Josephine Hoh Department of Environmental Health Sciences Yale University School of Medicine Biography Publications Institution JoVE Articles Josephine Hoh has not added a biography. If you are Josephine Hoh and would like to personalize this page please email our Author Liaison for assistance. Publications 2016: A 'Mitochondria' Odyssey Trends in Molecular Medicine. Apr, 2016 | Pubmed ID: 27151392 Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia American Journal of Hypertension. Jan, 2016 | Pubmed ID: 26002928 Generation and Characterization of Mice with a Conditional Null Allele of the HtrA4 Gene Molecular Medicine Reports. Nov, 2015 | Pubmed ID: 26353049 Loss of HtrA1-induced Attenuation of TGF-β Signaling in Fibroblasts Might Not Be the Main Mechanism of CARASIL Pathogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25770224 Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models Investigative Ophthalmology & Visual Science. Feb, 2015 | Pubmed ID: 25717153 Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia American Journal of Hypertension. Jul, 2015 | Pubmed ID: 25523295 Neural-specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1 PloS One. 2014 | Pubmed ID: 25531304 Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease PloS One. 2014 | Pubmed ID: 25506911 Scan Statistics in Human Gene Mapping American Journal of Human Genetics. Nov, 2012 | Pubmed ID: 23122592 Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation in Vivo PloS One. 2012 | Pubmed ID: 23056497 Genome-wide Association Study Identifies a Maternal Copy-number Deletion in PSG11 Enriched Among Preeclampsia Patients BMC Pregnancy and Childbirth. 2012 | Pubmed ID: 22748001 Genetic Signatures of Exceptional Longevity in Humans PloS One. 2012 | Pubmed ID: 22279548 Disease Risk Prediction with Rare and Common Variants BMC Proceedings. 2011 | Pubmed ID: 22373337 A Comparison of Association Methods Correcting for Population Stratification in Case-control Studies Annals of Human Genetics. May, 2011 | Pubmed ID: 21281271 A Pilot Genome-wide Association Study Shows Genomic Variants Enriched in the Non-tumor Cells of Patients with Well-differentiated Neuroendocrine Tumors of the Ileum Endocrine-related Cancer. Feb, 2011 | Pubmed ID: 21139019 PDE11A Associations with Asthma: Results of a Genome-wide Association Scan The Journal of Allergy and Clinical Immunology. Oct, 2010 | Pubmed ID: 20920776 Common Variants Near CAV1 and CAV2 Are Associated with Primary Open-angle Glaucoma Nature Genetics. Oct, 2010 | Pubmed ID: 20835238 Association Between Reduced Copy-number at T-cell Receptor Gamma (TCRgamma) and Childhood Allergic Asthma: A Possible Role for Somatic Mosaicism Mutation Research. Aug, 2010 | Pubmed ID: 20553737 A Genome-wide Association Study on African-ancestry Populations for Asthma The Journal of Allergy and Clinical Immunology. Feb, 2010 | Pubmed ID: 19910028 Detecting Essential and Removable Interactions in Genome-wide Association Studies Statistics and Its Interface. Jan, 2009 | Pubmed ID: 21165165 Common Variants on Chromosome 2 and Risk of Primary Open-angle Glaucoma in the Afro-Caribbean Population of Barbados Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19805132 CCR3: Shedding New Light on a Dark Problem? Journal of Molecular Cell Biology. Oct, 2009 | Pubmed ID: 19684049 Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: a Meta-analysis JAMA. Jun, 2009 | Pubmed ID: 19531786 Mitochondrial DNA Variants of Respiratory Complex I That Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-related Macular Degeneration PloS One. 2009 | Pubmed ID: 19434233 Sequence Variants in HTRA1 and LOC387715/ARMS2 and Phenotype and Response to Photodynamic Therapy in Neovascular Age-related Macular Degeneration in Populations from Israel Molecular Vision. 2008 | Pubmed ID: 19065273 Joint Effects of Polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH Genes on AMD in a Caucasian Population Molecular Vision. 2008 | Pubmed ID: 18682806 The NEI/NCBI DbGAP Database: Genotypes and Haplotypes That May Specifically Predispose to Risk of Neovascular Age-related Macular Degeneration BMC Medical Genetics. 2008 | Pubmed ID: 18541031 The Signatures of Autozygosity Among Patients with Colorectal Cancer Cancer Research. Apr, 2008 | Pubmed ID: 18375840 HTRA1 Variants in Exudative Age-related Macular Degeneration and Interactions with Smoking and CFH Investigative Ophthalmology & Visual Science. Jun, 2008 | Pubmed ID: 18316707 Functional and Structural Implications of the Complement Factor H Y402H Polymorphism Associated with Age-related Macular Degeneration Investigative Ophthalmology & Visual Science. May, 2008 | Pubmed ID: 18263814 Further Mapping of 10q26 Supports Strong Association of HTRA1 Polymorphisms with Age-related Macular Degeneration Vision Research. Feb, 2008 | Pubmed ID: 18207215 Linkage Disequilibrium Mapping for Complex Disease Genes Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 17984540 Replicating Genotype-phenotype Associations Nature. Jun, 2007 | Pubmed ID: 17554299 Two Genetic Pathways for Age-related Macular Degeneration Current Opinion in Genetics & Development. Jun, 2007 | Pubmed ID: 17467263 Origin of Dendritic Cells in Peripheral Lymphoid Organs of Mice Nature Immunology. Jun, 2007 | Pubmed ID: 17450143 HTRA1 Promoter Polymorphism Predisposes Japanese to Age-related Macular Degeneration Molecular Vision. 2007 | Pubmed ID: 17438519 Fine-scale Linkage Disequilibrium Mapping of Age-related Macular Degeneration in the Complement Factor H Gene Region The British Journal of Ophthalmology. Jul, 2007 | Pubmed ID: 17314151 A Variant of the HTRA1 Gene Increases Susceptibility to Age-related Macular Degeneration Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17053109 HTRA1 Promoter Polymorphism in Wet Age-related Macular Degeneration Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17053108 Systematic Review and Meta-analysis of the Association Between Complement Factor H Y402H Polymorphisms and Age-related Macular Degeneration Human Molecular Genetics. Sep, 2006 | Pubmed ID: 16905558 Association of Angiotensinogen Gene Polymorphisms with Essential Hypertension in African-Americans and Caucasians Human Heredity. 2005 | Pubmed ID: 16210856 Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-related Macular Degeneration American Journal of Human Genetics. Jul, 2005 | Pubmed ID: 15895326 Complement Factor H Polymorphism in Age-related Macular Degeneration Science (New York, N.Y.). Apr, 2005 | Pubmed ID: 15761122 Genetic Dissection of Diseases: Design and Methods Current Opinion in Genetics & Development. Jun, 2004 | Pubmed ID: 15172663 Sum Statistics for the Joint Detection of Multiple Disease Loci in Case-control Association Studies with SNP Markers Genetic Epidemiology. Dec, 2003 | Pubmed ID: 14639704 Mathematical Multi-locus Approaches to Localizing Complex Human Trait Genes Nature Reviews. Genetics. Sep, 2003 | Pubmed ID: 12951571 Set Association Analysis of SNP Case-control and Microarray Data Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 2003 | Pubmed ID: 12935345 Statistical Methods for Analyzing Microarray Feature Data with Replications Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 2003 | Pubmed ID: 12804089 Efficiency of Single-nucleotide Polymorphism Haplotype Estimation from Pooled DNA Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12777616 SNP Haplotype Tagging from DNA Pools of Two Individuals BMC Bioinformatics. Apr, 2003 | Pubmed ID: 12709267 Pharmacogenetic Analysis of Adverse Drug Effect Reveals Genetic Variant for Susceptibility to Liver Toxicity The Pharmacogenomics Journal. 2002 | Pubmed ID: 12439739 A Protein Kinase A-dependent Molecular Switch in Synapsins Regulates Neurite Outgrowth Nature Neuroscience. May, 2002 | Pubmed ID: 11976703 Asthma, Allergy, and Airway Hyperresponsiveness Are Not Linked to the Beta(2)-adrenoceptor Gene Chest. Mar, 2002 | Pubmed ID: 11888952 En Fenotypning Regimen för genetiskt modifierade möss för att studera gener inblandade i mänskliga sjukdomar av att åldras Victoria L. Patterson*1, Brian S. Thompson*1, Catherine Cherry*1, Shao-bin Wang2, Bo Chen2, Josephine Hoh1,2 1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine Medicine
En Fenotypning Regimen för genetiskt modifierade möss för att studera gener inblandade i mänskliga sjukdomar av att åldras Victoria L. Patterson*1, Brian S. Thompson*1, Catherine Cherry*1, Shao-bin Wang2, Bo Chen2, Josephine Hoh1,2 1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine Medicine