Howard S. Fox Department of Neurological Sciences University of Nebraska Medical Center Biography Publications Institution JoVE Articles Howard S. Fox has not added a biography. If you are Howard S. Fox and would like to personalize this page please email our Author Liaison for assistance. Publications Chronic Morphine Administration Differentially Modulates Viral Reservoirs in SIVmac251 Infected Rhesus Macaque Model Journal of Virology. Dec, 2020 | Pubmed ID: 33328304 Methamphetamine Increases the Proportion of SIV-Infected Microglia/Macrophages, Alters Metabolic Pathways, and Elevates Cell Death Pathways: A Single-Cell Analysis Viruses. 11, 2020 | Pubmed ID: 33198269 The Age-related Trajectory of Visual Attention Neural Function is Altered in Adults Living with HIV: A Cross-sectional MEG Study EBioMedicine. Nov, 2020 | Pubmed ID: 33099087 Pharmacologic Approaches to HIV-associated Neurocognitive Disorders Current Opinion in Pharmacology. Oct, 2020 | Pubmed ID: 33049585 Prefrontal Gating of Sensory Input Differentiates Cognitively Impaired and Unimpaired Aging Adults with HIV Brain Communications. 2020 | Pubmed ID: 32954330 Association of Epigenetic Metrics of Biological Age With Cortical Thickness JAMA Network Open. 09, 2020 | Pubmed ID: 32926115 Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop Pathogens & Immunity. 2020 | Pubmed ID: 32856008 Deletion of DJ-1 in Rats Affects Protein Abundance and Mitochondrial Function at the Synapse Scientific Reports. 08, 2020 | Pubmed ID: 32792613 Interactions of Monocytes, HIV, and ART Identified by an Innovative ScRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities MBio. 07, 2020 | Pubmed ID: 32723919 HIV-1 Tat-mediated Astrocytic Amyloidosis involves the HIF-1α/lncRNA BACE1-AS Axis PLoS Biology. 05, 2020 | Pubmed ID: 32453744 A Year-long Extended Release Nanoformulated Cabotegravir Prodrug Nature Materials. 08, 2020 | Pubmed ID: 32341511 Interactive Effects of HIV and Ageing on Neural Oscillations: Independence from Neuropsychological Performance Brain Communications. 2020 | Pubmed ID: 32322820 Age-related Visual Dynamics in HIV-infected Adults with Cognitive Impairment Neurology(R) Neuroimmunology & Neuroinflammation. 05, 2020 | Pubmed ID: 32102916 Epigenetic Markers of Aging Predict the Neural Oscillations Serving Selective Attention Cerebral Cortex (New York, N.Y. : 1991). 03, 2020 | Pubmed ID: 31504270 Defining Cerebrospinal Fluid HIV RNA Escape: Editorial Review AIDS AIDS (London, England). 12, 2019 | Pubmed ID: 31790376 Creation of a Long-acting Rilpivirine Prodrug Nanoformulation Journal of Controlled Release : Official Journal of the Controlled Release Society. 10, 2019 | Pubmed ID: 31491432 Secreted Metabolome of Human Macrophages Exposed to Methamphetamine Analytical Chemistry. 07, 2019 | Pubmed ID: 31265257 Downregulation of an Evolutionary Young MiR-1290 in an IPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder Stem Cells International. 2019 | Pubmed ID: 31191687 Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development Developmental Neurobiology. 04, 2019 | Pubmed ID: 31050203 A Mouse Model of Seizures in Anti-N-methyl-d-aspartate Receptor Encephalitis Epilepsia. 03, 2019 | Pubmed ID: 30740690 The Integrated National NeuroAIDS Tissue Consortium Database: a Rich Platform for NeuroHIV Research Database : the Journal of Biological Databases and Curation. 01, 2019 | Pubmed ID: 30624650 Pharmacokinetic Testing of a First-generation Cabotegravir Prodrug in Rhesus Macaques AIDS (London, England). 03, 2019 | Pubmed ID: 30289818 Neural Dynamics of Selective Attention Deficits in HIV-associated Neurocognitive Disorder Neurology. 11, 2018 | Pubmed ID: 30333162 Proteomic and Functional Data Sets on Synaptic Mitochondria from Rats with Genetic Ablation of Data in Brief. Oct, 2018 | Pubmed ID: 30197913 Aberrant Oscillatory Dynamics During Somatosensory Processing in HIV-infected Adults NeuroImage. Clinical. 2018 | Pubmed ID: 30094159 Molecular Mechanisms of Long Noncoding RNAs and Their Role in Disease Pathogenesis Oncotarget. Apr, 2018 | Pubmed ID: 29719633 Aberrant Occipital Dynamics Differentiate HIV-infected Patients with and Without Cognitive Impairment Brain : a Journal of Neurology. 06, 2018 | Pubmed ID: 29672678 Multimodal Theranostic Nanoformulations Permit Magnetic Resonance Bioimaging of Antiretroviral Drug Particle Tissue-Cell Biodistribution Theranostics. 2018 | Pubmed ID: 29290806 Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. 06, 2018 | Pubmed ID: 29280055 Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques Antimicrobial Agents and Chemotherapy. 01, 2018 | Pubmed ID: 29061742 Creation of a Nanoformulated Cabotegravir Prodrug with Improved Antiretroviral Profiles Biomaterials. Jan, 2018 | Pubmed ID: 29059541 Central Nervous System-penetrating Antiretrovirals Impair Energetic Reserve in Striatal Nerve Terminals Journal of Neurovirology. Dec, 2017 | Pubmed ID: 28895059 Osteopontin Impacts Pathogenesis and Resistance by Regulating Inflammasome Components and Cell Death in the Central Nervous System at Early Time Points Mediators of Inflammation. 2017 | Pubmed ID: 28811681 Induction of MiR-155 After Brain Injury Promotes Type 1 Interferon and Has a Neuroprotective Effect Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 28804446 Measures of Physical and Mental Independence Among HIV-Positive Individuals: Impact of Substance Use Disorder AIDS Research and Human Retroviruses. Oct, 2017 | Pubmed ID: 28288515 Tat-Mediated Induction of MiRs-34a & -138 Promotes Astrocytic Activation Via Downregulation of SIRT1: Implications for Aging in HAND Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Feb, 2017 | Pubmed ID: 28236278 Aberrant Neuronal Dynamics During Working Memory Operations in the Aging HIV-Infected Brain Scientific Reports. 02, 2017 | Pubmed ID: 28155864 Emerging Roles of Extracellular Vesicles in Neurodegenerative Disorders: Focus on HIV-associated Neurological Complications Cell Death & Disease. Nov, 2016 | Pubmed ID: 27882942 SWATH-MS Proteome Profiling Data Comparison of DJ-1, Parkin, and PINK1 Knockout Rat Striatal Mitochondria Data in Brief. Dec, 2016 | Pubmed ID: 27761515 Loss of Pink1 Modulates Synaptic Mitochondrial Bioenergetics in the Rat Striatum Prior to Motor Symptoms: Concomitant Complex I Respiratory Defects and Increased Complex II-mediated Respiration Proteomics. Clinical Applications. 12, 2016 | Pubmed ID: 27568932 Traumatic Brain Injury Increases Levels of MiR-21 in Extracellular Vesicles: Implications for Neuroinflammation FEBS Open Bio. 08, 2016 | Pubmed ID: 27516962 Metabolic Drift in the Aging Brain Aging. 05, 2016 | Pubmed ID: 27182841 Methamphetamine Abuse Affects Gene Expression in Brain-derived Microglia of SIV-infected Macaques to Enhance Inflammation and Promote Virus Targets BMC Immunology. 04, 2016 | Pubmed ID: 27107567 Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA Molecular Cell. 04, 2016 | Pubmed ID: 27105112 Neonatal Mitochondrial Abnormalities Due to PINK1 Deficiency: Proteomics Reveals Early Changes Relevant to Parkinson׳s Disease Data in Brief. Mar, 2016 | Pubmed ID: 26866053 HIV-1 Transgenic Rats Display Mitochondrial Abnormalities Consistent with Abnormal Energy Generation and Distribution Journal of Neurovirology. 10, 2016 | Pubmed ID: 26843384 The Proteomic Characterization of Plasma or Serum from HIV-Infected Patients Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26714720 Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats Molecular Neurobiology. Jan, 2016 | Pubmed ID: 25421206 Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB Alcoholism, Clinical and Experimental Research. Dec, 2015 | Pubmed ID: 26556759 Coexpression Network Analysis of MiRNA-142 Overexpression in Neuronal Cells BioMed Research International. 2015 | Pubmed ID: 26539539 Phenotypic Changes in the Brain of SIV-infected Macaques Exposed to Methamphetamine Parallel Macrophage Activation Patterns Induced by the Common Gamma-chain Cytokine System Frontiers in Microbiology. 2015 | Pubmed ID: 26441851 The National NeuroAIDS Tissue Consortium (NNTC) Database: an Integrated Database for HIV-related Studies Database : the Journal of Biological Databases and Curation. 2015 | Pubmed ID: 26228431 Data for Mitochondrial Proteomic Alterations in the Aging Mouse Brain Data in Brief. Sep, 2015 | Pubmed ID: 26217775 MiR-21 in Extracellular Vesicles Leads to Neurotoxicity Via TLR7 Signaling in SIV Neurological Disease PLoS Pathogens. Jul, 2015 | Pubmed ID: 26154133 Chronic SIV and Morphine Treatment Increases Heat Shock Protein 5 Expression at the Synapse Journal of Neurovirology. Oct, 2015 | Pubmed ID: 26037114 Proteomic Analysis and Functional Characterization of Mouse Brain Mitochondria During Aging Reveal Alterations in Energy Metabolism Proteomics. May, 2015 | Pubmed ID: 25546256 Multimodal Neuroimaging Evidence of Alterations in Cortical Structure and Function in HIV-infected Older Adults Human Brain Mapping. Mar, 2015 | Pubmed ID: 25376125 CD8+ T Cells Maintain Suppression of Simian Immunodeficiency Virus in the Central Nervous System The Journal of Infectious Diseases. Jan, 2015 | Pubmed ID: 25035516 Data for Mitochondrial Proteomic Alterations in the Developing Rat Brain Data in Brief. Dec, 2014 | Pubmed ID: 26217684 Osteopontin Expression in the Brain Triggers Localized Inflammation and Cell Death when Immune Cells Are Activated by Pertussis Toxin Mediators of Inflammation. 2014 | Pubmed ID: 25525298 Brain Region Mapping Using Global Metabolomics Chemistry & Biology. Nov, 2014 | Pubmed ID: 25457182 A New Rhesus Macaque Assembly and Annotation for Next-generation Sequencing Analyses Biology Direct. Oct, 2014 | Pubmed ID: 25319552 Enhanced Methamphetamine Metabolism in Rhesus Macaque As Compared with Human: an Analysis Using a Novel Method of Liquid Chromatography with Tandem Mass Spectrometry, Kinetic Study, and Substrate Docking Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2014 | Pubmed ID: 25301936 Pharmacokinetics, Biodistribution, and Toxicity of Folic Acid-coated Antiretroviral Nanoformulations Antimicrobial Agents and Chemotherapy. Dec, 2014 | Pubmed ID: 25288084 Efavirenz Induces Neuronal Autophagy and Mitochondrial Alterations The Journal of Pharmacology and Experimental Therapeutics. Nov, 2014 | Pubmed ID: 25161171 Proteomic Analysis of the Mitochondria from Embryonic and Postnatal Rat Brains Reveals Response to Developmental Changes in Energy Demands Journal of Proteomics. Sep, 2014 | Pubmed ID: 25046836 Aging Synaptic Mitochondria Exhibit Dynamic Proteomic Changes While Maintaining Bioenergetic Function Aging. Apr, 2014 | Pubmed ID: 24827396 Cellular Interactions and Signaling in NeuroAIDS: Emerging Issues Colloquium Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2014 | Pubmed ID: 24789373 Quantitative Proteomics of Synaptic and Nonsynaptic Mitochondria: Insights for Synaptic Mitochondrial Vulnerability Journal of Proteome Research. May, 2014 | Pubmed ID: 24708184 The 20th Scientific Conference of the Society on NeuroImmune Pharmacology Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2014 | Pubmed ID: 24573530 Quantitative Proteomics by SWATH-MS Reveals Altered Expression of Nucleic Acid Binding and Regulatory Proteins in HIV-1-infected Macrophages Journal of Proteome Research. Apr, 2014 | Pubmed ID: 24564501 Decreased MEG Beta Oscillations in HIV-infected Older Adults During the Resting State Journal of Neurovirology. Dec, 2013 | Pubmed ID: 24297500 Biomarkers for NeuroAIDS: Recent Progress in the Field Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Dec, 2013 | Pubmed ID: 24292958 MicroRNA-142 Reduces Monoamine Oxidase A Expression and Activity in Neuronal Cells by Downregulating SIRT1 PloS One. 2013 | Pubmed ID: 24244526 Combined Fluorescent in Situ Hybridization for Detection of MicroRNAs and Immunofluorescent Labeling for Cell-type Markers Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 24065888 Quantitative Proteomics Reveals Oxygen-dependent Changes in Neuronal Mitochondria Affecting Function and Sensitivity to Rotenone Journal of Proteome Research. Oct, 2013 | Pubmed ID: 23971408 Autophagy-mediated Turnover of Dynamin-related Protein 1 BMC Neuroscience. Aug, 2013 | Pubmed ID: 23937156 Pilot Study of Younger and Older HIV-infected Adults Using Traditional and Novel Functional Assessments HIV Clinical Trials. Jul-Aug, 2013 | Pubmed ID: 23924589 Abnormal MEG Oscillatory Activity During Visual Processing in the Prefrontal Cortices and Frontal Eye-fields of the Aging HIV Brain PloS One. 2013 | Pubmed ID: 23840428 Transcriptome Meta-analysis Reveals a Central Role for Sex Steroids in the Degeneration of Hippocampal Neurons in Alzheimer's Disease BMC Systems Biology. Jun, 2013 | Pubmed ID: 23803348 Up-regulation of MicroRNA-142 in Simian Immunodeficiency Virus Encephalitis Leads to Repression of Sirtuin1 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2013 | Pubmed ID: 23752207 Functional Brain Abnormalities During Finger-tapping in HIV-infected Older Adults: a Magnetoencephalography Study Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2013 | Pubmed ID: 23749418 Preclinical Pharmacokinetics and Tissue Distribution of Long-acting Nanoformulated Antiretroviral Therapy Antimicrobial Agents and Chemotherapy. Jul, 2013 | Pubmed ID: 23612193 N-methyl-D-aspartate Receptor-mediated Axonal Injury in Adult Rat Corpus Callosum Journal of Neuroscience Research. Feb, 2013 | Pubmed ID: 23161705 Methamphetamine Administration Targets Multiple Immune Subsets and Induces Phenotypic Alterations Suggestive of Immunosuppression PloS One. 2012 | Pubmed ID: 23227154 The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-associated Neurocognitive Impairment PloS One. 2012 | Pubmed ID: 23049970 Protective Role for the Disulfide Isomerase PDIA3 in Methamphetamine Neurotoxicity PloS One. 2012 | Pubmed ID: 22715419 Methamphetamine and Inflammatory Cytokines Increase Neuronal Na+/K+-ATPase Isoform 3: Relevance for HIV Associated Neurocognitive Disorders PloS One. 2012 | Pubmed ID: 22662178 Comparison of 4-plex to 8-plex ITRAQ Quantitative Measurements of Proteins in Human Plasma Samples Journal of Proteome Research. Jul, 2012 | Pubmed ID: 22594965 Commentary: Animal Models of NeuroAIDS Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2012 | Pubmed ID: 22549136 Translating the Brain Transcriptome in NeuroAIDS: from Non-human Primates to Humans Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2012 | Pubmed ID: 22367717 Proteasome Activity and Autophagosome Content in Liver Are Reciprocally Regulated by Ethanol Treatment Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142844 Changes in the Plasma Proteome Follows Chronic Opiate Administration in Simian Immunodeficiency Virus Infected Rhesus Macaques Drug and Alcohol Dependence. Jan, 2012 | Pubmed ID: 21821369 Upregulation of Cathepsin D in the Caudate Nucleus of Primates with Experimental Parkinsonism Molecular Neurodegeneration. Jul, 2011 | Pubmed ID: 21777416 Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions Between HIV-1 and the Monocyte-derived Macrophage Journal of Proteome Research. Jun, 2011 | Pubmed ID: 21500866 Short Communication: Quantitative Proteomic Plasma Profiling Reveals Activation of Host Defense to Oxidative Stress in Chronic SIV and Methamphetamine Comorbidity AIDS Research and Human Retroviruses. Feb, 2011 | Pubmed ID: 20929344 Epithelial Progenitor 1, a Novel Factor Associated with Epithelial Cell Growth and Differentiation Endocrine. Apr, 2010 | Pubmed ID: 20960269 Plasma Proteomic Analysis of Simian Immunodeficiency Virus Infection of Rhesus Macaques Journal of Proteome Research. Sep, 2010 | Pubmed ID: 20677826 Proteomic and Metabolomic Strategies to Investigate HIV-associated Neurocognitive Disorders Genome Medicine. Mar, 2010 | Pubmed ID: 20353544 Advances in the "omics" for Diagnosis, Pathogenesis, and Therapeutic Development Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2010 | Pubmed ID: 20143174 Quantitative Plasma Proteomic Profiling Identifies the Vitamin E Binding Protein Afamin As a Potential Pathogenic Factor in SIV Induced CNS Disease Journal of Proteome Research. Jan, 2010 | Pubmed ID: 19908921 Defining Larger Roles for "tiny" RNA Molecules: Role of MiRNAs in Neurodegeneration Research Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Mar, 2010 | Pubmed ID: 19757077 A Coat of Many Colors: Neuroimmune Crosstalk in Human Immunodeficiency Virus Infection Neuron. Oct, 2009 | Pubmed ID: 19840555 An Integrated Systems Analysis Implicates EGR1 Downregulation in Simian Immunodeficiency Virus Encephalitis-induced Neural Dysfunction The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19812322 Cerebrospinal Fluid Proteomics Reveals Potential Pathogenic Changes in the Brains of SIV-infected Monkeys Journal of Proteome Research. May, 2009 | Pubmed ID: 19281240 Decreased Neuronal Autophagy in HIV Dementia: a Mechanism of Indirect Neurotoxicity Autophagy. Oct, 2008 | Pubmed ID: 18772620 יישום מערכת RatWalker לניתוח הליכה במודל חולדה גנטי של מחלת פרקינסון Kelly L. Stauch1, Steven Totusek1, Trey Farmer1, Benjamin G. Lamberty1, Kelsey N. Dyball1, Mohannad A. Almikhlafi1, Howard S. Fox1 1Department of Neurological Sciences, University of Nebraska Medical Center JoVE 62002 Neuroscience
יישום מערכת RatWalker לניתוח הליכה במודל חולדה גנטי של מחלת פרקינסון Kelly L. Stauch1, Steven Totusek1, Trey Farmer1, Benjamin G. Lamberty1, Kelsey N. Dyball1, Mohannad A. Almikhlafi1, Howard S. Fox1 1Department of Neurological Sciences, University of Nebraska Medical Center JoVE 62002 Neuroscience