Howard Y. Chang Howard Hughes Medical Institute and Program in Epithelial Biology Stanford University School of Medicine Biography Publications Institution JoVE Articles Howard Y. Chang has not added a biography. If you are Howard Y. Chang and would like to personalize this page please email our Author Liaison for assistance. Publications Suppression of Progenitor Differentiation Requires the Long Noncoding RNA ANCR Genes & Development. Feb, 2012 | Pubmed ID: 22302877 Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock Cell. Jan, 2012 | Pubmed ID: 22265401 A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells Stem Cells and Development. Feb, 2012 | Pubmed ID: 22236333 Active Chromatin and Noncoding RNAs: an Intimate Relationship Current Opinion in Genetics & Development. Dec, 2011 | Pubmed ID: 22154525 Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-chromatin Interactions Molecular Cell. Nov, 2011 | Pubmed ID: 21963238 Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons Cell Stem Cell. Oct, 2011 | Pubmed ID: 21962918 Molecular Mechanisms of Long Noncoding RNAs Molecular Cell. Sep, 2011 | Pubmed ID: 21925379 Understanding the Transcriptome Through RNA Structure Nature Reviews. Genetics. Sep, 2011 | Pubmed ID: 21850044 Disruption of PPARγ/β-catenin-mediated Regulation of Apelin Impairs BMP-induced Mouse and Human Pulmonary Arterial EC Survival The Journal of Clinical Investigation. Sep, 2011 | Pubmed ID: 21821917 Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-related Transcriptional Networks PLoS Genetics. Jun, 2011 | Pubmed ID: 21738489 Crystal Structure of the N-terminal Region of Human Ash2L Shows a Winged-helix Motif Involved in DNA Binding EMBO Reports. Aug, 2011 | Pubmed ID: 21660059 Extensive and Coordinated Transcription of Noncoding RNAs Within Cell-cycle Promoters Nature Genetics. Jul, 2011 | Pubmed ID: 21642992 Long Noncoding RNAs and Human Disease Trends in Cell Biology. Jun, 2011 | Pubmed ID: 21550244 A Long Noncoding RNA Maintains Active Chromatin to Coordinate Homeotic Gene Expression Nature. Apr, 2011 | Pubmed ID: 21423168 RNA Templating the Epigenome: Long Noncoding RNAs As Molecular Scaffolds Epigenetics : Official Journal of the DNA Methylation Society. May, 2011 | Pubmed ID: 21393997 Long Intergenic Noncoding RNAs: New Links in Cancer Progression Cancer Research. Jan, 2011 | Pubmed ID: 21199792 Noncoding RNA Landmarks of Pluripotency and Reprogramming Cell Stem Cell. Dec, 2010 | Pubmed ID: 21112559 G1 Arrest and Differentiation Can Occur Independently of Rb Family Function The Journal of Cell Biology. Nov, 2010 | Pubmed ID: 21059851 Long Noncoding RNA in Genome Regulation: Prospects and Mechanisms RNA Biology. Sep-Oct, 2010 | Pubmed ID: 20930520 HOTAIR: Flight of Noncoding RNAs in Cancer Metastasis Cell Cycle (Georgetown, Tex.). Sep, 2010 | Pubmed ID: 20864820 Genome-wide Measurement of RNA Secondary Structure in Yeast Nature. Sep, 2010 | Pubmed ID: 20811459 Long Noncoding RNA As Modular Scaffold of Histone Modification Complexes Science (New York, N.Y.). Aug, 2010 | Pubmed ID: 20616235 Tumor Suppression by the Histone Demethylase UTX Cell Cycle (Georgetown, Tex.). Jun, 2010 | Pubmed ID: 20505331 Long Non-coding RNA HOTAIR Reprograms Chromatin State to Promote Cancer Metastasis Nature. Apr, 2010 | Pubmed ID: 20393566 The Histone Demethylase UTX Enables RB-dependent Cell Fate Control Genes & Development. Feb, 2010 | Pubmed ID: 20123895 A TGFbeta-responsive Gene Signature is Associated with a Subset of Diffuse Scleroderma with Increased Disease Severity The Journal of Investigative Dermatology. Mar, 2010 | Pubmed ID: 19812599 Anatomic Demarcation of Cells: Genes to Patterns Science (New York, N.Y.). Nov, 2009 | Pubmed ID: 19965461 Identification, Molecular Characterization, Clinical Prognosis, and Therapeutic Targeting of Human Bladder Tumor-initiating Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666525 HOXA3 Modulates Injury-induced Mobilization and Recruitment of Bone Marrow-derived Cells Stem Cells (Dayton, Ohio). Jul, 2009 | Pubmed ID: 19544454 Gene Dates, Parties and Galas. Symposium on Chromatin Dynamics and Higher Order Organization EMBO Reports. Jul, 2009 | Pubmed ID: 19525922 Tumor Vasculature is Regulated by PHD2-mediated Angiogenesis and Bone Marrow-derived Cell Recruitment Cancer Cell. Jun, 2009 | Pubmed ID: 19477431 Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression Cancer Cell. Jun, 2009 | Pubmed ID: 19477427 Regeneration, Repair and Remembering Identity: the Three Rs of Hox Gene Expression Trends in Cell Biology. Jun, 2009 | Pubmed ID: 19428253 Genome-wide Views of Chromatin Structure Annual Review of Biochemistry. 2009 | Pubmed ID: 19317649 Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200802 ING4 Mediates Crosstalk Between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation Molecular Cell. Jan, 2009 | Pubmed ID: 19187765 Molecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis Arthritis and Rheumatism. Feb, 2009 | Pubmed ID: 19180499 SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappaB-dependent Gene Expression and Organismal Life Span Cell. Jan, 2009 | Pubmed ID: 19135889 Opioid-induced Bowel Dysfunction Current Treatment Options in Gastroenterology. Feb, 2008 | Pubmed ID: 21063859 Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes PloS One. 2008 | Pubmed ID: 19107207 Stemness, Cancer and Cancer Stem Cells Cell Cycle (Georgetown, Tex.). Dec, 2008 | Pubmed ID: 19029796 Combining Biological Gene Expression Signatures in Predicting Outcome in Breast Cancer: An Alternative to Supervised Classification European Journal of Cancer (Oxford, England : 1990). Oct, 2008 | Pubmed ID: 18715778 Deletional Tolerance Mediated by Extrathymic Aire-expressing Cells Science (New York, N.Y.). Aug, 2008 | Pubmed ID: 18687966 Control of Differentiation in a Self-renewing Mammalian Tissue by the Histone Demethylase JMJD3 Genes & Development. Jul, 2008 | Pubmed ID: 18628393 Mechanisms of an Autoimmunity Syndrome in Mice Caused by a Dominant Mutation in Aire The Journal of Clinical Investigation. May, 2008 | Pubmed ID: 18414681 Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells Cell Stem Cell. Apr, 2008 | Pubmed ID: 18397753 SIRT6 is a Histone H3 Lysine 9 Deacetylase That Modulates Telomeric Chromatin Nature. Mar, 2008 | Pubmed ID: 18337721 A Systems Biology Approach to Anatomic Diversity of Skin The Journal of Investigative Dermatology. Apr, 2008 | Pubmed ID: 18337710 Reversal of Aging by NFkappaB Blockade Cell Cycle (Georgetown, Tex.). Mar, 2008 | Pubmed ID: 18256548 Systematic Functional Characterization of Cis-regulatory Motifs in Human Core Promoters Genome Research. Mar, 2008 | Pubmed ID: 18256240 A Dermal HOX Transcriptional Program Regulates Site-specific Epidermal Fate Genes & Development. Feb, 2008 | Pubmed ID: 18245445 CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression Cancer Research. Jan, 2008 | Pubmed ID: 18199546 Revealing Targeted Therapy for Human Cancer by Gene Module Maps Cancer Research. Jan, 2008 | Pubmed ID: 18199530 Motif Module Map Reveals Enforcement of Aging by Continual NF-kappaB Activity Genes & Development. Dec, 2007 | Pubmed ID: 18055696 A Histone H3 Lysine 27 Demethylase Regulates Animal Posterior Development Nature. Oct, 2007 | Pubmed ID: 17851529 Turning Skin into Embryonic Stem Cells Nature Medicine. Jul, 2007 | Pubmed ID: 17618266 Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs Cell. Jun, 2007 | Pubmed ID: 17604720 A Transcriptional Program Mediating Entry into Cellular Quiescence PLoS Genetics. Jun, 2007 | Pubmed ID: 17559306 Genome-wide Analysis of KAP1 Binding Suggests Autoregulation of KRAB-ZNFs PLoS Genetics. Jun, 2007 | Pubmed ID: 17542650 Decoding Global Gene Expression Programs in Liver Cancer by Noninvasive Imaging Nature Biotechnology. Jun, 2007 | Pubmed ID: 17515910 Patterning Skin Pigmentation Via Dickkopf The Journal of Investigative Dermatology. May, 2007 | Pubmed ID: 17435783 Microarray Analysis of Stem Cells and Differentiation Methods in Enzymology. 2006 | Pubmed ID: 17161699 Predicting a Local Recurrence After Breast-conserving Therapy by Gene Expression Profiling Breast Cancer Research : BCR. 2006 | Pubmed ID: 17069664 Bone Morphogenetic Protein Antagonist Gremlin 1 is Widely Expressed by Cancer-associated Stromal Cells and Can Promote Tumor Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17003113 Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs PLoS Genetics. Jul, 2006 | Pubmed ID: 16895450 Current Gut-directed Therapies for Irritable Bowel Syndrome Current Treatment Options in Gastroenterology. Jul, 2006 | Pubmed ID: 16836950 MYC Can Induce DNA Breaks in Vivo and in Vitro Independent of Reactive Oxygen Species Cancer Research. Jul, 2006 | Pubmed ID: 16818632 From Description to Causality: Mechanisms of Gene Expression Signatures in Cancer Cell Cycle (Georgetown, Tex.). Jun, 2006 | Pubmed ID: 16721055 Genetic Regulators of Large-scale Transcriptional Signatures in Cancer Nature Genetics. Apr, 2006 | Pubmed ID: 16518402 Learning More from Microarrays: Insights from Modules and Networks The Journal of Investigative Dermatology. Aug, 2005 | Pubmed ID: 16098025 The Death Domain-associated Protein Modulates Activity of the Transcription Co-factor Skip/NcoA62 FEBS Letters. May, 2005 | Pubmed ID: 15878163 Robustness, Scalability, and Integration of a Wound-response Gene Expression Signature in Predicting Breast Cancer Survival Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15701700 Kinetics and Specificity of Fas Ligand Induction in Toxic Epidermal Necrolysis Archives of Dermatology. Feb, 2004 | Pubmed ID: 14967808 Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities Between Tumors and Wounds PLoS Biology. Feb, 2004 | Pubmed ID: 14737219 Endothelial Cell Diversity Revealed by Global Expression Profiling Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12963823 Eruptive Xanthomas Associated with Olanzapine Use Archives of Dermatology. Aug, 2003 | Pubmed ID: 12925394 Myelogenous Leukemia Cutis Resembling Stasis Dermatitis Journal of the American Academy of Dermatology. Jul, 2003 | Pubmed ID: 12833025 Genomewide View of Gene Silencing by Small Interfering RNAs Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12730368 Musings on the Wanderer: What's New in Our Understanding of Vago-vagal Reflex? IV. Current Concepts of Vagal Efferent Projections to the Gut American Journal of Physiology. Gastrointestinal and Liver Physiology. Mar, 2003 | Pubmed ID: 12576302 Knowledge, Attitudes, and Practice Styles of North American Pediatric Gastroenterologists: Helicobacter Pylori Infection Journal of Pediatric Gastroenterology and Nutrition. Feb, 2003 | Pubmed ID: 12548060 Diversity, Topographic Differentiation, and Positional Memory in Human Fibroblasts Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12297622 Chromatin Isolation by RNA Purification (ChIRP) Ci Chu1, Jeffrey Quinn1, Howard Y. Chang1 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine JoVE 3912 Biology
Chromatin Isolation by RNA Purification (ChIRP) Ci Chu1, Jeffrey Quinn1, Howard Y. Chang1 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine JoVE 3912 Biology