Irmgard Tegeder Institute of Clinical Pharmacology University Hospital Frankfurt Biography Publications Institution JoVE Articles Irmgard Tegeder has not added a biography. If you are Irmgard Tegeder and would like to personalize this page please email our Author Liaison for assistance. Publications Redox-guided Axonal Regrowth Requires Cyclic GMP Dependent Protein Kinase 1: Implication for Neuropathic Pain Redox Biology. Apr, 2017 | Pubmed ID: 27978504 Progranulin Protects Against Exaggerated Axonal Injury and Astrogliosis Following Traumatic Brain Injury Glia. Feb, 2017 | Pubmed ID: 27778404 R-Flurbiprofen Traps Prostaglandins Within Cells by Inhibition of Multidrug Resistance-Associated Protein-4 International Journal of Molecular Sciences. Dec, 2016 | Pubmed ID: 28042832 Data File of a Deep Proteome Analysis of the Prefrontal Cortex in Aged Mice with Progranulin Deficiency or Neuronal Overexpression of Progranulin Data in Brief. Dec, 2016 | Pubmed ID: 27921079 Yeast-2-Hybrid Data File Showing Progranulin Interactions in Human Fetal Brain and Bone Marrow Libraries Data in Brief. Dec, 2016 | Pubmed ID: 27921076 Progranulin Promotes Peripheral Nerve Regeneration and Reinnervation: Role of Notch Signaling Molecular Neurodegeneration. Oct, 2016 | Pubmed ID: 27770818 Progranulin Overexpression in Sensory Neurons Attenuates Neuropathic Pain in Mice: Role of Autophagy Neurobiology of Disease. Dec, 2016 | Pubmed ID: 27629805 Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling Journal of Crohn's & Colitis. Feb, 2016 | Pubmed ID: 26928964 Endocannabinoids As Guardians of Metastasis International Journal of Molecular Sciences. Feb, 2016 | Pubmed ID: 26875980 Expression and Regulation of Redoxins at Nociceptive Signaling Sites After Sciatic Nerve Injury in Mice Data in Brief. Dec, 2015 | Pubmed ID: 26693520 Molecular Cause and Functional Impact of Altered Synaptic Lipid Signaling Due to a Prg-1 Gene SNP EMBO Molecular Medicine. 2015 | Pubmed ID: 26671989 Redoxins in Peripheral Neurons After Sciatic Nerve Injury Free Radical Biology & Medicine. Dec, 2015 | Pubmed ID: 26456799 COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2015 | Pubmed ID: 26311764 Reduction of Neuropathic and Inflammatory Pain Through Inhibition of the Tetrahydrobiopterin Pathway Neuron. Jun, 2015 | Pubmed ID: 26087165 "Disease Modifying Nutricals" for Multiple Sclerosis Pharmacology & Therapeutics. Apr, 2015 | Pubmed ID: 25435020 Regulation of Circulating Endocannabinoids Associated with Cancer and Metastases in Mice and Humans Oncoscience. 2014 | Pubmed ID: 25594019 R-flurbiprofen Attenuates Experimental Autoimmune Encephalomyelitis in Mice EMBO Molecular Medicine. Nov, 2014 | Pubmed ID: 25269445 Hypoxia-inducible Factor 1 Regulates Heat and Cold Pain Sensitivity and Persistence Antioxidants & Redox Signaling. Jun, 2014 | Pubmed ID: 24144405 Learning and Memory with Neuropathic Pain: Impact of Old Age and Progranulin Deficiency Frontiers in Behavioral Neuroscience. 2013 | Pubmed ID: 24319417 Exogenous Delta⁹-tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans Journal of Clinical Psychopharmacology. Oct, 2013 | Pubmed ID: 23899642 Dichotomy of CCL21 and CXCR3 in Nerve Injury-evoked and Autoimmunity-evoked Hyperalgesia Brain, Behavior, and Immunity. Aug, 2013 | Pubmed ID: 23643685 Anandamide Deficiency and Heightened Neuropathic Pain in Aged Mice Neuropharmacology. Aug, 2013 | Pubmed ID: 23597506 Author's Reply to Kapoor S. GTP Cyclohydrolase and Cancer Pain International Journal of Cancer. Apr, 2013 | Pubmed ID: 23011772 Inhibition of GTP Cyclohydrolase Attenuates Tumor Growth by Reducing Angiogenesis and M2-like Polarization of Tumor Associated Macrophages International Journal of Cancer. Feb, 2013 | Pubmed ID: 22753274 Peripheral Nerve Injury Produces a Sustained Shift in the Balance Between Glutamate Release and Uptake in the Dorsal Horn of the Spinal Cord Pain. Dec, 2012 | Pubmed ID: 23021150 Inhibition of GTP Cyclohydrolase Reduces Cancer Pain in Mice and Enhances Analgesic Effects of Morphine Journal of Molecular Medicine (Berlin, Germany). Dec, 2012 | Pubmed ID: 22706600 Protein S-nitrosylation and Denitrosylation in the Mouse Spinal Cord Upon Injury of the Sciatic Nerve Journal of Proteomics. Jul, 2012 | Pubmed ID: 22588120 Inhibitor Kappa B Kinase Beta Dependent Cytokine Upregulation in Nociceptive Neurons Contributes to Nociceptive Hypersensitivity After Sciatic Nerve Injury The Journal of Pain : Official Journal of the American Pain Society. May, 2012 | Pubmed ID: 22564672 Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity PLoS Biology. 2012 | Pubmed ID: 22427743 Gα(q/11) Signaling Tonically Modulates Nociceptor Function and Contributes to Activity-dependent Sensitization Pain. Jan, 2012 | Pubmed ID: 22071319 Progranulin Contributes to Endogenous Mechanisms of Pain Defense After Nerve Injury in Mice Journal of Cellular and Molecular Medicine. Apr, 2012 | Pubmed ID: 21645236 The Protein Kinase IKKε is a Potential Target for the Treatment of Inflammatory Hyperalgesia Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21813779 CNGA3: a Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011 | Pubmed ID: 21813679 Emerging Country Pharmacology: a 10-year Perspective from Naunyn-Schmiedeberg's Archives of Pharmacology Naunyn-Schmiedeberg's Archives of Pharmacology. Sep, 2011 | Pubmed ID: 21656233 Nerve Injury Evoked Loss of Latexin Expression in Spinal Cord Neurons Contributes to the Development of Neuropathic Pain PloS One. 2011 | Pubmed ID: 21572518 SNO-ing at the Nociceptive Synapse? Pharmacological Reviews. Jun, 2011 | Pubmed ID: 21436345 Peripheral Calcium-permeable AMPA Receptors Regulate Chronic Inflammatory Pain in Mice The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21383497 Opioid-mediated Drug Actions Cannot Be Concluded from Naloxone Induced Reversal of Anti-nociceptive Effects in Behavioural Tests Only European Journal of Pain (London, England). Nov, 2010 | Pubmed ID: 21070957 Inter-strain Differences of Serotonergic Inhibitory Pain Control in Inbred Mice Molecular Pain. Oct, 2010 | Pubmed ID: 20977736 R-flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids PloS One. 2010 | Pubmed ID: 20498712 Inhibitor KappaB Kinase Beta Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828806 Analgesic Efficacy of Tramadol, Pregabalin and Ibuprofen in Menthol-evoked Cold Hyperalgesia Pain. Dec, 2009 | Pubmed ID: 19762153 Genetic Modulation of the Pharmacological Treatment of Pain Pharmacology & Therapeutics. Nov, 2009 | Pubmed ID: 19615406 No NO, No Pain? The Role of Nitric Oxide and CGMP in Spinal Pain Processing Trends in Neurosciences. Jun, 2009 | Pubmed ID: 19414201 Current Evidence for a Modulation of Low Back Pain by Human Genetic Variants Journal of Cellular and Molecular Medicine. Aug, 2009 | Pubmed ID: 19228264 Comparison of Nociceptive Behavior in Prostaglandin E, F, D, Prostacyclin and Thromboxane Receptor Knockout Mice European Journal of Pain (London, England). Aug, 2009 | Pubmed ID: 18938093 CGMP Produced by NO-sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from CGMP-dependent Protein Kinase I The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2008 | Pubmed ID: 18716216 Genetic Deletion of Synapsin II Reduces Neuropathic Pain Due to Reduced Glutamate but Increased GABA in the Spinal Cord Dorsal Horn Pain. Oct, 2008 | Pubmed ID: 18701217 GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease Effects on Vascular Superoxide Production and Endothelial Function Journal of the American College of Cardiology. Jul, 2008 | Pubmed ID: 18598896 Clinical Genetics of Functionally Mild Non-coding GTP Cyclohydrolase 1 (GCH1) Polymorphisms Modulating Pain and Cardiovascular Risk Mutation Research. Sep-Oct, 2008 | Pubmed ID: 18515178 Reduced Hyperalgesia in Homozygous Carriers of a GTP Cyclohydrolase 1 Haplotype European Journal of Pain (London, England). Nov, 2008 | Pubmed ID: 18374612 Ro5-4864 Promotes Neonatal Motor Neuron Survival and Nerve Regeneration in Adult Rats The European Journal of Neuroscience. Feb, 2008 | Pubmed ID: 18333964 Cysteine-rich Protein 2, a Novel Downstream Effector of CGMP/cGMP-dependent Protein Kinase I-mediated Persistent Inflammatory Pain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18256252 Low-dose Methotrexate Reduces Peripheral Nerve Injury-evoked Spinal Microglial Activation and Neuropathic Pain Behavior in Rats Pain. Aug, 2008 | Pubmed ID: 18215468 The Impact of CREB and Its Phosphorylation at Ser142 on Inflammatory Nociception Biochemical and Biophysical Research Communications. Oct, 2007 | Pubmed ID: 17692820 Cannabinoids Mediate Analgesia Largely Via Peripheral Type 1 Cannabinoid Receptors in Nociceptors Nature Neuroscience. Jul, 2007 | Pubmed ID: 17558404 Reliable Screening for a Pain-protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms Clinical Chemistry. Jun, 2007 | Pubmed ID: 17363416 GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Pain Sensitivity and Persistence Nature Medicine. Nov, 2006 | Pubmed ID: 17057711 Pathophysiology and Treatment of Pain in Joint Disease Advanced Drug Delivery Reviews. May, 2006 | Pubmed ID: 16626837 Cardiovascular Risk with Cyclooxygenase Inhibitors: General Problem with Substance Specific Differences? Naunyn-Schmiedeberg's Archives of Pharmacology. Apr, 2006 | Pubmed ID: 16586083 Comparative Proteomic Analysis of the Rat Spinal Cord in Inflammatory and Neuropathic Pain Models Neuroscience Letters. Jun, 2005 | Pubmed ID: 15896486 Essential Role of the Synaptic Vesicle Protein Synapsin II in Formalin-induced Hyperalgesia and Glutamate Release in the Spinal Cord Pain. May, 2005 | Pubmed ID: 15836980 Opioids As Modulators of Cell Death and Survival--unraveling Mechanisms and Revealing New Indications Pharmacological Reviews. Sep, 2004 | Pubmed ID: 15317908 The Calpain Inhibitor MDL 28170 Prevents Inflammation-induced Neurofilament Light Chain Breakdown in the Spinal Cord and Reduces Thermal Hyperalgesia Pain. Jul, 2004 | Pubmed ID: 15275793 Specific Inhibition of IkappaB Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004 | Pubmed ID: 14973242 Reduced Inflammatory Hyperalgesia with Preservation of Acute Thermal Nociception in Mice Lacking CGMP-dependent Protein Kinase I Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14973199 Protein Associated with Myc (PAM) is Involved in Spinal Nociceptive Processing Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14756816 Determination of 8-methoxypsoralen in Human Plasma, and Microdialysates Using Liquid Chromatography-tandem Mass Spectrometry Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2003 | Pubmed ID: 14643501 Peripheral and Central Antihyperalgesic Effects of Diclofenac in a Model of Human Inflammatory Pain Clinical Pharmacology and Therapeutics. Aug, 2003 | Pubmed ID: 12891221 Activation of C-Jun-N-terminal-kinase is Crucial for the Induction of a Cell Cycle Arrest in Human Colon Carcinoma Cells Caused by Flurbiprofen Enantiomers FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2003 | Pubmed ID: 12759338 Cisplatin Tumor Concentrations After Intra-arterial Cisplatin Infusion or Embolization in Patients with Oral Cancer Clinical Pharmacology and Therapeutics. May, 2003 | Pubmed ID: 12732842 G Protein-independent G1 Cell Cycle Block and Apoptosis with Morphine in Adenocarcinoma Cells: Involvement of P53 Phosphorylation Cancer Research. Apr, 2003 | Pubmed ID: 12702572 Peripheral Opioid Analgesia in Experimental Human Pain Models Brain : a Journal of Neurology. May, 2003 | Pubmed ID: 12690049 Inhibition of Cyclic Guanosine 5'-monophosphate-dependent Protein Kinase I (PKG-I) in Lumbar Spinal Cord Reduces Formalin-induced Hyperalgesia and PKG Upregulation Nitric Oxide : Biology and Chemistry. Mar, 2003 | Pubmed ID: 12620371 Opposite Effects of Rofecoxib on Nuclear Factor-kappaB and Activating Protein-1 Activation The Journal of Pharmacology and Experimental Therapeutics. Mar, 2003 | Pubmed ID: 12604692 Spatial Distribution of 8-methoxypsoralen Penetration into Human Skin After Systemic or Topical Administration British Journal of Clinical Pharmacology. Nov, 2002 | Pubmed ID: 12445034 Validation of a New Fluorogenic Real-time PCR Assay for Detection of CYP2C9 Allelic Variants and CYP2C9 Allelic Distribution in a German Population British Journal of Clinical Pharmacology. Nov, 2002 | Pubmed ID: 12445031 Increased CNS Uptake and Enhanced Antinociception of Morphine-6-glucuronide in Rats After Inhibition of P-glycoprotein Journal of Neurochemistry. Oct, 2002 | Pubmed ID: 12423235 Dual Effects of Spinally Delivered 8-bromo-cyclic Guanosine Mono-phosphate (8-bromo-cGMP) in Formalin-induced Nociception in Rats Neuroscience Letters. Oct, 2002 | Pubmed ID: 12384231 The Influence of Inhibition of Probenecid Sensitive Transporters on the Central Nervous System (CNS) Uptake and the Antinociceptive Activity of Morphine-6-glucuronide in Rats Neuroscience Letters. Aug, 2002 | Pubmed ID: 12165398 Tissue Distribution of Imipenem in Critically Ill Patients Clinical Pharmacology and Therapeutics. May, 2002 | Pubmed ID: 12011818 Time Course of 8-methoxypsoralen Concentrations in Skin and Plasma After Topical (bath and Cream) and Oral Administration of 8-methoxypsoralen Clinical Pharmacology and Therapeutics. Mar, 2002 | Pubmed ID: 11907489 Drug Interactions with Patient-controlled Analgesia Clinical Pharmacokinetics. 2002 | Pubmed ID: 11825096 تلألؤ بيولوجي والقريبة من تحت الحمراء التصوير من التهاب العصب البصري والمخ التهاب في نموذج EAE من مرض التصلب العصبي المتعدد في الفئران Katja Schmitz1, Irmgard Tegeder1 1Institute of Clinical Pharmacology, University Hospital Frankfurt JoVE 55321 Medicine
تلألؤ بيولوجي والقريبة من تحت الحمراء التصوير من التهاب العصب البصري والمخ التهاب في نموذج EAE من مرض التصلب العصبي المتعدد في الفئران Katja Schmitz1, Irmgard Tegeder1 1Institute of Clinical Pharmacology, University Hospital Frankfurt JoVE 55321 Medicine