Jean-Pierre Gorvel Centre d’Immunologie de Marseille-Luminy Université de la Méditérannée UM2, INSERM U1104 CNRS UM7280 Biography Publications Institution JoVE Articles Jean-Pierre Gorvel has not added a biography. If you are Jean-Pierre Gorvel and would like to personalize this page please email our Author Liaison for assistance. Publications Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells EBioMedicine. Mar, 2016 | Pubmed ID: 27077111 Effector Proteins Support the Asymmetric Apportioning of Salmonella During Cytokinesis Virulence. Aug, 2016 | Pubmed ID: 27046257 Structural Studies of Lipopolysaccharide-defective Mutants from Brucella Melitensis Identify a Core Oligosaccharide Critical in Virulence The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26867577 Brucella Discriminates Between Mouse Dendritic Cell Subsets Upon in Vitro Infection Virulence. 2016 | Pubmed ID: 26606688 Gene Expression Profiling of the Peyer's Patch Mononuclear Phagocyte System Genomics Data. Sep, 2015 | Pubmed ID: 26484215 Subversion of Mouse Dendritic Cell Subset Function by Bacterial Pathogens Microbial Pathogenesis. Dec, 2015 | Pubmed ID: 26453826 RUN and FYVE Domain-containing Protein 4 Enhances Autophagy and Lysosome Tethering in Response to Interleukin-4 The Journal of Cell Biology. Sep, 2015 | Pubmed ID: 26416964 The Salmonella Effector Protein SifA Plays a Dual Role in Virulence Scientific Reports. 2015 | Pubmed ID: 26268777 Brucella Abortus Induces the Premature Death of Human Neutrophils Through the Action of Its Lipopolysaccharide PLoS Pathogens. May, 2015 | Pubmed ID: 25946018 Innate and Adaptive Immune Functions of Peyer's Patch Monocyte-derived Cells Cell Reports. May, 2015 | Pubmed ID: 25921539 Escherichia Coli α-hemolysin Counteracts the Anti-virulence Innate Immune Response Triggered by the Rho GTPase Activating Toxin CNF1 During Bacteremia PLoS Pathogens. Mar, 2015 | Pubmed ID: 25781937 Brucella CβG Induces a Dual Pro- and Anti-inflammatory Response Leading to a Transient Neutrophil Recruitment Virulence. 2015 | Pubmed ID: 25654761 Cervical Lymph Nodes As a Selective Niche for Brucella During Oral Infections PloS One. 2014 | Pubmed ID: 25919005 Myeloid Decidual Dendritic Cells and Immunoregulation of Pregnancy: Defective Responsiveness to Coxiella Burnetii and Brucella Abortus Frontiers in Cellular and Infection Microbiology. 2014 | Pubmed ID: 25566514 Intracellular Bacteria Interfere with Dendritic Cell Functions: Role of the Type I Interferon Pathway PloS One. 2014 | Pubmed ID: 24915541 "If You Bring an Alarm, We Will Destroy It," Said Brucella to the Host Cell Virulence. May, 2014 | Pubmed ID: 24786767 Human Plasma Cells Express Granzyme B European Journal of Immunology. Jan, 2014 | Pubmed ID: 24114594 A Toxin-antitoxin Module of Salmonella Promotes Virulence in Mice PLoS Pathogens. 2013 | Pubmed ID: 24385907 In Vivo Identification and Characterization of CD4⁺ Cytotoxic T Cells Induced by Virulent Brucella Abortus Infection PloS One. 2013 | Pubmed ID: 24367519 Bartonella and Brucella--weapons and Strategies for Stealth Attack Cold Spring Harbor Perspectives in Medicine. Aug, 2013 | Pubmed ID: 23906880 BtpB, a Novel Brucella TIR-containing Effector Protein with Immune Modulatory Functions Frontiers in Cellular and Infection Microbiology. 2013 | Pubmed ID: 23847770 Neutrophils Exert a Suppressive Effect on Th1 Responses to Intracellular Pathogen Brucella Abortus PLoS Pathogens. Feb, 2013 | Pubmed ID: 23458832 Lipopolysaccharides with Acylation Defects Potentiate TLR4 Signaling and Shape T Cell Responses PloS One. 2013 | Pubmed ID: 23390517 Brucella Evasion of Adaptive Immunity Future Microbiology. Feb, 2013 | Pubmed ID: 23374122 Brucella T4SS: the VIP Pass Inside Host Cells Current Opinion in Microbiology. Feb, 2013 | Pubmed ID: 23318140 Pathogenic Brucellae Replicate in Human Trophoblasts The Journal of Infectious Diseases. Apr, 2013 | Pubmed ID: 23303808 Lipopolysaccharide As a Target for Brucellosis Vaccine Design Microbial Pathogenesis. May, 2013 | Pubmed ID: 23219811 Small GTPases and Brucella Entry into the Endoplasmic Reticulum Biochemical Society Transactions. Dec, 2012 | Pubmed ID: 23176479 Brucella β 1,2 Cyclic Glucan is an Activator of Human and Mouse Dendritic Cells PLoS Pathogens. 2012 | Pubmed ID: 23166489 The Lipopolysaccharide Core of Brucella Abortus Acts As a Shield Against Innate Immunity Recognition PLoS Pathogens. 2012 | Pubmed ID: 22589715 The Differential Production of Cytokines by Human Langerhans Cells and Dermal CD14(+) DCs Controls CTL Priming Blood. Jun, 2012 | Pubmed ID: 22535664 What Have We Learned from Brucellosis in the Mouse Model? Veterinary Research. 2012 | Pubmed ID: 22500859 Internal Affairs: Investigating the Brucella Intracellular Lifestyle FEMS Microbiology Reviews. May, 2012 | Pubmed ID: 22373010 Peyer's Patch Dendritic Cells Sample Antigens by Extending Dendrites Through M Cell-specific Transcellular Pores Gastroenterology. Mar, 2012 | Pubmed ID: 22155637 In Search of Brucella Abortus Type IV Secretion Substrates: Screening and Identification of Four Proteins Translocated into Host Cells Through VirB System Cellular Microbiology. Aug, 2011 | Pubmed ID: 21707904 Identification of a Brucella Spp. Secreted Effector Specifically Interacting with Human Small GTPase Rab2 Cellular Microbiology. Jul, 2011 | Pubmed ID: 21501366 Salmonella Detoxifying Enzymes Are Sufficient to Cope with the Host Oxidative Burst Molecular Microbiology. May, 2011 | Pubmed ID: 21362067 An Evolutionary Strategy for a Stealthy Intracellular Brucella Pathogen Immunological Reviews. Mar, 2011 | Pubmed ID: 21349096 Brucella Abortus Ornithine Lipids Are Dispensable Outer Membrane Components Devoid of a Marked Pathogen-associated Molecular Pattern PloS One. 2011 | Pubmed ID: 21249206 Contrasting Roles of Macrophages and Dendritic Cells in Controlling Initial Pulmonary Brucella Infection European Journal of Immunology. Dec, 2010 | Pubmed ID: 21108467 The Virulence Protein SopD2 Regulates Membrane Dynamics of Salmonella-containing Vacuoles PLoS Pathogens. 2010 | Pubmed ID: 20664790 Inactivation of Formyltransferase (wbkC) Gene Generates a Brucella Abortus Rough Strain That is Attenuated in Macrophages and in Mice Vaccine. Aug, 2010 | Pubmed ID: 20580469 Helicobacter Pylori Impairs Murine Dendritic Cell Responses to Infection PloS One. 2010 | Pubmed ID: 20523725 Transcriptome Analysis of the Brucella Abortus BvrR/BvrS Two-component Regulatory System PloS One. 2010 | Pubmed ID: 20422049 SKIP, the Host Target of the Salmonella Virulence Factor SifA, Promotes Kinesin-1-dependent Vacuolar Membrane Exchanges Traffic (Copenhagen, Denmark). Jul, 2010 | Pubmed ID: 20406420 The Brucella Abortus Phosphoglycerate Kinase Mutant is Highly Attenuated and Induces Protection Superior to That of Vaccine Strain 19 in Immunocompromised and Immunocompetent Mice Infection and Immunity. May, 2010 | Pubmed ID: 20194591 Bacterial Manipulation of Innate Immunity to Promote Infection Nature Reviews. Microbiology. Feb, 2010 | Pubmed ID: 20075926 Pathogenic Bacteria and Dead Cells Are Internalized by a Unique Subset of Peyer's Patch Dendritic Cells That Express Lysozyme Gastroenterology. Jan, 2010 | Pubmed ID: 19800337 Interaction Between the SifA Virulence Factor and Its Host Target SKIP is Essential for Salmonella Pathogenesis The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19801640 Brucella Abortus Induces Irgm3 and Irga6 Expression Via Type-I IFN by a MyD88-dependent Pathway, Without the Requirement of TLR2, TLR4, TLR5 and TLR9 Microbial Pathogenesis. Dec, 2009 | Pubmed ID: 19747534 The Glyceraldehyde-3-phosphate Dehydrogenase and the Small GTPase Rab 2 Are Crucial for Brucella Replication PLoS Pathogens. Jun, 2009 | Pubmed ID: 19557163 The Differential Interaction of Brucella and Ochrobactrum with Innate Immunity Reveals Traits Related to the Evolution of Stealthy Pathogens PloS One. 2009 | Pubmed ID: 19529776 Is Brucella an Enteric Pathogen? Nature Reviews. Microbiology. Mar, 2009 | Pubmed ID: 19172149 Brucella: a Mr "Hide" Converted into Dr Jekyll Microbes and Infection / Institut Pasteur. Jul, 2008 | Pubmed ID: 18664389 Brucellosis Vaccines: Assessment of Brucella Melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-polysaccharide Synthesis and Export PloS One. 2008 | Pubmed ID: 18648644 Nanobacteria Are Mineralo Fetuin Complexes PLoS Pathogens. Feb, 2008 | Pubmed ID: 18282102 Brucella Control of Dendritic Cell Maturation is Dependent on the TIR-containing Protein Btp1 PLoS Pathogens. Feb, 2008 | Pubmed ID: 18266466 Analysis of Kinesin Accumulation on Salmonella-containing Vacuoles Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 18363240 Virulence Factors in Brucellosis: Implications for Aetiopathogenesis and Treatment Expert Reviews in Molecular Medicine. 2007 | Pubmed ID: 18088444 Proteome Analysis of Rickettsia Felis Highlights the Expression Profile of Intracellular Bacteria Proteomics. Apr, 2007 | Pubmed ID: 17385819 Microbiology. Bacterial Bushwacking Through a Microtubule Jungle Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17095683 The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required to Establish an Intracellular Replication Niche Infection and Immunity. Dec, 2006 | Pubmed ID: 17015457 Mimivirus Giant Particles Incorporate a Large Fraction of Anonymous and Unique Gene Products Journal of Virology. Dec, 2006 | Pubmed ID: 16971431 The Salmonella Effector Protein PipB2 is a Linker for Kinesin-1 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16938850 Synthesis of Phosphatidylcholine, a Typical Eukaryotic Phospholipid, is Necessary for Full Virulence of the Intracellular Bacterial Parasite Brucella Abortus Cellular Microbiology. Aug, 2006 | Pubmed ID: 16882035 Identification of Two Putative Rickettsial Adhesins by Proteomic Analysis Research in Microbiology. Sep, 2006 | Pubmed ID: 16574381 Pathogen-endoplasmic-reticulum Interactions: in Through the out Door Nature Reviews. Immunology. Feb, 2006 | Pubmed ID: 16491138 Differential Inductions of TNF-alpha and IGTP, IIGP by Structurally Diverse Classic and Non-classic Lipopolysaccharides Cellular Microbiology. Mar, 2006 | Pubmed ID: 16469053 Characterization of Brucella Abortus Lipopolysaccharide Macrodomains As Mega Rafts Cellular Microbiology. Feb, 2006 | Pubmed ID: 16441431 Molecular Motors Hijacking by Intracellular Pathogens Cellular Microbiology. Jan, 2006 | Pubmed ID: 16367863 Rickettsia Conorii and R. Prowazekii Proteome Analysis by 2DE-MS: a Step Toward Functional Analysis of Rickettsial Genomes Annals of the New York Academy of Sciences. Dec, 2005 | Pubmed ID: 16481497 Identification and Structural Characterization of an Unusual Mycobacterial Monomeromycolyl-diacylglycerol Molecular Microbiology. Aug, 2005 | Pubmed ID: 16091048 The Intracellular Fate of Salmonella Depends on the Recruitment of Kinesin Science (New York, N.Y.). May, 2005 | Pubmed ID: 15905402 Antimicrobial Activity of Myotoxic Phospholipases A2 from Crotalid Snake Venoms and Synthetic Peptide Variants Derived from Their C-terminal Region Toxicon : Official Journal of the International Society on Toxinology. Jun, 2005 | Pubmed ID: 15904676 Cyclic Beta-1,2-glucan is a Brucella Virulence Factor Required for Intracellular Survival Nature Immunology. Jun, 2005 | Pubmed ID: 15880113 Proteome Analysis of Rickettsia Conorii by Two-dimensional Gel Electrophoresis Coupled with Mass Spectrometry FEMS Microbiology Letters. Apr, 2005 | Pubmed ID: 15837377 Bactericidal and Antiendotoxic Properties of Short Cationic Peptides Derived from a Snake Venom Lys49 Phospholipase A2 Antimicrobial Agents and Chemotherapy. Apr, 2005 | Pubmed ID: 15793109 Intracellular Trafficking of Parachlamydia Acanthamoebae Cellular Microbiology. Apr, 2005 | Pubmed ID: 15760458 Brucella Lipopolysaccharide Acts As a Virulence Factor Current Opinion in Microbiology. Feb, 2005 | Pubmed ID: 15694858 Bacteria Spurned by Self-absorbed Cells Nature Medicine. Jan, 2005 | Pubmed ID: 15635436 Brucella Coopts the Small GTPase Sar1 for Intracellular Replication Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15632218 Link Between Impaired Maturation of Phagosomes and Defective Coxiella Burnetii Killing in Patients with Chronic Q Fever The Journal of Infectious Diseases. Nov, 2004 | Pubmed ID: 15499532 Macropinocytosis of Polyplexes and Recycling of Plasmid Via the Clathrin-dependent Pathway Impair the Transfection Efficiency of Human Hepatocarcinoma Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2004 | Pubmed ID: 15294184 Improved Methods for Producing Outer Membrane Vesicles in Gram-negative Bacteria Research in Microbiology. Jul-Aug, 2004 | Pubmed ID: 15249060 Intracellular Trafficking Study of a RB51 B. Abortus Vaccinal Strain Isolated from Cow Milk Veterinary Microbiology. Mar, 2004 | Pubmed ID: 15036539 Organelle Robbery: Brucella Interactions with the Endoplasmic Reticulum Current Opinion in Microbiology. Feb, 2004 | Pubmed ID: 15036147 Brucella Evades Macrophage Killing Via VirB-dependent Sustained Interactions with the Endoplasmic Reticulum The Journal of Experimental Medicine. Aug, 2003 | Pubmed ID: 12925673 Facteurs De Virulence Du Pathogène Humain Opportuniste Serratia Marcescens Identifiés Par Dépistage in Vivo The EMBO Journal. Apr, 2003 | Pubmed ID: 12660152 Salmonella Typhimurium SifA Effector Protein Requires Its Membrane-anchoring C-terminal Hexapeptide for Its Biological Function The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12574170 Brucella Intracellular Life: from Invasion to Intracellular Replication Veterinary Microbiology. Dec, 2002 | Pubmed ID: 12414149 Coxiella Burnetii Survival in THP-1 Monocytes Involves the Impairment of Phagosome Maturation: IFN-gamma Mediates Its Restoration and Bacterial Killing Journal of Immunology (Baltimore, Md. : 1950). Oct, 2002 | Pubmed ID: 12370385 Activation of Rho and Rab GTPases Dissociates Brucella Abortus Internalization from Intracellular Trafficking Cellular Microbiology. Oct, 2002 | Pubmed ID: 12366403 The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology Molecular Biology of the Cell. Jun, 2002 | Pubmed ID: 12058053 Survival of Tropheryma Whipplei, the Agent of Whipple's Disease, Requires Phagosome Acidification Infection and Immunity. Mar, 2002 | Pubmed ID: 11854238 Les analyses microscopiques de Criblage à haut débit des facteurs de l'hôte impliqués dans Alain Casanova*1, Shyan H. Low*1, Mario Emmenlauer*1,4, Raquel Conde-Alvarez*1,3, Suzana P. Salcedo2, Jean-Pierre Gorvel2, Christoph Dehio1 1Focal Area Infection Biology, Biozentrum, University of Basel, 2Centre d’Immunologie de Marseille-Luminy, Université de la Méditérannée UM2, INSERM U1104 CNRS UM7280, 3Departmento de Microbiologìa and Instituto de Salud Tropical, Universidad de Navarra, 4BioDataAnalysis GmbH Immunology and Infection
Les analyses microscopiques de Criblage à haut débit des facteurs de l'hôte impliqués dans Alain Casanova*1, Shyan H. Low*1, Mario Emmenlauer*1,4, Raquel Conde-Alvarez*1,3, Suzana P. Salcedo2, Jean-Pierre Gorvel2, Christoph Dehio1 1Focal Area Infection Biology, Biozentrum, University of Basel, 2Centre d’Immunologie de Marseille-Luminy, Université de la Méditérannée UM2, INSERM U1104 CNRS UM7280, 3Departmento de Microbiologìa and Instituto de Salud Tropical, Universidad de Navarra, 4BioDataAnalysis GmbH Immunology and Infection