Geert Bultynck Department of Cellular and Molecular Medicine, Laboratory of Molecular and Cellular Signaling KU Leuven Biography Publications Institution JoVE Articles Geert Bultynck has not added a biography. If you are Geert Bultynck and would like to personalize this page please email our Author Liaison for assistance. Publications Endothelial Calcium Dynamics; Connexin Channels and Blood Brain Barrier Function Progress in Neurobiology. Jul, 2013 | Pubmed ID: 23851106 Regulation of Connexin- and Pannexin-based Channels by Post-translational Modifications Biology of the Cell / Under the Auspices of the European Cell Biology Organization. May, 2013 | Pubmed ID: 23718186 Peptides and Peptide-derived Molecules Targeting the Intracellular Domains of Cx43: Gap Junctions Versus Hemichannels Neuropharmacology. May, 2013 | Pubmed ID: 23664811 Curcumin Affects Proprotein Convertase Activity: Elucidation of the Molecular and Subcellular Mechanism Biochimica Et Biophysica Acta. Aug, 2013 | Pubmed ID: 23583304 MTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling PloS One. 2013 | Pubmed ID: 23565295 HA14-1, but Not the BH3 Mimetic ABT-737, Causes Ca2+ Dysregulation in Platelets and Human Cell Lines Haematologica. Apr, 2013 | Pubmed ID: 23403318 Regulation of Inositol 1,4,5-trisphosphate Receptors During Endoplasmic Reticulum Stress Biochimica Et Biophysica Acta. Jul, 2013 | Pubmed ID: 23380704 Negatively Charged Residues (Asp378 and Asp379) in the Last Ten Amino Acids of the C-terminal Tail of Cx43 Hemichannels Are Essential for Loop/tail Interactions Biochemical and Biophysical Research Communications. Mar, 2013 | Pubmed ID: 23376080 IP3, a Small Molecule with a Powerful Message Biochimica Et Biophysica Acta. Jul, 2013 | Pubmed ID: 23291251 Altered Ca(2+) Signaling in Cancer Cells: Proto-oncogenes and Tumor Suppressors Targeting IP3 Receptors Biochimica Et Biophysica Acta. Apr, 2013 | Pubmed ID: 23232185 Selective Inhibition of Cx43 Hemichannels by Gap19 and Its Impact on Myocardial Ischemia/reperfusion Injury Basic Research in Cardiology. Jan, 2013 | Pubmed ID: 23184389 The Selective BH4-domain Biology of Bcl-2-family Members: IP3Rs and Beyond Cellular and Molecular Life Sciences : CMLS. Apr, 2013 | Pubmed ID: 22955373 Paracrine Signaling Through Plasma Membrane Hemichannels Biochimica Et Biophysica Acta. Jan, 2013 | Pubmed ID: 22796188 Neuronal Overexpression of IP₃ Receptor 2 is Detrimental in Mutant SOD1 Mice Biochemical and Biophysical Research Communications. Dec, 2012 | Pubmed ID: 23131553 Profiling of the Bcl-2/Bcl-X(L)-binding Sites on Type 1 IP(3) Receptor Biochemical and Biophysical Research Communications. Nov, 2012 | Pubmed ID: 23058917 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Manipulating Connexin Communication Channels: Use of Peptidomimetics and the Translational Outputs The Journal of Membrane Biology. Aug, 2012 | Pubmed ID: 22886208 RhoA GTPase Switch Controls Cx43-hemichannel Activity Through the Contractile System PloS One. 2012 | Pubmed ID: 22860057 Low Extracellular Ca2+ Conditions Induce an Increase in Brain Endothelial Permeability That Involves Intercellular Ca2+ Waves Brain Research. Dec, 2012 | Pubmed ID: 22789903 Role of the Inositol 1,4,5-trisphosphate Receptor/Ca2+-release Channel in Autophagy Cell Communication and Signaling : CCS. 2012 | Pubmed ID: 22770472 Release of Gliotransmitters Through Astroglial Connexin 43 Hemichannels is Necessary for Fear Memory Consolidation in the Basolateral Amygdala FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2012 | Pubmed ID: 22665389 The Contractile System As a Negative Regulator of the Connexin 43 Hemichannel Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Jul, 2012 | Pubmed ID: 22375941 Connexin 43 Hemichannels Contribute to Cytoplasmic Ca2+ Oscillations by Providing a Bimodal Ca2+-dependent Ca2+ Entry Pathway The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22351781 The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22128171 Non-channel Functions of Connexins in Cell Growth and Cell Death Biochimica Et Biophysica Acta. Aug, 2012 | Pubmed ID: 21718687 Ins(1,4,5)P3 Receptor-mediated Ca2+ Signaling and Autophagy Induction Are Interrelated Autophagy. Dec, 2011 | Pubmed ID: 22082873 STIM1 As a Key Regulator for Ca2+ Homeostasis in Skeletal-muscle Development and Function Skeletal Muscle. 2011 | Pubmed ID: 21798093 Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood-brain Barrier Permeability Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Sep, 2011 | Pubmed ID: 21654699 Calcium and Connexin-based Intercellular Communication, a Deadly Catch? Cell Calcium. Sep, 2011 | Pubmed ID: 21621840 A Dual Role for Ca(2+) in Autophagy Regulation Cell Calcium. Sep, 2011 | Pubmed ID: 21571367 Endoplasmic-reticulum Calcium Depletion and Disease Cold Spring Harbor Perspectives in Biology. Jun, 2011 | Pubmed ID: 21441595 IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging Journal of Aging Research. 2011 | Pubmed ID: 21423550 Induction of Ca²+-driven Apoptosis in Chronic Lymphocytic Leukemia Cells by Peptide-mediated Disruption of Bcl-2-IP3 Receptor Interaction Blood. Mar, 2011 | Pubmed ID: 21193695 The IP(3) Receptor-mitochondria Connection in Apoptosis and Autophagy Biochimica Et Biophysica Acta. May, 2011 | Pubmed ID: 21146562 Development of Inositol-based Antagonists for the D-myo-inositol 1,4,5-trisphosphate Receptor Chemical Communications (Cambridge, England). Jan, 2011 | Pubmed ID: 20938532 Connexins: Sensors and Regulators of Cell Cycling Biochimica Et Biophysica Acta. Jan, 2011 | Pubmed ID: 20801193 Pannexin Channels in ATP Release and Beyond: an Unexpected Rendezvous at the Endoplasmic Reticulum Cellular Signalling. Feb, 2011 | Pubmed ID: 20688156 Unraveling the Role of Polycystin-2/inositol 1,4,5-trisphosphate Receptor Interaction in Ca Signaling Communicative & Integrative Biology. Nov, 2010 | Pubmed ID: 21331231 STIM1, but Not STIM2, is Required for Proper Agonist-induced Ca2+ Signaling Cell Calcium. Aug-Sep, 2010 | Pubmed ID: 20801505 Intramolecular Loop/tail Interactions Are Essential for Connexin 43-hemichannel Activity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2010 | Pubmed ID: 20634352 Polycystin-2 Activation by Inositol 1,4,5-trisphosphate-induced Ca2+ Release Requires Its Direct Association with the Inositol 1,4,5-trisphosphate Receptor in a Signaling Microdomain The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20375013 Intracellular Ca2+ Storage in Health and Disease: a Dynamic Equilibrium Cell Calcium. Apr, 2010 | Pubmed ID: 20189643 The BH4 Domain of Bcl-2 Inhibits ER Calcium Release and Apoptosis by Binding the Regulatory and Coupling Domain of the IP3 Receptor Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19706527 Pannexins, Distant Relatives of the Connexin Family with Specific Cellular Functions? BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2009 | Pubmed ID: 19644918 Regulation of Inositol 1,4,5-trisphosphate Receptor Type 1 Function During Oocyte Maturation by MPM-2 Phosphorylation Cell Calcium. Jul, 2009 | Pubmed ID: 19482353 Regioselective Deprotection of Orthobenzoates for the Synthesis of Inositol Phosphates Organic & Biomolecular Chemistry. Apr, 2009 | Pubmed ID: 19343261 Regulation of Inositol 1,4,5-trisphosphate-induced Ca2+ Release by Reversible Phosphorylation and Dephosphorylation Biochimica Et Biophysica Acta. Jun, 2009 | Pubmed ID: 19133301 Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals Molecular Cell. Jul, 2008 | Pubmed ID: 18657507 The Myosin II ATPase Inhibitor Blebbistatin Prevents Thrombin-induced Inhibition of Intercellular Calcium Wave Propagation in Corneal Endothelial Cells Investigative Ophthalmology & Visual Science. Nov, 2008 | Pubmed ID: 18614806 Caspase-3-truncated Type 1 Inositol 1,4,5-trisphosphate Receptor Enhances Intracellular Ca2+ Leak and Disturbs Ca2+ Signalling Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Jan, 2008 | Pubmed ID: 17868032 The Tumor Suppressor EIF3e Mediates Calcium-dependent Internalization of the L-type Calcium Channel CaV1.2 Neuron. Aug, 2007 | Pubmed ID: 17698014 Synthesis and Biological Action of Novel 4-position-modified Derivatives of D-myo-inositol 1,4,5-trisphosphate The Journal of Organic Chemistry. Jul, 2007 | Pubmed ID: 17585817 Slm1 and Slm2 Are Novel Substrates of the Calcineurin Phosphatase Required for Heat Stress-induced Endocytosis of the Yeast Uracil Permease Molecular and Cellular Biology. Jun, 2006 | Pubmed ID: 16738335 The Suppressor Domain of Inositol 1,4,5-trisphosphate Receptor Plays an Essential Role in the Protection Against Apoptosis Cell Calcium. Apr, 2006 | Pubmed ID: 16458354 The Protein Phosphatase 2A Phosphatase Activator is a Novel Peptidyl-prolyl Cis/trans-isomerase The Journal of Biological Chemistry. Mar, 2006 | Pubmed ID: 16380387 Suramin and Disulfonated Stilbene Derivatives Stimulate the Ca2+-induced Ca2+ -release Mechanism in A7r5 Cells Molecular Pharmacology. Jul, 2005 | Pubmed ID: 15851651 Caspase-3-induced Truncation of Type 1 Inositol Trisphosphate Receptor Accelerates Apoptotic Cell Death and Induces Inositol Trisphosphate-independent Calcium Release During Apoptosis The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15284241 The N-terminal Ca2+-independent Calmodulin-binding Site on the Inositol 1,4,5-trisphosphate Receptor is Responsible for Calmodulin Inhibition, Even Though This Inhibition Requires Ca2+ Molecular Pharmacology. Aug, 2004 | Pubmed ID: 15266018 Thimerosal Stimulates Ca2+ Flux Through Inositol 1,4,5-trisphosphate Receptor Type 1, but Not Type 3, Via Modulation of an Isoform-specific Ca2+-dependent Intramolecular Interaction The Biochemical Journal. Jul, 2004 | Pubmed ID: 15015936 The 12 KDa FK506-binding Protein, FKBP12, Modulates the Ca(2+)-flux Properties of the Type-3 Ryanodine Receptor Journal of Cell Science. Mar, 2004 | Pubmed ID: 14970260 Regulation of InsP3 Receptor Activity by Neuronal Ca2+-binding Proteins The EMBO Journal. Jan, 2004 | Pubmed ID: 14685260 The Role of Calmodulin for Inositol 1,4,5-trisphosphate Receptor Function Biochimica Et Biophysica Acta. Nov, 2002 | Pubmed ID: 12445455 تحفيز الميكانيكية التي يسببها الكالسيوم انتشار الموجات في الخلية monolayers: مثال من الأبقار الخلايا البطانية القرنية Catheleyne D'hondt1, Bernard Himpens1, Geert Bultynck1 1Department of Cellular and Molecular Medicine, Laboratory of Molecular and Cellular Signaling, KU Leuven JoVE 50443 Biology
تحفيز الميكانيكية التي يسببها الكالسيوم انتشار الموجات في الخلية monolayers: مثال من الأبقار الخلايا البطانية القرنية Catheleyne D'hondt1, Bernard Himpens1, Geert Bultynck1 1Department of Cellular and Molecular Medicine, Laboratory of Molecular and Cellular Signaling, KU Leuven JoVE 50443 Biology