Kevin R Brown Donnelly Centre University of Toronto Biography Publications Institution JoVE Articles Kevin R Brown has not added a biography. If you are Kevin R Brown and would like to personalize this page please email our Author Liaison for assistance. Publications CRISPR Screens Are Feasible in TP53 Wild-type Cells Molecular Systems Biology. Aug, 2019 | Pubmed ID: 31464370 Bmi1 Regulates Human Glioblastoma Stem Cells Through Activation of Differential Gene Networks in CD133+ Brain Tumor Initiating Cells Journal of Neuro-oncology. Jul, 2019 | Pubmed ID: 31115870 Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Reports. Apr, 2019 | Pubmed ID: 30970261 A Rapid in Vitro Methodology for Simultaneous Target Discovery and Antibody Generation Against Functional Cell Subpopulations Scientific Reports. Jan, 2019 | Pubmed ID: 30696911 Functional Genomic Characterization of a Synthetic Anti-HER3 Antibody Reveals a Role for Ubiquitination by RNF41 in the Anti-proliferative Response The Journal of Biological Chemistry. 01, 2019 | Pubmed ID: 30523157 Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma Cancer Research. Sep, 2018 | Pubmed ID: 29945963 RNAi Screen Identifies Essential Regulators of Human Brain Metastasis-initiating Cells Acta Neuropathologica. 12, 2017 | Pubmed ID: 28766011 Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens G3 (Bethesda, Md.). 08, 2017 | Pubmed ID: 28655737 Targeting the Centriolar Replication Factor STIL Synergizes with DNA Damaging Agents for Treatment of Ovarian Cancer Oncotarget. Apr, 2017 | Pubmed ID: 28423708 Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer Cell Reports. 03, 2017 | Pubmed ID: 28273451 Genome-wide CRISPR Screens Reveal a Wnt-FZD5 Signaling Circuit As a Druggable Vulnerability of RNF43-mutant Pancreatic Tumors Nature Medicine. Jan, 2017 | Pubmed ID: 27869803 An Oncogenic KRAS Transcription Program Activates the RHOGEF ARHGEF2 to Mediate Transformed Phenotypes in Pancreatic Cancer Oncotarget. Jan, 2017 | Pubmed ID: 27835861 Efficient Generation of Patient-matched Malignant and Normal Primary Cell Cultures from Clear Cell Renal Cell Carcinoma Patients: Clinically Relevant Models for Research and Personalized Medicine BMC Cancer. 07, 2016 | Pubmed ID: 27422173 System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes Molecular Cell. Apr, 2016 | Pubmed ID: 26949039 Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance Cell. Jan, 2016 | Pubmed ID: 26771497 High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities Cell. Dec, 2015 | Pubmed ID: 26627737 Genome-wide RNAi Analysis Reveals That Simultaneous Inhibition of Specific Mevalonate Pathway Genes Potentiates Tumor Cell Death Oncotarget. Sep, 2015 | Pubmed ID: 26353928 Identification of P450 Oxidoreductase As a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs Cancer Research. Oct, 2015 | Pubmed ID: 26297733 Measuring Error Rates in Genomic Perturbation Screens: Gold Standards for Human Functional Genomics Molecular Systems Biology. Jul, 2014 | Pubmed ID: 24987113 A Negative Genetic Interaction Map in Isogenic Cancer Cell Lines Reveals Cancer Cell Vulnerabilities Molecular Systems Biology. Oct, 2013 | Pubmed ID: 24104479 Integrated Genomic, Transcriptomic, and RNA-interference Analysis of Genes in Somatic Copy Number Gains in Pancreatic Ductal Adenocarcinoma Pancreas. Aug, 2013 | Pubmed ID: 23851435 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Identification of Novel ATP13A2 Interactors and Their Role in α-synuclein Misfolding and Toxicity Human Molecular Genetics. Sep, 2012 | Pubmed ID: 22645275 Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells Cancer Discovery. Feb, 2012 | Pubmed ID: 22585861 COLT-Cancer: Functional Genetic Screening Resource for Essential Genes in Human Cancer Cell Lines Nucleic Acids Research. Jan, 2012 | Pubmed ID: 22102578 A Comprehensive Platform for Highly Multiplexed Mammalian Functional Genetic Screens BMC Genomics. 2011 | Pubmed ID: 21548937 NAViGaTOR: Network Analysis, Visualization and Graphing Toronto Bioinformatics (Oxford, England). Dec, 2009 | Pubmed ID: 19837718 Unequal Evolutionary Conservation of Human Protein Interactions in Interologous Networks Genome Biology. 2007 | Pubmed ID: 17535438 Online Predicted Human Interaction Database Bioinformatics (Oxford, England). May, 2005 | Pubmed ID: 15657099 Объединенные ГЕНЕТИЧЕСКИе экраны на основе CRISPR в клетках млекопитающих Katherine Chan*1, Amy Hin Yan Tong*1, Kevin R Brown1, Patricia Mero1, Jason Moffat1,2,3 1Donnelly Centre, University of Toronto, 2Department of Molecular Genetics, University of Toronto, 3Institute for Biomaterials and Biomedical Engineering, University of Toronto JoVE 59780 Genetics
Объединенные ГЕНЕТИЧЕСКИе экраны на основе CRISPR в клетках млекопитающих Katherine Chan*1, Amy Hin Yan Tong*1, Kevin R Brown1, Patricia Mero1, Jason Moffat1,2,3 1Donnelly Centre, University of Toronto, 2Department of Molecular Genetics, University of Toronto, 3Institute for Biomaterials and Biomedical Engineering, University of Toronto JoVE 59780 Genetics