Javier González-Maeso Department of Psychiatry Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Javier González-Maeso has not added a biography. If you are Javier González-Maeso and would like to personalize this page please email our Author Liaison for assistance. Publications Cross-signaling in Metabotropic Glutamate 2 and Serotonin 2A Receptor Heteromers in Mammalian Cells Pflügers Archiv : European Journal of Physiology. May, 2016 | Pubmed ID: 26780666 Allosteric Signaling Through an MGlu2 and 5-HT2A Heteromeric Receptor Complex and Its Potential Contribution to Schizophrenia Science Signaling. Jan, 2016 | Pubmed ID: 26758213 Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptors in Schizophrenia Treatment Trends in Neurosciences. Aug, 2015 | Pubmed ID: 26148747 Epigenetic Signaling in Schizophrenia Cellular Signalling. Oct, 2015 | Pubmed ID: 26120009 Epigenetic Mechanisms of Serotonin Signaling ACS Chemical Neuroscience. Jul, 2015 | Pubmed ID: 25734378 G Protein-coupled Receptor Signaling to Kir Channels in Xenopus Oocytes Current Pharmaceutical Biotechnology. 2014 | Pubmed ID: 25374032 Family a GPCR Heteromers in Animal Models Frontiers in Pharmacology. 2014 | Pubmed ID: 25346690 Evaluation of 5-HT2A and MGlu2/3 Receptors in Postmortem Prefrontal Cortex of Subjects with Major Depressive Disorder: Effect of Antidepressant Treatment Neuropharmacology. Nov, 2014 | Pubmed ID: 25150943 Preclinical Models of Antipsychotic Drug Action The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Nov, 2013 | Pubmed ID: 23745738 The HIV Antiretroviral Drug Efavirenz Has LSD-like Properties Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2013 | Pubmed ID: 23702798 G Protein-coupled Receptor Heterocomplexes in Neuropsychiatric Disorders Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23663970 Repressive Epigenetic Changes at the MGlu2 Promoter in Frontal Cortex of 5-HT2A Knockout Mice Molecular Pharmacology. Jun, 2013 | Pubmed ID: 23508685 Epigenetic Regulation of RAC1 Induces Synaptic Remodeling in Stress Disorders and Depression Nature Medicine. Mar, 2013 | Pubmed ID: 23416703 Animal Models of Serotonergic Psychedelics ACS Chemical Neuroscience. Jan, 2013 | Pubmed ID: 23336043 Chronic Treatment with LY341495 Decreases 5-HT(2A) Receptor Binding and Hallucinogenic Effects of LSD in Mice Neuroscience Letters. Mar, 2013 | Pubmed ID: 23333599 Prenatal Stress Induces Schizophrenia-like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2013 | Pubmed ID: 23325246 HDAC2 As a New Target to Improve Schizophrenia Treatment Expert Review of Neurotherapeutics. Jan, 2013 | Pubmed ID: 23253383 Dysregulated 5-HT(2A) Receptor Binding in Postmortem Frontal Cortex of Schizophrenic Subjects European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. Aug, 2013 | Pubmed ID: 23176747 Persistent Effects of Chronic Clozapine on the Cellular and Behavioral Responses to LSD in Mice Psychopharmacology. Jan, 2013 | Pubmed ID: 22842765 Identification of Three Residues Essential for 5-hydroxytryptamine 2A-metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23129762 HDAC2 Regulates Atypical Antipsychotic Responses Through the Modulation of MGlu2 Promoter Activity Nature Neuroscience. Sep, 2012 | Pubmed ID: 22864611 Reduced Levels of Serotonin 2A Receptors Underlie Resistance of Egr3-deficient Mice to Locomotor Suppression by Clozapine Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2012 | Pubmed ID: 22692564 Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs Cell. Nov, 2011 | Pubmed ID: 22118459 Functional Crosstalk and Heteromerization of Serotonin 5-HT2A and Dopamine D2 Receptors Neuropharmacology. Sep, 2011 | Pubmed ID: 21645528 GPCR Oligomers in Pharmacology and Signaling Molecular Brain. 2011 | Pubmed ID: 21619615 Maternal Influenza Viral Infection Causes Schizophrenia-like Alterations of 5-HT₂A and MGlu₂ Receptors in the Adult Offspring The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21289196 Metabotropic Glutamate MGlu2 Receptor is Necessary for the Pharmacological and Behavioral Effects Induced by Hallucinogenic 5-HT2A Receptor Agonists Neuroscience Letters. Apr, 2011 | Pubmed ID: 21276828 α₂-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims Biological Psychiatry. Nov, 2010 | Pubmed ID: 20864091 Heteromerization of G Protein-coupled Receptors: Relevance to Neurological Disorders and Neurotherapeutics CNS & Neurological Disorders Drug Targets. Nov, 2010 | Pubmed ID: 20632964 Anxious Interactions Nature Neuroscience. May, 2010 | Pubmed ID: 20421895 Group II Metabotropic Glutamate Receptors and Schizophrenia Cellular and Molecular Life Sciences : CMLS. Dec, 2009 | Pubmed ID: 19707855 Agonist-trafficking and Hallucinogens Current Medicinal Chemistry. 2009 | Pubmed ID: 19275609 Psychedelics and Schizophrenia Trends in Neurosciences. Apr, 2009 | Pubmed ID: 19269047 Receptor Pair for Schizophrenia Pediatric Research. Jul, 2008 | Pubmed ID: 18574404 Identification of a Serotonin/glutamate Receptor Complex Implicated in Psychosis Nature. Mar, 2008 | Pubmed ID: 18297054 Hallucinogens Recruit Specific Cortical 5-HT(2A) Receptor-mediated Signaling Pathways to Affect Behavior Neuron. Feb, 2007 | Pubmed ID: 17270739 Heterotrimeric G Proteins: Insights into the Neurobiology of Mood Disorders Current Neuropharmacology. Apr, 2006 | Pubmed ID: 18615130 P53 Mediates Nontranscriptional Cell Death in Dopaminergic Cells in Response to Proteasome Inhibition The Journal of Biological Chemistry. Dec, 2006 | Pubmed ID: 17060322 Cortical 5-HT2A Receptor Signaling Modulates Anxiety-like Behaviors in Mice Science (New York, N.Y.). Jul, 2006 | Pubmed ID: 16873667 Method for Multiplex Cellular Detection of MRNAs Using Quantum Dot Fluorescent in Situ Hybridization Nucleic Acids Research. 2005 | Pubmed ID: 16224100 Epsilon-sarcoglycan Immunoreactivity and MRNA Expression in Mouse Brain The Journal of Comparative Neurology. Jan, 2005 | Pubmed ID: 15612018 Agonist-induced Desensitization and Endocytosis of Heterodimeric GABAB Receptors in CHO-K1 Cells European Journal of Pharmacology. Nov, 2003 | Pubmed ID: 14637170 Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2003 | Pubmed ID: 14523084 Validated Genomic Approach to Study Differentially Expressed Genes in Complex Tissues Neurochemical Research. Oct, 2002 | Pubmed ID: 12462402 Quantitative Stoichiometry of G-proteins Activated by Mu-opioid Receptors in Postmortem Human Brain European Journal of Pharmacology. Sep, 2002 | Pubmed ID: 12323382 Effects of Age, Postmortem Delay and Storage Time on Receptor-mediated Activation of G-proteins in Human Brain Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Apr, 2002 | Pubmed ID: 11927171 Distribution of Prolyl Endopeptidase Activities in Rat and Human Brain Neurochemistry International. Apr, 2002 | Pubmed ID: 11792464 HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice Terrell Holloway1, Jose L. Moreno1, Javier González-Maeso1,2,3,4 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 2Department of Neurology, Icahn School of Medicine at Mount Sinai, 3Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 4Department of Physiology and Biophysics, Virginia Commonwealth University Medical School JoVE 53717 Neuroscience
HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice Terrell Holloway1, Jose L. Moreno1, Javier González-Maeso1,2,3,4 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 2Department of Neurology, Icahn School of Medicine at Mount Sinai, 3Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 4Department of Physiology and Biophysics, Virginia Commonwealth University Medical School JoVE 53717 Neuroscience