James J. Moon Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital Biography Publications Institution JoVE Articles James J. Moon has not added a biography. If you are James J. Moon and would like to personalize this page please email our Author Liaison for assistance. Publications Identification of Mouse CD4 T Cell Epitopes in SARS-CoV-2 BA.1 Spike and Nucleocapsid for Use in Peptide:MHCII Tetramers Frontiers in Immunology. 2024 | Pubmed ID: 38529279 Identification of Mouse CD4 T Cell Epitopes in SARS-CoV-2 BA.1 Spike and Nucleocapsid for Use in Peptide:MHCII Tetramers BioRxiv : the Preprint Server for Biology. Nov, 2023 | Pubmed ID: 38014059 Mapping the T Cell Repertoire to a Complex Gut Bacterial Community Nature. Sep, 2023 | Pubmed ID: 37587342 Lung Injury Induces a Polarized Immune Response by Self-antigen-specific CD4 Foxp3 Regulatory T cells Cell Reports. Aug, 2023 | Pubmed ID: 37471223 Autoimmunity to Synovial Extracellular Matrix Proteins in Patients with Postinfectious Lyme Arthritis The Journal of Clinical Investigation. Sep, 2023 | Pubmed ID: 37471146 Tumor-associated Macrophages Expressing the Transcription Factor IRF8 Promote T cell Exhaustion in Cancer Immunity. Nov, 2022 | Pubmed ID: 36288724 IRF4 Expression by Lung Dendritic Cells Drives Acute but Not Trm Cell-dependent Memory Th2 Responses JCI Insight. Nov, 2022 | Pubmed ID: 36194494 The CD4 T Cell Response to a Commensal-derived Epitope Transitions from a Tolerant to an Inflammatory State in Crohn's Disease Immunity. Oct, 2022 | Pubmed ID: 36115338 Combined Regulatory T-Lymphocyte and IL-2 Treatment Is Safe, Tolerable, and Biologically Active for 1 Year in Persons With Amyotrophic Lateral Sclerosis Neurology(R) Neuroimmunology & Neuroinflammation. Nov, 2022 | Pubmed ID: 36038262 A Conserved Bacteroidetes Antigen Induces Anti-inflammatory Intestinal T Lymphocytes Science (New York, N.Y.). Aug, 2022 | Pubmed ID: 35926021 SARS-CoV-2 Epitope-specific CD4 Memory T Cell Responses Across COVID-19 Disease Severity and Antibody Durability Science Immunology. Jul, 2022 | Pubmed ID: 35857584 Rejection of Benign Melanocytic Nevi by Nevus-resident CD4 T Cells Science Advances. Jun, 2021 | Pubmed ID: 34162549 Identification of Antigen-specific TCR Sequences Based on Biological and Statistical Enrichment in Unselected Individuals JCI Insight. Jul, 2021 | Pubmed ID: 34032640 Interleukin-33 Activates Regulatory T Cells to Suppress Innate γδ T Cell Responses in the Lung Nature Immunology. Nov, 2020 | Pubmed ID: 32989331 Differential Expression of Tissue-restricted Antigens Among MTEC is Associated with Distinct Autoreactive T Cell Fates Nature Communications. Jul, 2020 | Pubmed ID: 32709894 Systemic Lupus Erythematosus Favors the Generation of IL-17 Producing Double Negative T Cells Nature Communications. Jun, 2020 | Pubmed ID: 32503973 In Vivo Engineering of Lymphocytes After Systemic Exosome-associated AAV Delivery Scientific Reports. Mar, 2020 | Pubmed ID: 32161326 DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8 T Cell Compartment by Negatively Regulating Tonic TCR Triggering Journal of Immunology (Baltimore, Md. : 1950). Jan, 2020 | Pubmed ID: 31740487 Opposing Peripheral Fates of Tissue-restricted Self Antigen-specific Conventional and Regulatory CD4 T Cells European Journal of Immunology. Jan, 2020 | Pubmed ID: 31580477 Natural Tr1-like Cells Do Not Confer Long-term Tolerogenic Memory ELife. 10, 2019 | Pubmed ID: 31603425 Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function Following Viral Infection Cell Reports. Aug, 2019 | Pubmed ID: 31412245 Induces Intestinal Adaptive Immune Responses During Homeostasis Science (New York, N.Y.). Jun, 2019 | Pubmed ID: 31221858 Differential IL-2 Expression Defines Developmental Fates of Follicular Versus Nonfollicular Helper T Cells Science (New York, N.Y.). Sep, 2018 | Pubmed ID: 30213884 Distinct Graft-Specific TCR Avidity Profiles During Acute Rejection and Tolerance Cell Reports. Aug, 2018 | Pubmed ID: 30134172 Generation of Allergen-Specific Tetramers for a Murine Model of Airway Inflammation Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956152 Epitope Mapping and Kinetics of CD4 T Cell Immunity to Pneumonia Virus of Mice in the C57BL/6 Strain Scientific Reports. Jun, 2017 | Pubmed ID: 28615708 Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota Journal of Immunology (Baltimore, Md. : 1950). Jul, 2017 | Pubmed ID: 28539431 Allergic Asthma is Distinguished by Sensitivity of Allergen-specific CD4+ T Cells and Airway Structural Cells to Type 2 Inflammation Science Translational Medicine. Oct, 2016 | Pubmed ID: 27708065 LYN- and AIRE-mediated Tolerance Checkpoint Defects Synergize to Trigger Organ-specific Autoimmunity The Journal of Clinical Investigation. Oct, 2016 | Pubmed ID: 27571405 Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Aug, 2016 | Pubmed ID: 26928966 Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma Immunity. Jan, 2016 | Pubmed ID: 26750312 A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes Immunity. Nov, 2015 | Pubmed ID: 26588783 CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion Immunity. Nov, 2015 | Pubmed ID: 26572061 Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype Investigative Ophthalmology & Visual Science. Aug, 2015 | Pubmed ID: 26284549 The Human T-cell Repertoire Grows Up Immunology and Cell Biology. Aug, 2015 | Pubmed ID: 25939281 T Cell Receptor Cross-reactivity Between Similar Foreign and Self Peptides Influences Naive Cell Population Size and Autoimmunity Immunity. Jan, 2015 | Pubmed ID: 25601203 A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93 PloS One. 2014 | Pubmed ID: 24404140 Cutting Edge: Type 1 Diabetes Occurs Despite Robust Anergy Among Endogenous Insulin-specific CD4 T Cells in NOD Mice Journal of Immunology (Baltimore, Md. : 1950). Nov, 2013 | Pubmed ID: 24123682 Adjuvant Formulation Structure and Composition Are Critical for the Development of an Effective Vaccine Against Tuberculosis Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013 | Pubmed ID: 23933525 CXCR3 Chemokine Receptor-ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation Immunity. Dec, 2012 | Pubmed ID: 23123063 Detection of an Autoreactive T-cell Population Within the Polyclonal Repertoire That Undergoes Distinct Autoimmune Regulator (Aire)-mediated Selection Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22552229 The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude Journal of Immunology (Baltimore, Md. : 1950). May, 2012 | Pubmed ID: 22517866 Enhancing Humoral Responses to a Malaria Antigen with Nanoparticle Vaccines That Expand Tfh Cells and Promote Germinal Center Induction Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22247289 CARMA1 is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma Journal of Immunology (Baltimore, Md. : 1950). Dec, 2011 | Pubmed ID: 22075698 Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus is Dependent on IL-6 and Intranasal Route of Infection PLoS Pathogens. Sep, 2011 | Pubmed ID: 21966268 Quantitative Impact of Thymic Selection on Foxp3+ and Foxp3- Subsets of Self-peptide/MHC Class II-specific CD4+ T Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21873213 Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers Daniel S. Shin1,2,3, Juliana Barreto de Albuquerque1,3, James J. Moon1,3,4 1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 2Division of Immunology, Boston Children's Hospital, 3Harvard Medical School, 4Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital JoVE 66939 Immunology and Infection Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells Francois P. Legoux1, James J. Moon1 1Center for Immunology and Inflammatory Diseases, and Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School JoVE 4420 Immunology and Infection
Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers Daniel S. Shin1,2,3, Juliana Barreto de Albuquerque1,3, James J. Moon1,3,4 1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, 2Division of Immunology, Boston Children's Hospital, 3Harvard Medical School, 4Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital JoVE 66939 Immunology and Infection
Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells Francois P. Legoux1, James J. Moon1 1Center for Immunology and Inflammatory Diseases, and Pulmonary and Critical Care Unit, Massachusetts General Hospital and Harvard Medical School JoVE 4420 Immunology and Infection
