Irina Pokrovskaya Biography Publications JoVE Articles Irina Pokrovskaya has not added a biography. If you are Irina Pokrovskaya and would like to personalize this page please email our Author Liaison for assistance. Publications Essential Role of the Conserved Oligomeric Golgi Complex in MBio. Nov, 2023 | Pubmed ID: 37966241 Deep Learning, 3D Ultrastructural Analysis Reveals Quantitative Differences in Platelet and Organelle Packing in COVID-19/SARSCoV2 Patient-derived Platelets Platelets. Dec, 2023 | Pubmed ID: 37933490 A Missense Mouse Model for Smith-McCort Dysplasia Shows Bone Resorption Defects and Altered Protein Glycosylation Frontiers in Genetics. 2023 | Pubmed ID: 37359363 Syntaxin-5's Flexibility in SNARE Pairing Supports Golgi Functions Traffic (Copenhagen, Denmark). Aug, 2023 | Pubmed ID: 37340984 Tethered Platelet Capture Provides a Mechanism for Restricting Circulating Platelet Activation to the Wound Site Research and Practice in Thrombosis and Haemostasis. Feb, 2023 | Pubmed ID: 36865905 Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System Methods in Molecular Biology (Clifton, N.J.). 2023 | Pubmed ID: 36512227 High-Pressure Freezing Followed by Freeze Substitution: An Optimal Electron Microscope Technique to Study Golgi Apparatus Organization and Membrane Trafficking Methods in Molecular Biology (Clifton, N.J.). 2023 | Pubmed ID: 36512217 Acute COG Complex Inactivation Unveiled Its Immediate Impact on Golgi and Illuminated the Nature of Intra-Golgi Recycling Vesicles Traffic (Copenhagen, Denmark). Feb, 2023 | Pubmed ID: 36468177 GARP Dysfunction Results in COPI Displacement, Depletion of Golgi V-SNAREs and Calcium Homeostasis Proteins Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 36578782 Development and Initial Characterization of Cellular Models for COG Complex-Related CDG-II Diseases Frontiers in Genetics. 2021 | Pubmed ID: 34603392 Venous Puncture Wound Hemostasis Results in a Vaulted Thrombus Structured by Locally Nucleated Platelet Aggregates Communications Biology. Sep, 2021 | Pubmed ID: 34531522 Dense Cellular Segmentation for EM Using 2D-3D Neural Network Ensembles Scientific Reports. Jan, 2021 | Pubmed ID: 33510185 Platelet α-granule Cargo Packaging and Release Are Affected by the Luminal Proteoglycan, Serglycin Journal of Thrombosis and Haemostasis : JTH. Apr, 2021 | Pubmed ID: 33448622 Structural Analysis of Resting Mouse Platelets by 3D-EM Reveals an Unexpected Variation in α-granule Shape Platelets. Jul, 2021 | Pubmed ID: 32815431 Canalicular System Reorganization During Mouse Platelet Activation As Revealed by 3D Ultrastructural Analysis Platelets. Jan, 2021 | Pubmed ID: 32000578 3D Ultrastructural Analysis of α-granule, Dense Granule, Mitochondria, and Canalicular System Arrangement in Resting Human Platelets Research and Practice in Thrombosis and Haemostasis. Jan, 2020 | Pubmed ID: 31989087 Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosomal System in Human Cells Frontiers in Cell and Developmental Biology. 2019 | Pubmed ID: 31334232 Autophagy in Platelets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30610718 SNARE-dependent Membrane Fusion Initiates α-granule Matrix Decondensation in Mouse Platelets Blood Advances. Nov, 2018 | Pubmed ID: 30401752 Alterations in Platelet Secretion Differentially Affect Thrombosis and Hemostasis Blood Advances. Sep, 2018 | Pubmed ID: 30185436 More Than Just Sugars: Conserved Oligomeric Golgi Complex Deficiency Causes Glycosylation-independent Cellular Defects Traffic (Copenhagen, Denmark). Jun, 2018 | Pubmed ID: 29573151 Membrane Detachment is Not Essential for COG Complex Function Molecular Biology of the Cell. Apr, 2018 | Pubmed ID: 29467253 Golgi Proteins in Circulating Human Platelets Are Distributed Across Non-stacked, Scattered Structures Platelets. Jun, 2017 | Pubmed ID: 27753523 COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits Frontiers in Cell and Developmental Biology. 2016 | Pubmed ID: 27066481 STEM Tomography Reveals That the Canalicular System and α-granules Remain Separate Compartments During Early Secretion Stages in Blood Platelets Journal of Thrombosis and Haemostasis : JTH. Mar, 2016 | Pubmed ID: 26663480 Cog5-Cog7 Crystal Structure Reveals Interactions Essential for the Function of a Multisubunit Tethering Complex Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25331899 Fluorescent Microscopy As a Tool to Elucidate Dysfunction and Mislocalization of Golgi Glycosyltransferases in COG Complex Depleted Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23765654 COG Complexes Form Spatial Landmarks for Distinct SNARE Complexes Nature Communications. 2013 | Pubmed ID: 23462996 COG6 Interacts with a Subset of the Golgi SNAREs and is Important for the Golgi Complex Integrity Traffic (Copenhagen, Denmark). Feb, 2013 | Pubmed ID: 23057818 The Lipoprotein Lipase (LPL) S447X Gain of Function Variant Involves Increased MRNA Translation Atherosclerosis. Mar, 2012 | Pubmed ID: 22244040 Conserved Oligomeric Golgi Complex Specifically Regulates the Maintenance of Golgi Glycosylation Machinery Glycobiology. Dec, 2011 | Pubmed ID: 21421995 The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway That is Exploited by SubAB Toxin Traffic (Copenhagen, Denmark). Oct, 2009 | Pubmed ID: 19678899 Adiponectin Translation is Increased by the PPARgamma Agonists Pioglitazone and Omega-3 Fatty Acids American Journal of Physiology. Endocrinology and Metabolism. Mar, 2009 | Pubmed ID: 19088251 Translational Regulation of Lipoprotein Lipase in Adipocytes: Depletion of Cellular Protein Kinase Calpha Activates Binding of the C Subunit of Protein Kinase A to the 3'-untranslated Region of the Lipoprotein Lipase MRNA The Biochemical Journal. Jul, 2008 | Pubmed ID: 18387001 The Lipogenic Enzymes DGAT1, FAS, and LPL in Adipose Tissue: Effects of Obesity, Insulin Resistance, and TZD Treatment Journal of Lipid Research. Nov, 2006 | Pubmed ID: 16894240 Role of A Kinase Anchor Proteins in the Tissue-specific Regulation of Lipoprotein Lipase Molecular Endocrinology (Baltimore, Md.). Oct, 2005 | Pubmed ID: 15961507 The Translational Regulation of Lipoprotein Lipase by Epinephrine Involves an RNA Binding Complex Including the Catalytic Subunit of Protein Kinase A The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12218046 Nuclear UDP-glucuronosyltransferases: Identification of UGT2B7 and UGT1A6 in Human Liver Nuclear Membranes Archives of Biochemistry and Biophysics. Mar, 2002 | Pubmed ID: 11883901 Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis JoVE 66479 Medicine تجلط الدم الشرياني الناجم عن كلوريد الحديديك وجمع العينات لتحليل المجهر الإلكتروني 3D Smita Joshi*1, Alexis N. Smith1, Kanakanagavalli Shravani Prakhya1, Hammodah R. Alfar1, Joshua Lykins1, Ming Zhang1, Irina Pokrovskaya2, Maria Aronova3, Richard D. Leapman3, Brian Storrie2, Sidney W. Whiteheart*1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, 3Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health JoVE 64985 Medicine
Puncture Wound Hemostasis and Preparation of Samples for Montaged Wide-Area Electron Microscopy Analysis JoVE 66479 Medicine
تجلط الدم الشرياني الناجم عن كلوريد الحديديك وجمع العينات لتحليل المجهر الإلكتروني 3D Smita Joshi*1, Alexis N. Smith1, Kanakanagavalli Shravani Prakhya1, Hammodah R. Alfar1, Joshua Lykins1, Ming Zhang1, Irina Pokrovskaya2, Maria Aronova3, Richard D. Leapman3, Brian Storrie2, Sidney W. Whiteheart*1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, 3Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health JoVE 64985 Medicine