James Broach Department of Molecular Biology Princeton University Biography Publications Institution JoVE Articles James Broach has not added a biography. If you are James Broach and would like to personalize this page please email our Author Liaison for assistance. Publications A Dynamic Interplay of Nucleosome and Msn2 Binding Regulates Kinetics of Gene Activation and Repression Following Stress Nucleic Acids Research. May, 2014 | Pubmed ID: 24598258 Genetic Heterogeneity of Amyotrophic Lateral Sclerosis: Implications for Clinical Practice and Research Muscle & Nerve. Jun, 2014 | Pubmed ID: 24488689 The Yeast Environmental Stress Response Regulates Mutagenesis Induced by Proteotoxic Stress PLoS Genetics. 2013 | Pubmed ID: 23935537 Nucleotide Degradation and Ribose Salvage in Yeast Molecular Systems Biology. 2013 | Pubmed ID: 23670538 Noise and Interlocking Signaling Pathways Promote Distinct Transcription Factor Dynamics in Response to Different Stresses Molecular Biology of the Cell. Jun, 2013 | Pubmed ID: 23615444 High Hydrostatic Pressure Activates Gene Expression That Leads to Ethanol Production Enhancement in a Saccharomyces Cerevisiae Distillery Strain Applied Microbiology and Biotechnology. Mar, 2013 | Pubmed ID: 22915193 High Hydrostatic Pressure Activates Transcription Factors Involved in Saccharomyces Cerevisiae Stress Tolerance Current Pharmaceutical Biotechnology. Dec, 2012 | Pubmed ID: 23072392 Nutritional Control of Growth and Development in Yeast Genetics. Sep, 2012 | Pubmed ID: 22964838 Regulation of Yeast Pyruvate Kinase by Ultrasensitive Allostery Independent of Phosphorylation Molecular Cell. Oct, 2012 | Pubmed ID: 22902555 Decoding Complex Chemical Mixtures with a Physical Model of a Sensor Array PLoS Computational Biology. Oct, 2011 | Pubmed ID: 22046111 Chromatin Remodelers Clear Nucleosomes from Intrinsically Unfavorable Sites to Establish Nucleosome-depleted Regions at Promoters Molecular Biology of the Cell. Jun, 2011 | Pubmed ID: 21508315 Yeast Cells Can Access Distinct Quiescent States Genes & Development. Feb, 2011 | Pubmed ID: 21289062 Initiation of the TORC1-regulated G0 Program Requires Igo1/2, Which License Specific MRNAs to Evade Degradation Via the 5'-3' MRNA Decay Pathway Molecular Cell. May, 2010 | Pubmed ID: 20471941 The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication PLoS Genetics. Dec, 2009 | Pubmed ID: 19997491 Protein Kinase A and TORC1 Activate Genes for Ribosomal Biogenesis by Inactivating Repressors Encoded by Dot6 and Its Homolog Tod6 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19901341 Chromatin-dependent Transcription Factor Accessibility Rather Than Nucleosome Remodeling Predominates During Global Transcriptional Restructuring in Saccharomyces Cerevisiae Molecular Biology of the Cell. Aug, 2009 | Pubmed ID: 19494041 Expression of CXCR4, a G-protein-coupled Receptor for CXCL12 in Yeast Identification of New-generation Inverse Agonists Methods in Enzymology. 2009 | Pubmed ID: 19446737 Microarray Profiling of Phage-display Selections for Rapid Mapping of Transcription Factor-DNA Interactions PLoS Genetics. Apr, 2009 | Pubmed ID: 19360118 Glucose Regulates Transcription in Yeast Through a Network of Signaling Pathways Molecular Systems Biology. 2009 | Pubmed ID: 19225458 Predicting Cellular Growth from Gene Expression Signatures PLoS Computational Biology. Jan, 2009 | Pubmed ID: 19119411 Ph.D. Training in Cancer Biology Cancer Research. Nov, 2008 | Pubmed ID: 19010881 Microarray Data Mining: a Novel Optimization-based Approach to Uncover Biologically Coherent Structures BMC Bioinformatics. 2008 | Pubmed ID: 18538024 How Saccharomyces Responds to Nutrients Annual Review of Genetics. 2008 | Pubmed ID: 18303986 Evaluation of Normalization and Pre-clustering Issues in a Novel Clustering Approach: Global Optimum Search with Enhanced Positioning Journal of Bioinformatics and Computational Biology. Aug, 2007 | Pubmed ID: 17787062 Protein Kinase A and Sch9 Cooperatively Regulate Induction of Autophagy in Saccharomyces Cerevisiae Molecular Biology of the Cell. Oct, 2007 | Pubmed ID: 17699586 Sch9 is a Major Target of TORC1 in Saccharomyces Cerevisiae Molecular Cell. Jun, 2007 | Pubmed ID: 17560372 Cross-talk and Decision Making in MAP Kinase Pathways Nature Genetics. Mar, 2007 | Pubmed ID: 17259986 Functional Expression of CXCR4 in Saccharomyces Cerevisiae in the Development of Powerful Tools for the Pharmacological Characterization of CXCR4 Methods in Molecular Biology (Clifton, N.J.). 2006 | Pubmed ID: 16878688 Single-cell Observations Reveal Intermediate Transcriptional Silencing States Molecular Cell. Jul, 2006 | Pubmed ID: 16857588 The Dynamics of Homologous Pairing During Mating Type Interconversion in Budding Yeast PLoS Genetics. Jun, 2006 | Pubmed ID: 16789829 Creation of GPCR-based Chemical Sensors by Directed Evolution in Yeast Protein Engineering, Design & Selection : PEDS. Jan, 2006 | Pubmed ID: 16263727 Design and Synthesis of Downsized Metastin (45-54) Analogs with Maintenance of High GPR54 Agonistic Activity Bioorganic & Medicinal Chemistry Letters. Jan, 2006 | Pubmed ID: 16242330 Mutations in the Nucleosome Core Enhance Transcriptional Silencing Molecular and Cellular Biology. Mar, 2005 | Pubmed ID: 15713639 Sense and Sensibility: Nutritional Response and Signal Integration in Yeast Current Opinion in Microbiology. Dec, 2004 | Pubmed ID: 15556035 Making the Right Choice--long-range Chromosomal Interactions in Development Cell. Nov, 2004 | Pubmed ID: 15550239 PP2A Phosphatase Activity is Required for Stress and Tor Kinase Regulation of Yeast Stress Response Factor Msn2p Eukaryotic Cell. Oct, 2004 | Pubmed ID: 15470255 A Dynamic Transcriptional Network Communicates Growth Potential to Ribosome Synthesis and Critical Cell Size Genes & Development. Oct, 2004 | Pubmed ID: 15466158 Ras and Gpa2 Mediate One Branch of a Redundant Glucose Signaling Pathway in Yeast PLoS Biology. May, 2004 | Pubmed ID: 15138498 The Saccharomyces Cerevisiae Recombination Enhancer Biases Recombination During Interchromosomal Mating-type Switching but Not in Interchromosomal Homologous Recombination Genetics. Mar, 2004 | Pubmed ID: 15082540 Metastin and Its Variant Forms Suppress Migration of Pancreatic Cancer Cells Biochemical and Biophysical Research Communications. Feb, 2004 | Pubmed ID: 15013429 The Ras/protein Kinase A Pathway Acts in Parallel with the Mob2/Cbk1 Pathway to Effect Cell Cycle Progression and Proper Bud Site Selection Eukaryotic Cell. Feb, 2004 | Pubmed ID: 14871942 Theoretical and Computational Studies of the Glucose Signaling Pathways in Yeast Using Global Gene Expression Data Biotechnology and Bioengineering. Dec, 2003 | Pubmed ID: 14708127 Molecular-size Reduction of a Potent CXCR4-chemokine Antagonist Using Orthogonal Combination of Conformation- and Sequence-based Libraries Angewandte Chemie (International Ed. in English). Jul, 2003 | Pubmed ID: 12876735 Constitutive Activation of CCR5 and CCR2 Induced by Conformational Changes in the Conserved TXP Motif in Transmembrane Helix 2 The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12837756 Multiple Roles of Tap42 in Mediating Rapamycin-induced Transcriptional Changes in Yeast Molecular Cell. Jun, 2003 | Pubmed ID: 12820961 Making Good Neighbors: the Right Fence for the Right Job Nature Structural Biology. Apr, 2003 | Pubmed ID: 12660719 Rap1p and Other Transcriptional Regulators Can Function in Defining Distinct Domains of Gene Expression Nucleic Acids Research. Feb, 2003 | Pubmed ID: 12582242 Directional Bias During Mating Type Switching in Saccharomyces is Independent of Chromosomal Architecture The EMBO Journal. May, 2002 | Pubmed ID: 11980725 A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals That T140 is an Inverse Agonist and That AMD3100 and ALX40-4C Are Weak Partial Agonists The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11923301 טכניקה מהירה עבור ויזואליזציה של תאים חיים שמרים ללא יכולת לזוז Karl Zawadzki1, James Broach1 1Department of Molecular Biology, Princeton University JoVE 84 Biology Assay עבור הידבקות ואת הפלישה אגר ב cerevisiae ס Cemile G Guldal1, James Broach1 1Department of Molecular Biology, Princeton University JoVE 64 Biology
טכניקה מהירה עבור ויזואליזציה של תאים חיים שמרים ללא יכולת לזוז Karl Zawadzki1, James Broach1 1Department of Molecular Biology, Princeton University JoVE 84 Biology
Assay עבור הידבקות ואת הפלישה אגר ב cerevisiae ס Cemile G Guldal1, James Broach1 1Department of Molecular Biology, Princeton University JoVE 64 Biology