Jun-ichi Abe Department of Cardiology, Division of Internal Medicine University of Texas MD Anderson Cancer Center Biography Publications Institution JoVE Articles Jun-ichi Abe has not added a biography. If you are Jun-ichi Abe and would like to personalize this page please email our Author Liaison for assistance. Publications STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2017 | Pubmed ID: 28302626 Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases Advances in Experimental Medicine and Biology. 2017 | Pubmed ID: 28197922 Sub-cellular Localization Specific SUMOylation in the Heart Biochimica Et Biophysica Acta. Jan, 2017 | Pubmed ID: 28130202 Flow Signaling and Atherosclerosis Cellular and Molecular Life Sciences : CMLS. May, 2017 | Pubmed ID: 28039525 The Future of Onco-Cardiology: We Are Not Just "Side Effect Hunters" Circulation Research. Sep, 2016 | Pubmed ID: 27688305 Multiple Functions of Protein Inhibitor of Activated STAT1 in Regulating Endothelial Cell Proliferation and Inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2016 | Pubmed ID: 27559144 Comparison of Chain-Length Preferences and Glucan Specificities of Isoamylase-Type α-Glucan Debranching Enzymes from Rice, Cyanobacteria, and Bacteria PloS One. 2016 | Pubmed ID: 27309534 Pyroptosis As a Regulated Form of Necrosis: PI+/Annexin V-/High Caspase 1/Low Caspase 9 Activity in Cells = Pyroptosis? Circulation Research. May, 2016 | Pubmed ID: 27174943 Kinase-SUMO Networks in Diabetes-mediated Cardiovascular Disease Metabolism: Clinical and Experimental. May, 2016 | Pubmed ID: 27085771 Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events Antioxidants & Redox Signaling. Sep, 2016 | Pubmed ID: 26714841 The Acquisition Process of Musical Tonal Schema: Implications from Connectionist Modeling Frontiers in Psychology. 2015 | Pubmed ID: 26441725 Axl Modulates Immune Activation of Smooth Muscle Cells in Vein Graft Remodeling American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2015 | Pubmed ID: 26276821 Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion Circulation. Jul, 2015 | Pubmed ID: 25934838 PDZK1 Prevents Neointima Formation Via Suppression of Breakpoint Cluster Region Kinase in Vascular Smooth Muscle PloS One. 2015 | Pubmed ID: 25886360 High-mobility Group Box 1-mediated Heat Shock Protein Beta 1 Expression Attenuates Mitochondrial Dysfunction and Apoptosis Journal of Molecular and Cellular Cardiology. May, 2015 | Pubmed ID: 25736854 Disturbed Flow-activated P90RSK Kinase Accelerates Atherosclerosis by Inhibiting SENP2 Function The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25689261 ¹³⁷Cs Concentrations in Foliose Lichens Within Tsukuba-city As a Reflection of Radioactive Fallout from the Fukushima Dai-ichi Nuclear Power Plant Accident Journal of Environmental Radioactivity. Mar, 2015 | Pubmed ID: 25521042 Novel Mechanisms of Endothelial Mechanotransduction Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2014 | Pubmed ID: 25301843 Identification of Activators of ERK5 Transcriptional Activity by High-throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25187658 ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis Circulation. Jul, 2014 | Pubmed ID: 25001623 Shear Stress and Atherosclerosis Molecules and Cells. Jun, 2014 | Pubmed ID: 24781409 Functional Modulations in Brain Activity for the First and Second Music: a Comparison of High- and Low-proficiency Bimusicals Neuropsychologia. Feb, 2014 | Pubmed ID: 24365653 Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24036112 Cyclic Nucleotide Phosphodiesterase 3A1 Protects the Heart Against Ischemia-reperfusion Injury Journal of Molecular and Cellular Cardiology. Nov, 2013 | Pubmed ID: 23988739 Atheroprone Flow Activation of the Sterol Regulatory Element Binding Protein 2 and Nod-like Receptor Protein 3 Inflammasome Mediates Focal Atherosclerosis Circulation. Aug, 2013 | Pubmed ID: 23838164 Cezanne Paints Inflammation by Regulating Ubiquitination Circulation Research. Jun, 2013 | Pubmed ID: 23743222 Cardiac Nuclear High Mobility Group Box 1 Prevents the Development of Cardiac Hypertrophy and Heart Failure Cardiovascular Research. Sep, 2013 | Pubmed ID: 23708738 Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation International Journal of Inflammation. 2013 | Pubmed ID: 23555068 De-SUMOylation Enzyme of Sentrin/SUMO-specific Protease 2 Regulates Disturbed Flow-induced SUMOylation of ERK5 and P53 That Leads to Endothelial Dysfunction and Atherosclerosis Circulation Research. Mar, 2013 | Pubmed ID: 23381569 A Crucial Role for P90RSK-mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis Circulation. Jan, 2013 | Pubmed ID: 23243209 Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-activated Protein Kinase-2 Inhibits Endothelial Inflammation Via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase Activity Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013 | Pubmed ID: 23202365 Magnetoencephalography Evidence for Different Brain Subregions Serving Two Musical Cultures Neuropsychologia. Dec, 2012 | Pubmed ID: 23063935 P62 Binding to Protein Kinase C ζ Regulates Tumor Necrosis Factor α-induced Apoptotic Pathway in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2012 | Pubmed ID: 23023376 Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation International Journal of Inflammation. 2012 | Pubmed ID: 22991685 Glucagon-like Peptide-1 and Its Cardiovascular Effects Current Atherosclerosis Reports. Oct, 2012 | Pubmed ID: 22878937 Does Simile Comprehension Differ from Metaphor Comprehension? A Functional MRI Study Brain and Language. Jun, 2012 | Pubmed ID: 22534570 P90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction Circulation Research. Feb, 2012 | Pubmed ID: 22267842 Disturbed-flow-mediated Vascular Reactive Oxygen Species Induce Endothelial Dysfunction Circulation Journal : Official Journal of the Japanese Circulation Society. 2011 | Pubmed ID: 22076424 Neural Processing Associated with Comprehension of an Indirect Reply During a Scenario Reading Task Neuropsychologia. Nov, 2011 | Pubmed ID: 21930137 Fast Optical Channel Recovery in Field Demonstration of 100-Gbit/s Ethernet over OTN Using Real-time DSP Optics Express. Jul, 2011 | Pubmed ID: 21747472 PKCζ Mediates Disturbed Flow-induced Endothelial Apoptosis Via P53 SUMOylation The Journal of Cell Biology. May, 2011 | Pubmed ID: 21624955 P90 Ribosomal S6 Kinase Regulates Activity of the Renin-angiotensin System: a Pathogenic Mechanism for Ischemia-reperfusion Injury Journal of Molecular and Cellular Cardiology. Aug, 2011 | Pubmed ID: 21609719 Cyclophilin A is an Inflammatory Mediator That Promotes Atherosclerosis in Apolipoprotein E-deficient Mice The Journal of Experimental Medicine. Jan, 2011 | Pubmed ID: 21173104 MK2 SUMOylation Regulates Actin Filament Remodeling and Subsequent Migration in Endothelial Cells by Inhibiting MK2 Kinase and HSP27 Phosphorylation Blood. Feb, 2011 | Pubmed ID: 21131586 Flow Shear Stress and Atherosclerosis: a Matter of Site Specificity Antioxidants & Redox Signaling. Sep, 2011 | Pubmed ID: 21050140 Ca2+/calmodulin-stimulated PDE1 Regulates the Beta-catenin/TCF Signaling Through PP2A B56 Gamma Subunit in Proliferating Vascular Smooth Muscle Cells The FEBS Journal. Dec, 2010 | Pubmed ID: 21078118 Novel Role of C Terminus of Hsc70-interacting Protein (CHIP) Ubiquitin Ligase on Inhibiting Cardiac Apoptosis and Dysfunction Via Regulating ERK5-mediated Degradation of Inducible CAMP Early Repressor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010 | Pubmed ID: 20724525 1,5-anhydro-D-fructose and Its Derivatives: Biosynthesis, Preparation and Potential Medical Applications Planta Medica. Oct, 2010 | Pubmed ID: 20645241 PKCzeta Decreases ENOS Protein Stability Via Inhibitory Phosphorylation of ERK5 Blood. Sep, 2010 | Pubmed ID: 20538799 Vinpocetine Inhibits NF-kappaB-dependent Inflammation Via an IKK-dependent but PDE-independent Mechanism Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20448200 CCN Notch Signaling in Vascular Smooth Muscle Cells: Good or Bad? Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2010 | Pubmed ID: 20237327 [Is the Victim of Irony Identified by Echoic Mention?] Shinrigaku Kenkyu : The Japanese Journal of Psychology. Feb, 2010 | Pubmed ID: 20235473 SUMO--a Post-translational Modification with Therapeutic Potential? Current Opinion in Pharmacology. Apr, 2010 | Pubmed ID: 20079693 Targeted Deletion of the Extracellular Signal-regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload-induced Apoptosis in the Heart Circulation Research. Mar, 2010 | Pubmed ID: 20075332 Neural Substrates of Irony Comprehension: A Functional MRI Study Brain Research. Jan, 2010 | Pubmed ID: 19853585 역할의 Ca2 + Cardiomyocyte 비 대 중재에서 Calmodulin 자극 주기적 뉴클레오티드 포스 1 Circulation Research. Nov, 2009 | Pubmed ID: 19797176 TR4 Nuclear Receptor Functions As a Fatty Acid Sensor to Modulate CD36 Expression and Foam Cell Formation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666541 Cyclophilin A Enhances Vascular Oxidative Stress and the Development of Angiotensin II-induced Aortic Aneurysms Nature Medicine. Jun, 2009 | Pubmed ID: 19430489 NADPH Oxidase in Vascular Injury: a New Insight About Its Regulation and Role in T Cells Circulation Research. Jan, 2009 | Pubmed ID: 19179667 Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome-proliferator-activated Receptor Gamma Transcriptional Activity in Vascular Smooth Muscle Cells Circulation Research. Jan, 2009 | Pubmed ID: 19023129 [The Effect of L1 Word Reading System on L2 English Word Recognition: a Comparison of Japanese and Chinese Native Speakers] Shinrigaku Kenkyu : The Japanese Journal of Psychology. Oct, 2008 | Pubmed ID: 19069116 Reactive Oxygen Species-induced Activation of P90 Ribosomal S6 Kinase Prolongs Cardiac Repolarization Through Inhibiting Outward K+ Channel Activity Circulation Research. Aug, 2008 | Pubmed ID: 18599872 Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation Circulation. Jun, 2008 | Pubmed ID: 18541741 Effects of MEK5/ERK5 Association on Small Ubiquitin-related Modification of ERK5: Implications for Diabetic Ventricular Dysfunction After Myocardial Infarction Circulation Research. Jun, 2008 | Pubmed ID: 18467627 Fluid Shear Stress Inhibits TNF-mediated JNK Activation Via MEK5-BMK1 in Endothelial Cells Biochemical and Biophysical Research Communications. May, 2008 | Pubmed ID: 18358237 Extracellular Signal-regulated Kinase 5 SUMOylation Antagonizes Shear Stress-induced Antiinflammatory Response and Endothelial Nitric Oxide Synthase Expression in Endothelial Cells Circulation Research. Mar, 2008 | Pubmed ID: 18218985 프로 테아 제-활성화 수용 체 1 심장 리 모델링 및 비 대에 기여 한다 Circulation. Nov, 2007 | Pubmed ID: 17967980 Role of PKCs and NF-kappaB Activation in Myocardial Inflammation: Enemy or Ally? Journal of Molecular and Cellular Cardiology. Oct, 2007 | Pubmed ID: 17707396 Neural Mechanisms Involved in the Comprehension of Metaphoric and Literal Sentences: an FMRI Study Brain Research. Aug, 2007 | Pubmed ID: 17662699 Flow Antagonizes TNF-alpha Signaling in Endothelial Cells by Inhibiting Caspase-dependent PKC Zeta Processing Circulation Research. Jul, 2007 | Pubmed ID: 17525369 Regulation of Phosphodiesterase 3 and Inducible CAMP Early Repressor in the Heart Circulation Research. Mar, 2007 | Pubmed ID: 17332439 세포 외 신호 통제 키 니 아 제 5 활성화 심장 Apoptosis와 포스 3A/유도할 수 있는 캠프 조기 진압 피드백 루프의 저해를 통해 장애를 줄여 준다 Circulation Research. Mar, 2007 | Pubmed ID: 17272811 ERK5 Activation Inhibits Inflammatory Responses Via Peroxisome Proliferator-activated Receptor Delta (PPARdelta) Stimulation The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16943204 Perlecan Proteolysis Induces an Alpha2beta1 Integrin- and Src Family Kinase-dependent Anti-apoptotic Pathway in Fibroblasts in the Absence of Focal Adhesion Kinase Activation The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16882656 Bone Morphogenetic Protein (BMP) Family, SMAD Signaling and Id Helix-loop-helix Proteins in the Vasculature: the Continuous Mystery of BMPs Pleotropic Effects Journal of Molecular and Cellular Cardiology. Jul, 2006 | Pubmed ID: 16762360 Central Role of Endogenous Toll-like Receptor-2 Activation in Regulating Inflammation, Reactive Oxygen Species Production, and Subsequent Neointimal Formation After Vascular Injury Biochemical and Biophysical Research Communications. Jul, 2006 | Pubmed ID: 16730663 억제 P90 받게 Ribosomal S6 Kinase를 방지 (Na +)-H + 교환기 중재 심장 허 혈-reperfusion 부상 Circulation. May, 2006 | Pubmed ID: 16717153 P90 받게 Ribosomal S6 Kinase 중재 Prorenin 변환 효소 허 혈 성 및 당뇨병 심근에서의 역할 Circulation. Apr, 2006 | Pubmed ID: 16585392 Cardiac-specific Overexpression of Diacylglycerol Kinase Zeta Prevents Gq Protein-coupled Receptor Agonist-induced Cardiac Hypertrophy in Transgenic Mice Circulation. Jan, 2006 | Pubmed ID: 16380548 (PDE3) 포스 3의 긍정적인 피드백 루프와 유도할 수 있는 캠프 초기 진압 (ICER) Cardiomyocyte Apoptosis를 리드 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2005 | Pubmed ID: 16186489 BMK1/ERK5 is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1alpha Circulation Research. Jun, 2005 | Pubmed ID: 15879308 3 Cardiomyocyte Apoptosis에 포스의 기능적 역할: 심장 마비에 암시 Circulation. May, 2005 | Pubmed ID: 15867171 Mitochondrial Dok-4 Recruits Src Kinase and Regulates NF-kappaB Activation in Endothelial Cells The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15855164 Role of P90 Ribosomal S6 Kinase (p90RSK) in Reactive Oxygen Species and Protein Kinase C Beta (PKC-beta)-mediated Cardiac Troponin I Phosphorylation The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15840586 Adenovirus-mediated Overexpression of Diacylglycerol Kinase-zeta Inhibits Endothelin-1-induced Cardiomyocyte Hypertrophy Circulation. Mar, 2005 | Pubmed ID: 15781737 The Hinge-helix 1 Region of Peroxisome Proliferator-activated Receptor Gamma1 (PPARgamma1) Mediates Interaction with Extracellular Signal-regulated Kinase 5 and PPARgamma1 Transcriptional Activation: Involvement in Flow-induced PPARgamma Activation in Endothelial Cells Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15367687 Activation of Big MAP Kinase 1 (BMK1/ERK5) Inhibits Cardiac Injury After Myocardial Ischemia and Reperfusion FEBS Letters. May, 2004 | Pubmed ID: 15147905 ERK1/2 Associates with the C-Met-binding Domain of Growth Factor Receptor-bound Protein 2 (Grb2)-associated Binder-1 (Gab1): Role in ERK1/2 and Early Growth Response Factor-1 (Egr-1) Nuclear Accumulation The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15078886 Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14963042 Differential Role of MEK5alpha and MEK5beta in BMK1/ERK5 Activation The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14583600 Preparation and Reactivity of a Novel Disaccharide, Glucosyl 1,5-anhydro-D-fructose (1,5-anhydro-3-O-alpha-glucopyranosyl-D-fructose) Carbohydrate Research. Oct, 2003 | Pubmed ID: 14553983 Inhibition of Tumor Necrosis Factor-[alpha]-induced SHP-2 Phosphatase Activity by Shear Stress: a Mechanism to Reduce Endothelial Inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2003 | Pubmed ID: 12947019 Role of Phosphodiesterase 3 in NO/cGMP-mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells Circulation Research. Sep, 2003 | Pubmed ID: 12919948 Stress and Vascular Responses: Atheroprotective Effect of Laminar Fluid Shear Stress in Endothelial Cells: Possible Role of Mitogen-activated Protein Kinases Journal of Pharmacological Sciences. Mar, 2003 | Pubmed ID: 12686737 Regulation of Epidermal Growth Factor-induced Connexin 43 Gap Junction Communication by Big Mitogen-activated Protein Kinase1/ERK5 but Not ERK1/2 Kinase Activation The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12637502 Fluid Shear Stress Activates Proline-rich Tyrosine Kinase Via Reactive Oxygen Species-dependent Pathway Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2002 | Pubmed ID: 12426206 Hypoxia and HIF-1alpha Stability: Another Stress-sensing Mechanism for Shc Circulation Research. Jul, 2002 | Pubmed ID: 12114314 Insulin-like Growth Factor-1 Enhances Inflammatory Responses in Endothelial Cells: Role of Gab1 and MEKK3 in TNF-alpha-induced C-Jun and NF-kappaB Activation and Adhesion Molecule Expression Circulation Research. Jun, 2002 | Pubmed ID: 12065326 The Novel Role of the C-terminal Region of SHP-2. Involvement of Gab1 and SHP-2 Phosphatase Activity in Elk-1 Activation The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12011040 Protein Kinase C-alpha and Protein Kinase C-epsilon Are Required for Grb2-associated Binder-1 Tyrosine Phosphorylation in Response to Platelet-derived Growth Factor The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11940581 Activation of Mitogen-activated Protein Kinases and P90 Ribosomal S6 Kinase in Failing Human Hearts with Dilated Cardiomyopathy Cardiovascular Research. Jan, 2002 | Pubmed ID: 11744021 마우스 혈관의 얼굴 준비 Kyung Ae Ko1, Keigi Fujiwara1, Sunil Krishnan2, Jun-ichi Abe1 1Department of Cardiology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, 2Department of Radiation Oncology, University of Texas MD Anderson Cancer Center JoVE 55460 Biology
마우스 혈관의 얼굴 준비 Kyung Ae Ko1, Keigi Fujiwara1, Sunil Krishnan2, Jun-ichi Abe1 1Department of Cardiology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, 2Department of Radiation Oncology, University of Texas MD Anderson Cancer Center JoVE 55460 Biology