George K. Gittes Biography Publications JoVE Articles George K. Gittes has not added a biography. If you are George K. Gittes and would like to personalize this page please email our Author Liaison for assistance. Publications Intra-Amniotic Sildenafil and Rosiglitazone Late in Gestation Ameliorate the Pulmonary Hypertension Phenotype in Congenital Diaphragmatic Hernia Journal of Pediatric Surgery. Jan, 2024 | Pubmed ID: 38350773 Intra-amniotic Sildenafil Treatment Improves Lung Blood Flow and Pulmonary Hypertension in Congenital Diaphragmatic Hernia Rats Frontiers in Bioengineering and Biotechnology. 2023 | Pubmed ID: 37545896 Time-dependent Effects of Endogenous Hyperglucagonemia on Glucose Homeostasis and Hepatic Glucagon Action JCI Insight. Jun, 2023 | Pubmed ID: 37140984 Intra-amniotic Sildenafil Administration in Rabbits: Safety, Pharmacokinetics, Organ Distribution and Histologic Evaluation Toxicology and Applied Pharmacology. Jun, 2023 | Pubmed ID: 37080362 A Neurodevelopmental Epigenetic Programme Mediated by SMARCD3-DAB1-Reelin Signalling is Hijacked to Promote Medulloblastoma Metastasis Nature Cell Biology. Mar, 2023 | Pubmed ID: 36849558 Bone-marrow Derived Cells Do Not Contribute to New Beta-cells in the Inflamed Pancreas Frontiers in Immunology. 2023 | Pubmed ID: 36733483 Ionizable Lipid Nanoparticles Deliver MRNA to Pancreatic β Cells Via Macrophage-mediated Gene Transfer Science Advances. Jan, 2023 | Pubmed ID: 36706177 Polarized Macrophages Promote Gestational Beta Cell Growth Through Extracellular Signal-regulated Kinase 5 Signalling Diabetes, Obesity & Metabolism. Sep, 2022 | Pubmed ID: 35546452 Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 () Mutants Frontiers in Physiology. 2021 | Pubmed ID: 34366878 Chitinase-3-like 1 Protein Complexes Modulate Macrophage-mediated Immune Suppression in Glioblastoma The Journal of Clinical Investigation. Aug, 2021 | Pubmed ID: 34228644 Insulin-positive Ductal Cells Do Not Migrate into Preexisting Islets During Pregnancy Experimental & Molecular Medicine. Apr, 2021 | Pubmed ID: 33820959 Chemical Pancreatectomy Treats Chronic Pancreatitis While Preserving Endocrine Function in Preclinical Models The Journal of Clinical Investigation. Feb, 2021 | Pubmed ID: 33351784 Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia Diabetes. Feb, 2021 | Pubmed ID: 33239450 Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality Frontiers in Physiology. 2020 | Pubmed ID: 33192543 Intra-Amniotic Sildenafil Treatment Promotes Lung Growth and Attenuates Vascular Remodeling in an Experimental Model of Congenital Diaphragmatic Hernia Fetal Diagnosis and Therapy. 2020 | Pubmed ID: 32663823 Placental Growth Factor in Beta Cells Plays an Essential Role in Gestational Beta-cell Growth BMJ Open Diabetes Research & Care. 03, 2020 | Pubmed ID: 32144129 SMAD7 Enhances Adult β-cell Proliferation Without Significantly Affecting β-cell Function in Mice The Journal of Biological Chemistry. 04, 2020 | Pubmed ID: 32122971 Cellular Autophagy in Cells Plays a Role in the Maintenance of Islet Architecture Journal of the Endocrine Society. Nov, 2019 | Pubmed ID: 31620668 Evidence of a Developmental Origin for β-cell Heterogeneity Using a Dual Lineage-tracing Technology Development (Cambridge, England). 06, 2019 | Pubmed ID: 31160417 Islet α-cell Inflammation Induced By NF-κB Inducing Kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice Theranostics. 2018 | Pubmed ID: 30613274 Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes Cell Stem Cell. 01, 2018 | Pubmed ID: 29304344 Autophagy Protects Pancreatic Beta Cell Mass and Function in the Setting of a High-fat and High-glucose Diet Scientific Reports. 11, 2017 | Pubmed ID: 29180700 Loss of MTORC1 Signaling Alters Pancreatic α Cell Mass and Impairs Glucagon Secretion The Journal of Clinical Investigation. Dec, 2017 | Pubmed ID: 29106387 Gcg Knockin Mice As a Tool for Genetic Manipulation in Pancreatic Alpha Cells Diabetologia. 12, 2017 | Pubmed ID: 28884202 GLP-1/Exendin-4 Induces β-cell Proliferation Via the Epidermal Growth Factor Receptor Scientific Reports. 08, 2017 | Pubmed ID: 28831150 SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes Diabetes. 10, 2017 | Pubmed ID: 28775125 Targeted Inhibition of Pancreatic Acinar Cell Calcineurin is a Novel Strategy to Prevent Post-ERCP Pancreatitis Cellular and Molecular Gastroenterology and Hepatology. Jan, 2017 | Pubmed ID: 28090570 Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice The Journal of Biological Chemistry. 02, 2017 | Pubmed ID: 28057752 Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice The Journal of Biological Chemistry. Oct, 2016 | Pubmed ID: 27587395 A Synopsis of Factors Regulating Beta Cell Development and Beta Cell Mass Cellular and Molecular Life Sciences : CMLS. 10, 2016 | Pubmed ID: 27105622 Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects Against Experimental Murine Colitis The Journal of Biological Chemistry. May, 2016 | Pubmed ID: 26969166 PNA Lectin for Purifying Mouse Acinar Cells from the Inflamed Pancreas Scientific Reports. Feb, 2016 | Pubmed ID: 26884345 Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation Endocrinology. Apr, 2016 | Pubmed ID: 26872091 Multiple Roles for TGFβ Receptor Type II in Regulating the Pancreatic Response in Acute Pancreatitis The Journal of Pathology. Apr, 2016 | Pubmed ID: 26608971 Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells Endocrinology. Jan, 2016 | Pubmed ID: 26505114 The Role of ARF6 in Biliary Atresia PloS One. 2015 | Pubmed ID: 26379158 Defective Parasympathetic Innervation is Associated with Airway Branching Abnormalities in Experimental CDH American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2015 | Pubmed ID: 25934671 Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation Stem Cells Translational Medicine. Jun, 2015 | Pubmed ID: 25900729 Dynamic Imaging of Pancreatic Nuclear Factor κB (NF-κB) Activation in Live Mice Using Adeno-associated Virus (AAV) Infusion and Bioluminescence The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25802340 Pancreatic Cell Tracing, Lineage Tagging and Targeted Genetic Manipulations in Multiple Cell Types Using Pancreatic Ductal Infusion of Adeno-associated Viral Vectors And/or Cell-tagging Dyes Nature Protocols. Dec, 2014 | Pubmed ID: 25356582 Renal Blood Flow and Oxygenation Drive Nephron Progenitor Differentiation American Journal of Physiology. Renal Physiology. Aug, 2014 | Pubmed ID: 24920757 M2 Macrophages Promote Beta-cell Proliferation by Up-regulation of SMAD7 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24639504 Pancreatic Duct Cells As a Source of VEGF in Mice Diabetologia. May, 2014 | Pubmed ID: 24535231 Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis The Journal of Biological Chemistry. Apr, 2014 | Pubmed ID: 24519940 α-Cells Are Dispensable in Postnatal Morphogenesis and Maturation of Mouse Pancreatic Islets American Journal of Physiology. Endocrinology and Metabolism. Oct, 2013 | Pubmed ID: 23982158 Neurogenin3 Activation is Not Sufficient to Direct Duct-to-beta Cell Transdifferentiation in the Adult Pancreas The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23867457 No Evidence for β Cell Neogenesis in Murine Adult Pancreas The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23619362 Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells As a Regulator of Beta Cell Mass The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23378532 TGFβ Receptor Signaling is Essential for Inflammation-induced but Not β-cell Workload-induced β-cell Proliferation Diabetes. Apr, 2013 | Pubmed ID: 23248173 Intestinal Epithelial Toll-like Receptor 4 Regulates Goblet Cell Development and is Required for Necrotizing Enterocolitis in Mice Gastroenterology. Sep, 2012 | Pubmed ID: 22796522 Amniotic Fluid Inhibits Toll-like Receptor 4 Signaling in the Fetal and Neonatal Intestinal Epithelium Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22733781 Defective Pulmonary Innervation and Autonomic Imbalance in Congenital Diaphragmatic Hernia American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2012 | Pubmed ID: 22114150 Assessing Vesicoureteral Reflux in Live Inbred Mice Via Ultrasound with a Microbubble Contrast Agent American Journal of Physiology. Renal Physiology. May, 2011 | Pubmed ID: 21325495 Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19109197 Developmental Biology of the Pancreas: a Comprehensive Review Developmental Biology. Feb, 2009 | Pubmed ID: 19013144 TGF-beta Isoform Signaling Regulates Secondary Transition and Mesenchymal-induced Endocrine Development in the Embryonic Mouse Pancreas Developmental Biology. May, 2007 | Pubmed ID: 17418116 A Streamlined and Standardized Procedure for Generating High-Titer, High-Quality Adeno-Associated Virus Vectors Utilizing a Cell Factory Platform JoVE 66741 Bioengineering Infusion av bukspottskörteln: En effektiv och selektiv metod för läkemedels- och virusleverans Joseph C. Fusco*1, Chen Congde*2, Xiangwei Xiao1, Krishna Prasadan1, David Ricks1, George K. Gittes1 1Department of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, 2Department of Pediatric Surgery, The 2nd Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University JoVE 55332 Medicine
A Streamlined and Standardized Procedure for Generating High-Titer, High-Quality Adeno-Associated Virus Vectors Utilizing a Cell Factory Platform JoVE 66741 Bioengineering
Infusion av bukspottskörteln: En effektiv och selektiv metod för läkemedels- och virusleverans Joseph C. Fusco*1, Chen Congde*2, Xiangwei Xiao1, Krishna Prasadan1, David Ricks1, George K. Gittes1 1Department of Pediatric Surgery, Children's Hospital of Pittsburgh of UPMC, 2Department of Pediatric Surgery, The 2nd Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University JoVE 55332 Medicine