Karine Auclair Department of Chemistry McGill University Biography Publications Institution JoVE Articles Karine Auclair has not added a biography. If you are Karine Auclair and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibitors of Aminoglycoside Resistance Activated in Cells ACS Chemical Biology. Jan, 2012 | Pubmed ID: 22217014 Inhibition of Aminoglycoside-deactivating Enzymes APH(3')-IIIa and AAC(6')-Ii by Amphiphilic Paromomycin O2''-ether Analogues ChemMedChem. Nov, 2011 | Pubmed ID: 21905229 Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4 Journal of the American Chemical Society. May, 2011 | Pubmed ID: 21528858 Geminal Dialkyl Derivatives of N-substituted Pantothenamides: Synthesis and Antibacterial Activity Bioorganic & Medicinal Chemistry. Apr, 2011 | Pubmed ID: 21440446 Competing Allosteric Mechanisms Modulate Substrate Binding in a Dimeric Enzyme Nature Structural & Molecular Biology. Mar, 2011 | Pubmed ID: 21278754 Synthesis of 4'-aminopantetheine and Derivatives to Probe Aminoglycoside N-6'-acetyltransferase Organic & Biomolecular Chemistry. Mar, 2011 | Pubmed ID: 21225062 Elucidating Protein Binding Mechanisms by Variable-c ITC Chembiochem : a European Journal of Chemical Biology. Dec, 2009 | Pubmed ID: 19856370 Synthesis of a Phosphonate-linked Aminoglycoside-coenzyme a Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance Chemistry (Weinheim an Der Bergstrasse, Germany). 2009 | Pubmed ID: 19152351 The Activity of Human CYP2D6 in Low Water Organic Solvents Biotechnology and Bioengineering. Mar, 2009 | Pubmed ID: 18988262 Synthesis and Use of Sulfonamide-, Sulfoxide-, or Sulfone-containing Aminoglycoside-CoA Bisubstrates As Mechanistic Probes for Aminoglycoside N-6'-acetyltransferase Bioorganic & Medicinal Chemistry Letters. Oct, 2008 | Pubmed ID: 18805003 Ginkgo Biloba Extract EGb 761 Has Anti-inflammatory Properties and Ameliorates Colitis in Mice by Driving Effector T Cell Apoptosis Carcinogenesis. Sep, 2008 | Pubmed ID: 18567620 Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-acetyltransferase Biochemistry. Jan, 2008 | Pubmed ID: 18095712 Sugar-mediated Lyoprotection of Purified Human CYP3A4 and CYP2D6 Journal of Biotechnology. Jul, 2007 | Pubmed ID: 17599599 CYP3A4 Activity in the Presence of Organic Cosolvents, Ionic Liquids, or Water-immiscible Organic Solvents Chembiochem : a European Journal of Chemical Biology. Jul, 2007 | Pubmed ID: 17526062 Activity of Human P450 2D6 in Biphasic Solvent Systems Biotechnology and Bioengineering. Oct, 2007 | Pubmed ID: 17461428 The Use of Aminoglycoside Derivatives to Study the Mechanism of Aminoglycoside 6'-N-acetyltransferase and the Role of 6'-NH2 in Antibacterial Activity Bioorganic & Medicinal Chemistry. Apr, 2007 | Pubmed ID: 17317190 Progress Towards the Easier Use of P450 Enzymes Molecular BioSystems. Oct, 2006 | Pubmed ID: 17216026 Synthesis and Structure-activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6'-N-acetyltransferases Journal of Medicinal Chemistry. Aug, 2006 | Pubmed ID: 16913716 Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6 Chembiochem : a European Journal of Chemical Biology. Jun, 2006 | Pubmed ID: 16671126 Regio- and Chemoselective 6'-N-derivatization of Aminoglycosides: Bisubstrate Inhibitors As Probes to Study Aminoglycoside 6'-N-acetyltransferases Angewandte Chemie (International Ed. in English). Oct, 2005 | Pubmed ID: 16206301 Composition and Biological Activity of Traditional and Commercial Kava Extracts Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15313185 Inhibition of Human P450 Enzymes by Multiple Constituents of the Ginkgo Biloba Extract Biochemical and Biophysical Research Communications. Jun, 2004 | Pubmed ID: 15147983 Inhibition of Human P450 Enzymes by Nicotinic Acid and Nicotinamide Biochemical and Biophysical Research Communications. May, 2004 | Pubmed ID: 15081432 1H NMR Investigation of the Solution Structure of Substrate-free Human Heme Oxygenase: Comparison to the Cyanide-inhibited, Substrate-bound Complex The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14660632 Solution 1H, 15N NMR Spectroscopic Characterization of Substrate-bound, Cyanide-inhibited Human Heme Oxygenase: Water Occupation of the Distal Cavity Journal of the American Chemical Society. Nov, 2003 | Pubmed ID: 14583035 Transformations of Cyclic Nonaketides by Aspergillus Terreus Mutants Blocked for Lovastatin Biosynthesis at the LovA and LovC Genes Organic & Biomolecular Chemistry. Jan, 2003 | Pubmed ID: 12929390 Cloning and Expression of a Heme Binding Protein from the Genome of Saccharomyces Cerevisiae Protein Expression and Purification. Apr, 2003 | Pubmed ID: 12699699 1H NMR Detection of Immobilized Water Molecules Within a Strong Distal Hydrogen-bonding Network of Substrate-bound Human Heme Oxygenase-1 Journal of the American Chemical Society. Dec, 2002 | Pubmed ID: 12452690 Solution NMR Characterization of an Unusual Distal H-bond Network in the Active Site of the Cyanide-inhibited, Human Heme Oxygenase Complex of the Symmetric Substrate, 2,4-dimethyldeuterohemin The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12070167 Revisiting the Mechanism of P450 Enzymes with the Radical Clocks Norcarane and Spiro[2,5]octane Journal of the American Chemical Society. May, 2002 | Pubmed ID: 12022835 Collecting Variable-concentration Isothermal Titration Calorimetry Datasets in Order to Determine Binding Mechanisms Lee A. Freiburger1, Anthony K. Mittermaier1, Karine Auclair1 1Department of Chemistry, McGill University JoVE 2529 Biology
Collecting Variable-concentration Isothermal Titration Calorimetry Datasets in Order to Determine Binding Mechanisms Lee A. Freiburger1, Anthony K. Mittermaier1, Karine Auclair1 1Department of Chemistry, McGill University JoVE 2529 Biology