Glen F. Tibbits Department of Biomedical Physiology and Kinesiology Simon Fraser University Biography Publications Institution JoVE Articles Glen F. Tibbits has not added a biography. If you are Glen F. Tibbits and would like to personalize this page please email our Author Liaison for assistance. Publications Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes to Understand the Mechanisms Driving Cardiomyocyte Maturation Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 36061558 The Effect of Mg on Ca Binding to Cardiac Troponin C in Hypertrophic Cardiomyopathy Associated TNNC1 Variants The FEBS Journal. Jul, 2022 | Pubmed ID: 35838319 RARG S427L Attenuates the DNA Repair Response to Doxorubicin in Induced Pluripotent Stem Cell-derived Cardiomyocytes Stem Cell Reports. 04, 2022 | Pubmed ID: 35364012 Investigating Inherited Arrhythmias Using HiPSC-derived Cardiomyocytes Methods (San Diego, Calif.). 07, 2022 | Pubmed ID: 34197925 Atrial-specific HiPSC-derived Cardiomyocytes in Drug Discovery and Disease Modeling Methods (San Diego, Calif.). 07, 2022 | Pubmed ID: 34144175 Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T () Variant I79N Frontiers in Cell and Developmental Biology. 2021 | Pubmed ID: 34977031 Using HiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia Current Protocols. Dec, 2021 | Pubmed ID: 34958715 Pediatric Catecholaminergic Polymorphic Ventricular Tachycardia: A Translational Perspective for the Clinician-Scientist International Journal of Molecular Sciences. Aug, 2021 | Pubmed ID: 34502196 Electrophysiological Characterization of the HERG R56Q LQTS Variant and Targeted Rescue by the Activator RPR260243 The Journal of General Physiology. 10, 2021 | Pubmed ID: 34398210 Binding of Calcium and Magnesium to Human Cardiac Troponin C The Journal of Biological Chemistry. Jan-Jun, 2021 | Pubmed ID: 33548225 Drug Screening Platform Using Human Induced Pluripotent Stem Cell-derived Atrial Cardiomyocytes and Optical Mapping Stem Cells Translational Medicine. 01, 2021 | Pubmed ID: 32927497 Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome Frontiers in Physiology. 2020 | Pubmed ID: 33519527 Variation in RARG Increases Susceptibility to Doxorubicin-induced Cardiotoxicity in Patient Specific Induced Pluripotent Stem Cell-derived Cardiomyocytes Scientific Reports. 06, 2020 | Pubmed ID: 32587261 The HERG Channel Activator, RPR260243, Enhances Protective Current Early in the Refractory Period Reducing Arrhythmogenicity in Zebrafish Hearts American Journal of Physiology. Heart and Circulatory Physiology. 08, 2020 | Pubmed ID: 32559136 Physiological Phenotyping of the Adult Zebrafish Heart Marine Genomics. Feb, 2020 | Pubmed ID: 31451352 Investigating the Utility of Adult Zebrafish Ex Vivo Whole Hearts to Pharmacologically Screen HERG Channel Activator Compounds American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 12, 2019 | Pubmed ID: 31664867 Ibrutinib Displays Atrial-Specific Toxicity in Human Stem Cell-Derived Cardiomyocytes Stem Cell Reports. 05, 2019 | Pubmed ID: 31031187 In Vitro Analyses of Suspected Arrhythmogenic Thin Filament Variants As a Cause of Sudden Cardiac Death in Infants Proceedings of the National Academy of Sciences of the United States of America. 04, 2019 | Pubmed ID: 30886088 In Vivo Characterization of Doxycycline-mediated Protection of Aortic Function and Structure in a Mouse Model of Marfan Syndrome-associated Aortic Aneurysm Scientific Reports. 02, 2019 | Pubmed ID: 30765726 ROCK2 Promotes Ryanodine Receptor Phosphorylation and Arrhythmic Calcium Release in Diabetic Cardiomyocytes International Journal of Cardiology. Apr, 2019 | Pubmed ID: 30728103 Zebrafish As a Model of Mammalian Cardiac Function: Optically Mapping the Interplay of Temperature and Rate on Voltage and Calcium Dynamics Progress in Biophysics and Molecular Biology. 10, 2018 | Pubmed ID: 30017908 Functional Characterization of a Novel HERG Variant in a Family with Recurrent Sudden Infant Death Syndrome: Retracting a Genetic Diagnosis Forensic Science International. Mar, 2018 | Pubmed ID: 29331839 PH Recovery from a Proton Load in Rat Cardiomyocytes: Effects of Chronic Exercise American Journal of Physiology. Heart and Circulatory Physiology. 02, 2018 | Pubmed ID: 29101173 Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis Circulation. Cardiovascular Genetics. Aug, 2017 | Pubmed ID: 28807990 Modeling Atrial Fibrillation Using Human Embryonic Stem Cell-Derived Atrial Tissue Scientific Reports. 07, 2017 | Pubmed ID: 28706272 Changes in the Dynamics of the Cardiac Troponin C Molecule Explain the Effects of Ca-sensitizing Mutations The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28533433 Aortic and Cardiac Structure and Function Using High-Resolution Echocardiography and Optical Coherence Tomography in a Mouse Model of Marfan Syndrome PloS One. 2016 | Pubmed ID: 27824871 The Zebrafish Heart As a Model of Mammalian Cardiac Function Reviews of Physiology, Biochemistry and Pharmacology. 2016 | Pubmed ID: 27538987 Ischemia-reperfusion Destabilizes Rhythmicity in Immature Atrioventricular Pacemakers: A Predisposing Factor for Postoperative Arrhythmias in Neonate Rabbits Heart Rhythm. 12, 2016 | Pubmed ID: 27451283 Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation And ITC Biophysical Journal. Jul, 2016 | Pubmed ID: 27410732 Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC Genome Biology and Evolution. Apr, 2016 | Pubmed ID: 26979795 Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio Rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography PloS One. 2016 | Pubmed ID: 26730947 Construction and Use of a Zebrafish Heart Voltage and Calcium Optical Mapping System, with Integrated Electrocardiogram and Programmable Electrical Stimulation American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2015 | Pubmed ID: 25740339 Morphological Phenotyping of Mouse Hearts Using Optical Coherence Tomography Journal of Biomedical Optics. 2014 | Pubmed ID: 25393967 Optical Mapping of the Electrical Activity of Isolated Adult Zebrafish Hearts: Acute Effects of Temperature American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2014 | Pubmed ID: 24671241 Phenotype-dependent Role of the L-type Calcium Current in Embryonic Stem Cell Derived Cardiomyocytes American Journal of Stem Cells. 2014 | Pubmed ID: 24660113 Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-dependent Activation and Functional Effects of Phosphomimetic Troponin I* PloS One. 2013 | Pubmed ID: 24260207 Adult Teleost Heart Expresses Two Distinct Troponin C Paralogs: Cardiac TnC and a Novel and Teleost-specific SsTnC in a Chamber- and Temperature-dependent Manner Physiological Genomics. Sep, 2013 | Pubmed ID: 23881286 The Structure of Cardiac Troponin C Regulatory Domain with Bound Cd2+ Reveals a Closed Conformation and Unique Ion Coordination Acta Crystallographica. Section D, Biological Crystallography. May, 2013 | Pubmed ID: 23633581 Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation Journal of Molecular Biology. Oct, 2011 | Pubmed ID: 21920370 Colocalization of Voltage-gated Na+ Channels with the Na+/Ca2+ Exchanger in Rabbit Cardiomyocytes During Development American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2011 | Pubmed ID: 20971761 Calcium Handling in Zebrafish Ventricular Myocytes American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jan, 2011 | Pubmed ID: 20926764 Mechanistic Basis for LQT1 Caused by S3 Mutations in the KCNQ1 Subunit of IKs The Journal of General Physiology. May, 2010 | Pubmed ID: 20421371 Distribution Patterns of the Na+-Ca2+ Exchanger and Caveolin-3 in Developing Rabbit Cardiomyocytes Cell Calcium. Apr, 2009 | Pubmed ID: 19250668 Characterization of Zebrafish (Danio Rerio) NCX4: a Novel NCX with Distinct Electrophysiological Properties American Journal of Physiology. Cell Physiology. Jan, 2009 | Pubmed ID: 18971388 Gene Structure Evolution of the Na+-Ca2+ Exchanger (NCX) Family BMC Evolutionary Biology. Apr, 2008 | Pubmed ID: 18447948 Familial Hypertrophic Cardiomyopathy-related Cardiac Troponin C Mutation L29Q Affects Ca2+ Binding and Myofilament Contractility Physiological Genomics. Apr, 2008 | Pubmed ID: 18285522 Ontogeny of Ca2+-induced Ca2+ Release in Rabbit Ventricular Myocytes American Journal of Physiology. Cell Physiology. Feb, 2008 | Pubmed ID: 18094144 Hyperpolarization-activated Cyclic Nucleotide-modulated 'HCN' Channels Confer Regular and Faster Rhythmicity to Beating Mouse Embryonic Stem Cells The Journal of Physiology. Feb, 2008 | Pubmed ID: 18033814 Real-time Monitoring of Intracellular Calcium Dynamic Mobilization of a Single Cardiomyocyte in a Microfluidic Chip Pertaining to Drug Discovery Electrophoresis. Dec, 2007 | Pubmed ID: 18072214 SR Ca2+ Refilling Upon Depletion and SR Ca2+ Uptake Rates During Development in Rabbit Ventricular Myocytes American Journal of Physiology. Cell Physiology. Dec, 2007 | Pubmed ID: 17928539 Three-dimensional Distribution of Cardiac Na+-Ca2+ Exchanger and Ryanodine Receptor During Development Biophysical Journal. Oct, 2007 | Pubmed ID: 17557789 L-type Ca2+ Channel Function and Expression in Neonatal Rabbit Ventricular Myocytes American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2006 | Pubmed ID: 16339821 CDNA Cloning and Expression of the Cardiac Na+/Ca2+ Exchanger from Mozambique Tilapia (Oreochromis Mossambicus) Reveal a Teleost Membrane Transporter with Mammalian Temperature Dependence The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15937330 Phylogeny of Na+/Ca2+ Exchanger (NCX) Genes from Genomic Data Identifies New Gene Duplications and a New Family Member in Fish Species Physiological Genomics. Apr, 2005 | Pubmed ID: 15741504 Na+/Ca2+ Exchange Activity in Neonatal Rabbit Ventricular Myocytes American Journal of Physiology. Cell Physiology. Jan, 2005 | Pubmed ID: 15317663 Deconvolution of Confocal Images of Dihydropyridine and Ryanodine Receptors in Developing Cardiomyocytes Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2004 | Pubmed ID: 15064297 Effect of Temperature and the F27W Mutation on the Ca2+ Activated Structural Transition of Trout Cardiac Troponin C Biochemistry. Jun, 2003 | Pubmed ID: 12767223 Sequence Mutations in Teleost Cardiac Troponin C That Are Permissive of High Ca2+ Affinity of Site II American Journal of Physiology. Cell Physiology. May, 2003 | Pubmed ID: 12519747 Temperature Dependence of Cardiac Na+/Ca2+ Exchanger Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12502547 Determinants of Cardiac Na(+)/Ca(2+) Exchanger Temperature Dependence: NH(2)-terminal Transmembrane Segments American Journal of Physiology. Cell Physiology. Aug, 2002 | Pubmed ID: 12107061 Beating the Cold: the Functional Evolution of Troponin C in Teleost Fish Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Aug, 2002 | Pubmed ID: 12095861 Ontogeny of Excitation-contraction Coupling in the Mammalian Heart Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. Aug, 2002 | Pubmed ID: 12095856 CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts Kyle E. Simpson1, Shoaib Faizi1, Ravichandra Venkateshappa1, Mandy Yip1, Raj Johal1, Damon Poburko1, Yen May Cheng1, Diana Hunter1, Eric Lin1, Glen F. Tibbits1, Thomas W. Claydon1 1Department of Biomedical Physiology and Kinesiology, Simon Fraser University JoVE 64209 Biology
CRISPR-Cas9-Mediated Precise Knock-In Edits in Zebrafish Hearts Kyle E. Simpson1, Shoaib Faizi1, Ravichandra Venkateshappa1, Mandy Yip1, Raj Johal1, Damon Poburko1, Yen May Cheng1, Diana Hunter1, Eric Lin1, Glen F. Tibbits1, Thomas W. Claydon1 1Department of Biomedical Physiology and Kinesiology, Simon Fraser University JoVE 64209 Biology