Hamid I. Akbarali Pharmacology and Toxicology Virginia Commonwealth University Biography Publications Institution JoVE Articles Hamid I. Akbarali has not added a biography. If you are Hamid I. Akbarali and would like to personalize this page please email our Author Liaison for assistance. Publications Sepiapterin Ameliorates Chemically-induced Murine Colitis and Azoxymethane-induced Colon Cancer The Journal of Pharmacology and Experimental Therapeutics. Aug, 2013 | Pubmed ID: 23912334 Electrophysiological Characteristics of Enteric Neurons Isolated from the Immortomouse Digestive Diseases and Sciences. Jun, 2013 | Pubmed ID: 23371009 Hydrogen Sulfide As an Allosteric Modulator of ATP-sensitive Potassium Channels in Colonic Inflammation Molecular Pharmacology. Jan, 2013 | Pubmed ID: 23115325 Novel Insights on the Effect of Nicotine in a Murine Colitis Model The Journal of Pharmacology and Experimental Therapeutics. Jan, 2013 | Pubmed ID: 23115221 Design, Synthesis, and Biological Evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan Derivatives As Peripheral Selective μ Opioid Receptor Agents Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23116124 Morphine Decreases Enteric Neuron Excitability Via Inhibition of Sodium Channels PloS One. 2012 | Pubmed ID: 23028881 Evidence for the Putative Cannabinoid Receptor (GPR55)-mediated Inhibitory Effects on Intestinal Contractility in Mice Pharmacology. 2012 | Pubmed ID: 22759743 6β-N-heterocyclic Substituted Naltrexamine Derivative NAP As a Potential Lead to Develop Peripheral Mu Opioid Receptor Selective Antagonists Bioorganic & Medicinal Chemistry Letters. Jul, 2012 | Pubmed ID: 22683223 Differences in the Characteristics of Tolerance to μ-opioid Receptor Agonists in the Colon from Wild Type and β-arrestin2 Knockout Mice European Journal of Pharmacology. Jun, 2012 | Pubmed ID: 22521552 Up-regulation of Brain-derived Neurotrophic Factor in Primary Afferent Pathway Regulates Colon-to-bladder Cross-sensitization in Rat Journal of Neuroinflammation. 2012 | Pubmed ID: 22335898 Nicotine Suppresses Hyperexcitability of Colonic Sensory Neurons and Visceral Hypersensivity in Mouse Model of Colonic Inflammation American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2012 | Pubmed ID: 22241859 Opioid-induced Hypernociception is Associated with Hyperexcitability and Altered Tetrodotoxin-resistant Na+ Channel Function of Dorsal Root Ganglia American Journal of Physiology. Cell Physiology. Apr, 2012 | Pubmed ID: 22189556 The Role of β-arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract The Journal of Pharmacology and Experimental Therapeutics. Mar, 2012 | Pubmed ID: 22129596 Blockade of Endocannabinoid Hydrolytic Enzymes Attenuates Precipitated Opioid Withdrawal Symptoms in Mice The Journal of Pharmacology and Experimental Therapeutics. Oct, 2011 | Pubmed ID: 21719468 {alpha}7-nAChR-mediated Suppression of Hyperexcitability of Colonic Dorsal Root Ganglia Neurons in Experimental Colitis American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2010 | Pubmed ID: 20595621 Colonic Inflammation Alters Src Kinase-dependent Gating Properties of Single Ca2+ Channels Via Tyrosine Nitration American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2010 | Pubmed ID: 20378833 Morphine Tolerance in the Mouse Ileum and Colon The Journal of Pharmacology and Experimental Therapeutics. Nov, 2008 | Pubmed ID: 18682567 Denitration of L-type Calcium Channel FEBS Letters. Sep, 2008 | Pubmed ID: 18675806 COOH-terminal Association of Human Smooth Muscle Calcium Channel Ca(v)1.2b with Src Kinase Protein Binding Domains: Effect of Nitrotyrosylation American Journal of Physiology. Cell Physiology. Dec, 2007 | Pubmed ID: 17942635 Nitrotyrosylation of Ca2+ Channels Prevents C-Src Kinase Regulation of Colonic Smooth Muscle Contractility in Experimental Colitis The Journal of Pharmacology and Experimental Therapeutics. Sep, 2007 | Pubmed ID: 17551092 The Effects of Sevoflurane and Propofol on QT Interval and Heterologously Expressed Human Ether-a-go-go Related Gene Currents in Xenopus Oocytes Anesthesia and Analgesia. Jan, 2006 | Pubmed ID: 16368812 Cross-organ Sensitization of Lumbosacral Spinal Neurons Receiving Urinary Bladder Input in Rats with Inflamed Colon Gastroenterology. Dec, 2005 | Pubmed ID: 16344065 PKD2 Functions As an Epidermal Growth Factor-activated Plasma Membrane Channel Molecular and Cellular Biology. Sep, 2005 | Pubmed ID: 16135816 Signal-transduction Pathways That Regulate Smooth Muscle Function. II. Receptor-ion Channel Coupling Mechanisms in Gastrointestinal Smooth Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2005 | Pubmed ID: 15764809 Calcium Carbonate Antacids Alter Esophageal Motility in Heartburn Sufferers Digestive Diseases and Sciences. Nov-Dec, 2004 | Pubmed ID: 15628717 Colonic Inflammation Increases Na+ Currents in Bladder Sensory Neurons Neuroreport. Dec, 2004 | Pubmed ID: 15570160 Inflammation-induced "channelopathies" in the Gastrointestinal Smooth Muscle Cell Biochemistry and Biophysics. 2004 | Pubmed ID: 15475616 Protein and Gene Expression of Ca2+ Channel Isoforms in Murine Colon: Effect of Inflammation Pflügers Archiv : European Journal of Physiology. Dec, 2004 | Pubmed ID: 15452714 Modulation of TRPV1 by Nonreceptor Tyrosine Kinase, C-Src Kinase American Journal of Physiology. Cell Physiology. Aug, 2004 | Pubmed ID: 15084474 Altered Gene Expression and Increased Bursting Activity of Colonic Smooth Muscle ATP-sensitive K+ Channels in Experimental Colitis American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2004 | Pubmed ID: 14962845 ERG K+ Currents Regulate Pacemaker Activity in ICC American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2003 | Pubmed ID: 12958021 Cloning and Functional Characterization of the Smooth Muscle Ether-a-go-go-related Gene K+ Channel. Potential Role of a Conserved Amino Acid Substitution in the S4 Region The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12427763 Fenamate-induced Enhancement of Heterologously Expressed HERG Currents in Xenopus Oocytes European Journal of Pharmacology. Oct, 2002 | Pubmed ID: 12359267 Coupling of M2 Muscarinic Receptor to L-type Ca Channel Via C-src Kinase in Rabbit Colonic Circular Smooth Muscle Gastroenterology. Sep, 2002 | Pubmed ID: 12198709 Bir Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University JoVE 50688 Neuroscience
Bir Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University JoVE 50688 Neuroscience