beta Phosphorylates Tau at Both Primed and Unprimed Sites. Differential Impact on Microtubule Binding The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12409305 Transient Osmotic Stress Facilitates Mutant Huntingtin Aggregation Neuroreport. Dec, 2002 | Pubmed ID: 12499864 Tau, Where Are We Now? Journal of Alzheimer's Disease : JAD. Oct, 2002 | Pubmed ID: 12446970 Axin Negatively Affects Tau Phosphorylation by Glycogen Synthase Kinase 3beta Journal of Neurochemistry. Nov, 2002 | Pubmed ID: 12421363 Identification of the N-terminal Functional Domains of Cdk5 by Molecular Truncation and Computer Modeling Proteins. Aug, 2002 | Pubmed ID: 12112670 Tissue Transglutaminase Differentially Modulates Apoptosis in a Stimuli-dependent Manner Journal of Neurochemistry. May, 2002 | Pubmed ID: 12065637 Cdk5 Phosphorylates P53 and Regulates Its Activity Journal of Neurochemistry. Apr, 2002 | Pubmed ID: 12064478 Direct, Activating Interaction Between Glycogen Synthase Kinase-3beta and P53 After DNA Damage Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12048243 Mutant Huntingtin Aggregates Do Not Sensitize Cells to Apoptotic Stressors FEBS Letters. Mar, 2002 | Pubmed ID: 11943195 Does Tissue Transglutaminase Play a Role in Huntington's Disease? Neurochemistry International. Jan, 2002 | Pubmed ID: 11738471 Tillämpningen av permanenta Mellanöstern Cerebral Artery Ligation i musen Gozde Colak1, Anthony J. Filiano2, Gail V.W. Johnson3 1Department of Pharmacology and Physiology, University of Rochester, 2Department of Neurology, University of Alabama at Birmingham, 3Departments of Anesthesiology, Pharmacology and Physiology, University of Rochester JoVE 3039 Medicine
Tillämpningen av permanenta Mellanöstern Cerebral Artery Ligation i musen Gozde Colak1, Anthony J. Filiano2, Gail V.W. Johnson3 1Department of Pharmacology and Physiology, University of Rochester, 2Department of Neurology, University of Alabama at Birmingham, 3Departments of Anesthesiology, Pharmacology and Physiology, University of Rochester JoVE 3039 Medicine