Hugues Lortat-Jacob Institut de Biologie Structurale Biography Publications Institution JoVE Articles Hugues Lortat-Jacob has not added a biography. If you are Hugues Lortat-Jacob and would like to personalize this page please email our Author Liaison for assistance. Publications Well-defined Biomimetic Surfaces to Characterize Glycosaminoglycan-mediated Interactions on the Molecular, Supramolecular and Cellular Levels Biomaterials. Oct, 2014 | Pubmed ID: 25088726 Importance of the Polarity of the Glycosaminoglycan Chain on the Interaction with FGF-1 Glycobiology. Jul, 2014 | Pubmed ID: 25015527 The Effect of Delivering the Chemokine SDF-1α in a Matrix-bound Manner on Myogenesis Biomaterials. May, 2014 | Pubmed ID: 24612919 Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer Frontiers in Oncology. Jan, 2014 | Pubmed ID: 24459635 Human Immunodeficiency Virus and Heparan Sulfate: from Attachment to Entry Inhibition Frontiers in Immunology. 2013 | Pubmed ID: 24312095 The Disulfide Bond Between Cysteine 10 and Cysteine 34 is Required for CCL18 Activity Cytokine. Oct, 2013 | Pubmed ID: 23742785 Insights into the Mechanism by Which Interferon-γ Basic Amino Acid Clusters Mediate Protein Binding to Heparan Sulfate Journal of the American Chemical Society. Jun, 2013 | Pubmed ID: 23734709 HSulf Sulfatases Catalyze Processive and Oriented 6-O-desulfation of Heparan Sulfate That Differentially Regulates Fibroblast Growth Factor Activity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2013 | Pubmed ID: 23457216 Toward Libraries of Biotinylated Chondroitin Sulfate Analogues: from Synthesis to in Vivo Studies Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2013 | Pubmed ID: 23154924 Inflammatory Chemokines Direct and Restrict Leukocyte Migration Within Live Tissues As Glycan-bound Gradients Current Biology : CB. Dec, 2012 | Pubmed ID: 23219724 A New C-Xyloside Induces Modifications of GAG Expression, Structure and Functional Properties PloS One. 2012 | Pubmed ID: 23110134 Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/proteoglycan Interactions Circulation. Oct, 2012 | Pubmed ID: 23035208 Continuous Evolution Profiles for Electronic-tongue-based Analysis Angewandte Chemie (International Ed. in English). Oct, 2012 | Pubmed ID: 22968809 Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate The Journal of Biological Chemistry. Sep, 2012 | Pubmed ID: 22815489 Transglutaminase-2 Interaction with Heparin: Identification of a Heparin Binding Site That Regulates Cell Adhesion to Fibronectin-transglutaminase-2 Matrix The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22442151 Cell Surface Proteoglycans Syndecan-1 and -4 Bind Overlapping but Distinct Sites in Laminin α3 LG45 Protein Domain The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22351752 A Synthetic Heparan Sulfate-mimetic Peptide Conjugated to a Mini CD4 Displays Very High Anti- HIV-1 Activity Independently of Coreceptor Usage Chemistry & Biology. Jan, 2012 | Pubmed ID: 22284360 Semen Clusterin is a Novel DC-SIGN Ligand Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 22013110 Cxcl12 Evolution--subfunctionalization of a Ligand Through Altered Interaction with the Chemokine Receptor Development (Cambridge, England). Jul, 2011 | Pubmed ID: 21693511 13C-labeled Heparan Sulfate Analogue As a Tool to Study Protein/heparan Sulfate Interactions by NMR Spectroscopy: Application to the CXCL12α Chemokine Journal of the American Chemical Society. Jun, 2011 | Pubmed ID: 21634378 Identification of Tubular Heparan Sulfate As a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21135110 Hijacking of the Pleiotropic Cytokine Interferon-γ by the Type III Secretion System of Yersinia Pestis PloS One. 2010 | Pubmed ID: 21179438 Characterization and Binding Activity of the Chondroitin/dermatan Sulfate Chain from Endocan, a Soluble Endothelial Proteoglycan Glycobiology. Nov, 2010 | Pubmed ID: 20581009 Cutting Edge: C1q Binds Deoxyribose and Heparan Sulfate Through Neighboring Sites of Its Recognition Domain Journal of Immunology (Baltimore, Md. : 1950). Jul, 2010 | Pubmed ID: 20548024 Dynamics of Heparan Sulfate Explored by Neutron Scattering Physical Chemistry Chemical Physics : PCCP. Apr, 2010 | Pubmed ID: 20336244 HABA-based Ionic Liquid Matrices for UV-MALDI-MS Analysis of Heparin and Heparan Sulfate Oligosaccharides Glycobiology. Feb, 2010 | Pubmed ID: 19858171 A Cell-penetrating Peptide Derived from Human Lactoferrin with Conformation-dependent Uptake Efficiency The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19858187 The Molecular Basis and Functional Implications of Chemokine Interactions with Heparan Sulphate Current Opinion in Structural Biology. Oct, 2009 | Pubmed ID: 19800217 A Synthetic CD4-heparan Sulfate Glycoconjugate Inhibits CCR5 and CXCR4 HIV-1 Attachment and Entry Nature Chemical Biology. Oct, 2009 | Pubmed ID: 19734912 Structure and Functional Relevance of the Slit2 Homodimerization Domain EMBO Reports. Jul, 2009 | Pubmed ID: 19498462 Heparan Sulfate Proteoglycans Are Receptors for the Cell-surface Trafficking and Biological Activity of Transglutaminase-2 The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19398782 The Signal Peptide of Staphylococcus Aureus Panton Valentine Leukocidin LukS Component Mediates Increased Adhesion to Heparan Sulfates PloS One. 2009 | Pubmed ID: 19347045 Tyrosine Dephosphorylation of the Syndecan-1 PDZ Binding Domain Regulates Syntenin-1 Recruitment The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19228696 The Cell Adhesion Molecule "CAR" and Sialic Acid on Human Erythrocytes Influence Adenovirus in Vivo Biodistribution PLoS Pathogens. Jan, 2009 | Pubmed ID: 19119424 The CXCL12gamma Chemokine Displays Unprecedented Structural and Functional Properties That Make It a Paradigm of Chemoattractant Proteins PloS One. 2008 | Pubmed ID: 18648536 Direct Peptide Interaction with Surface Glycosaminoglycans Contributes to the Cell Penetration of Maurocalcine The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18603532 The HIV-1 Envelope Glycoprotein Gp120 Features Four Heparan Sulfate Binding Domains, Including the Co-receptor Binding Site The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18378683 Polypyrrole Oligosaccharide Array and Surface Plasmon Resonance Imaging for the Measurement of Glycosaminoglycan Binding Interactions Analytical Chemistry. May, 2008 | Pubmed ID: 18348577 Relationships Between Glycosaminoglycan and Receptor Binding Sites in Chemokines-the CXCL12 Example Carbohydrate Research. Aug, 2008 | Pubmed ID: 18334249 Efficient Long-term and High-yielded Production of a Recombinant Proteoglycan in Eukaryotic HEK293 Cells Using a Membrane-based Bioreactor Biochemical and Biophysical Research Communications. May, 2008 | Pubmed ID: 18261977 Adenovirus Dodecahedron Cell Attachment and Entry Are Mediated by Heparan Sulfate and Integrins and Vary Along the Cell Cycle Virology. Feb, 2008 | Pubmed ID: 17950396 The Novel CXCL12gamma Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4 PloS One. 2007 | Pubmed ID: 17971873 Structural View of Glycosaminoglycan-protein Interactions Carbohydrate Research. Feb, 2007 | Pubmed ID: 17229412 Organization of Human Interferon Gamma-heparin Complexes from Solution Properties and Hydrodynamics Biochemistry. Nov, 2006 | Pubmed ID: 17073444 Structural and Mutational Analysis of Human Ad37 and Canine Adenovirus 2 Fiber Heads in Complex with the D1 Domain of Coxsackie and Adenovirus Receptor The Journal of Biological Chemistry. Nov, 2006 | Pubmed ID: 16923808 Mannose Hyperbranched Dendritic Polymers Interact with Clustered Organization of DC-SIGN and Inhibit Gp120 Binding FEBS Letters. May, 2006 | Pubmed ID: 16616922 Heparan Sulphate Proteoglycans and Viral Vectors : Ally or Foe? Current Gene Therapy. Feb, 2006 | Pubmed ID: 16475944 Heparan Sulfate Mimicry: a Synthetic Glycoconjugate That Recognizes the Heparin Binding Domain of Interferon-gamma Inhibits the Cytokine Activity The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16155294 The Fucose-binding Lectin from Ralstonia Solanacearum. A New Type of Beta-propeller Architecture Formed by Oligomerization and Interacting with Fucoside, Fucosyllactose, and Plant Xyloglucan The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15923179 Heparan Sulfate Targets the HIV-1 Envelope Glycoprotein Gp120 Coreceptor Binding Site The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15797855 Glycosaminoglycans and Protein Disulfide Isomerase-mediated Reduction of HIV Env Molecular Pharmacology. Apr, 2005 | Pubmed ID: 15644496 A Novel Strategy for Defining Critical Amino Acid Residues Involved in Protein/glycosaminoglycan Interactions The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15485868 Synthesis of Tailor-made Glycoconjugate Mimetics of Heparan Sulfate That Bind IFN-gamma in the Nanomolar Range Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2004 | Pubmed ID: 15352109 Heparan Sulfate/heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 Against Proteolysis Induced by CD26/dipeptidyl Peptidase IV The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15292258 NMR Characterization of the Interaction Between the C-terminal Domain of Interferon-gamma and Heparin-derived Oligosaccharides The Biochemical Journal. Nov, 2004 | Pubmed ID: 15270718 Heparan Sulfate Proteoglycan Mediates the Selective Attachment and Internalization of Serotype 3 Human Adenovirus Dodecahedron Virology. Apr, 2004 | Pubmed ID: 15051392 Characterization of Endostatin Binding to Heparin and Heparan Sulfate by Surface Plasmon Resonance and Molecular Modeling: Role of Divalent Cations The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14585835 Normal Human Keratinocytes Bind to the Alpha3LG4/5 Domain of Unprocessed Laminin-5 Through the Receptor Syndecan-1 The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12947106 DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2 The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12609975 A Kinetics and Modeling Study of RANTES(9-68) Binding to Heparin Reveals a Mechanism of Cooperative Oligomerization Biochemistry. Dec, 2002 | Pubmed ID: 12475226 Adenovirus Protein Involved in Virus Internalization Recruits Ubiquitin-protein Ligases Biochemistry. Dec, 2002 | Pubmed ID: 12450395 Human Cytomegalovirus Binding to DC-SIGN is Required for Dendritic Cell Infection and Target Cell Trans-infection Immunity. Nov, 2002 | Pubmed ID: 12433371 Heparin-aggregated RANTES Can Be Crystallised Acta Crystallographica. Section D, Biological Crystallography. Oct, 2002 | Pubmed ID: 12351884 Cellular Glycosaminoglycans and Low Density Lipoprotein Receptor Are Involved in Hepatitis C Virus Adsorption Journal of Medical Virology. Oct, 2002 | Pubmed ID: 12210409 Cell Membrane GM1 Ganglioside is a Functional Coreceptor for Fibroblast Growth Factor 2 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11917140 Heparan Sulfate-mediated Binding of Infectious Dengue Virus Type 2 and Yellow Fever Virus Virology. Jan, 2002 | Pubmed ID: 11878919 Structural Diversity of Heparan Sulfate Binding Domains in Chemokines Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11830659 Sulfated Polysaccharides Increase Plasma Levels of SDF-1 in Monkeys and Mice: Involvement in Mobilization of Stem/progenitor Cells Blood. Jan, 2002 | Pubmed ID: 11756151 प्रोटीन विश्लेषण के लिए सतत मान्यता पैटर्न उत्पन्न इलेक्ट्रॉनिक जीभ Yanxia Hou1, Maria Genua1, Laurie-Amandine Garçon1, Arnaud Buhot1, Roberto Calemczuk1, David Bonnaffé2, Hugues Lortat-Jacob3, Thierry Livache1 1Structure et Propriétés d'Architectures Moléculaires, Institut Nanosciences et Cryogénie, CEA-Grenoble, 2Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, 3Institut de Biologie Structurale Bioengineering
प्रोटीन विश्लेषण के लिए सतत मान्यता पैटर्न उत्पन्न इलेक्ट्रॉनिक जीभ Yanxia Hou1, Maria Genua1, Laurie-Amandine Garçon1, Arnaud Buhot1, Roberto Calemczuk1, David Bonnaffé2, Hugues Lortat-Jacob3, Thierry Livache1 1Structure et Propriétés d'Architectures Moléculaires, Institut Nanosciences et Cryogénie, CEA-Grenoble, 2Institut de Chimie Moléculaire et des Matériaux d'Orsay, Université Paris-Sud, 3Institut de Biologie Structurale Bioengineering