Josef Penninger School of Biomedical Engineering University of British Columbia Biography Publications Institution JoVE Articles Josef Penninger has not added a biography. If you are Josef Penninger and would like to personalize this page please email our Author Liaison for assistance. Publications Electric Field Stimulation Boosts Neuronal Differentiation of Neural Stem Cells for Spinal Cord Injury Treatment Via PI3K/Akt/GSK-3β/β-catenin Activation Cell & Bioscience. Jan, 2023 | Pubmed ID: 36624495 Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19 American Journal of Respiratory and Critical Care Medicine. Jan, 2023 | Pubmed ID: 35926164 Protocol for SARS-CoV-2 Infection of Kidney Organoids Derived from Human Pluripotent Stem Cells STAR Protocols. Dec, 2022 | Pubmed ID: 36595951 Force-tuned Avidity of Spike Variant-ACE2 Interactions Viewed on the Single-molecule Level Nature Communications. Dec, 2022 | Pubmed ID: 36566234 RANKL and RANK in Cancer Therapy Physiology (Bethesda, Md.). Dec, 2022 | Pubmed ID: 36473204 Targeting APLN/APJ Restores Blood-testis Barrier and Improves Spermatogenesis in Murine and Human Diabetic Models Nature Communications. Nov, 2022 | Pubmed ID: 36443325 The HUSH Complex Controls Brain Architecture and Protocadherin Fidelity Science Advances. Nov, 2022 | Pubmed ID: 36332029 On the Essentiality of the Angiotensin Converting Enzyme 2 Receptor for SARS-CoV-2 Infection and the Potential of Soluble Angiotensin Converting Enzyme 2 Proteins As Universal Approach for Variants Causing COVID-19 Clinical and Translational Medicine. Oct, 2022 | Pubmed ID: 36229914 A Molecularly Engineered, Broad-spectrum Anti-coronavirus Lectin Inhibits SARS-CoV-2 and MERS-CoV Infection In vivo Cell Reports. Medicine. Oct, 2022 | Pubmed ID: 36195094 The Impact of Heme Biosynthesis Regulation on Glioma Aggressiveness: Correlations with Diagnostic Molecular Markers Frontiers in Molecular Neuroscience. 2022 | Pubmed ID: 36187350 AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury Molecular Neurobiology. Nov, 2022 | Pubmed ID: 35974295 FIBCD1 is an Endocytic GAG Receptor Associated with a Novel Neurodevelopmental Disorder EMBO Molecular Medicine. Sep, 2022 | Pubmed ID: 35916241 ACE2-like Enzyme B38-CAP Suppresses Abdominal Sepsis and Severe Acute Lung Injury PloS One. 2022 | Pubmed ID: 35867642 Targeting Glycans for CAR Therapy: The Advent of Sweet CARs Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2022 | Pubmed ID: 35821636 Development of an Aerosol Intervention for COVID-19 Disease: Tolerability of Soluble ACE2 (APN01) Administered Via Nebulizer PloS One. 2022 | Pubmed ID: 35816490 Clinical Grade ACE2 As a Universal Agent to Block SARS-CoV-2 Variants EMBO Molecular Medicine. Aug, 2022 | Pubmed ID: 35781796 Neuropeptide Neuromedin B Does Not Alter Body Weight and Glucose Homeostasis nor Does It Act As an Insulin-releasing Peptide Scientific Reports. Jun, 2022 | Pubmed ID: 35672347 Contact-dependent Signaling Triggers Tumor-like Proliferation of CCM3 Knockout Endothelial Cells in Co-culture with Wild-type Cells Cellular and Molecular Life Sciences : CMLS. Jun, 2022 | Pubmed ID: 35661927 Redirecting Imipramine Against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study Pathogens (Basel, Switzerland). May, 2022 | Pubmed ID: 35631123 Evidence in Favor of the Essentiality of Human Cell Membrane-bound ACE2 and Against Soluble ACE2 for SARS-CoV-2 Infectivity Cell. May, 2022 | Pubmed ID: 35623327 A Diabetic Milieu Increases ACE2 Expression and Cellular Susceptibility to SARS-CoV-2 Infections in Human Kidney Organoids and Patient Cells Cell Metabolism. Jun, 2022 | Pubmed ID: 35561674 Recalibrating Vascular Malformations and Mechanotransduction by Pharmacological Intervention The Journal of Clinical Investigation. Apr, 2022 | Pubmed ID: 35426368 Adult T-cells Impair Neonatal Cardiac Regeneration European Heart Journal. Jul, 2022 | Pubmed ID: 35417553 Correction: TSPAN6 is a Suppressor of Ras-driven Cancer Oncogene. Apr, 2022 | Pubmed ID: 35292775 TSPAN6 is a Suppressor of Ras-driven Cancer Oncogene. Apr, 2022 | Pubmed ID: 35184157 Transcription Factor Mesenchyme Homeobox Protein 2 (MEOX2) Modulates Nociceptor Function The FEBS Journal. Jun, 2022 | Pubmed ID: 35029322 ACE2 is the Critical in Vivo Receptor for SARS-CoV-2 in a Novel COVID-19 Mouse Model with TNF- and IFNγ-driven Immunopathology ELife. Jan, 2022 | Pubmed ID: 35023830 Author Correction: Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-performance Search Strategies for Serum Glycopeptide Analysis Nature Methods. Jan, 2022 | Pubmed ID: 34893784 Comparative Proteome Signatures of Trace Samples by Multiplexed Data-Independent Acquisition Molecular & Cellular Proteomics : MCP. Jan, 2022 | Pubmed ID: 34793982 Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19 Frontiers in Immunology. 2021 | Pubmed ID: 35003058 Structure-guided Glyco-engineering of ACE2 for Improved Potency As Soluble SARS-CoV-2 Decoy Receptor ELife. Dec, 2021 | Pubmed ID: 34927585 ACE2-like Carboxypeptidase B38-CAP Protects from SARS-CoV-2-induced Lung Injury Nature Communications. Nov, 2021 | Pubmed ID: 34815389 The Ubiquitin Ligase HOIL-1L Regulates Immune Responses by Interacting with Linear Ubiquitin Chains IScience. Nov, 2021 | Pubmed ID: 34755089 Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-performance Search Strategies for Serum Glycopeptide Analysis Nature Methods. 11, 2021 | Pubmed ID: 34725484 PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 34646120 Erratum To: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Nov, 2021 | Pubmed ID: 34550333 Clinical Grade ACE2 As a Universal Agent to Block SARS-CoV-2 Variants BioRxiv : the Preprint Server for Biology. Sep, 2021 | Pubmed ID: 34545368 Development of a Novel, Pan-variant Aerosol Intervention for COVID-19 BioRxiv : the Preprint Server for Biology. Sep, 2021 | Pubmed ID: 34545364 Autophagy in Major Human Diseases The EMBO Journal. Oct, 2021 | Pubmed ID: 34459017 Identification of Lectin Receptors for Conserved SARS-CoV-2 Glycosylation Sites The EMBO Journal. Oct, 2021 | Pubmed ID: 34375000 Modeling a Human CLP1 Mutation in Mouse Identifies an Accumulation of Tyrosine Pre-tRNA Fragments Causing Pontocerebellar Hypoplasia Type 10 Biochemical and Biophysical Research Communications. Sep, 2021 | Pubmed ID: 34273619 A Critical Relationship Between Bone and Fat: the Role of Bone Marrow Adipose-derived RANKL in Bone Metabolism EMBO Reports. Jul, 2021 | Pubmed ID: 34121307 Ferritinophagy and Ferroptosis in the Management of Metabolic Diseases Trends in Endocrinology and Metabolism: TEM. Jul, 2021 | Pubmed ID: 34006412 The Oxidoreductase PYROXD1 Uses NAD(P) As an Antioxidant to Sustain TRNA Ligase Activity in Pre-tRNA Splicing and Unfolded Protein Response Molecular Cell. Jun, 2021 | Pubmed ID: 33930333 Targeting Autophagy in Ischemic Stroke: From Molecular Mechanisms to Clinical Therapeutics Pharmacology & Therapeutics. Sep, 2021 | Pubmed ID: 33823204 HACE1 Blocks HIF1α Accumulation Under Hypoxia in a RAC1 Dependent Manner Oncogene. Mar, 2021 | Pubmed ID: 33603169 Heme Biosynthesis MRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas Cancers. Feb, 2021 | Pubmed ID: 33562253 RANK Links Thymic Regulatory T Cells to Fetal Loss and Gestational Diabetes in Pregnancy Nature. Jan, 2021 | Pubmed ID: 33361811 JAK Inhibition Reduces SARS-CoV-2 Liver Infectivity and Modulates Inflammatory Responses to Reduce Morbidity and Mortality Science Advances. Jan, 2021 | Pubmed ID: 33187978 Human Soluble ACE2 Improves the Effect of Remdesivir in SARS-CoV-2 Infection EMBO Molecular Medicine. Jan, 2021 | Pubmed ID: 33179852 The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection Gastroenterology. Jan, 2021 | Pubmed ID: 33130103 MKK7 Deficiency in Mature Neurons Impairs Parental Behavior in Mice Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jan, 2021 | Pubmed ID: 33098150 Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Nov, 2021 | Pubmed ID: 32997739 Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice Hepatology (Baltimore, Md.). Jun, 2021 | Pubmed ID: 32969030 A Crucial Role for Jagunal Homolog 1 in Humoral Immunity and Antibody Glycosylation in Mice and Humans The Journal of Experimental Medicine. Jan, 2021 | Pubmed ID: 32930709 Inhibition of RANK Signaling in Breast Cancer Induces an Anti-tumor Immune Response Orchestrated by CD8+ T Cells Nature Communications. Dec, 2020 | Pubmed ID: 33303745 Stepwise Cell Fate Decision Pathways During Osteoclastogenesis at Single-cell Resolution Nature Metabolism. Dec, 2020 | Pubmed ID: 33288951 Site-specific Ubiquitination of the E3 Ligase HOIP Regulates Apoptosis and Immune Signaling The EMBO Journal. Dec, 2020 | Pubmed ID: 33215740 Human Recombinant Soluble ACE2 in Severe COVID-19 The Lancet. Respiratory Medicine. Nov, 2020 | Pubmed ID: 33131609 Targeting the RANKL/RANK/OPG Axis for Cancer Therapy Frontiers in Oncology. 2020 | Pubmed ID: 32850393 Fibroblasts As a Source of Self-antigens for Central Immune Tolerance Nature Immunology. Oct, 2020 | Pubmed ID: 32839611 Sclerostin Expression in Trabecular Bone is Downregulated by Osteoclasts Scientific Reports. Aug, 2020 | Pubmed ID: 32792620 Dysregulation in Akt/mTOR/HIF-1 Signaling Identified by Proteo-transcriptomics of SARS-CoV-2 Infected Cells Emerging Microbes & Infections. Dec, 2020 | Pubmed ID: 32691695 Salmonella-based Platform for Efficient Delivery of Functional Binding Proteins to the Cytosol Communications Biology. Jul, 2020 | Pubmed ID: 32620833 Identification of ALK in Thinness Cell. Jun, 2020 | Pubmed ID: 32442405 HACE1 Prevents Lung Carcinogenesis Via Inhibition of RAC-Family GTPases Cancer Research. Jul, 2020 | Pubmed ID: 32366477 Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 Cell. May, 2020 | Pubmed ID: 32333836 Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth Frontiers in Bioengineering and Biotechnology. 2020 | Pubmed ID: 32211389 RANKL and OPG and Their Influence on Breast Volume Changes During Pregnancy in Healthy Women Scientific Reports. Mar, 2020 | Pubmed ID: 32198488 Sigma-1 Receptors Control Neuropathic Pain and Macrophage Infiltration into the Dorsal Root Ganglion After Peripheral Nerve Injury FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2020 | Pubmed ID: 32157739 Tyrosine Pre-transfer RNA Fragments Are Linked to P53-dependent Neuronal Cell Death Via PKM2 Biochemical and Biophysical Research Communications. May, 2020 | Pubmed ID: 32143824 Angiotensin-converting Enzyme 2 (ACE2) As a SARS-CoV-2 Receptor: Molecular Mechanisms and Potential Therapeutic Target Intensive Care Medicine. Apr, 2020 | Pubmed ID: 32125455 B38-CAP is a Bacteria-derived ACE2-like Enzyme That Suppresses Hypertension and Cardiac Dysfunction Nature Communications. Feb, 2020 | Pubmed ID: 32103002 CLP1 Acts As the Main RNA Kinase in Mice Biochemical and Biophysical Research Communications. Feb, 2020 | Pubmed ID: 32081435 A Synthetic Peptide Library for Benchmarking Crosslinking-mass Spectrometry Search Engines for Proteins and Protein Complexes Nature Communications. Feb, 2020 | Pubmed ID: 32029734 Overexpression of Apoptosis Inducing Factor Aggravates Hypoxic-ischemic Brain Injury in Neonatal Mice Cell Death & Disease. Jan, 2020 | Pubmed ID: 32001673 The Role of Iron Regulation in Immunometabolism and Immune-Related Disease Frontiers in Molecular Biosciences. 2019 | Pubmed ID: 31824960 Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography Analytical Chemistry. Nov, 2019 | Pubmed ID: 31612716 Generation of Blood Vessel Organoids from Human Pluripotent Stem Cells Nature Protocols. Nov, 2019 | Pubmed ID: 31554955 HACE1 Deficiency Leads to Structural and Functional Neurodevelopmental Defects Neurology. Genetics. Jun, 2019 | Pubmed ID: 31321300 Apelin Inhibition Prevents Resistance and Metastasis Associated with Anti-angiogenic Therapy EMBO Molecular Medicine. Aug, 2019 | Pubmed ID: 31267692 Apelin Protects Against Abdominal Aortic Aneurysm and the Therapeutic Role of Neutral Endopeptidase Resistant Apelin Analogs Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31189595 Derivation and Maintenance of Mouse Haploid Embryonic Stem Cells Nature Protocols. Jul, 2019 | Pubmed ID: 31160788 AIF-regulated Oxidative Phosphorylation Supports Lung Cancer Development Cell Research. Jul, 2019 | Pubmed ID: 31133695 Human Blood Vessel Organoids As A model Of diabetic Vasculopathy Nature. Jan, 2019 | Pubmed ID: 30651639 Pulmonary Phagocyte-derived NPY Controls the Pathology of Severe Influenza Virus Infection Nature Microbiology. Feb, 2019 | Pubmed ID: 30455472 The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate Cell Reports. May, 2016 | Pubmed ID: 27160902 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 HACE1-dependent Protein Degradation Provides Cardiac Protection in Response to Haemodynamic Stress Nature Communications. Mar, 2014 | Pubmed ID: 24614889 HACE1 Reduces Oxidative Stress and Mutant Huntingtin Toxicity by Promoting the NRF2 Response Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24516159 Hace1 Controls ROS Generation of Vertebrate Rac1-dependent NADPH Oxidase Complexes Nature Communications. 2013 | Pubmed ID: 23864022 Differential Expression of a Novel Ankyrin Containing E3 Ubiquitin-protein Ligase, Hace1, in Sporadic Wilms' Tumor Versus Normal Kidney Human Molecular Genetics. Sep, 2004 | Pubmed ID: 15254018 从多能干细胞生成人体血管类器官 Nicolas Werschler1,2, Josef Penninger1,2,3,4 1School of Biomedical Engineering, University of British Columbia, 2Life Sciences Institute, University of British Columbia, 3Department of Medical Genetics, University of British Columbia, 4Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) JoVE 64715 Bioengineering
从多能干细胞生成人体血管类器官 Nicolas Werschler1,2, Josef Penninger1,2,3,4 1School of Biomedical Engineering, University of British Columbia, 2Life Sciences Institute, University of British Columbia, 3Department of Medical Genetics, University of British Columbia, 4Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) JoVE 64715 Bioengineering