Hao Lai Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital Fudan University Biography Publications Institution JoVE Articles Hao Lai has not added a biography. If you are Hao Lai and would like to personalize this page please email our Author Liaison for assistance. Publications Patient-derived Microphysiological Model Identifies the Therapeutic Potential of Metformin for Thoracic Aortic Aneurysm EBioMedicine. May, 2022 | Pubmed ID: 35636318 Preoperative and Intraoperative Risk Factors of Postoperative Stroke in Total Aortic Arch Replacement and Stent Elephant Trunk Implantation EClinicalMedicine. May, 2022 | Pubmed ID: 35518120 CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm Journal of Inflammation Research. 2022 | Pubmed ID: 35321320 Mini-Invasive Bentall Procedure Performed a Right Anterior Thoracotomy Approach With a Costochondral Cartilage Sparing Frontiers in Cardiovascular Medicine. 2022 | Pubmed ID: 35310990 Gender Differences in the Dissection Properties of Ascending Thoracic Aortic Aneurysms Interactive Cardiovascular and Thoracic Surgery. Mar, 2022 | Pubmed ID: 35285896 Outcomes of Thoracic Endovascular Aortic Repair for Penetrating Aortic Ulcers Involving the Left Subclavian Artery with the Castor Single-branched Stent Graft European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Mar, 2022 | Pubmed ID: 35274139 Hypertrophic Obstructive Cardiomyopathy with a Basal Septal Thickness of 16 mm or Less: Clinical Characteristics and Surgical Results Surgery Today. Jan, 2022 | Pubmed ID: 35079897 Low Ambient Temperature and Temperature Drop Between Neighbouring Days and Acute Aortic Dissection: a Case-crossover Study European Heart Journal. Jan, 2022 | Pubmed ID: 34849712 Hypertrophic Cardiomyopathy with Latent Obstruction: Clinical Characteristics and Surgical Results Journal of Cardiology. 01, 2022 | Pubmed ID: 34551867 Long-Term Outcomes of Surgical Treatment for Acute Type-A Aortic Dissection with Coronary Artery Involvement International Heart Journal. 2021 | Pubmed ID: 34588406 Aorta Smooth Muscle-on-a-chip Reveals Impaired Mitochondrial Dynamics As a Therapeutic Target for Aortic Aneurysm in Bicuspid Aortic Valve Disease ELife. 09, 2021 | Pubmed ID: 34486519 Plasma Proteomic Profiling Reveals Biomarkers Associated with Aortic Dilation in Patients with Bicuspid Aortic Valve Annals of Translational Medicine. Jul, 2021 | Pubmed ID: 34430623 Veno-Arterial Extracorporeal Membrane Oxygenation for Patients Undergoing Acute Type A Aortic Dissection Surgery: A Six-Year Experience Frontiers in Cardiovascular Medicine. 2021 | Pubmed ID: 34079828 Current Pharmacological Management of Aortic Aneurysm Journal of Cardiovascular Pharmacology. 08, 2021 | Pubmed ID: 33990514 Engineering a Human Pluripotent Stem Cell-Based Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells Frontiers in Bioengineering and Biotechnology. 2021 | Pubmed ID: 33816448 Surgical Septal Myectomy for the Treatment of Residual Left Ventricular Outflow Tract Obstruction Following Failed Alcohol Septal Ablation International Heart Journal. Mar, 2021 | Pubmed ID: 33731518 Mini-invasive Surgical Instruments in Transaortic Myectomy for Hypertrophic Obstructive Cardiomyopathy: a Single-center Experience with 168 Cases Journal of Cardiothoracic Surgery. Mar, 2021 | Pubmed ID: 33731165 Inhaled Nitric Oxide Reduces the Intrapulmonary Shunt to Ameliorate Severe Hypoxemia After Acute Type A Aortic Dissection Surgery Nitric Oxide : Biology and Chemistry. 05, 2021 | Pubmed ID: 33667622 Modeling Aortic Diseases Using Induced Pluripotent Stem Cells Stem Cells Translational Medicine. 02, 2021 | Pubmed ID: 33179450 Postoperative Hypothermia After Total Aortic Arch Replacement in Acute Type A Aortic Dissection-multivariate Analysis and Risk Identification for Postoperative Hypothermia Occurrence Journal of Thoracic Disease. Dec, 2020 | Pubmed ID: 33447397 Early Risk Stratification of Acute Type A Aortic Dissection: Development and Validation of a Predictive Score Cardiovascular Diagnosis and Therapy. Dec, 2020 | Pubmed ID: 33381427 Learning Curve of Mitral Valve Repair: Cumulative Sum Failure Analysis from Single High-volume Center Journal of Thoracic Disease. Nov, 2020 | Pubmed ID: 33282358 Nano-Biomaterials for the Delivery of Therapeutic and Monitoring Cues for Aortic Diseases Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 33224934 Mitral Valve Repair for Degenerative Mitral Regurgitation in Patients with Left Ventricular Systolic Dysfunction: Early and Mid-term Outcomes Journal of Cardiothoracic Surgery. Oct, 2020 | Pubmed ID: 33004041 Quantifying the Learning Curve of Emergent Total Arch Replacement in Acute Type A Aortic Dissection Journal of Thoracic Disease. Aug, 2020 | Pubmed ID: 32944318 Outcomes of Emergency or Urgent Mitral Valve Repair in Patients with Papillary Muscle Rupture and Active Infective Endocarditis Asian Cardiovascular & Thoracic Annals. Sep, 2020 | Pubmed ID: 32938206 Effect of Sequential Noninvasive Ventilation on Early Extubation After Acute Type A Aortic Dissection Respiratory Care. Aug, 2020 | Pubmed ID: 32712583 Association Between Fine Particulate Matter Air Pollution and Acute Aortic Dissections: A Time-series Study in Shanghai, China Chemosphere. Mar, 2020 | Pubmed ID: 31760286 David Reimplantation with Simultaneous Total Arch Replacement and Stented Elephant Trunk for Acute Type A Aortic Dissection The Journal of Thoracic and Cardiovascular Surgery. Nov, 2019 | Pubmed ID: 31955927 Bioprinting a 3D Vascular Construct for Engineering a Vessel-on-a-chip Biomedical Microdevices. 12, 2019 | Pubmed ID: 31875940 An An Open-Label, Single Center, Retrospective Study to Evaluate Clinical Outcomes with Surgical Sealant in Bentall Procedures: A Cohort Study The Heart Surgery Forum. Sep, 2019 | Pubmed ID: 31596719 LncRNA LOXL1-AS is Up-regulated in Thoracic Aortic Aneurysm and Regulated Proliferation and Apoptosis of Aortic Smooth Muscle Cells Bioscience Reports. Sep, 2019 | Pubmed ID: 31471532 Correction To: SPECT/CT Imaging of Apoptosis in Aortic Aneurysm with Radiolabeled Duramycin Apoptosis : an International Journal on Programmed Cell Death. Oct, 2019 | Pubmed ID: 31422488 SPECT/CT Imaging of Apoptosis in Aortic Aneurysm with Radiolabeled Duramycin Apoptosis : an International Journal on Programmed Cell Death. 10, 2019 | Pubmed ID: 31227933 Initial Clinical Impact of Inhaled Nitric Oxide Therapy for Refractory Hypoxemia Following Type A Acute Aortic Dissection Surgery Journal of Thoracic Disease. Feb, 2019 | Pubmed ID: 30962993 Benefits of Early Surgery on Clinical Outcomes After Degenerative Mitral Valve Repair The Annals of Thoracic Surgery. Oct, 2018 | Pubmed ID: 29883645 Sequential Grafting of in Situ Skeletonized Left Internal Mammary Artery to the Left Coronary System International Heart Journal. Jul, 2018 | Pubmed ID: 29794393 Surgical and Early Outcomes for Type A Aortic Dissection with Preoperative Renal Dysfunction Stratified by Estimated Glomerular Filtration Rate European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2018 | Pubmed ID: 29672685 In Situ Skeletonized Right Internal Mammary Artery Bypass Grafting to Left Anterior Descending Artery International Heart Journal. Jan, 2018 | Pubmed ID: 29279526 Annuloplasty Band Implantation in Adults with Partial Atrioventricular Septal Defect: a Propensity-matched Study Interactive Cardiovascular and Thoracic Surgery. Mar, 2018 | Pubmed ID: 29069357 Marfan Syndrome with Pneumothorax: Case Report and Review of Literatures Journal of Thoracic Disease. Dec, 2017 | Pubmed ID: 29312774 Should Sinus of Valsalva Be Preserved in Patients with Bicuspid Aortic Valve and Aortic Dilation? Journal of Thoracic Disease. Sep, 2017 | Pubmed ID: 29221290 Mid-term Graft Patency of Right Versus Left Internal Mammary Artery As Arterial Conduit Usage for Left Anterior Descending Artery Revascularisation: Insights from a Single-centre Study of Propensity-matched Data International Journal of Surgery (London, England). Dec, 2017 | Pubmed ID: 29061389 Impact of Presurgical Mild Acute Respiratory Distress Syndrome on Surgical Mortality After Surgical Repair of Acute Type A Aortic Dissection International Heart Journal. Oct, 2017 | Pubmed ID: 28966309 Revascularization of Left Coronary System Using a Skeletonized Left Internal Mammary Artery - Sequential Vs. Separate Grafting Circulation Journal : Official Journal of the Japanese Circulation Society. 12, 2017 | Pubmed ID: 28794353 Contemporary In-Hospital and Long-Term Outcomes of Surgical Management for Fungal Endocarditis International Heart Journal. Aug, 2017 | Pubmed ID: 28690300 DNA Methylome Analysis Reveals Distinct Epigenetic Patterns of Ascending Aortic Dissection and Bicuspid Aortic Valve Cardiovascular Research. May, 2017 | Pubmed ID: 28444195 Generation of an Induced Pluripotent Stem Cell Line from a Loeys-Dietz Syndrome Patient with Transforming Growth Factor-beta Receptor-2 Gene Mutation Stem Cell Research. 04, 2017 | Pubmed ID: 28395736 A New Venous Drainage Technique in Minimally Invasive Redo Tricuspid Surgery: Vacuum-Assist Venous Drainage Via a Single Femoral Venous Cannula Heart, Lung & Circulation. Feb, 2017 | Pubmed ID: 27601288 Developing MiRNA Therapeutics for Cardiac Repair in Ischemic Heart Disease Journal of Thoracic Disease. Sep, 2016 | Pubmed ID: 27747027 Open Aortic Arch Reconstruction for Acute Type a Aortic Dissection: a Single-center Experience with 267 Consecutive Patients Journal of Cardiothoracic Surgery. Jul, 2016 | Pubmed ID: 27444037 Nanoparticles-Assisted Stem Cell Therapy for Ischemic Heart Disease Stem Cells International. 2016 | Pubmed ID: 26839552 Nanoparticle-enhanced Generation of Gene-transfected Mesenchymal Stem Cells for In vivo Cardiac Repair Biomaterials. Jan, 2016 | Pubmed ID: 26461114 Early Assistance With Left Ventricular Assist Device Limits Left Ventricular Remodeling After Acute Myocardial Infarction in a Swine Model Artificial Organs. Mar, 2016 | Pubmed ID: 26332939 Severe Aortic Regurgitation and Partial Anomalous Pulmonary Venous Connection in a Turner Syndrome Patient Journal of Thoracic Disease. Nov, 2015 | Pubmed ID: 26716053 Type A Aortic Dissection Occurring After Previous Cardiac Surgery Journal of Cardiac Surgery. Nov, 2015 | Pubmed ID: 26447329 Intramyocardial Autologous Bone Marrow-derived Stem Cells Injection for Ischemic Heart Disease Ineligible for Revascularization: A Systematic Review and Meta-analysis Archives of Medical Research. May, 2015 | Pubmed ID: 26070842 Off-pump Skeletonized Versus Pedicled Left Internal Mammary Artery Grafting: Mid-term Results Journal of Cardiac Surgery. Jun, 2015 | Pubmed ID: 25873143 Fibrin Patch-based Insulin-like Growth Factor-1 Gene-modified Stem Cell Transplantation Repairs Ischemic Myocardium Experimental Biology and Medicine (Maywood, N.J.). May, 2015 | Pubmed ID: 25767192 Enhanced Infarct Myocardium Repair Mediated by Thermosensitive Copolymer Hydrogel-based Stem Cell Transplantation Experimental Biology and Medicine (Maywood, N.J.). May, 2015 | Pubmed ID: 25432986 Combination of IGF‑1 Gene Manipulation and 5‑AZA Treatment Promotes Differentiation of Mesenchymal Stem Cells into Cardiomyocyte‑like Cells Molecular Medicine Reports. Feb, 2015 | Pubmed ID: 25351395 Palliative Stent Graft Placement Combined with Subsequent Open Surgery for Retrograde Ascending Dissection Intra-thoracic Endovascular Aortic Repair Journal of Thoracic Disease. Dec, 2014 | Pubmed ID: 25590002 Reprogramming Fibroblasts to Pluripotency Using Arginine-terminated Polyamidoamine Nanoparticles Based Non-viral Gene Delivery System International Journal of Nanomedicine. 2014 | Pubmed ID: 25540584 Nanovector-based Prolyl Hydroxylase Domain 2 Silencing System Enhances the Efficiency of Stem Cell Transplantation for Infarcted Myocardium Repair International Journal of Nanomedicine. 2014 | Pubmed ID: 25429216 Aortic Reoperation in a Patient with Loeys-Dietz Syndrome Chinese Medical Journal. 2014 | Pubmed ID: 24931266 Patch Repair of Anomalous Origin of the Left Main Coronary Artery from the Anterior Aortic Sinus The Annals of Thoracic Surgery. Mar, 2014 | Pubmed ID: 24580950 Prognostic Analysis for Survival After Resections of Localized Primary Cardiac Sarcomas: a Single-institution Experience The Annals of Thoracic Surgery. Apr, 2014 | Pubmed ID: 24565404 Very Severe Chronic Ventricular Tachycardia Due to an Aneurysm In the Left Main Coronary Artery and a Giant Aneurysm-related Pseudoaneurysm The Journal of Thoracic and Cardiovascular Surgery. Apr, 2014 | Pubmed ID: 24079877 Emerging Role of Echocardiographic Strain/strain Rate Imaging and Twist in Systolic Function Evaluation and Operative Procedure in Patients with Aortic Stenosis Interactive Cardiovascular and Thoracic Surgery. Aug, 2013 | Pubmed ID: 23644729 Transplantation of Novel Vascular Endothelial Growth Factor Gene Delivery System Manipulated Skeletal Myoblasts Promote Myocardial Repair International Journal of Cardiology. Oct, 2013 | Pubmed ID: 23578891 Surgical Management for Acute Type A Aortic Dissection in Patients over 70 Years-old Journal of Cardiothoracic Surgery. Apr, 2013 | Pubmed ID: 23577777 Open Triple-branched Stent Graft Placement for the Surgical Treatment of Acute Aortic Arch Dissection Journal of Cardiothoracic Surgery. Dec, 2012 | Pubmed ID: 23241278 Novel Vascular Endothelial Growth Factor Gene Delivery System-manipulated Mesenchymal Stem Cells Repair Infarcted Myocardium Experimental Biology and Medicine (Maywood, N.J.). Jun, 2012 | Pubmed ID: 22728704 Bilateral Versus Unilateral Antegrade Cerebral Perfusion in Arch Reconstruction for Aortic Dissection The Annals of Thoracic Surgery. Jun, 2012 | Pubmed ID: 22560261 Surgical Treatment for Retrograde Type A Aortic Dissection After Endovascular Stent Graft Placement for Type B Dissection Interactive Cardiovascular and Thoracic Surgery. May, 2012 | Pubmed ID: 22361126 Novel Hyperbranched Polyamidoamine Nanoparticle Based Gene Delivery: Transfection, Cytotoxicity and in Vitro Evaluation International Journal of Pharmaceutics. Feb, 2012 | Pubmed ID: 22209826 Novel Hyperbranched Polyamidoamine Nanoparticles for Transfecting Skeletal Myoblasts with Vascular Endothelial Growth Factor Gene for Cardiac Repair Journal of Materials Science. Materials in Medicine. Nov, 2011 | Pubmed ID: 21870080 Surgical Management of Aortoesophageal Fistula Caused by Foreign Bodies European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Jul, 2011 | Pubmed ID: 21145250 [Orthotopic Heart Transplantation: Clinical Experience on 56 Patients] Zhonghua Yi Xue Za Zhi. Oct, 2004 | Pubmed ID: 15569450 [Infection After Cardiac Transplantation: Prevention and Management] Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]. Jan, 2004 | Pubmed ID: 15009984 Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall Mieradilijiang Abudupataer*1, Xiujie Yin*1, Bitao Xiang*1, Nan Chen1, Shiqiang Yan2, Shichao Zhu1, Yang Ming1, Gang Liu1, Xiaonan Zhou1, Hao Lai1, Chunsheng Wang1, Kai Zhu1, Jun Li1 1Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 2Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University JoVE 64122 Bioengineering
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall Mieradilijiang Abudupataer*1, Xiujie Yin*1, Bitao Xiang*1, Nan Chen1, Shiqiang Yan2, Shichao Zhu1, Yang Ming1, Gang Liu1, Xiaonan Zhou1, Hao Lai1, Chunsheng Wang1, Kai Zhu1, Jun Li1 1Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 2Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University JoVE 64122 Bioengineering