John Disterhoft Department of Physiology Northwestern University Biography Publications Institution JoVE Articles John Disterhoft has not added a biography. If you are John Disterhoft and would like to personalize this page please email our Author Liaison for assistance. Publications The Development of Rapastinel (Formerly GLYX-13); a Rapid Acting and Long Lasting Antidepressant Current Neuropharmacology. Mar, 2016 | Pubmed ID: 26997507 Pretrial Functional Connectivity Differentiates Behavioral Outcomes During Trace Eyeblink Conditioning in the Rabbit Learning & Memory (Cold Spring Harbor, N.Y.). Apr, 2016 | Pubmed ID: 26980784 Intrinsic Connectivity of Neural Networks in the Awake Rabbit NeuroImage. Apr, 2016 | Pubmed ID: 26774609 Activity-induced Manganese-dependent MRI (AIM-MRI) and Functional MRI in Awake Rabbits During Somatosensory Stimulation NeuroImage. Feb, 2016 | Pubmed ID: 26589332 Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases Frontiers in Psychiatry. 2015 | Pubmed ID: 26500564 Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26400949 Hippocampectomy Disrupts Trace Eye-blink Conditioning in Rabbits Behavioral Neuroscience. Aug, 2015 | Pubmed ID: 26214217 The Impact of Hippocampal Lesions on Trace-eyeblink Conditioning and Forebrain-cerebellar Interactions Behavioral Neuroscience. Aug, 2015 | Pubmed ID: 26214216 Rapastinel (GLYX-13) Has Therapeutic Potential for the Treatment of Post-traumatic Stress Disorder: Characterization of a NMDA Receptor-mediated Metaplasticity Process in the Medial Prefrontal Cortex of Rats Behavioural Brain Research. Nov, 2015 | Pubmed ID: 26210936 Robust Hippocampal Responsivity During Retrieval of Consolidated Associative Memory Hippocampus. May, 2015 | Pubmed ID: 25515308 Increased Excitability of Both Principal Neurons and Interneurons During Associative Learning The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Aug, 2015 | Pubmed ID: 24946769 Age-related Impairments on One Hippocampal-dependent Task Predict Impairments on a Subsequent Hippocampal-dependent Task Behavioral Neuroscience. Dec, 2014 | Pubmed ID: 25420127 Dendritic Spinopathy in Transgenic Mice Expressing ALS/dementia-linked Mutant UBQLN2 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25246588 Functional Reorganization of a Prefrontal Cortical Network Mediating Consolidation of Trace Eyeblink Conditioning The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2014 | Pubmed ID: 24453332 GLYX-13, an NMDA Receptor Glycine Site Functional Partial Agonist Enhances Cognition and Produces Antidepressant Effects Without the Psychotomimetic Side Effects of NMDA Receptor Antagonists Expert Opinion on Investigational Drugs. Feb, 2014 | Pubmed ID: 24251380 Surface L-type Ca2+ Channel Expression Levels Are Increased in Aged Hippocampus Aging Cell. Feb, 2014 | Pubmed ID: 24033980 Functional MRI of Cerebellar Activity During Eyeblink Classical Conditioning in Children and Adults Human Brain Mapping. Apr, 2014 | Pubmed ID: 23674498 Altered Calcium Metabolism in Aging CA1 Hippocampal Pyramidal Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2013 | Pubmed ID: 23637181 Learning Increases Intrinsic Excitability of Hippocampal Interneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013 | Pubmed ID: 23536065 Caudate Nucleus in Retrieval of Trace Eyeblink Conditioning After Consolidation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2013 | Pubmed ID: 23407942 Perirhinal and Postrhinal, but Not Lateral Entorhinal, Cortices Are Essential for Acquisition of Trace Eyeblink Conditioning Learning & Memory (Cold Spring Harbor, N.Y.). 2013 | Pubmed ID: 23322556 Infragranular Barrel Cortex Activity is Enhanced with Learning Journal of Neurophysiology. Sep, 2012 | Pubmed ID: 22696544 Increasing SK2 Channel Activity Impairs Associative Learning Journal of Neurophysiology. Aug, 2012 | Pubmed ID: 22552186 A MRI-compatible System for Whisker Stimulation Journal of Neuroscience Methods. Apr, 2012 | Pubmed ID: 22322316 Reevaluating Hippocampus-dependent Learning in FVB/N Mice Behavioral Neuroscience. Dec, 2011 | Pubmed ID: 22122148 Physiological and Anatomical Studies of Associative Learning: Convergence with Learning Studies of W.T. Greenough Developmental Psychobiology. Jul, 2011 | Pubmed ID: 21678397 Exploring Prefrontal Cortical Memory Mechanisms with Eyeblink Conditioning Behavioral Neuroscience. Jun, 2011 | Pubmed ID: 21517143 Age-related Deficits in a Forebrain-dependent Task, Trace-eyeblink Conditioning Neurobiology of Aging. Oct, 2011 | Pubmed ID: 20018411 The N-methyl-D-aspartate Receptor Modulator GLYX-13 Enhances Learning and Memory, in Young Adult and Learning Impaired Aging Rats Neurobiology of Aging. Apr, 2011 | Pubmed ID: 19446371 Cellular Mechanisms for Altered Learning in Aging Future Neurology. Jan, 2010 | Pubmed ID: 23525658 The Effects of Aging in Delay and Trace Human Eyeblink Conditioning Psychology and Aging. Sep, 2010 | Pubmed ID: 20677885 Learning and Aging Related Changes in Intrinsic Neuronal Excitability Frontiers in Aging Neuroscience. 2010 | Pubmed ID: 20552042 Synaptic Strength and Postsynaptically Silent Synapses Through Advanced Aging in Rat Hippocampal CA1 Pyramidal Neurons Neurobiology of Aging. May, 2010 | Pubmed ID: 18620783 Caudate Nucleus is Critically Involved in Trace Eyeblink Conditioning The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2009 | Pubmed ID: 19923285 BMP Signaling Mediates Effects of Exercise on Hippocampal Neurogenesis and Cognition in Mice PloS One. 2009 | Pubmed ID: 19841742 Intrinsic Neuronal Excitability is Reversibly Altered by a Single Experience in Fear Conditioning Journal of Neurophysiology. Nov, 2009 | Pubmed ID: 19726729 Kalirin Regulates Cortical Spine Morphogenesis and Disease-related Behavioral Phenotypes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19625617 Balanced Gene Regulation by an Embryonic Brain NcRNA is Critical for Adult Hippocampal GABA Circuitry Nature Neuroscience. Aug, 2009 | Pubmed ID: 19620975 Memory Deficits Are Associated with Impaired Ability to Modulate Neuronal Excitability in Middle-aged Mice Learning & Memory (Cold Spring Harbor, N.Y.). Jun, 2009 | Pubmed ID: 19470651 The Fast and Slow Afterhyperpolarizations Are Differentially Modulated in Hippocampal Neurons by Aging and Learning The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19369544 Autophosphorylation of AlphaCaMKII Downregulates Excitability of CA1 Pyramidal Neurons Following Synaptic Stimulation Neurobiology of Learning and Memory. Jul, 2009 | Pubmed ID: 19245842 Blocking the BK Channel Impedes Acquisition of Trace Eyeblink Conditioning Learning & Memory (Cold Spring Harbor, N.Y.). Feb, 2009 | Pubmed ID: 19181615 Learning-related Postburst Afterhyperpolarization Reduction in CA1 Pyramidal Neurons is Mediated by Protein Kinase A Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19164584 A Novel Method for Precisely Timed Stimulation of Mouse Whiskers in a Freely Moving Preparation: Application for Delivery of the Conditioned Stimulus in Trace Eyeblink Conditioning Journal of Neuroscience Methods. Mar, 2009 | Pubmed ID: 19041891 The BK-mediated FAHP is Modulated by Learning a Hippocampus-dependent Task Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18799739 Coupling of L-type Ca2+ Channels to KV7/KCNQ Channels Creates a Novel, Activity-dependent, Homeostatic Intrinsic Plasticity Journal of Neurophysiology. Oct, 2008 | Pubmed ID: 18715900 Evoking Blinks with Natural Stimulation and Detecting Them with a Noninvasive Optical Device: a Simple, Inexpensive Method for Use with Freely Moving Animals Journal of Neuroscience Methods. Aug, 2008 | Pubmed ID: 18598716 Neural Substrates Underlying Human Delay and Trace Eyeblink Conditioning Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18523017 Functional Magnetic Resonance Imaging of Delay and Trace Eyeblink Conditioning in the Primary Visual Cortex of the Rabbit The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008 | Pubmed ID: 18463251 Procedural Memory System Supports Single Cue Trace Eyeblink Conditioning in Medial Temporal Lobe Amnesia Neuropsychology. Mar, 2008 | Pubmed ID: 18331171 Delay Discrimination and Reversal Eyeblink Classical Conditioning in Abstinent Chronic Alcoholics Neuropsychology. Mar, 2008 | Pubmed ID: 18331162 Where is the Trace in Trace Conditioning? Trends in Neurosciences. Feb, 2008 | Pubmed ID: 18199490 Enhanced Neuronal Excitability in Rat CA1 Pyramidal Neurons Following Trace Eyeblink Conditioning Acquisition is Not Due to Alterations in I M Neurobiology of Learning and Memory. Feb, 2008 | Pubmed ID: 17703960 Alterations in Intrinsic Neuronal Excitability During Normal Aging Aging Cell. Jun, 2007 | Pubmed ID: 17517042 Cortical Barrel Lesions Impair Whisker-CS Trace Eyeblink Conditioning Learning & Memory (Cold Spring Harbor, N.Y.). Jan-Feb, 2007 | Pubmed ID: 17272654 BACE1 Gene Deletion Prevents Neuron Loss and Memory Deficits in 5XFAD APP/PS1 Transgenic Mice Neurobiology of Disease. Apr, 2007 | Pubmed ID: 17258906 Stability and Plasticity of Intrinsic Membrane Properties in Hippocampal CA1 Pyramidal Neurons: Effects of Internal Anions The Journal of Physiology. Feb, 2007 | Pubmed ID: 17138601 Forebrain-Cerebellar Interactions During Learning Cellscience. Oct, 2006 | Pubmed ID: 26617664 Intraneuronal Beta-amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2006 | Pubmed ID: 17021169 Learning, Aging and Intrinsic Neuronal Plasticity Trends in Neurosciences. Oct, 2006 | Pubmed ID: 16942805 Vibrissa-signaled Eyeblink Conditioning Induces Somatosensory Cortical Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006 | Pubmed ID: 16738249 Differential Effects of AlphaCaMKII Mutation on Hippocampal Learning and Changes in Intrinsic Neuronal Excitability The European Journal of Neuroscience. Apr, 2006 | Pubmed ID: 16630070 Simultaneous Training on Two Hippocampus-dependent Tasks Facilitates Acquisition of Trace Eyeblink Conditioning Learning & Memory (Cold Spring Harbor, N.Y.). Mar-Apr, 2006 | Pubmed ID: 16585795 Pharmacological and Molecular Enhancement of Learning in Aging and Alzheimer's Disease Journal of Physiology, Paris. Mar-May, 2006 | Pubmed ID: 16458491 Temporal Memory Deficits in Alzheimer's Mouse Models: Rescue by Genetic Deletion of BACE1 The European Journal of Neuroscience. Jan, 2006 | Pubmed ID: 16420434 GLYX-13: a Monoclonal Antibody-derived Peptide That Acts As an N-methyl-D-aspartate Receptor Modulator Neuropharmacology. Dec, 2005 | Pubmed ID: 16051282 Trace Eyeblink Conditioning Requires the Hippocampus but Not Autophosphorylation of AlphaCaMKII in Mice Learning & Memory (Cold Spring Harbor, N.Y.). May-Jun, 2005 | Pubmed ID: 15897256 Acute Stress Facilitates Trace Eyeblink Conditioning in C57BL/6 Male Mice and Increases the Excitability of Their CA1 Pyramidal Neurons Learning & Memory (Cold Spring Harbor, N.Y.). Mar-Apr, 2005 | Pubmed ID: 15805311 Trace Eyeblink Conditioning in Abstinent Alcoholic Individuals: Effects of Complex Task Demands and Prior Conditioning Neuropsychology. Mar, 2005 | Pubmed ID: 15769200 A Fiber Optic-based System for Behavioral Eyeblink Measurement in a MRI Environment Journal of Neuroscience Methods. Jan, 2005 | Pubmed ID: 15585291 Biophysical Alterations of Hippocampal Pyramidal Neurons in Learning, Ageing and Alzheimer's Disease Ageing Research Reviews. Nov, 2004 | Pubmed ID: 15541708 Slow Afterhyperpolarization Governs the Development of NMDA Receptor-dependent Afterdepolarization in CA1 Pyramidal Neurons During Synaptic Stimulation Journal of Neurophysiology. Oct, 2004 | Pubmed ID: 15190096 Galantamine Facilitates Acquisition of Hippocampus-dependent Trace Eyeblink Conditioning in Aged Rabbits Learning & Memory (Cold Spring Harbor, N.Y.). Jan-Feb, 2004 | Pubmed ID: 14747524 BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease Neuron. Jan, 2004 | Pubmed ID: 14715132 FMRI of the Conscious Rabbit During Unilateral Classical Eyeblink Conditioning Reveals Bilateral Cerebellar Activation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14684877 Conditional Discrimination Learning in Patients with Bilateral Medial Temporal Lobe Amnesia Behavioral Neuroscience. Dec, 2003 | Pubmed ID: 14674839 Functional Magnetic Resonance Imaging in the Awake Rabbit: a System for Stimulus Presentation and Response Detection During Eyeblink Conditioning Journal of Neuroscience Methods. Nov, 2003 | Pubmed ID: 14583403 Modulation of Cholinergic Transmission Enhances Excitability of Hippocampal Pyramidal Neurons and Ameliorates Learning Impairments in Aging Animals Neurobiology of Learning and Memory. Nov, 2003 | Pubmed ID: 14521865 Lubeluzole and Conditioned Learning After Cerebral Ischemia Experimental Brain Research. Oct, 2003 | Pubmed ID: 12904938 Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons Journal of Neurophysiology. Oct, 2003 | Pubmed ID: 12815013 Activity Profiles of Single Neurons in Caudal Anterior Cingulate Cortex During Trace Eyeblink Conditioning in the Rabbit Journal of Neurophysiology. Aug, 2003 | Pubmed ID: 12750412 Single Neurons in CA1 Hippocampus Encode Trace Interval Duration During Trace Heart Rate (fear) Conditioning in Rabbit The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2003 | Pubmed ID: 12598642 Age-related Enhancement of the Slow Outward Calcium-activated Potassium Current in Hippocampal CA1 Pyramidal Neurons in Vitro The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2002 | Pubmed ID: 12177218 Temporal Discrimination Learning in Abstinent Chronic Alcoholics Alcoholism, Clinical and Experimental Research. Jun, 2002 | Pubmed ID: 12068248 Age-related Biophysical Alterations of Hippocampal Pyramidal Neurons: Implications for Learning and Memory Ageing Research Reviews. Apr, 2002 | Pubmed ID: 12039438 Баки-сигнализировал Классическая кондиционирования ока в голове фиксированных мышей Carmen Lin1, John Disterhoft1, Craig Weiss1 1Department of Physiology, Northwestern University Behavior
Баки-сигнализировал Классическая кондиционирования ока в голове фиксированных мышей Carmen Lin1, John Disterhoft1, Craig Weiss1 1Department of Physiology, Northwestern University Behavior