Irmgard Tegeder Institute of Clinical Pharmacology University Hospital Frankfurt Biography Publications Institution JoVE Articles Irmgard Tegeder has not added a biography. If you are Irmgard Tegeder and would like to personalize this page please email our Author Liaison for assistance. Publications Redox-guided Axonal Regrowth Requires Cyclic GMP Dependent Protein Kinase 1: Implication for Neuropathic Pain Redox Biology. Apr, 2017 | Pubmed ID: 27978504 Progranulin Protects Against Exaggerated Axonal Injury and Astrogliosis Following Traumatic Brain Injury Glia. Feb, 2017 | Pubmed ID: 27778404 R-Flurbiprofen Traps Prostaglandins Within Cells by Inhibition of Multidrug Resistance-Associated Protein-4 International Journal of Molecular Sciences. Dec, 2016 | Pubmed ID: 28042832 Data File of a Deep Proteome Analysis of the Prefrontal Cortex in Aged Mice with Progranulin Deficiency or Neuronal Overexpression of Progranulin Data in Brief. Dec, 2016 | Pubmed ID: 27921079 Yeast-2-Hybrid Data File Showing Progranulin Interactions in Human Fetal Brain and Bone Marrow Libraries Data in Brief. Dec, 2016 | Pubmed ID: 27921076 Progranulin Promotes Peripheral Nerve Regeneration and Reinnervation: Role of Notch Signaling Molecular Neurodegeneration. Oct, 2016 | Pubmed ID: 27770818 Progranulin Overexpression in Sensory Neurons Attenuates Neuropathic Pain in Mice: Role of Autophagy Neurobiology of Disease. Dec, 2016 | Pubmed ID: 27629805 Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling Journal of Crohn's & Colitis. Feb, 2016 | Pubmed ID: 26928964 Endocannabinoids As Guardians of Metastasis International Journal of Molecular Sciences. Feb, 2016 | Pubmed ID: 26875980 Expression and Regulation of Redoxins at Nociceptive Signaling Sites After Sciatic Nerve Injury in Mice Data in Brief. Dec, 2015 | Pubmed ID: 26693520 Molecular Cause and Functional Impact of Altered Synaptic Lipid Signaling Due to a Prg-1 Gene SNP EMBO Molecular Medicine. 2015 | Pubmed ID: 26671989 Redoxins in Peripheral Neurons After Sciatic Nerve Injury Free Radical Biology & Medicine. Dec, 2015 | Pubmed ID: 26456799 COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2015 | Pubmed ID: 26311764 Reduction of Neuropathic and Inflammatory Pain Through Inhibition of the Tetrahydrobiopterin Pathway Neuron. Jun, 2015 | Pubmed ID: 26087165 "Disease Modifying Nutricals" for Multiple Sclerosis Pharmacology & Therapeutics. Apr, 2015 | Pubmed ID: 25435020 Regulation of Circulating Endocannabinoids Associated with Cancer and Metastases in Mice and Humans Oncoscience. 2014 | Pubmed ID: 25594019 R-flurbiprofen Attenuates Experimental Autoimmune Encephalomyelitis in Mice EMBO Molecular Medicine. Nov, 2014 | Pubmed ID: 25269445 Hypoxia-inducible Factor 1 Regulates Heat and Cold Pain Sensitivity and Persistence Antioxidants & Redox Signaling. Jun, 2014 | Pubmed ID: 24144405 Learning and Memory with Neuropathic Pain: Impact of Old Age and Progranulin Deficiency Frontiers in Behavioral Neuroscience. 2013 | Pubmed ID: 24319417 Exogenous Delta⁹-tetrahydrocannabinol Influences Circulating Endogenous Cannabinoids in Humans Journal of Clinical Psychopharmacology. Oct, 2013 | Pubmed ID: 23899642 Dichotomy of CCL21 and CXCR3 in Nerve Injury-evoked and Autoimmunity-evoked Hyperalgesia Brain, Behavior, and Immunity. Aug, 2013 | Pubmed ID: 23643685 Anandamide Deficiency and Heightened Neuropathic Pain in Aged Mice Neuropharmacology. Aug, 2013 | Pubmed ID: 23597506 Author's Reply to Kapoor S. GTP Cyclohydrolase and Cancer Pain International Journal of Cancer. Apr, 2013 | Pubmed ID: 23011772 Inhibition of GTP Cyclohydrolase Attenuates Tumor Growth by Reducing Angiogenesis and M2-like Polarization of Tumor Associated Macrophages International Journal of Cancer. Feb, 2013 | Pubmed ID: 22753274 Peripheral Nerve Injury Produces a Sustained Shift in the Balance Between Glutamate Release and Uptake in the Dorsal Horn of the Spinal Cord Pain. Dec, 2012 | Pubmed ID: 23021150 Inhibition of GTP Cyclohydrolase Reduces Cancer Pain in Mice and Enhances Analgesic Effects of Morphine Journal of Molecular Medicine (Berlin, Germany). Dec, 2012 | Pubmed ID: 22706600 Protein S-nitrosylation and Denitrosylation in the Mouse Spinal Cord Upon Injury of the Sciatic Nerve Journal of Proteomics. Jul, 2012 | Pubmed ID: 22588120 Inhibitor Kappa B Kinase Beta Dependent Cytokine Upregulation in Nociceptive Neurons Contributes to Nociceptive Hypersensitivity After Sciatic Nerve Injury The Journal of Pain : Official Journal of the American Pain Society. May, 2012 | Pubmed ID: 22564672 Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity PLoS Biology. 2012 | Pubmed ID: 22427743 Gα(q/11) Signaling Tonically Modulates Nociceptor Function and Contributes to Activity-dependent Sensitization Pain. Jan, 2012 | Pubmed ID: 22071319 Progranulin Contributes to Endogenous Mechanisms of Pain Defense After Nerve Injury in Mice Journal of Cellular and Molecular Medicine. Apr, 2012 | Pubmed ID: 21645236 The Protein Kinase IKKε is a Potential Target for the Treatment of Inflammatory Hyperalgesia Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21813779 CNGA3: a Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011 | Pubmed ID: 21813679 Emerging Country Pharmacology: a 10-year Perspective from Naunyn-Schmiedeberg's Archives of Pharmacology Naunyn-Schmiedeberg's Archives of Pharmacology. Sep, 2011 | Pubmed ID: 21656233 Nerve Injury Evoked Loss of Latexin Expression in Spinal Cord Neurons Contributes to the Development of Neuropathic Pain PloS One. 2011 | Pubmed ID: 21572518 SNO-ing at the Nociceptive Synapse? Pharmacological Reviews. Jun, 2011 | Pubmed ID: 21436345 Peripheral Calcium-permeable AMPA Receptors Regulate Chronic Inflammatory Pain in Mice The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21383497 Opioid-mediated Drug Actions Cannot Be Concluded from Naloxone Induced Reversal of Anti-nociceptive Effects in Behavioural Tests Only European Journal of Pain (London, England). Nov, 2010 | Pubmed ID: 21070957 Inter-strain Differences of Serotonergic Inhibitory Pain Control in Inbred Mice Molecular Pain. Oct, 2010 | Pubmed ID: 20977736 R-flurbiprofen Reduces Neuropathic Pain in Rodents by Restoring Endogenous Cannabinoids PloS One. 2010 | Pubmed ID: 20498712 Inhibitor KappaB Kinase Beta Deficiency in Primary Nociceptive Neurons Increases TRP Channel Sensitivity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828806 Analgesic Efficacy of Tramadol, Pregabalin and Ibuprofen in Menthol-evoked Cold Hyperalgesia Pain. Dec, 2009 | Pubmed ID: 19762153 Genetic Modulation of the Pharmacological Treatment of Pain Pharmacology & Therapeutics. Nov, 2009 | Pubmed ID: 19615406 No NO, No Pain? The Role of Nitric Oxide and CGMP in Spinal Pain Processing Trends in Neurosciences. Jun, 2009 | Pubmed ID: 19414201 Current Evidence for a Modulation of Low Back Pain by Human Genetic Variants Journal of Cellular and Molecular Medicine. Aug, 2009 | Pubmed ID: 19228264 Comparison of Nociceptive Behavior in Prostaglandin E, F, D, Prostacyclin and Thromboxane Receptor Knockout Mice European Journal of Pain (London, England). Aug, 2009 | Pubmed ID: 18938093 CGMP Produced by NO-sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from CGMP-dependent Protein Kinase I The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2008 | Pubmed ID: 18716216 Genetic Deletion of Synapsin II Reduces Neuropathic Pain Due to Reduced Glutamate but Increased GABA in the Spinal Cord Dorsal Horn Pain. Oct, 2008 | Pubmed ID: 18701217 GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease Effects on Vascular Superoxide Production and Endothelial Function Journal of the American College of Cardiology. Jul, 2008 | Pubmed ID: 18598896 Clinical Genetics of Functionally Mild Non-coding GTP Cyclohydrolase 1 (GCH1) Polymorphisms Modulating Pain and Cardiovascular Risk Mutation Research. Sep-Oct, 2008 | Pubmed ID: 18515178 Reduced Hyperalgesia in Homozygous Carriers of a GTP Cyclohydrolase 1 Haplotype European Journal of Pain (London, England). Nov, 2008 | Pubmed ID: 18374612 Ro5-4864 Promotes Neonatal Motor Neuron Survival and Nerve Regeneration in Adult Rats The European Journal of Neuroscience. Feb, 2008 | Pubmed ID: 18333964 Cysteine-rich Protein 2, a Novel Downstream Effector of CGMP/cGMP-dependent Protein Kinase I-mediated Persistent Inflammatory Pain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18256252 Low-dose Methotrexate Reduces Peripheral Nerve Injury-evoked Spinal Microglial Activation and Neuropathic Pain Behavior in Rats Pain. Aug, 2008 | Pubmed ID: 18215468 The Impact of CREB and Its Phosphorylation at Ser142 on Inflammatory Nociception Biochemical and Biophysical Research Communications. Oct, 2007 | Pubmed ID: 17692820 Cannabinoids Mediate Analgesia Largely Via Peripheral Type 1 Cannabinoid Receptors in Nociceptors Nature Neuroscience. Jul, 2007 | Pubmed ID: 17558404 Reliable Screening for a Pain-protective Haplotype in the GTP Cyclohydrolase 1 Gene (GCH1) Through the Use of 3 or Fewer Single Nucleotide Polymorphisms Clinical Chemistry. Jun, 2007 | Pubmed ID: 17363416 GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Pain Sensitivity and Persistence Nature Medicine. Nov, 2006 | Pubmed ID: 17057711 Pathophysiologie Und Behandlung Von Schmerzen in Der Gemeinsamen Krankheit Advanced Drug Delivery Reviews. May, 2006 | Pubmed ID: 16626837 Cardiovascular Risk with Cyclooxygenase Inhibitors: General Problem with Substance Specific Differences? Naunyn-Schmiedeberg's Archives of Pharmacology. Apr, 2006 | Pubmed ID: 16586083 Comparative Proteomic Analysis of the Rat Spinal Cord in Inflammatory and Neuropathic Pain Models Neuroscience Letters. Jun, 2005 | Pubmed ID: 15896486 Essential Role of the Synaptic Vesicle Protein Synapsin II in Formalin-induced Hyperalgesia and Glutamate Release in the Spinal Cord Pain. May, 2005 | Pubmed ID: 15836980 Opioids As Modulators of Cell Death and Survival--unraveling Mechanisms and Revealing New Indications Pharmacological Reviews. Sep, 2004 | Pubmed ID: 15317908 The Calpain Inhibitor MDL 28170 Prevents Inflammation-induced Neurofilament Light Chain Breakdown in the Spinal Cord and Reduces Thermal Hyperalgesia Pain. Jul, 2004 | Pubmed ID: 15275793 Specific Inhibition of IkappaB Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2004 | Pubmed ID: 14973242 Reduced Inflammatory Hyperalgesia with Preservation of Acute Thermal Nociception in Mice Lacking CGMP-dependent Protein Kinase I Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14973199 Protein Associated with Myc (PAM) is Involved in Spinal Nociceptive Processing Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14756816 Determination of 8-methoxypsoralen in Human Plasma, and Microdialysates Using Liquid Chromatography-tandem Mass Spectrometry Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2003 | Pubmed ID: 14643501 Peripheral and Central Antihyperalgesic Effects of Diclofenac in a Model of Human Inflammatory Pain Clinical Pharmacology and Therapeutics. Aug, 2003 | Pubmed ID: 12891221 Activation of C-Jun-N-terminal-kinase is Crucial for the Induction of a Cell Cycle Arrest in Human Colon Carcinoma Cells Caused by Flurbiprofen Enantiomers FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2003 | Pubmed ID: 12759338 Cisplatin Tumor Concentrations After Intra-arterial Cisplatin Infusion or Embolization in Patients with Oral Cancer Clinical Pharmacology and Therapeutics. May, 2003 | Pubmed ID: 12732842 G Protein-independent G1 Cell Cycle Block and Apoptosis with Morphine in Adenocarcinoma Cells: Involvement of P53 Phosphorylation Cancer Research. Apr, 2003 | Pubmed ID: 12702572 Peripheral Opioid Analgesia in Experimental Human Pain Models Brain : a Journal of Neurology. May, 2003 | Pubmed ID: 12690049 Inhibition of Cyclic Guanosine 5'-monophosphate-dependent Protein Kinase I (PKG-I) in Lumbar Spinal Cord Reduces Formalin-induced Hyperalgesia and PKG Upregulation Nitric Oxide : Biology and Chemistry. Mar, 2003 | Pubmed ID: 12620371 Opposite Effects of Rofecoxib on Nuclear Factor-kappaB and Activating Protein-1 Activation The Journal of Pharmacology and Experimental Therapeutics. Mar, 2003 | Pubmed ID: 12604692 Spatial Distribution of 8-methoxypsoralen Penetration into Human Skin After Systemic or Topical Administration British Journal of Clinical Pharmacology. Nov, 2002 | Pubmed ID: 12445034 Validation of a New Fluorogenic Real-time PCR Assay for Detection of CYP2C9 Allelic Variants and CYP2C9 Allelic Distribution in a German Population British Journal of Clinical Pharmacology. Nov, 2002 | Pubmed ID: 12445031 Increased CNS Uptake and Enhanced Antinociception of Morphine-6-glucuronide in Rats After Inhibition of P-glycoprotein Journal of Neurochemistry. Oct, 2002 | Pubmed ID: 12423235 Dual Effects of Spinally Delivered 8-bromo-cyclic Guanosine Mono-phosphate (8-bromo-cGMP) in Formalin-induced Nociception in Rats Neuroscience Letters. Oct, 2002 | Pubmed ID: 12384231 The Influence of Inhibition of Probenecid Sensitive Transporters on the Central Nervous System (CNS) Uptake and the Antinociceptive Activity of Morphine-6-glucuronide in Rats Neuroscience Letters. Aug, 2002 | Pubmed ID: 12165398 Tissue Distribution of Imipenem in Critically Ill Patients Clinical Pharmacology and Therapeutics. May, 2002 | Pubmed ID: 12011818 Time Course of 8-methoxypsoralen Concentrations in Skin and Plasma After Topical (bath and Cream) and Oral Administration of 8-methoxypsoralen Clinical Pharmacology and Therapeutics. Mar, 2002 | Pubmed ID: 11907489 Drug Interactions with Patient-controlled Analgesia Clinical Pharmacokinetics. 2002 | Pubmed ID: 11825096 Biolumineszenz und Nah-Infrarot-Imaging von Neuritis und Gehirnentzündung im EAE-Modell der Multiplen Sklerose in Mäusen Katja Schmitz1, Irmgard Tegeder1 1Institute of Clinical Pharmacology, University Hospital Frankfurt JoVE 55321 Medicine
Biolumineszenz und Nah-Infrarot-Imaging von Neuritis und Gehirnentzündung im EAE-Modell der Multiplen Sklerose in Mäusen Katja Schmitz1, Irmgard Tegeder1 1Institute of Clinical Pharmacology, University Hospital Frankfurt JoVE 55321 Medicine