Joan Mecsas Department of Molecular Biology and Microbiology Tufts University Biography Publications Institution JoVE Articles Joan Mecsas has not added a biography. If you are Joan Mecsas and would like to personalize this page please email our Author Liaison for assistance. Publications Unraveling Neutrophil- Interactions During Tissue Infection F1000Research. 2019 | Pubmed ID: 31327994 Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31177435 Amino Acid Biosynthetic Pathways Are Required for Growth in Immunocompromised Lungs and Are Druggable Targets During Infection Antimicrobial Agents and Chemotherapy. May, 2019 | Pubmed ID: 31109974 New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems Microbiology Spectrum. 03, 2019 | Pubmed ID: 30848233 Promises and Challenges of the Type Three Secretion System Injectisome As an Antivirulence Target EcoSal Plus. 02, 2019 | Pubmed ID: 30706846 Pre-colonization with the Commensal Fungus Candida Albicans Reduces Murine Susceptibility to Clostridium Difficile Infection Gut Microbes. 11, 2018 | Pubmed ID: 29667487 Editorial Overview: Host-pathogen Interactions Shaped Through Evolutionary and Regulatory Processes Current Opinion in Microbiology. 02, 2018 | Pubmed ID: 29559085 A 3D Intestinal Tissue Model Supports Clostridioides Difficile Germination, Colonization, Toxin Production and Epithelial Damage Anaerobe. Apr, 2018 | Pubmed ID: 29462695 Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance Frontiers in Cellular and Infection Microbiology. 2017 | Pubmed ID: 28890882 Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide Journal of Immunology (Baltimore, Md. : 1950). 06, 2017 | Pubmed ID: 28461567 The Yersinia Pestis Effector YopM Inhibits Pyrin Inflammasome Activation PLoS Pathogens. Dec, 2016 | Pubmed ID: 27911947 Fis Is Essential for Yersinia Pseudotuberculosis Virulence and Protects Against Reactive Oxygen Species Produced by Phagocytic Cells During Infection PLoS Pathogens. Sep, 2016 | Pubmed ID: 27689357 Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas Aeruginosa Pathogenicity and Inflammasome Activation The Journal of Infectious Diseases. 10, 2016 | Pubmed ID: 27412581 Klebsiella Pneumoniae: Going on the Offense with a Strong Defense Microbiology and Molecular Biology Reviews : MMBR. 09, 2016 | Pubmed ID: 27307579 Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 07, 2016 | Pubmed ID: 27025826 Bacterial Secretion Systems: An Overview Microbiology Spectrum. Feb, 2016 | Pubmed ID: 26999395 A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4 Cell Host & Microbe. Dec, 2015 | Pubmed ID: 26651944 Robust Bioengineered 3D Functional Human Intestinal Epithelium Scientific Reports. 2015 | Pubmed ID: 26374193 Intestinal Alkaline Phosphatase Deficiency Leads to Lipopolysaccharide Desensitization and Faster Weight Gain Infection and Immunity. Jan, 2015 | Pubmed ID: 25348635 Mutations in the Pseudomonas Aeruginosa Needle Protein Gene PscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System Antimicrobial Agents and Chemotherapy. 2014 | Pubmed ID: 24468789 Yersinia Pseudotuberculosis Uses Ail and YadA to Circumvent Neutrophils by Directing Yop Translocation During Lung Infection Cellular Microbiology. Feb, 2014 | Pubmed ID: 24119087 Identifying Yersinia YopH-targeted Signal Transduction Pathways That Impair Neutrophil Responses During in Vivo Murine Infection Cell Host & Microbe. Sep, 2013 | Pubmed ID: 24034616 Adhesins and Host Serum Factors Drive Yop Translocation by Yersinia into Professional Phagocytes During Animal Infection PLoS Pathogens. 2013 | Pubmed ID: 23818844 A Mutant with Aberrant Extracellular LcrV-YscF Interactions Fails to Form Pores and Translocate Yop Effector Proteins but Retains the Ability to Trigger Yop Secretion in Response to Host Cell Contact Journal of Bacteriology. May, 2013 | Pubmed ID: 23475976 Identification of MrtAB, an ABC Transporter Specifically Required for Yersinia Pseudotuberculosis to Colonize the Mesenteric Lymph Nodes PLoS Pathogens. 2012 | Pubmed ID: 22876175 The NLRP12 Inflammasome Recognizes Yersinia Pestis Immunity. Jul, 2012 | Pubmed ID: 22840842 Yersinia Pestis AcrAB-TolC in Antibiotic Resistance and Virulence Antimicrobial Agents and Chemotherapy. Feb, 2012 | Pubmed ID: 22083483 Development of a Vaccinia Virus Based Reservoir-targeted Vaccine Against Yersinia Pestis Vaccine. Nov, 2010 | Pubmed ID: 20875494 Small Molecule Inhibitors of LcrF, a Yersinia Pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia Model Infection and Immunity. Nov, 2010 | Pubmed ID: 20823209 Identification and Characterization of Small-molecule Inhibitors of Yop Translocation in Yersinia Pseudotuberculosis Antimicrobial Agents and Chemotherapy. Aug, 2010 | Pubmed ID: 20498321 The C-terminal Tail of Yersinia Pseudotuberculosis YopM is Critical for Interacting with RSK1 and for Virulence Infection and Immunity. Jun, 2010 | Pubmed ID: 20368345 A Dominant-negative Needle Mutant Blocks Type III Secretion of Early but Not Late Substrates in Yersinia Molecular Microbiology. Apr, 2010 | Pubmed ID: 20199604 ROS-inhibitory Activity of YopE is Required for Full Virulence of Yersinia in Mice Cellular Microbiology. Jul, 2010 | Pubmed ID: 20148901 The Presence of Professional Phagocytes Dictates the Number of Host Cells Targeted for Yop Translocation During Infection Cellular Microbiology. Aug, 2010 | Pubmed ID: 20148898 Effect of MarA-like Proteins on Antibiotic Resistance and Virulence in Yersinia Pestis Infection and Immunity. Jan, 2010 | Pubmed ID: 19841071 CD8(+) T Cells Restrict Yersinia Pseudotuberculosis Infection: Bypass of Anti-phagocytosis by Targeting Antigen-presenting Cells PLoS Pathogens. Sep, 2009 | Pubmed ID: 19730693 Effect of Age on Susceptibility to Salmonella Typhimurium Infection in C57BL/6 Mice Journal of Medical Microbiology. Dec, 2009 | Pubmed ID: 19729455 Self-regulation of Candida Albicans Population Size During GI Colonization PLoS Pathogens. Dec, 2007 | Pubmed ID: 18069889 Oral Inoculation with Type III Secretion Mutants of Yersinia Pseudotuberculosis Provides Protection from Oral, Intraperitoneal, or Intranasal Challenge with Virulent Yersinia Vaccine. Feb, 2007 | Pubmed ID: 17194509 Intranasal Inoculation of Mice with Yersinia Pseudotuberculosis Causes a Lethal Lung Infection That is Dependent on Yersinia Outer Proteins and PhoP Infection and Immunity. Jan, 2007 | Pubmed ID: 17074849 Mutations in the Yersinia Pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells Journal of Bacteriology. Jan, 2007 | Pubmed ID: 17071752 Yersinia Has a Tropism for B and T Cell Zones of Lymph Nodes That is Independent of the Type III Secretion System PLoS Pathogens. Sep, 2006 | Pubmed ID: 16948531 A Non-invasive Quantitative Assay to Measure Murine Intestinal Inflammation Using the Neutrophil Marker Lactoferrin Journal of Immunological Methods. Jun, 2006 | Pubmed ID: 16806255 Yersinia Pseudotuberculosis Disseminates Directly from a Replicating Bacterial Pool in the Intestine The Journal of Experimental Medicine. Jun, 2006 | Pubmed ID: 16754724 The Proinflammatory Response Induced by Wild-type Yersinia Pseudotuberculosis Infection Inhibits Survival of Yop Mutants in the Gastrointestinal Tract and Peyer's Patches Infection and Immunity. Mar, 2006 | Pubmed ID: 16495522 Requirement of the Yersinia Pseudotuberculosis Effectors YopH and YopE in Colonization and Persistence in Intestinal and Lymph Tissues Infection and Immunity. Aug, 2003 | Pubmed ID: 12874339 Use of Signature-tagged Mutagenesis in Pathogenesis Studies Current Opinion in Microbiology. Feb, 2002 | Pubmed ID: 11834366 Identification of Attenuated Yersinia Pseudotuberculosis Strains and Characterization of an Orogastric Infection in BALB/c Mice on Day 5 Postinfection by Signature-tagged Mutagenesis Infection and Immunity. May, 2001 | Pubmed ID: 11292689 Insan kök hücresinde M hücre benzeri hücrelerin kaynaklı farklılaşma-türev ıleal Enteroid Monolayers Alyssa C. Fasciano1, Sarah E. Blutt2, Mary K. Estes2, Joan Mecsas3 1Program in Immunology, Sackler School of Graduate Biomedical Sciences, 2Department of Molecular Virology and Microbiology, Baylor College of Medicine, 3Department of Molecular Biology and Microbiology, Tufts University JoVE 59894 Immunology and Infection
Insan kök hücresinde M hücre benzeri hücrelerin kaynaklı farklılaşma-türev ıleal Enteroid Monolayers Alyssa C. Fasciano1, Sarah E. Blutt2, Mary K. Estes2, Joan Mecsas3 1Program in Immunology, Sackler School of Graduate Biomedical Sciences, 2Department of Molecular Virology and Microbiology, Baylor College of Medicine, 3Department of Molecular Biology and Microbiology, Tufts University JoVE 59894 Immunology and Infection