Jen-Tsan Chi Department of Molecular Genetics and Microbiology Duke University School of Medicine Biography Publications Institution JoVE Articles Jen-Tsan Chi has not added a biography. If you are Jen-Tsan Chi and would like to personalize this page please email our Author Liaison for assistance. Publications A Comprehensive Joint Analysis of the Long and Short RNA Transcriptomes of Human Erythrocytes BMC Genomics. 2015 | Pubmed ID: 26573221 FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target Radiation Research. Nov, 2015 | Pubmed ID: 26488758 ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 Via α-ketoglutarate PLoS Genetics. Oct, 2015 | Pubmed ID: 26452058 Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition Journal of Medicinal Chemistry. Oct, 2015 | Pubmed ID: 26394152 A Paclitaxel-loaded Recombinant Polypeptide Nanoparticle Outperforms Abraxane in Multiple Murine Cancer Models Nature Communications. 2015 | Pubmed ID: 26239362 Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma Cell Reports. Jul, 2015 | Pubmed ID: 26119730 Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers International Journal of Radiation Oncology, Biology, Physics. Jul, 2015 | Pubmed ID: 26104938 Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis PloS One. 2015 | Pubmed ID: 26075887 Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2015 | Pubmed ID: 26071485 E2F1-Mediated Induction of NFYB Attenuates Apoptosis Via Joint Regulation of a Pro-Survival Transcriptional Program PloS One. 2015 | Pubmed ID: 26039627 Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-deprived Response Dependent on Intact Creatine Biosynthesis PLoS Genetics. Apr, 2015 | Pubmed ID: 25849282 Alternative Fuels for Cancer Cells Cancer Journal (Sudbury, Mass.). Mar-Apr, 2015 | Pubmed ID: 25815843 Whole Blood Gene Expression Profiles Distinguish Clinical Phenotypes of Venous Thromboembolism Thrombosis Research. Apr, 2015 | Pubmed ID: 25684211 Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78 Molecular Cancer Therapeutics. Mar, 2015 | Pubmed ID: 25589495 An Unexpected Alliance Between Stress Responses to Drive Oncogenesis Breast Cancer Research : BCR. 2014 | Pubmed ID: 25927911 Utilization of the Eμ-Myc Mouse to Model Heterogeneity of Therapeutic Response Molecular Cancer Therapeutics. Dec, 2014 | Pubmed ID: 25349303 Glycolysis-dependent Histone Deacetylase 4 Degradation Regulates Inflammatory Cytokine Production Molecular Biology of the Cell. Nov, 2014 | Pubmed ID: 25187650 A Joint Analysis of Metabolomics and Genetics of Breast Cancer Breast Cancer Research : BCR. 2014 | Pubmed ID: 25091696 Alveolar Rhabdomyosarcoma-associated PAX3-FOXO1 Promotes Tumorigenesis Via Hippo Pathway Suppression The Journal of Clinical Investigation. Jan, 2014 | Pubmed ID: 24334454 Acidosis Induces Reprogramming of Cellular Metabolism to Mitigate Oxidative Stress Cancer & Metabolism. 2013 | Pubmed ID: 24359630 Catabolism of Exogenous Lactate Reveals It As a Legitimate Metabolic Substrate in Breast Cancer PloS One. 2013 | Pubmed ID: 24069390 Understanding the Tumor Microenvironment and Radioresistance by Combining Functional Imaging with Global Gene Expression Seminars in Radiation Oncology. Oct, 2013 | Pubmed ID: 24012344 Aspirin Exposure Reveals Novel Genes Associated with Platelet Function and Cardiovascular Events Journal of the American College of Cardiology. Oct, 2013 | Pubmed ID: 23831034 Acidosis Activation of the Proton-sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis PloS One. 2013 | Pubmed ID: 23613998 Iron-responsive MiR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin PLoS Genetics. Apr, 2013 | Pubmed ID: 23593016 Global Identification of MLL2-targeted Loci Reveals MLL2's Role in Diverse Signaling Pathways Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045699 Associations Between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans Journal of Cancer Epidemiology. 2012 | Pubmed ID: 22927849 Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium Falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance Cell Host & Microbe. Aug, 2012 | Pubmed ID: 22901539 A Heterozygous IDH1R132H/WT Mutation Induces Genome-wide Alterations in DNA Methylation Genome Research. Dec, 2012 | Pubmed ID: 22899282 Time-dependent Changes in Non-COX-1-dependent Platelet Function with Daily Aspirin Therapy Journal of Thrombosis and Thrombolysis. Apr, 2012 | Pubmed ID: 22294277 Functional Interaction Between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs Cancer Research. Jan, 2012 | Pubmed ID: 22135092 Glutamine Synthetase is a Genetic Determinant of Cell Type-specific Glutamine Independence in Breast Epithelia PLoS Genetics. Aug, 2011 | Pubmed ID: 21852960 Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality Science Translational Medicine. Aug, 2011 | Pubmed ID: 21813754 Whole Blood Gene Expression Analyses in Patients with Single Versus Recurrent Venous Thromboembolism Thrombosis Research. Dec, 2011 | Pubmed ID: 21737128 Analysis of Tumor Environmental Response and Oncogenic Pathway Activation Identifies Distinct Basal and Luminal Features in HER2-related Breast Tumor Subtypes Breast Cancer Research : BCR. 2011 | Pubmed ID: 21672245 Polysome Profiling of the Malaria Parasite Plasmodium Falciparum Molecular and Biochemical Parasitology. Sep, 2011 | Pubmed ID: 21605599 Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21292819 Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP Through MondoA PLoS Genetics. Sep, 2010 | Pubmed ID: 20844768 Isolation and Characterization of MicroRNAs of Human Mature Erythrocytes Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20827535 Latent Factor Analysis to Discover Pathway-associated Putative Segmental Aneuploidies in Human Cancers PLoS Computational Biology. 2010 | Pubmed ID: 20824128 MicroRNA MiR-144 Modulates Oxidative Stress Tolerance and Associates with Anemia Severity in Sickle Cell Disease Blood. Nov, 2010 | Pubmed ID: 20709907 Pleiotrophin Regulates the Expansion and Regeneration of Hematopoietic Stem Cells Nature Medicine. Apr, 2010 | Pubmed ID: 20305662 AN INTEGRATIVE ANALYSIS OF CANCER GENE EXPRESSION STUDIES USING BAYESIAN LATENT FACTOR MODELING The Annals of Applied Statistics. 2009 | Pubmed ID: 20953268 P38gamma Mitogen-activated Protein Kinase is a Key Regulator in Skeletal Muscle Metabolic Adaptation in Mice PloS One. 2009 | Pubmed ID: 19936205 Tumor Vasculature is Regulated by PHD2-mediated Angiogenesis and Bone Marrow-derived Cell Recruitment Cancer Cell. Jun, 2009 | Pubmed ID: 19477431 Cross-study Projections of Genomic Biomarkers: an Evaluation in Cancer Genomics PloS One. 2009 | Pubmed ID: 19225561 The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers PLoS Genetics. Dec, 2008 | Pubmed ID: 19057672 Combining Biological Gene Expression Signatures in Predicting Outcome in Breast Cancer: An Alternative to Supervised Classification European Journal of Cancer (Oxford, England : 1990). Oct, 2008 | Pubmed ID: 18715778 The Genomic Analysis of Erythrocyte MicroRNA Expression in Sickle Cell Diseases PloS One. 2008 | Pubmed ID: 18523662 Modeling Cancer Progression Via Pathway Dependencies PLoS Computational Biology. Feb, 2008 | Pubmed ID: 18282083 A Viral MicroRNA Functions As an Orthologue of Cellular MiR-155 Nature. Dec, 2007 | Pubmed ID: 18075594 Gene Expression Programs of Human Smooth Muscle Cells: Tissue-specific Differentiation and Prognostic Significance in Breast Cancers PLoS Genetics. Sep, 2007 | Pubmed ID: 17907811 The Potential Role of Intrinsic Hypoxia Markers As Prognostic Variables in Cancer Antioxidants & Redox Signaling. Aug, 2007 | Pubmed ID: 17571959 Minimizing Off-target Effects by Using Diced SiRNAs for RNA Interference Journal of RNAi and Gene Silencing : an International Journal of RNA and Gene Targeting Research. 2006 | Pubmed ID: 19771225 Predicting a Local Recurrence After Breast-conserving Therapy by Gene Expression Profiling Breast Cancer Research : BCR. 2006 | Pubmed ID: 17069664 Lysyl Oxidase is Essential for Hypoxia-induced Metastasis Nature. Apr, 2006 | Pubmed ID: 16642001 Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers PLoS Medicine. Mar, 2006 | Pubmed ID: 16417408 Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities Between Tumors and Wounds PLoS Biology. Feb, 2004 | Pubmed ID: 14737219 Systemic and Cell Type-specific Gene Expression Patterns in Scleroderma Skin Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14530402 Endothelial Cell Diversity Revealed by Global Expression Profiling Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12963823 Genomewide View of Gene Silencing by Small Interfering RNAs Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12730368 Diversity, Topographic Differentiation, and Positional Memory in Human Fibroblasts Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12297622 Comprehensive Analysis of the Gene Expression Profiles in Human Gastric Cancer Cell Lines Oncogene. Sep, 2002 | Pubmed ID: 12226758 Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum Gregory LaMonte*1,2, Katelyn A. Walzer*1,2, Joshua Lacsina3, Christopher Nicchitta3, Jen-Tsan Chi1,2 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, 2Center for Genomic and Computational Biology, Duke University School of Medicine, 3Department of Cell Biology, Duke University School of Medicine JoVE 53214 Immunology and Infection
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum Gregory LaMonte*1,2, Katelyn A. Walzer*1,2, Joshua Lacsina3, Christopher Nicchitta3, Jen-Tsan Chi1,2 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, 2Center for Genomic and Computational Biology, Duke University School of Medicine, 3Department of Cell Biology, Duke University School of Medicine JoVE 53214 Immunology and Infection