Hanjoong Jo Department of Biomedical Engineering Emory University and Georgia Tech Biography Publications Institution JoVE Articles Hanjoong Jo Dr. Hanjoong Jo is Wallace Coulter Distinguished Chair Professor and Associate Chair in Wallace Coulter Department of Biomedical Engineering (BME) at Emory University and Georgia Tech and Professor of Medicine at Emory University. He directs the Cardiovascular Mechanobiology, Therapeutics, and Nanomedicine Lab. His lab studies the mechanisms by which the mechanical force of blood flow regulates vascular endothelial function, which leads to atherosclerosis and aortic valve disease. Based on the mechanobiological studies, his lab develops novel therapeutics by targeting flow-sensitive genes/proteins and nanotechnology for targeted therapeutics delivery to treat cardiovascular disease safely and effectively. He has published >200 peer-reviewed papers and written three books as an editor. He is an elected fellow of the American Association for Advancement of Science, the Biomedical Engineering Society, the American Institute of Medical and Biological Engineering, the American Heart Association, and the American Physiological Society. Publications Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells Metabolites. Sep, 2021 | Pubmed ID: 34564456 Very Late Vasomotor Responses and Gene Expression with Bioresorbable Scaffolds and Metallic Drug-eluting Stents Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions. Oct, 2021 | Pubmed ID: 34164905 Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino Ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide Advanced Healthcare Materials. 08, 2021 | Pubmed ID: 33448151 Recent Advances in Nanomaterials for Therapy and Diagnosis for Atherosclerosis Advanced Drug Delivery Reviews. 03, 2021 | Pubmed ID: 33428994 Deletion of NoxO1 Limits Atherosclerosis Development in Female Mice Redox Biology. 10, 2020 | Pubmed ID: 32949971 Conditional Deoxyribozyme-Nanoparticle Conjugates for MiRNA-Triggered Gene Regulation ACS Applied Materials & Interfaces. Aug, 2020 | Pubmed ID: 32803952 MiR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification Annals of Biomedical Engineering. Apr, 2019 | Pubmed ID: 30671754 Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) Via Loss of MiR-483-3p, Inducing Aortic Valve Calcification by the PVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. 03, 2019 | Pubmed ID: 30602302 Role of Flow-sensitive MicroRNAs and Long Noncoding RNAs in Vascular Dysfunction and Atherosclerosis Vascular Pharmacology. 03, 2019 | Pubmed ID: 30300747 ZBTB46 is a Shear-sensitive Transcription Factor Inhibiting Endothelial Cell Proliferation Via Gene Expression Regulation of Cell Cycle Proteins Laboratory Investigation; a Journal of Technical Methods and Pathology. 03, 2019 | Pubmed ID: 29884909 Oxidized Phospholipids Regulate Amino Acid Metabolism Through MTHFD2 to Facilitate Nucleotide Release in Endothelial Cells Nature Communications. 06, 2018 | Pubmed ID: 29895827 3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography Theranostics. Month, 2018 | Pubmed ID: 29721067 Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin Arteriosclerosis, Thrombosis, and Vascular Biology. 02, 2018 | Pubmed ID: 29269512 Mechanosensitive MicroRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3 Cardiovascular Engineering and Technology. 06, 2018 | Pubmed ID: 28236165 Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families Scientific Reports. 12, 2017 | Pubmed ID: 29222525 Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28882872 Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1 Circulation. Sep, 2017 | Pubmed ID: 28778947 Accelerated Atherosclerosis Development in C57Bl6 Mice by Overexpressing AAV-mediated PCSK9 and Partial Carotid Ligation Laboratory Investigation; a Journal of Technical Methods and Pathology. 08, 2017 | Pubmed ID: 28504688 KLF2 and KLF4 Control Endothelial Identity and Vascular Integrity JCI Insight. Feb, 2017 | Pubmed ID: 28239661 Functional Screening of Mammalian Mechanosensitive Genes Using Drosophila RNAi Library- Smarcd3/Bap60 is a Mechanosensitive Pro-inflammatory Gene Scientific Reports. 11, 2016 | Pubmed ID: 27819340 Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells Scientific Reports. 08, 2016 | Pubmed ID: 27492371 Deep Transcriptomic Profiling Reveals the Similarity Between Endothelial Cells Cultured Under Static and Oscillatory Shear Stress Conditions Physiological Genomics. 09, 2016 | Pubmed ID: 27449656 Discovery of Novel Peptides Targeting Pro-atherogenic Endothelium in Disturbed Flow Regions -Targeted SiRNA Delivery to Pro-atherogenic Endothelium in Vivo Scientific Reports. 05, 2016 | Pubmed ID: 27173134 Identification of Side- and Shear-dependent MicroRNAs Regulating Porcine Aortic Valve Pathogenesis Scientific Reports. 05, 2016 | Pubmed ID: 27151744 The Role of Endothelial Mechanosensitive Genes in Atherosclerosis and Omics Approaches Archives of Biochemistry and Biophysics. Feb, 2016 | Pubmed ID: 26686737 The NADPH Oxidase Nox4 Has Anti-atherosclerotic Functions European Heart Journal. Dec, 2015 | Pubmed ID: 26385958 Multifunctional Nanoparticles Facilitate Molecular Targeting and MiRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice ACS Nano. Sep, 2015 | Pubmed ID: 26308181 Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 As a SMC Receptor Regulating Proliferation and Inflammatory Response PloS One. Month, 2015 | Pubmed ID: 26305474 Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries PloS One. Month, 2015 | Pubmed ID: 26086218 Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces Circulation Research. Jul, 2015 | Pubmed ID: 26034042 The Role of Epigenetics in the Endothelial Cell Shear Stress Response and Atherosclerosis The International Journal of Biochemistry & Cell Biology. Oct, 2015 | Pubmed ID: 25979369 Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2015 | Pubmed ID: 25953647 Flow-dependent Regulation of Genome-wide MRNA and MicroRNA Expression in Endothelial Cells in Vivo Scientific Data. Month, 2014 | Pubmed ID: 25977794 The Role of Mechanical Stimulation in Recovery of Bone Loss-High Versus Low Magnitude and Frequency of Force Life (Basel, Switzerland). Apr, 2014 | Pubmed ID: 25370188 Fluid Mechanics, Arterial Disease, and Gene Expression Annual Review of Fluid Mechanics. Jan, 2014 | Pubmed ID: 25360054 Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei PloS One. Month, 2014 | Pubmed ID: 25265386 Role of Flow-sensitive MicroRNAs in Endothelial Dysfunction and Atherosclerosis: Mechanosensitive Athero-miRs Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2014 | Pubmed ID: 25012134 Flow-dependent Epigenetic DNA Methylation Regulates Endothelial Gene Expression and Atherosclerosis The Journal of Clinical Investigation. Jul, 2014 | Pubmed ID: 24865430 Prevention of Abdominal Aortic Aneurysm by Anti-microRNA-712 or Anti-microRNA-205 in Angiotensin II-infused Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2014 | Pubmed ID: 24812324 Development of Immortalized Mouse Aortic Endothelial Cell Lines Vascular Cell. Apr, 2014 | Pubmed ID: 24690145 The Atypical Mechanosensitive MicroRNA-712 Derived from Pre-ribosomal RNA Induces Endothelial Inflammation and Atherosclerosis Nature Communications. Month, 2013 | Pubmed ID: 24346612 Vascular Injury Involves the Overoxidation of Peroxiredoxin Type II and is Recovered by the Peroxiredoxin Activity Mimetic That Induces Reendothelialization Circulation. Aug, 2013 | Pubmed ID: 23820076 Anti-inflammatory and Antiatherogenic Role of BMP Receptor II in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2013 | Pubmed ID: 23559633 The Role of the Vascular Dendritic Cell Network in Atherosclerosis American Journal of Physiology. Cell Physiology. Jul, 2013 | Pubmed ID: 23552284 Aortic Valve: Mechanical Environment and Mechanobiology Annals of Biomedical Engineering. Jul, 2013 | Pubmed ID: 23515935 Piperlongumine Inhibits Atherosclerotic Plaque Formation and Vascular Smooth Muscle Cell Proliferation by Suppressing PDGF Receptor Signaling Biochemical and Biophysical Research Communications. Oct, 2012 | Pubmed ID: 22995306 Maturing EPCs into Endothelial Cells: May the Force Be with the EPCs: Focus on "Fluid Shear Stress Induces Differentiation of Circulating Phenotype Endothelial Progenitor Cells" American Journal of Physiology. Cell Physiology. Sep, 2012 | Pubmed ID: 22763124 Dynamic Immune Cell Accumulation During Flow-Induced Atherogenesis in Mouse Carotid Artery: An Expanded Flow Cytometry Method Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2012 | Pubmed ID: 22247254 Serum BMP-4 Levels in Relation to Arterial Stiffness and Carotid Atherosclerosis in Patients with Type 2 Diabetes Biomarkers in Medicine. Dec, 2011 | Pubmed ID: 22103619 Peroxiredoxin 2 Deficiency Exacerbates Atherosclerosis in Apolipoprotein E-deficient Mice Circulation Research. Sep, 2011 | Pubmed ID: 21835911 Discovery of Shear- and Side-specific MRNAs and MiRNAs in Human Aortic Valvular Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2011 | Pubmed ID: 21705672 Preferential Activation of SMAD1/5/8 on the Fibrosa Endothelium in Calcified Human Aortic Valves--association with Low BMP Antagonists and SMAD6 PloS One. Month, 2011 | Pubmed ID: 21698246 Disturbed Flow: P53 SUMOylation in the Turnover of Endothelial Cells The Journal of Cell Biology. May, 2011 | Pubmed ID: 21624951 Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21512164 Redox Going with Vascular Shear Stress Antioxidants & Redox Signaling. Sep, 2011 | Pubmed ID: 21457103 MicroRNA-663 Upregulated by Oscillatory Shear Stress Plays a Role in Inflammatory Response of Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. May, 2011 | Pubmed ID: 21378144 The Effects of Combined Cyclic Stretch and Pressure on the Aortic Valve Interstitial Cell Phenotype Annals of Biomedical Engineering. Jun, 2011 | Pubmed ID: 21347552 Angiotensin Type I Receptor Blockade in Conjunction with Enhanced Akt Activation Restores Coronary Collateral Growth in the Metabolic Syndrome American Journal of Physiology. Heart and Circulatory Physiology. May, 2011 | Pubmed ID: 21335466 Differences in Valvular and Vascular Cell Responses to Strain in Osteogenic Media Biomaterials. Apr, 2011 | Pubmed ID: 21284997 Detection of Low Levels of Nitric Oxide Using an Electrochemical Sensor Methods in Molecular Biology (Clifton, N.J.). Month, 2011 | Pubmed ID: 21161631 Animal, in Vitro, and Ex Vivo Models of Flow-dependent Atherosclerosis: Role of Oxidative Stress Antioxidants & Redox Signaling. Sep, 2011 | Pubmed ID: 20712399 Endothelial Metallothionein Expression and Intracellular Free Zinc Levels Are Regulated by Shear Stress American Journal of Physiology. Cell Physiology. Dec, 2010 | Pubmed ID: 20861469 Discovery of Novel Mechanosensitive Genes in Vivo Using Mouse Carotid Artery Endothelium Exposed to Disturbed Flow Blood. Oct, 2010 | Pubmed ID: 20551377 Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-dependent Manner The American Journal of Pathology. Jul, 2010 | Pubmed ID: 20489151 X-linked Inhibitor of Apoptosis Protein Controls Alpha5-integrin-mediated Cell Adhesion and Migration American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2010 | Pubmed ID: 20472758 Shear Stress and Plaque Development Expert Review of Cardiovascular Therapy. Apr, 2010 | Pubmed ID: 20397828 HuR Regulates the Expression of Stress-sensitive Genes and Mediates Inflammatory Response in Human Umbilical Vein Endothelial Cells Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351266 Intimal Cushions and Endothelial Nuclear Elongation Around Mouse Aortic Branches and Their Spatial Correspondence with Patterns of Lipid Deposition American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2010 | Pubmed ID: 19933414 GTP Cyclohydrolase I Phosphorylation and Interaction with GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide Circulation Research. Feb, 2010 | Pubmed ID: 19926872 Systems Analysis of the Role of Bone Morphogenic Protein 4 in Endothelial Inflammation Annals of Biomedical Engineering. Feb, 2010 | Pubmed ID: 19851868 Partial Carotid Ligation is a Model of Acutely Induced Disturbed Flow, Leading to Rapid Endothelial Dysfunction and Atherosclerosis American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2009 | Pubmed ID: 19684185 Redox-sensitive Akt and Src Regulate Coronary Collateral Growth in Metabolic Syndrome American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2009 | Pubmed ID: 19376806 Elevated Cyclic Stretch Alters Matrix Remodeling in Aortic Valve Cusps: Implications for Degenerative Aortic Valve Disease American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2009 | Pubmed ID: 19151254 Expression of CYP1A1 and CYP1B1 in Human Endothelial Cells: Regulation by Fluid Shear Stress Cardiovascular Research. Mar, 2009 | Pubmed ID: 19126602 Low Magnitude and High Frequency Mechanical Loading Prevents Decreased Bone Formation Responses of 2T3 Preosteoblasts Journal of Cellular Biochemistry. Feb, 2009 | Pubmed ID: 19125415 Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent Pathway Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2009 | Pubmed ID: 19023092 Laminar Shear Stress Inhibits Lipid Peroxidation Induced by High Glucose Plus Arachidonic Acid in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2008 | Pubmed ID: 18790833 Angiopoietin-2 Stimulates Blood Flow Recovery After Femoral Artery Occlusion by Inducing Inflammation and Arteriogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2008 | Pubmed ID: 18772493 Differential Proinflammatory and Prooxidant Effects of Bone Morphogenetic Protein-4 in Coronary and Pulmonary Arterial Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2008 | Pubmed ID: 18539760 Design of an Ex Vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue Journal of Biomechanical Engineering. Jun, 2008 | Pubmed ID: 18532871 X-linked Inhibitor of Apoptosis Protein is an Important Regulator of Vascular Endothelial Growth Factor-dependent Bovine Aortic Endothelial Cell Survival Circulation Research. Apr, 2008 | Pubmed ID: 18309102 Target Accessibility and Signal Specificity in Live-cell Detection of BMP-4 MRNA Using Molecular Beacons Nucleic Acids Research. Mar, 2008 | Pubmed ID: 18276638 Laminar Shear Stress Up-regulates Peroxiredoxins (PRX) in Endothelial Cells: PRX 1 As a Mechanosensitive Antioxidant The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 18024958 Bone Morphogenic Protein Antagonists Are Coexpressed with Bone Morphogenic Protein 4 in Endothelial Cells Exposed to Unstable Flow in Vitro in Mouse Aortas and in Human Coronary Arteries: Role of Bone Morphogenic Protein Antagonists in Inflammation and Atherosclerosis Circulation. Sep, 2007 | Pubmed ID: 17785623 Laminar Shear Inhibits Tubule Formation and Migration of Endothelial Cells by an Angiopoietin-2 Dependent Mechanism Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2007 | Pubmed ID: 17673702 NFKB1 Promoter Variation Implicates Shear-induced NOS3 Gene Expression and Endothelial Function in Prehypertensives and Stage I Hypertensives American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2007 | Pubmed ID: 17644577 Emerging Role of IGF-1R in Stretch-induced Neointimal Hyperplasia in Venous Grafts Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2007 | Pubmed ID: 17634521 Caveolin-1 Knockout Mice Have Increased Bone Size and Stiffness Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Sep, 2007 | Pubmed ID: 17550335 Reversible Glutathiolation of Caspase-3 by Glutaredoxin As a Novel Redox Signaling Mechanism in Tumor Necrosis Factor-alpha-induced Cell Death Circulation Research. Feb, 2007 | Pubmed ID: 17272816 Downregulation of Bone Morphogenetic Protein 4 Expression in Coronary Arterial Endothelial Cells: Role of Shear Stress and the CAMP/protein Kinase A Pathway Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2007 | Pubmed ID: 17272757 Identification of Mechanosensitive Genes in Osteoblasts by Comparative Microarray Studies Using the Rotating Wall Vessel and the Random Positioning Machine Journal of Cellular Biochemistry. Jun, 2007 | Pubmed ID: 17243119 Reactive Oxygen Species-selective Regulation of Aortic Inflammatory Gene Expression in Type 2 Diabetes American Journal of Physiology. Heart and Circulatory Physiology. May, 2007 | Pubmed ID: 17237245 Expression of Cathepsin K is Regulated by Shear Stress in Cultured Endothelial Cells and is Increased in Endothelium in Human Atherosclerosis American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2007 | Pubmed ID: 17098827 An Improved Method to Measure Nitrate/nitrite with an NO-selective Electrochemical Sensor Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Mar, 2007 | Pubmed ID: 17056288 Cyclic Pressure and Shear Stress Regulate Matrix Metalloproteinases and Cathepsin Activity in Porcine Aortic Valves The Journal of Heart Valve Disease. Sep, 2006 | Pubmed ID: 17044366 An Ex Vivo Study of the Biological Properties of Porcine Aortic Valves in Response to Circumferential Cyclic Stretch Annals of Biomedical Engineering. Nov, 2006 | Pubmed ID: 17031600 Regulation of Growth Plate Chondrocytes by 1,25-dihydroxyvitamin D3 Requires Caveolae and Caveolin-1 Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Oct, 2006 | Pubmed ID: 16995819 Role of NADPH Oxidases in Disturbed Flow- and BMP4- Induced Inflammation and Atherosclerosis Antioxidants & Redox Signaling. Sep-Oct, 2006 | Pubmed ID: 16987015 Early Determinants of H2O2-induced Endothelial Dysfunction Free Radical Biology & Medicine. Sep, 2006 | Pubmed ID: 16895801 Embryonic Stem Cell-derived Endothelial Cells May Lack Complete Functional Maturation in Vitro Journal of Vascular Research. Month, 2006 | Pubmed ID: 16877873 Coordinated Regulation of Endothelial Nitric Oxide Synthase Activity by Phosphorylation and Subcellular Localization Free Radical Biology & Medicine. Jul, 2006 | Pubmed ID: 16781462 Bone Morphogenic Protein-4 Induces Hypertension in Mice: Role of Noggin, Vascular NADPH Oxidases, and Impaired Vasorelaxation Circulation. Jun, 2006 | Pubmed ID: 16769910 Ascorbic Acid Synthesis Due to L-gulono-1,4-lactone Oxidase Expression Enhances NO Production in Endothelial Cells Biochemical and Biophysical Research Communications. Jul, 2006 | Pubmed ID: 16737683 Laminar Shear Stress Inhibits Cathepsin L Activity in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2006 | Pubmed ID: 16709945 Caveolin-1 is Transiently Dephosphorylated by Shear Stress-activated Protein Tyrosine Phosphatase Mu Biochemical and Biophysical Research Communications. Jan, 2006 | Pubmed ID: 16325778 Plasma Membrane Requirements for 1alpha,25(OH)2D3 Dependent PKC Signaling in Chondrocytes and Osteoblasts Steroids. Apr, 2006 | Pubmed ID: 16325216 Mechanical Inhibition of RANKL Expression is Regulated by H-Ras-GTPase The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16306046 Transcriptional Profiles of Valvular and Vascular Endothelial Cells Reveal Phenotypic Differences: Influence of Shear Stress Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2006 | Pubmed ID: 16293796 Simulated Microgravity Using the Random Positioning Machine Inhibits Differentiation and Alters Gene Expression Profiles of 2T3 Preosteoblasts American Journal of Physiology. Cell Physiology. Jun, 2005 | Pubmed ID: 15689415 Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production from a Nox1-based NADPH Oxidase Circulation Research. Oct, 2004 | Pubmed ID: 15388638 Bovine Caveolin-2 Cloning and Effects of Shear Stress on Its Localization in Bovine Aortic Endothelial Cells Endothelium : Journal of Endothelial Cell Research. May-Aug, 2004 | Pubmed ID: 15370296 High Glucose Induced NF-kappaB DNA-binding Activity in HAEC is Maintained Under Low Shear Stress but Inhibited Under High Shear Stress: Role of Nitric Oxide Atherosclerosis. Dec, 2003 | Pubmed ID: 14644391 Endothelial NO Synthase Phosphorylated at SER635 Produces NO Without Requiring Intracellular Calcium Increase Free Radical Biology & Medicine. Oct, 2003 | Pubmed ID: 14583337 Oscillatory Shear Stress Stimulates Endothelial Production of O2- from P47phox-dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12958309 Role of Xanthine Oxidoreductase and NAD(P)H Oxidase in Endothelial Superoxide Production in Response to Oscillatory Shear Stress American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2003 | Pubmed ID: 12958034 Flow-dependent Regulation of Endothelial Nitric Oxide Synthase: Role of Protein Kinases American Journal of Physiology. Cell Physiology. Sep, 2003 | Pubmed ID: 12900384 A Role for PYK2 in ANG II-dependent Regulation of the PHAS-1-eIF4E Complex by Multiple Signaling Cascades in Vascular Smooth Muscle American Journal of Physiology. Cell Physiology. Dec, 2003 | Pubmed ID: 12890645 Optimization of Isolation and Functional Characterization of Primary Murine Aortic Endothelial Cells Endothelium : Journal of Endothelial Cell Research. Month, 2003 | Pubmed ID: 12791518 Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Stimulates an Inflammatory Response The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12766166 Chronic Shear Induces Caveolae Formation and Alters ERK and Akt Responses in Endothelial Cells American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2003 | Pubmed ID: 12763750 IkappaBalpha-dependent Regulation of Low-shear Flow-induced NF-kappa B Activity: Role of Nitric Oxide American Journal of Physiology. Cell Physiology. Apr, 2003 | Pubmed ID: 12620896 Compensatory Phosphorylation and Protein-protein Interactions Revealed by Loss of Function and Gain of Function Mutants of Multiple Serine Phosphorylation Sites in Endothelial Nitric-oxide Synthase The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12591925 Shear Stress Stimulates Phosphorylation of ENOS at Ser(635) by a Protein Kinase A-dependent Mechanism American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2002 | Pubmed ID: 12384459 NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12377764 Role of P47(phox) in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II Hypertension. Oct, 2002 | Pubmed ID: 12364355 Activation of C-Jun N-terminal Kinase and Apoptosis in Endothelial Cells Mediated by Endogenous Generation of Hydrogen Peroxide Biological Chemistry. Mar-Apr, 2002 | Pubmed ID: 12033458 Shear Stress Stimulates Phosphorylation of Endothelial Nitric-oxide Synthase at Ser1179 by Akt-independent Mechanisms: Role of Protein Kinase A The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729190 단일 세포 다중 오믹스 실험을 위한 마우스 경동맥 내강에서 내피 세포 분리 Sandeep Kumar*1, Aitor Andueza*1, Nicolas Villa-Roel1, Juyoung Kim1, Dong-Won Kang1, Hanjoong Jo1,2 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 2Division of Cardiology, Georgia Institute of Technology and Emory University JoVE 63128 Biology 부분 결합하여 마우스 경동맥 동맥에있는 방해 흐름 유발 죽상 경화증과 경동맥 내피로부터 RNA 분리의 간단한 방법의 모델 Douglas Nam1, Chih-Wen Ni2, Amir Rezvan1, Jin Suo2, Klaudia Budzyn1, Alexander Llanos1, David G. Harrison1, Don P. Giddens2, Hanjoong Jo1,2,3 1Department of Medicine, Division of Cardiology, Emory University, 2Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, 3Department of Bioinspired Science, Ewha Womans University JoVE 1861 Medicine
단일 세포 다중 오믹스 실험을 위한 마우스 경동맥 내강에서 내피 세포 분리 Sandeep Kumar*1, Aitor Andueza*1, Nicolas Villa-Roel1, Juyoung Kim1, Dong-Won Kang1, Hanjoong Jo1,2 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 2Division of Cardiology, Georgia Institute of Technology and Emory University JoVE 63128 Biology
부분 결합하여 마우스 경동맥 동맥에있는 방해 흐름 유발 죽상 경화증과 경동맥 내피로부터 RNA 분리의 간단한 방법의 모델 Douglas Nam1, Chih-Wen Ni2, Amir Rezvan1, Jin Suo2, Klaudia Budzyn1, Alexander Llanos1, David G. Harrison1, Don P. Giddens2, Hanjoong Jo1,2,3 1Department of Medicine, Division of Cardiology, Emory University, 2Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, 3Department of Bioinspired Science, Ewha Womans University JoVE 1861 Medicine