Jun Fujita Department of Cardiology Keio University School of Medicine Biography Publications Institution JoVE Articles Jun Fujita has not added a biography. If you are Jun Fujita and would like to personalize this page please email our Author Liaison for assistance. Publications The Prevalence of Clinically Significant Ischemia in Patients Undergoing Percutaneous Coronary Intervention: A Report from the Multicenter Registry PloS One. 2015 | Pubmed ID: 26231033 Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function After Myocardial Infarction PloS One. 2015 | Pubmed ID: 26186362 Dual Phosphodiesterase Type 5 Inhibitor Therapy for Refractory Pulmonary Arterial Hypertension: a Pilot Study BMC Pulmonary Medicine. 2015 | Pubmed ID: 25971443 Three-dimensional Cardiac Cine Imaging Using the Kat ARC Acceleration: Initial Experience in Clinical Adult Patients at 3T Magnetic Resonance Imaging. Sep, 2015 | Pubmed ID: 25936683 Heat Shock Protein A4 Controls Cell Migration and Gastric Ulcer Healing Digestive Diseases and Sciences. Apr, 2015 | Pubmed ID: 25655005 Cold-inducible RNA-binding Protein Promotes the Development of Liver Cancer Cancer Science. Apr, 2015 | Pubmed ID: 25611373 Involvement of Heat Shock Protein A4/apg-2 in Refractory Inflammatory Bowel Disease Inflammatory Bowel Diseases. Jan, 2015 | Pubmed ID: 25437815 A Massive Suspension Culture System with Metabolic Purification for Human Pluripotent Stem Cell-derived Cardiomyocytes Stem Cells Translational Medicine. Dec, 2014 | Pubmed ID: 25355733 Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-associated Cancer Cancer Research. Nov, 2014 | Pubmed ID: 25187386 Expression of the Oncoprotein Gankyrin and Phosphorylated Retinoblastoma Protein in Human Testis and Testicular Germ Cell Tumor International Journal of Urology : Official Journal of the Japanese Urological Association. Oct, 2014 | Pubmed ID: 24861729 Derivation of Transgene-free Human Induced Pluripotent Stem Cells from Human Peripheral T Cells in Defined Culture Conditions PloS One. 2014 | Pubmed ID: 24824994 Cardiac Magnetic Resonance Imaging in Giant Cell Myocarditis: Intriguing Associations with Clinical and Pathological Features Circulation. Apr, 2014 | Pubmed ID: 24778123 Future Prospects for Regenerated Heart Using Induced Pluripotent Stem Cells Journal of Pharmacological Sciences. 2014 | Pubmed ID: 24739283 Generation and Characterization of Functional Cardiomyocytes Derived from Human T Cell-derived Induced Pluripotent Stem Cells PloS One. 2014 | Pubmed ID: 24465630 Tumor Necrosis Factor and Transforming Growth Factor β Regulate Clock Genes by Controlling the Expression of the Cold Inducible RNA-binding Protein (CIRBP) The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24337574 A Case of Lymphomatoid Gastropathy: a Self-limited Pseudomalignant Natural Killer (NK)-cell Proliferative Disease Mimicking NK/T-cell Lymphomas Clinical Journal of Gastroenterology. Aug, 2013 | Pubmed ID: 26181731 [Surgical Resection of Multiple Liver Metastases of Rectal Neuroendocrine Tumors] Gan to Kagaku Ryoho. Cancer & Chemotherapy. Nov, 2013 | Pubmed ID: 24393940 [A Case of Jejnal Cancer Who Was Controlled Peritoneal Metastasis, Successfully by Combination Therapy with Docetaxel and S-1] Gan to Kagaku Ryoho. Cancer & Chemotherapy. Nov, 2013 | Pubmed ID: 24393899 [Evaluation of Conversion Gastrectomy for Treatment of Stage IV Advanced Gastric Cancer] Gan to Kagaku Ryoho. Cancer & Chemotherapy. Nov, 2013 | Pubmed ID: 24393866 (18)F-FDG-PET CT Findings in a Patient with Early-phase Cardiac Sarcoidosis Internal Medicine (Tokyo, Japan). 2013 | Pubmed ID: 24292764 Hypothermia Protects Against Fulminant Hepatitis in Mice by Reducing Reactive Oxygen Species Production Digestive Diseases (Basel, Switzerland). 2013 | Pubmed ID: 24281018 Cold-inducible RNA-binding Protein (CIRP) Triggers Inflammatory Responses in Hemorrhagic Shock and Sepsis Nature Medicine. Nov, 2013 | Pubmed ID: 24097189 Overexpression of Gankyrin in Mouse Hepatocytes Induces Hemangioma by Suppressing Factor Inhibiting Hypoxia-inducible Factor-1 (FIH-1) and Activating Hypoxia-inducible Factor-1 Biochemical and Biophysical Research Communications. Mar, 2013 | Pubmed ID: 23376718 Report of the American Heart Association (AHA) Scientific Sessions 2012, Los Angeles Circulation Journal : Official Journal of the Japanese Circulation Society. 2013 | Pubmed ID: 23238304 Deleterious Effect of the IL-23/IL-17A Axis and γδT Cells on Left Ventricular Remodeling After Myocardial Infarction Journal of the American Heart Association. Oct, 2012 | Pubmed ID: 23316306 [Myocardial Regeneration with Cell Transplantation Therapy] Nihon Geka Gakkai Zasshi. Sep, 2012 | Pubmed ID: 23061366 Identification of a Novel Enhancer That Binds Sp1 and Contributes to Induction of Cold-inducible RNA-binding Protein (cirp) Expression in Mammalian Cells BMC Biotechnology. 2012 | Pubmed ID: 23046908 Human Pentraxin 3 (PTX3) As a Novel Biomarker for the Diagnosis of Pulmonary Arterial Hypertension PloS One. 2012 | Pubmed ID: 23029266 Myocardial Cell Sheet Therapy and Cardiac Function American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2012 | Pubmed ID: 23001836 In Situ Differentiation of CD8αα Τ Cells from CD4 T Cells in Peripheral Lymphoid Tissues Scientific Reports. 2012 | Pubmed ID: 22962636 Cold-inducible RNA-binding Protein Modulates Circadian Gene Expression Posttranscriptionally Science (New York, N.Y.). Oct, 2012 | Pubmed ID: 22923437 Cold-inducible RNA-binding Protein (Cirp) Interacts with Dyrk1b/Mirk and Promotes Proliferation of Immature Male Germ Cells in Mice Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22711815 Treatment of the Ventricular Tachycardia with Engraftment of Pluripotent Stem Cells-derived Cardiomyocytes Journal of Molecular and Cellular Cardiology. Jul, 2012 | Pubmed ID: 22543248 HTLV-I Tax Regulates the Cellular Proliferation Through the Down-regulation of PIP3-phosphatase Expressions Via the NF-κB Pathway International Journal of Biochemistry and Molecular Biology. 2012 | Pubmed ID: 22509484 The P53 MRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and is Required for P53 Activation Following DNA Damage Cancer Cell. Jan, 2012 | Pubmed ID: 22264786 Wnt2 Accelerates Cardiac Myocyte Differentiation from ES-cell Derived Mesodermal Cells Via Non-canonical Pathway Journal of Molecular and Cellular Cardiology. Mar, 2012 | Pubmed ID: 22146296 Adriamycin Enhances Proteasome-mediated Generation of the Proapoptotic Processed Form of MAGE-A4 in Hepatoma Cells Oncology. 2011 | Pubmed ID: 22212933 Olecranon Bursa with Fusarium Solani Infection in an Otherwise Healthy Patient Mycoses. Nov, 2011 | Pubmed ID: 21605189 [Black Esophagus Due to Acute Necrotizing Esophagitis: Four Case Reports] Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. May, 2011 | Pubmed ID: 21558743 Case of Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE Syndrome) Showing Dermatomyositis-like Eruption The Journal of Dermatology. Jan, 2010 | Pubmed ID: 20175831 Key Odor Components Responsible for the Impact on Olfactory Sense During Swine Feces Composting Bioresource Technology. Apr, 2010 | Pubmed ID: 19962882 [Evaluation of the Factor Which Has an Influence on Red Blood Cell Deformability in Patients with End-stage Renal Disease] Rinsho Byori. The Japanese Journal of Clinical Pathology. Oct, 2009 | Pubmed ID: 19928493 [In Vitro Susceptibilities to Levofloxacin and Various Antibacterial Agents of 12,919 Clinical Isolates Obtained from 72 Centers in 2007] The Japanese Journal of Antibiotics. Aug, 2009 | Pubmed ID: 19860322 MDM2 is a Novel E3 Ligase for HIV-1 Vif Retrovirology. 2009 | Pubmed ID: 19128510 Human T-cell Leukemia Virus Type I Tax Down-regulates the Expression of Phosphatidylinositol 3,4,5-trisphosphate Inositol Phosphatases Via the NF-kappaB Pathway The Journal of Biological Chemistry. Jan, 2009 | Pubmed ID: 19047050 G-CSF Augments Small Vessel and Cell Density in Canine Myocardial Infarciton The Keio Journal of Medicine. Sep, 2008 | Pubmed ID: 18854666 Analysis of Gene and Protein Expression of Cytochrome P450 and Stress-associated Molecules in Rat Liver After Spaceflight Pathology International. Sep, 2008 | Pubmed ID: 18801074 Caspase Activity Mediates the Differentiation of Embryonic Stem Cells Cell Stem Cell. Jun, 2008 | Pubmed ID: 18522852 Epidemiology of Sporadic (non-epidemic) Cases of Trichophyton Tonsurans Infection in Japan Based on PCR-RFLP Analysis of Non-transcribed Spacer Region of Ribosomal RNA Gene Japanese Journal of Infectious Diseases. May, 2008 | Pubmed ID: 18503175 Association of Gankyrin Protein Expression with Early Clinical Stages and Insulin-like Growth Factor-binding Protein 5 Expression in Human Hepatocellular Carcinoma Hepatology (Baltimore, Md.). Feb, 2008 | Pubmed ID: 18161051 Gankyrin Oncoprotein Overexpression As a Critical Factor for Tumor Growth in Human Esophageal Squamous Cell Carcinoma and Its Clinical Significance International Journal of Cancer. Journal International Du Cancer. Jan, 2008 | Pubmed ID: 17935131 [Nationwide Surveillance of Parenteral Antibiotics Containing Meropenem Activities Against Clinically Isolated Strains in 2006] The Japanese Journal of Antibiotics. Dec, 2007 | Pubmed ID: 18447206 Dose-dependent Differential Regulation of Cytokine Secretion from Macrophages by Fractalkine Journal of Immunology (Baltimore, Md. : 1950). Dec, 2007 | Pubmed ID: 18025192 The Oncoprotein Gankyrin Interacts with RelA and Suppresses NF-kappaB Activity Biochemical and Biophysical Research Communications. Nov, 2007 | Pubmed ID: 17904523 Bone Marrow Derived Cells Are Involved in the Pathogenesis of Cardiac Hypertrophy in Response to Pressure Overload Circulation. Sep, 2007 | Pubmed ID: 17698734 Administration of Granulocyte Colony-stimulating Factor After Myocardial Infarction Enhances the Recruitment of Hematopoietic Stem Cell-derived Myofibroblasts and Contributes to Cardiac Repair Stem Cells (Dayton, Ohio). Nov, 2007 | Pubmed ID: 17690181 Enhanced Deacetylation of P53 by the Anti-apoptotic Protein HSCO in Association with Histone Deacetylase 1 The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17353187 G-CSF and HGF: Combination of Vasculogenesis and Angiogenesis Synergistically Improves Recovery in Murine Hind Limb Ischemia Journal of Molecular and Cellular Cardiology. Mar, 2007 | Pubmed ID: 17223129 In Vivo Selection of Transduced Hematopoietic Stem Cells and Little Evidence of Their Conversion into Hepatocytes in Vivo Journal of Hepatology. Nov, 2006 | Pubmed ID: 16837099 Gankyrin: a New Oncoprotein and Regulator of PRb and P53 Trends in Cell Biology. May, 2006 | Pubmed ID: 16581249 Cirp Protects Against Tumor Necrosis Factor-alpha-induced Apoptosis Via Activation of Extracellular Signal-regulated Kinase Biochimica Et Biophysica Acta. Mar, 2006 | Pubmed ID: 16569452 Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/progenitor Cells and Transition of Bone Marrow-derived Neuronal Cells Circulation. Feb, 2006 | Pubmed ID: 16461843 Mesenchymal, but Not Hematopoietic, Stem Cells Can Be Mobilized and Differentiate into Cardiomyocytes After Myocardial Infarction in Mice Kidney International. Nov, 2005 | Pubmed ID: 16221170 The Oncoprotein Gankyrin Negatively Regulates Both P53 and RB by Enhancing Proteasomal Degradation Cell Cycle (Georgetown, Tex.). Oct, 2005 | Pubmed ID: 16177571 A Novel Protein Depp, Which is Induced by Progesterone in Human Endometrial Stromal Cells Activates Elk-1 Transcription Factor Molecular Human Reproduction. Jul, 2005 | Pubmed ID: 16123073 The Oncoprotein Gankyrin Binds to MDM2/HDM2, Enhancing Ubiquitylation and Degradation of P53 Cancer Cell. Jul, 2005 | Pubmed ID: 16023600 Low Temperature Protects Mammalian Cells from Apoptosis Initiated by Various Stimuli in Vitro Experimental Cell Research. Oct, 2005 | Pubmed ID: 16018998 Analysis of the Electrophysiological Properties and Arrhythmias in Directly Contacted Skeletal and Cardiac Muscle Cell Sheets Cardiovascular Research. Aug, 2005 | Pubmed ID: 15904904 Bone Marrow-derived Cells Contribute to Pulmonary Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Chest. May, 2005 | Pubmed ID: 15888860 Purified Cardiomyocytes from Bone Marrow Mesenchymal Stem Cells Produce Stable Intracardiac Grafts in Mice Cardiovascular Research. Feb, 2005 | Pubmed ID: 15639472 [A Case of Early Esophageal Adenocarcinoma Arising from Cardiac Glands, Resected by Endoscopic Mucosal Resection] Nihon Shokakibyo Gakkai Zasshi = The Japanese Journal of Gastro-enterology. Dec, 2004 | Pubmed ID: 15651393 Increased Expression of Calcium-binding Protein S100 in Human Uterine Smooth Muscle Tumours Molecular Human Reproduction. Oct, 2004 | Pubmed ID: 15322223 Nonhematopoietic Mesenchymal Stem Cells Can Be Mobilized and Differentiate into Cardiomyocytes After Myocardial Infarction Blood. Dec, 2004 | Pubmed ID: 15297308 [The Regenerative Therapy of Heart Failure with Adult Stem Cells and Cell Transplantation] Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. Mar, 2004 | Pubmed ID: 15148747 Cardiomyocytes Undergo Cells Division Following Myocardial Infarction is a Spatially and Temporally Restricted Event in Rats Molecular and Cellular Biochemistry. Apr, 2004 | Pubmed ID: 15124922 Oxygen-regulated Expression of the RNA-binding Proteins RBM3 and CIRP by a HIF-1-independent Mechanism Journal of Cell Science. Apr, 2004 | Pubmed ID: 15075239 Endothelin-1 Regulates Cardiac Sympathetic Innervation in the Rodent Heart by Controlling Nerve Growth Factor Expression The Journal of Clinical Investigation. Mar, 2004 | Pubmed ID: 15067320 Apg-2 Has a Chaperone-like Activity Similar to Hsp110 and is Overexpressed in Hepatocellular Carcinomas FEBS Letters. Feb, 2004 | Pubmed ID: 14987991 A Cleaved Form of MAGE-A4 Binds to Miz-1 and Induces Apoptosis in Human Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14739298 Recruitment of Bone Marrow-derived Endothelial Cells to Sites of Pancreatic Beta-cell Injury Diabetes. Jan, 2004 | Pubmed ID: 14693702 The Crystal Structure of Gankyrin, an Oncoprotein Found in Complexes with Cyclin-dependent Kinase 4, a 19 S Proteasomal ATPase Regulator, and the Tumor Suppressors Rb and P53 The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14573599 Engineered Long Terminal Repeats of Retroviral Vectors Enhance Transgene Expression in Hepatocytes in Vitro and in Vivo Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2003 | Pubmed ID: 14599813 PEP-19 Overexpression in Human Uterine Leiomyoma Molecular Human Reproduction. Nov, 2003 | Pubmed ID: 14561813 Role of a Novel Oncogenic Protein, Gankyrin, in Hepatocyte Proliferation Journal of Gastroenterology. 2003 | Pubmed ID: 14505129 Crystallization of Gankyrin, an Oncoprotein That Interacts with CDK4 and the S6b (rpt3) ATPase of the 19S Regulator of the 26S Proteasome Acta Crystallographica. Section D, Biological Crystallography. Jul, 2003 | Pubmed ID: 12832791 Expression of Cold-inducible RNA-binding Protein in the Normal Endometrium, Endometrial Hyperplasia, and Endometrial Carcinoma International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists. Jul, 2003 | Pubmed ID: 12819390 Cyclic AMP Enhances the Expression of an Extravillous Trophoblast Marker, Melanoma Cell Adhesion Molecule, in Choriocarcinoma Cell JEG3 and Human Chorionic Villous Explant Cultures Molecular Human Reproduction. Jun, 2003 | Pubmed ID: 12771237 Increased Islet Apoptosis in Pdx1+/- Mice The Journal of Clinical Investigation. Apr, 2003 | Pubmed ID: 12697734 MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12525503 A Novel Protein Overexpressed in Hepatoma Accelerates Export of NF-kappa B from the Nucleus and Inhibits P53-dependent Apoptosis Cancer Cell. Oct, 2002 | Pubmed ID: 12398897 Ouabain Suppresses Glucose-induced Mitochondrial ATP Production and Insulin Release by Generating Reactive Oxygen Species in Pancreatic Islets Diabetes. Aug, 2002 | Pubmed ID: 12145166 Secreted Frizzled Related Protein 1 is Overexpressed in Uterine Leiomyomas, Associated with a High Estrogenic Environment and Unrelated to Proliferative Activity The Journal of Clinical Endocrinology and Metabolism. Apr, 2002 | Pubmed ID: 11932307 Invited Review: Effects of Heat and Cold Stress on Mammalian Gene Expression Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2002 | Pubmed ID: 11896043 Gankyrin is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11779854 Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions Yoshikazu Kishino1, Tomohisa Seki2, Shinsuke Yuasa1, Jun Fujita1, Keiichi Fukuda1 1Department of Cardiology, Keio University School of Medicine, 2Department of Emergency and Critical Care Medicine, Keio University School of Medicine JoVE 53225 Developmental Biology
Generation of Induced Pluripotent Stem Cells from Human Peripheral T Cells Using Sendai Virus in Feeder-free Conditions Yoshikazu Kishino1, Tomohisa Seki2, Shinsuke Yuasa1, Jun Fujita1, Keiichi Fukuda1 1Department of Cardiology, Keio University School of Medicine, 2Department of Emergency and Critical Care Medicine, Keio University School of Medicine JoVE 53225 Developmental Biology