Jordan S. Orange Center for Human Immunobiology Texas Children's Hospital and Baylor College of Medicine Biography Publications Institution JoVE Articles Jordan S. Orange has not added a biography. If you are Jordan S. Orange and would like to personalize this page please email our Author Liaison for assistance. Publications Recommendations for Live Viral and Bacterial Vaccines In immunodeficient Patients and Their Close Contacts The Journal of Allergy and Clinical Immunology. Feb, 2014 | Pubmed ID: 24582311 INKT Cell Cytotoxic Responses Control T-lymphoma Growth in Vitro and in Vivo Cancer Immunology Research. Jan, 2014 | Pubmed ID: 24563871 Noncanonical NF-κB Signaling Is Limited by Classical NF-κB Activity Science Signaling. Feb, 2014 | Pubmed ID: 24497610 Cell Biological Steps and Checkpoints in Accessing NK Cell Cytotoxicity Immunology and Cell Biology. Mar, 2014 | Pubmed ID: 24445602 Modeling Primary Immunodeficiency Disease Epidemiology and Its Treatment to Estimate Latent Therapeutic Demand for Immunoglobulin Journal of Clinical Immunology. Feb, 2014 | Pubmed ID: 24338563 GATA2 Deficiency: a Protean Disorder of Hematopoiesis, Lymphatics, and Immunity Blood. Feb, 2014 | Pubmed ID: 24227816 Burden of Copy Number Variation in Common Variable Immunodeficiency Clinical and Experimental Immunology. Dec, 2013 | Pubmed ID: 24329717 Arf-like GTPase Arl8b Regulates Lytic Granule Polarization and Natural Killer Cell-mediated Cytotoxicity Molecular Biology of the Cell. Dec, 2013 | Pubmed ID: 24088571 Natural Killer Cell Deficiency The Journal of Allergy and Clinical Immunology. Sep, 2013 | Pubmed ID: 23993353 Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome Science (New York, N.Y.). Aug, 2013 | Pubmed ID: 23845947 Prioritization of Evidence-based Indications for Intravenous Immunoglobulin Journal of Clinical Immunology. Aug, 2013 | Pubmed ID: 23764872 Pro-asthmatic Cytokines Regulate Unliganded and Ligand-dependent Glucocorticoid Receptor Signaling in Airway Smooth Muscle PloS One. 2013 | Pubmed ID: 23593222 Bioavailability of IgG Administered by the Subcutaneous Route Journal of Clinical Immunology. Jul, 2013 | Pubmed ID: 23456255 Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations Journal of Immunology (Baltimore, Md. : 1950). Apr, 2013 | Pubmed ID: 23455505 The Adaptor Molecule SAP Plays Essential Roles During Invariant NKT Cell Cytotoxicity and Lytic Synapse Formation Blood. Apr, 2013 | Pubmed ID: 23430111 Murine Natural Killer Immunoreceptors Use Distinct Proximal Signaling Complexes to Direct Cell Function Blood. Apr, 2013 | Pubmed ID: 23407547 Rapid Activation Receptor- or IL-2-induced Lytic Granule Convergence in Human Natural Killer Cells Requires Src, but Not Downstream Signaling Blood. Apr, 2013 | Pubmed ID: 23380740 Defective Actin Accumulation Impairs Human Natural Killer Cell Function in Patients with Dedicator of Cytokinesis 8 Deficiency The Journal of Allergy and Clinical Immunology. Mar, 2013 | Pubmed ID: 23380217 Mutations in GATA2 Cause Human NK Cell Deficiency with Specific Loss of the CD56(bright) Subset Blood. Apr, 2013 | Pubmed ID: 23365458 Immunodeficiency in Patients with 49,XXXXY Chromosomal Variation American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. Feb, 2013 | Pubmed ID: 23345259 Severe Combined Immunodeficiency Resulting from Mutations in MTHFD1 Pediatrics. Feb, 2013 | Pubmed ID: 23296427 Reply: To PMID 22935624 The Journal of Allergy and Clinical Immunology. Feb, 2013 | Pubmed ID: 23273954 New Views of the Human NK Cell Immunological Synapse: Recent Advances Enabled by Super- and High-resolution Imaging Techniques Frontiers in Immunology. 2012 | Pubmed ID: 23316204 CD2 Promotes Human Natural Killer Cell Membrane Nanotube Formation PloS One. 2012 | Pubmed ID: 23112830 NK Cell Lytic Granules Are Highly Motile at the Immunological Synapse and Require F-actin for Post-degranulation Persistence Journal of Immunology (Baltimore, Md. : 1950). Nov, 2012 | Pubmed ID: 23066148 Human Immunodeficiency-causing Mutation Defines CD16 in Spontaneous NK Cell Cytotoxicity The Journal of Clinical Investigation. Oct, 2012 | Pubmed ID: 23006327 Use and Interpretation of Diagnostic Vaccination in Primary Immunodeficiency: a Working Group Report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology The Journal of Allergy and Clinical Immunology. Sep, 2012 | Pubmed ID: 22935624 Dual Channel STED Nanoscopy of Lytic Granules on Actin Filaments in Natural Killer Cells Communicative & Integrative Biology. Mar, 2012 | Pubmed ID: 22808328 Presentation of Hemophagocytic Lymphohistiocytosis Due to a Novel MUNC 13-4 Mutation Masked by Partial Therapeutic Immunosuppression Pediatric Rheumatology Online Journal. 2012 | Pubmed ID: 22554126 Commensal Bacteria-derived Signals Regulate Basophil Hematopoiesis and Allergic Inflammation Nature Medicine. Apr, 2012 | Pubmed ID: 22447074 Tumorigenic Adenovirus 12 Cells Evade NK Cell Lysis by Reducing the Expression of NKG2D Ligands Immunology Letters. May, 2012 | Pubmed ID: 22445355 Bilateral Adrenal EBV-associated Smooth Muscle Tumors in a Child with a Natural Killer Cell Deficiency Blood. Apr, 2012 | Pubmed ID: 22427204 Unraveling Human Natural Killer Cell Deficiency The Journal of Clinical Investigation. Mar, 2012 | Pubmed ID: 22354165 Novel Mutation in STXBP2 Prevents IL-2-induced Natural Killer Cell Cytotoxicity The Journal of Allergy and Clinical Immunology. Jun, 2012 | Pubmed ID: 22336081 CD27 Deficiency is Associated with Combined Immunodeficiency and Persistent Symptomatic EBV Viremia The Journal of Allergy and Clinical Immunology. Mar, 2012 | Pubmed ID: 22197273 Autoimmune Regulator (AIRE) Contributes to Dectin-1-induced TNF-α Production and Complexes with Caspase Recruitment Domain-containing Protein 9 (CARD9), Spleen Tyrosine Kinase (Syk), and Dectin-1 The Journal of Allergy and Clinical Immunology. Feb, 2012 | Pubmed ID: 21962774 Hypohidrotic Ectodermal Dysplasia and Immunodeficiency with Coincident NEMO and EDA Mutations Frontiers in Immunology. 2011 | Pubmed ID: 22566850 Multiple Distinct NK-cell Synapses Blood. Dec, 2011 | Pubmed ID: 22174302 Phosphorylation of the Myosin IIA Tailpiece Regulates Single Myosin IIA Molecule Association with Lytic Granules to Promote NK-cell Cytotoxicity Blood. Nov, 2011 | Pubmed ID: 22123909 Global Study of Primary Immunodeficiency Diseases (PI)--diagnosis, Treatment, and Economic Impact: an Updated Report from the Jeffrey Modell Foundation Immunologic Research. Oct, 2011 | Pubmed ID: 21935653 Natural Killer Cell Lytic Granule Secretion Occurs Through a Pervasive Actin Network at the Immune Synapse PLoS Biology. Sep, 2011 | Pubmed ID: 21931536 Novel Inborn Error of Folate Metabolism: Identification by Exome Capture and Sequencing of Mutations in the MTHFD1 Gene in a Single Proband Journal of Medical Genetics. Sep, 2011 | Pubmed ID: 21813566 Congenital Alterations of NEMO Glutamic Acid 223 Result in Hypohidrotic Ectodermal Dysplasia and Immunodeficiency with Normal Serum IgG Levels Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. Jul, 2011 | Pubmed ID: 21704885 Mutations in GATA2 Are Associated with the Autosomal Dominant and Sporadic Monocytopenia and Mycobacterial Infection (MonoMAC) Syndrome Blood. Sep, 2011 | Pubmed ID: 21670465 Eosinophilic Fasciitis Mimicking Angioedema and Treatment Response to Infliximab in a Pediatric Patient Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. May, 2011 | Pubmed ID: 21530881 Genome-wide Association Identifies Diverse Causes of Common Variable Immunodeficiency The Journal of Allergy and Clinical Immunology. Jun, 2011 | Pubmed ID: 21497890 Invariant Natural Killer T Cells from Children with Versus Without Food Allergy Exhibit Differential Responsiveness to Milk-derived Sphingomyelin The Journal of Allergy and Clinical Immunology. Jul, 2011 | Pubmed ID: 21458849 IL-2 Induces a WAVE2-dependent Pathway for Actin Reorganization That Enables WASp-independent Human NK Cell Function The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21383498 The Autoimmune Regulator (AIRE), Which is Defective in Autoimmune Polyendocrinopathy-candidiasis-ectodermal Dystrophy Patients, is Expressed in Human Epidermal and Follicular Keratinocytes and Associates with the Intermediate Filament Protein Cytokeratin 17 The American Journal of Pathology. Mar, 2011 | Pubmed ID: 21356351 Substance P Inhibits Natural Killer Cell Cytotoxicity Through the Neurokinin-1 Receptor Journal of Leukocyte Biology. Jan, 2011 | Pubmed ID: 20940324 Stem-cell Gene Therapy for the Wiskott-Aldrich Syndrome The New England Journal of Medicine. Nov, 2010 | Pubmed ID: 21067383 Complications of Tumor Necrosis Factor-α Blockade in Chronic Granulomatous Disease-related Colitis Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Dec, 2010 | Pubmed ID: 21058909 Therapeutic Use of Immunoglobulins Advances in Pediatrics. 2010 | Pubmed ID: 21056739 Cutting Edge: Association with I Kappa B Kinase Beta Regulates the Subcellular Localization of Homer3 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20693425 MiR-451 Protects Against Erythroid Oxidant Stress by Repressing 14-3-3zeta Genes & Development. Aug, 2010 | Pubmed ID: 20679398 Impact of Trough IgG on Pneumonia Incidence in Primary Immunodeficiency: A Meta-analysis of Clinical Studies Clinical Immunology (Orlando, Fla.). Oct, 2010 | Pubmed ID: 20675197 A Custom 148 Gene-based Resequencing Chip and the SNP Explorer Software: New Tools to Study Antibody Deficiency Human Mutation. Sep, 2010 | Pubmed ID: 20652909 A Novel Missense Mutation in the Nuclear Factor-κB Essential Modulator (NEMO) Gene Resulting in Impaired Activation of the NF-κB Pathway and a Unique Clinical Phenotype Presenting As MRSA Subdural Empyema Journal of Clinical Immunology. Nov, 2010 | Pubmed ID: 20652730 Latent Herpesviruses: Aligning Human and Murine NK Cells Blood. Jun, 2010 | Pubmed ID: 20522715 Efficacy and Safety of a New 20% Immunoglobulin Preparation for Subcutaneous Administration, IgPro20, in Patients with Primary Immunodeficiency Journal of Clinical Immunology. Sep, 2010 | Pubmed ID: 20454851 Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells is Dependent on Dynein but Not Cytolytic Commitment Molecular Biology of the Cell. Jul, 2010 | Pubmed ID: 20444980 Pediatric Common Variable Immunodeficiency: Immunologic and Phenotypic Associations with Switched Memory B Cells Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. Aug, 2010 | Pubmed ID: 20337966 Navigating Barriers: the Challenge of Directed Secretion at the Natural Killer Cell Lytic Immunological Synapse Journal of Clinical Immunology. May, 2010 | Pubmed ID: 20191315 Quantitative Measurement of F-actin Accumulation at the NK Cell Immunological Synapse Journal of Immunological Methods. Apr, 2010 | Pubmed ID: 20171970 Analysis of the NK Cell Immunological Synapse Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20033638 Variants of DENND1B Associated with Asthma in Children The New England Journal of Medicine. Jan, 2010 | Pubmed ID: 20032318 Use of Intravenous Immunoglobulin and Adjunctive Therapies in the Treatment of Primary Immunodeficiencies: A Working Group Report of and Study by the Primary Immunodeficiency Committee of the American Academy of Allergy Asthma and Immunology Clinical Immunology (Orlando, Fla.). May, 2010 | Pubmed ID: 19914873 Use of Cytokine Therapy in Primary Immunodeficiency Clinical Reviews in Allergy & Immunology. Feb, 2010 | Pubmed ID: 19449141 Chipping Away at Gamma-H2AX Foci Cell Cycle (Georgetown, Tex.). Oct, 2009 | Pubmed ID: 19770593 Comèl-Netherton Syndrome Defined As Primary Immunodeficiency The Journal of Allergy and Clinical Immunology. Sep, 2009 | Pubmed ID: 19683336 Myosin IIA Associates with NK Cell Lytic Granules to Enable Their Interaction with F-actin and Function at the Immunological Synapse Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19454694 Capsid Antigen Presentation Flags Human Hepatocytes for Destruction After Transduction by Adeno-associated Viral Vectors The Journal of Clinical Investigation. Jun, 2009 | Pubmed ID: 19436115 Rapid Up-regulation and Granule-independent Transport of Perforin to the Immunological Synapse Define a Novel Mechanism of Antigen-specific CD8+ T Cell Cytotoxic Activity Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19380804 Immune Dysregulation in Severe Influenza Journal of Leukocyte Biology. Jun, 2009 | Pubmed ID: 19276177 Formation and Function of the Lytic NK-cell Immunological Synapse Nature Reviews. Immunology. Sep, 2008 | Pubmed ID: 19172692 Allogeneic Transplantation Successfully Corrects Immune Defects, but Not Susceptibility to Colitis, in a Patient with Nuclear Factor-kappaB Essential Modulator Deficiency The Journal of Allergy and Clinical Immunology. Dec, 2008 | Pubmed ID: 18851875 Hypomorphic Nuclear Factor-kappaB Essential Modulator Mutation Database and Reconstitution System Identifies Phenotypic and Immunologic Diversity The Journal of Allergy and Clinical Immunology. Dec, 2008 | Pubmed ID: 18851874 Establishment of HIV-1 Resistance in CD4+ T Cells by Genome Editing Using Zinc-finger Nucleases Nature Biotechnology. Jul, 2008 | Pubmed ID: 18587387 Evaluation and Clinical Interpretation of Hypergammaglobulinemia E: Differentiating Atopy from Immunodeficiency Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. Apr, 2008 | Pubmed ID: 18450128 Immunodeficiency Disorders. Preface Immunology and Allergy Clinics of North America. May, 2008 | Pubmed ID: 18424330 Lymphotoxin-alpha 1 Beta 2 and LIGHT Induce Classical and Noncanonical NF-kappa B-dependent Proinflammatory Gene Expression in Vascular Endothelial Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2008 | Pubmed ID: 18292573 1. Lymphocytes The Journal of Allergy and Clinical Immunology. Feb, 2008 | Pubmed ID: 18241683 IKBKG (nuclear Factor-kappa B Essential Modulator) Mutation Can Be Associated with Opportunistic Infection Without Impairing Toll-like Receptor Function The Journal of Allergy and Clinical Immunology. Apr, 2008 | Pubmed ID: 18179816 NKp30 Ligation Induces Rapid Activation of the Canonical NF-kappaB Pathway in NK Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2007 | Pubmed ID: 18025182 Myosin IIA is Required for Cytolytic Granule Exocytosis in Human NK Cells The Journal of Experimental Medicine. Oct, 2007 | Pubmed ID: 17875677 Cdc42-interacting Protein-4 Functionally Links Actin and Microtubule Networks at the Cytolytic NK Cell Immunological Synapse The Journal of Experimental Medicine. Oct, 2007 | Pubmed ID: 17785506 The Lytic NK Cell Immunological Synapse and Sequential Steps in Its Formation Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17713009 A Genome-wide Association Study Identifies KIAA0350 As a Type 1 Diabetes Gene Nature. Aug, 2007 | Pubmed ID: 17632545 Hypogammaglobulinemia in a Pediatric Tertiary Care Setting Clinical Immunology (Orlando, Fla.). Oct, 2007 | Pubmed ID: 17631052 Superantigen Presentation by Airway Smooth Muscle to CD4+ T Lymphocytes Elicits Reciprocal Proasthmatic Changes in Airway Function Journal of Immunology (Baltimore, Md. : 1950). Mar, 2007 | Pubmed ID: 17339460 Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses Science (New York, N.Y.). Mar, 2007 | Pubmed ID: 17332376 Interleukin-1-induced NF-kappaB Activation is NEMO-dependent but Does Not Require IKKbeta The Journal of Biological Chemistry. Mar, 2007 | Pubmed ID: 17244613 Prevalence of Toll-like Receptor Signalling Defects in Apparently Healthy Children Who Developed Invasive Pneumococcal Infection Clinical Immunology (Orlando, Fla.). Mar, 2007 | Pubmed ID: 17157070 Impaired Specific Antibody Response and Increased B-cell Population in Transient Hypogammaglobulinemia of Infancy Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. Nov, 2006 | Pubmed ID: 17165264 Human Natural Killer Cell Deficiencies Current Opinion in Allergy and Clinical Immunology. Dec, 2006 | Pubmed ID: 17088643 Formation of a WIP-, WASp-, Actin-, and Myosin IIA-containing Multiprotein Complex in Activated NK Cells and Its Alteration by KIR Inhibitory Signaling The Journal of Cell Biology. Apr, 2006 | Pubmed ID: 16606694 Use of Intravenous Immunoglobulin in Human Disease: a Review of Evidence by Members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology The Journal of Allergy and Clinical Immunology. Apr, 2006 | Pubmed ID: 16580469 Development of a Clinical Assay to Evaluate Toll-like Receptor Function Clinical and Vaccine Immunology : CVI. Jan, 2006 | Pubmed ID: 16426002 Natural Killer Cells in Human Health and Disease Clinical Immunology (Orlando, Fla.). Jan, 2006 | Pubmed ID: 16337194 Effector and Memory CD8+ T Cell Fate Coupled by T-bet and Eomesodermin Nature Immunology. Dec, 2005 | Pubmed ID: 16273099 Practice Parameter for the Diagnosis and Management of Primary Immunodeficiency Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. May, 2005 | Pubmed ID: 15945566 Congenital Immunodeficiencies and Sepsis Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. May, 2005 | Pubmed ID: 15857568 Human Disease Resulting from Gene Mutations That Interfere with Appropriate Nuclear Factor-kappaB Activation Immunological Reviews. Feb, 2005 | Pubmed ID: 15661019 Specific NEMO Mutations Impair CD40-mediated C-Rel Activation and B Cell Terminal Differentiation The Journal of Clinical Investigation. Dec, 2004 | Pubmed ID: 15578091 Characteristics of Mycobacterial Infection in Patients with Immunodeficiency and Nuclear Factor-kappaB Essential Modulator Mutation, with or Without Ectodermal Dysplasia Journal of the American Academy of Dermatology. Nov, 2004 | Pubmed ID: 15523349 Human Nuclear Factor Kappa B Essential Modulator Mutation Can Result in Immunodeficiency Without Ectodermal Dysplasia The Journal of Allergy and Clinical Immunology. Sep, 2004 | Pubmed ID: 15356572 Natural Killer Cells Inhibit Hepatitis C Virus Expression Journal of Leukocyte Biology. Dec, 2004 | Pubmed ID: 15339939 The Presentation and Natural History of Immunodeficiency Caused by Nuclear Factor KappaB Essential Modulator Mutation The Journal of Allergy and Clinical Immunology. Apr, 2004 | Pubmed ID: 15100680 A Patient with Severe Black Fly (Simuliidae) Hypersensitivity Referred for Evaluation of Suspected Immunodeficiency Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. Feb, 2004 | Pubmed ID: 14989400 Management of an Anaphylactoid Reaction to Methotrexate with a Stepwise Graded Challenge Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. Oct, 2003 | Pubmed ID: 14641613 The Mature Activating Natural Killer Cell Immunologic Synapse is Formed in Distinct Stages Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14612578 Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential The Journal of Experimental Medicine. Oct, 2003 | Pubmed ID: 14568979 Finding NEMO: Genetic Disorders of NF-[kappa]B Activation The Journal of Clinical Investigation. Oct, 2003 | Pubmed ID: 14523034 Disseminated Varicella Infection Due to the Vaccine Strain of Varicella-zoster Virus, in a Patient with a Novel Deficiency in Natural Killer T Cells The Journal of Infectious Diseases. Oct, 2003 | Pubmed ID: 14513412 Acute Chylothorax in Children: Selective Retention of Memory T Cells and Natural Killer Cells The Journal of Pediatrics. Aug, 2003 | Pubmed ID: 12970641 Human Natural Killer Cell Deficiencies and Susceptibility to Infection Microbes and Infection / Institut Pasteur. Dec, 2002 | Pubmed ID: 12505527 Viral Evasion of Natural Killer Cells Nature Immunology. Nov, 2002 | Pubmed ID: 12407408 Wiskott-Aldrich Syndrome Protein is Required for NK Cell Cytotoxicity and Colocalizes with Actin to NK Cell-activating Immunologic Synapses Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12177428 Deficient Natural Killer Cell Cytotoxicity in Patients with IKK-gamma/NEMO Mutations The Journal of Clinical Investigation. Jun, 2002 | Pubmed ID: 12045264 تصور من قبل المناعية المشبك المزدوج اللون التوقيت بوابات-الانبعاث المستحث استنفاد (STED) Nanoscopy Emily M. Mace1, Jordan S. Orange1 1Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine JoVE 51100 Immunology and Infection
تصور من قبل المناعية المشبك المزدوج اللون التوقيت بوابات-الانبعاث المستحث استنفاد (STED) Nanoscopy Emily M. Mace1, Jordan S. Orange1 1Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine JoVE 51100 Immunology and Infection