Irina V. Kovtun Center for Individualized Medicine Mayo Clinic Biography Publications Institution JoVE Articles Irina V. Kovtun has not added a biography. If you are Irina V. Kovtun and would like to personalize this page please email our Author Liaison for assistance. Publications Large Chromosomal Rearrangements Yield Biomarkers to Distinguish Low-Risk From Intermediate- and High-Risk Prostate Cancer Mayo Clinic Proceedings. 01, 2019 | Pubmed ID: 30611450 Targeting HER2 in Patient-derived Xenograft Ovarian Cancer Models Sensitizes Tumors to Chemotherapy Molecular Oncology. 02, 2019 | Pubmed ID: 30499260 Frequently Rearranged and Overexpressed δ-catenin is Responsible for Low Sensitivity of Prostate Cancer Cells to Androgen Receptor and β-catenin Antagonists Oncotarget. May, 2018 | Pubmed ID: 29849951 EGFR Mediates Activation of RET in Lung Adenocarcinoma with Neuroendocrine Differentiation Characterized by ASCL1 Expression Oncotarget. Apr, 2017 | Pubmed ID: 28460442 Quantification of Somatic Chromosomal Rearrangements in Circulating Cell-Free DNA from Ovarian Cancers Scientific Reports. 07, 2016 | Pubmed ID: 27436510 Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression PloS One. 2015 | Pubmed ID: 26560244 Chromosomal Catastrophe is a Frequent Event in Clinically Insignificant Prostate Cancer Oncotarget. Oct, 2015 | Pubmed ID: 26337081 Lineage Relationship of Gleason Patterns in Gleason Score 7 Prostate Cancer Cancer Research. Jun, 2013 | Pubmed ID: 23695551 Genome-wide Analysis Reveals Recurrent Structural Abnormalities of TP63 and Other P53-related Genes in Peripheral T-cell Lymphomas Blood. Sep, 2012 | Pubmed ID: 22855598 Cockayne Syndrome B Protein Antagonizes OGG1 in Modulating CAG Repeat Length in Vivo Aging. May, 2011 | Pubmed ID: 21566259 Increased Incidence of Endometrioid Tumors Caused by Aberrations in E-cadherin Promoter of Mismatch Repair-deficient Mice Carcinogenesis. Jul, 2011 | Pubmed ID: 21551128 A Survey of Patient Advocates Within the National Cancer Institute's Prostate Cancer SPORE Program: Who Are They? What Motivates Them? What Might They Tell Us? Journal of Cancer Education : the Official Journal of the American Association for Cancer Education. 2008 | Pubmed ID: 19058069 Gene Panel Model Predictive of Outcome in Men at High-risk of Systemic Progression and Death from Prostate Cancer After Radical Retropubic Prostatectomy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2008 | Pubmed ID: 18711181 Features of Trinucleotide Repeat Instability in Vivo Cell Research. Jan, 2008 | Pubmed ID: 18166978 OGG1 Initiates Age-dependent CAG Trinucleotide Expansion in Somatic Cells Nature. May, 2007 | Pubmed ID: 17450122 Crosstalk of DNA Glycosylases with Pathways Other Than Base Excision Repair DNA Repair. Apr, 2007 | Pubmed ID: 17129768 Triplet Repeats and DNA Repair: Germ Cell and Somatic Cell Instability in Transgenic Mice Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 15201465 CAG Repeat Lengths in X- and Y-bearing Sperm Indicate That Gender Bias During Transmission of Huntington's Disease Gene is Determined in the Embryo The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14688268 Microtubule Destabilization and Nuclear Entry Are Sequential Steps Leading to Toxicity in Huntington's Disease Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14527999 Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts Piyan Zhang1, Irina V. Kovtun1,2 1Center for Individualized Medicine, Mayo Clinic, 2Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic JoVE 60646 Cancer Research
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts Piyan Zhang1, Irina V. Kovtun1,2 1Center for Individualized Medicine, Mayo Clinic, 2Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic JoVE 60646 Cancer Research