Isabel Varela-Nieto Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM Biography Publications Institution JoVE Articles Isabel Varela-Nieto has not added a biography. If you are Isabel Varela-Nieto and would like to personalize this page please email our Author Liaison for assistance. Publications Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice Frontiers in Aging Neuroscience. 2016 | Pubmed ID: 27630560 Autophagy Resolves Early Retinal Inflammation in Igf1-deficient Mice Disease Models & Mechanisms. Sep, 2016 | Pubmed ID: 27483352 Frailty in Mouse Ageing: A Conceptual Approach Mechanisms of Ageing and Development. Dec, 2016 | Pubmed ID: 27443148 Wbp2 is Required for Normal Glutamatergic Synapses in the Cochlea and is Crucial for Hearing EMBO Molecular Medicine. 03, 2016 | Pubmed ID: 26881968 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Mild Cognitive Decline. A Position Statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA) Maturitas. Jan, 2016 | Pubmed ID: 26520249 Public Investment in Biomedical Research in Europe Lancet (London, England). Oct, 2015 | Pubmed ID: 26460768 Comparative Gene Expression Study of the Vestibular Organ of the Igf1 Deficient Mouse Using Whole-transcript Arrays Hearing Research. Dec, 2015 | Pubmed ID: 26341476 Long-term Omega-3 Fatty Acid Supplementation Prevents Expression Changes in Cochlear Homocysteine Metabolism and Ameliorates Progressive Hearing Loss in C57BL/6J Mice The Journal of Nutritional Biochemistry. Dec, 2015 | Pubmed ID: 26321228 Editorial: Aging, Neurogenesis and Neuroinflammation in Hearing Loss and Protection Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 26236234 Age-regulated Function of Autophagy in the Mouse Inner Ear Hearing Research. Dec, 2015 | Pubmed ID: 26235979 Corrigendum To: Swept-sine Noise-induced Damage As a Hearing Loss Model for Preclinical Assays Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 26029100 Corrigendum: Transforming Growth Factor β1 Inhibition Protects from Noise-induced Hearing Loss Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 26005416 C-Raf Deficiency Leads to Hearing Loss and Increased Noise Susceptibility Cellular and Molecular Life Sciences : CMLS. Oct, 2015 | Pubmed ID: 25975225 Transforming Growth Factor β1 Inhibition Protects from Noise-induced Hearing Loss Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 25852546 Swept-sine Noise-induced Damage As a Hearing Loss Model for Preclinical Assays Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 25762930 Targeting Cholesterol Homeostasis to Fight Hearing Loss: a New Perspective Frontiers in Aging Neuroscience. 2015 | Pubmed ID: 25688206 Folic Acid Deficiency Induces Premature Hearing Loss Through Mechanisms Involving Cochlear Oxidative Stress and Impairment of Homocysteine Metabolism FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2015 | Pubmed ID: 25384423 Differential Organ Phenotypes After Postnatal Igf1r Gene Conditional Deletion Induced by Tamoxifen in UBC-CreERT2; Igf1r Fl/fl Double Transgenic Mice Transgenic Research. Apr, 2015 | Pubmed ID: 25238791 Loss of Lysophosphatidic Acid Receptor LPA1 Alters Oligodendrocyte Differentiation and Myelination in the Mouse Cerebral Cortex Brain Structure & Function. Nov, 2015 | Pubmed ID: 25226845 Treatment with N- and C-terminal Peptides of Parathyroid Hormone-related Protein Partly Compensate the Skeletal Abnormalities in IGF-I Deficient Mice PloS One. 2014 | Pubmed ID: 24503961 Programmed Cell Senescence During Mammalian Embryonic Development Cell. Nov, 2013 | Pubmed ID: 24238962 IGF-I Deficiency and Hearing Loss: Molecular Clues and Clinical Implications Pediatric Endocrinology Reviews : PER. Jul, 2013 | Pubmed ID: 23957197 Autophagy During Vertebrate Development Cells. Aug, 2012 | Pubmed ID: 24710484 Early Development of the Vertebrate Inner Ear Anatomical Record (Hoboken, N.J. : 2007). Nov, 2012 | Pubmed ID: 23044927 AKT Signaling Mediates IGF-I Survival Actions on Otic Neural Progenitors PloS One. 2012 | Pubmed ID: 22292041 Drug Delivery to the Inner Ear: Strategies and Their Therapeutic Implications for Sensorineural Hearing Loss Current Drug Delivery. May, 2012 | Pubmed ID: 22283653 Substrato Di Insulina Recettore 2 (IRS2)-deficient Mice Mostrano Ipoacusia Neurosensoriale Che è Ritardata Dalla Concomitante Proteina Tirosina Fosfatasi 1B (PTP1B) Perdita Di Funzione Molecular Medicine (Cambridge, Mass.). 2012 | Pubmed ID: 22160220 The Role of Insulin-like Growth Factor-I in the Physiopathology of Hearing Frontiers in Molecular Neuroscience. 2011 | Pubmed ID: 21845174 RAF Kinase Activity Regulates Neuroepithelial Cell Proliferation and Neuronal Progenitor Cell Differentiation During Early Inner Ear Development PloS One. Dec, 2010 | Pubmed ID: 21203386 A Comparative Study of Age-related Hearing Loss in Wild Type and Insulin-like Growth Factor I Deficient Mice Frontiers in Neuroanatomy. 2010 | Pubmed ID: 20661454 European Scientific, Ethical, and Legal Issues on Human Stem Cell Research and Regenerative Medicine Stem Cells (Dayton, Ohio). Jun, 2010 | Pubmed ID: 20533567 RNA Microarray Analysis in Prenatal Mouse Cochlea Reveals Novel IGF-I Target Genes: Implication of MEF2 and FOXM1 Transcription Factors PloS One. Jan, 2010 | Pubmed ID: 20111592 Melanin Precursors Prevent Premature Age-related and Noise-induced Hearing Loss in Albino Mice Pigment Cell & Melanoma Research. Feb, 2010 | Pubmed ID: 19843244 Direct Drug Application to the Round Window: a Comparative Study of Ototoxicity in Rats Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Nov, 2009 | Pubmed ID: 19861195 RasGRF1 Disruption Causes Retinal Photoreception Defects and Associated Transcriptomic Alterations Journal of Neurochemistry. Jul, 2009 | Pubmed ID: 19457086 Spatial and Temporal Segregation of Auditory and Vestibular Neurons in the Otic Placode Developmental Biology. Oct, 2008 | Pubmed ID: 18674529 A Network of Growth and Transcription Factors Controls Neuronal Differentation and Survival in the Developing Ear The International Journal of Developmental Biology. 2007 | Pubmed ID: 17891717 Anti-apoptotic Actions of Insulin-like Growth Factors: Lessons from Development and Implications in Neoplastic Cell Transformation Current Pharmaceutical Design. 2007 | Pubmed ID: 17346184 Regulation of Vertebrate Sensory Organ Development: a Scenario for Growth Hormone and Insulin-like Growth Factors Action Advances in Experimental Medicine and Biology. 2005 | Pubmed ID: 16370141 Phosphorylation of Glycosyl-phosphatidylinositol by Phosphatidylinositol 3-kinase Changes Its Properties As a Substrate for Phospholipases FEBS Letters. Jan, 2005 | Pubmed ID: 15620691 Trophic Effects of Insulin-like Growth Factor-I (IGF-I) in the Inner Ear Hearing Research. Oct, 2004 | Pubmed ID: 15464297 Hematotesticular Barrier is Altered from Early Stages of Liver Cirrhosis: Effect of Insulin-like Growth Factor 1 World Journal of Gastroenterology. Sep, 2004 | Pubmed ID: 15300898 Jejunal Microvilli Atrophy and Reduced Nutrient Transport in Rats with Advanced Liver Cirrhosis: Improvement by Insulin-like Growth Factor I BMC Gastroenterology. Jun, 2004 | Pubmed ID: 15196310 Acidic Sphingomyelinase Downregulates the Liver-specific Methionine Adenosyltransferase 1A, Contributing to Tumor Necrosis Factor-induced Lethal Hepatitis The Journal of Clinical Investigation. Mar, 2004 | Pubmed ID: 15067322 Growth Factors and Early Development of Otic Neurons: Interactions Between Intrinsic and Extrinsic Signals Current Topics in Developmental Biology. 2003 | Pubmed ID: 14674481 Cell Death in the Nervous System: Lessons from Insulin and Insulin-like Growth Factors Molecular Neurobiology. Aug, 2003 | Pubmed ID: 14514984 Programmed Cell Death in the Developing Inner Ear is Balanced by Nerve Growth Factor and Insulin-like Growth Factor I Journal of Cell Science. Feb, 2003 | Pubmed ID: 12508109 Expression and Function of Phospholipase A(2) in Brain FEBS Letters. Oct, 2002 | Pubmed ID: 12401195 Cochlear Abnormalities in Insulin-like Growth Factor-1 Mouse Mutants Hearing Research. Aug, 2002 | Pubmed ID: 12208536 Liver Cell Proliferation Requires Methionine Adenosyltransferase 2A MRNA Up-regulation Hepatology (Baltimore, Md.). Jun, 2002 | Pubmed ID: 12029623 Serum Deprivation Increases Ceramide Levels and Induces Apoptosis in Undifferentiated HN9.10e Cells Neurochemistry International. Apr, 2002 | Pubmed ID: 11792463 Uno studio comparato Drug metodi di consegna mirate per l'orecchio interno mouse: Bullostomy Silvia Murillo-Cuesta*1,2,3, Néstor Vallecillo*1, Rafael Cediel1,2,4, Adelaida M. Celaya1,2, Luis Lassaletta3,5, Isabel Varela-Nieto1,2,3, Julio Contreras1,2,4 1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria, Universidad Complutense de Madrid, 5Departmento de Otorrino laringología, Hospital Universitario La Paz Biology
Uno studio comparato Drug metodi di consegna mirate per l'orecchio interno mouse: Bullostomy Silvia Murillo-Cuesta*1,2,3, Néstor Vallecillo*1, Rafael Cediel1,2,4, Adelaida M. Celaya1,2, Luis Lassaletta3,5, Isabel Varela-Nieto1,2,3, Julio Contreras1,2,4 1Instituto de Investigaciones Biomédicas (IIBm) Alberto Sols CSIC-UAM, 2Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), 3Instituto de Investigación Sanitaria La Paz (IdiPAZ), 4Facultad de Veterinaria, Universidad Complutense de Madrid, 5Departmento de Otorrino laringología, Hospital Universitario La Paz Biology